Hong Fan, Kun Zhang, Lequn Shan, Fang Kuang, Kun Chen, Keqing Zhu, Heng Ma, Gong Ju, Ya-Zhou Wang
BACKGROUND: A unique feature of the pathological change after spinal cord injury (SCI) is the progressive enlargement of lesion area, which usually results in cavity formation and is accompanied by reactive astrogliosis and chronic inflammation. Reactive astrocytes line the spinal cavity, walling off the lesion core from the normal spinal tissue, and are thought to play multiple important roles in SCI. The contribution of cell death, particularly the apoptosis of neurons and oligodendrocytes during the process of cavitation has been extensively studied...
February 3, 2016: Molecular Neurodegeneration