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Low Ovarian reserv

M G Favoreto, B Loureiro, R L Ereno, A G Pupulim, V Queiroz, Natieli Andrade da Silva, C M Barros
The number of antral follicles counted by ultrasound (AFC) is associated with fertility in cattle. Cows with higher follicle count (HFC) have higher performance in reproductive-assisted technologies than cows with lower follicle count (LFC). In this study, we aimed to define the preantral follicle count by histology and to identify differentially expressed genes (DEGs) using a microarray in Nelore and Angus heifers with HFC and LFC. The ovaries of each animal were scanned with an ultrasound device 12-24 hours after estrus...
December 8, 2018: Molecular Reproduction and Development
Nathalie Sermondade, Charlotte Sonigo, Christophe Sifer, Sophie Valtat, Marianne Ziol, Florence Eustache, Michaël Grynberg
OBJECTIVE: To assess whether serum antimüllerian hormone (AMH) levels and antral follicle count (AFC) can predict primordial follicle density within ovarian cortex and the number of oocytes cryopreserved after in vitro maturation (IVM). DESIGN: Retrospective analysis of a case series of patients. SETTING: University hospital. PATIENT(S): Fifty-four women, 18 to 35 years of age, with breast cancer who were candidates for fertility preservation (FP) using ovarian tissue cryopreservation (OTC) associated with oocyte vitrification after unstimulated IVM between July 2013 and December 2016...
December 6, 2018: Fertility and Sterility
Abulizi Keremu, Aziguli Yaoliwasi, Mayire Tuerhong, Nafeisha Kadeer, Heyi, Adilijiang Yiming, Xiamixinuer Yilike
The purposes of this study were to establish and to explore the biological basis of the chronic stress induced premature ovarian failure (POF) model, also to explore the therapeutic effects of the traditional Chinese medicine Munziq. Sexually matured female SD rats were fed with spinach and cilantro in cold and wet conditions for about 20 weeks, until a chronic stress (CS) model was established. CS rats were divided into POF stress model group and stress model group according to weekly biological characteristics and hormone level detection (LH, FSF and E2)...
December 4, 2018: Molecular Reproduction and Development
Hui Chen, Wanjun Jiang, Ge Lin, Guangxiu Lu, Fei Gong
STUDY OBJECTIVE: To investigate the effectiveness of Tornado and Hilal (Cook Medical, Bloomington, Indiana, USA) hysteroscopic proximal tubal occlusion (HPTO) for hydrosalpinx (HX) treatment prior to in vitro fertilization (IVF) and embryo transfer (ET) in patients with dense pelvic adhesions or low ovarian reserve. DESIGN: Retrospective study of patients treated between May 2014 and May 2016 (Canadian Task Force classification III). SETTING: University-affiliated center...
November 30, 2018: Journal of Minimally Invasive Gynecology
Gonzalo Oubiña, Natalia Pascuali, Leopoldina Scotti, Mariana Di Pietro, Florenza A La Spina, Mariano G Buffone, Javier Higuera, Dalhia Abramovich, Fernanda Parborell
It is known that LLLT has beneficial effects on several pathological conditions including wound healing, pain and inflammation. LLLT modulates biological processes, including cell proliferation, apoptosis and angiogenesis. In the present study, we examined the effect of local application of LLLT on follicular dynamics, ovarian reserve, AMH expression, progesterone levels, apoptosis, angiogenesis, and reproductive outcome in adult mice. LLLT (200 J/cm2 ) increased the percentage of primary and preantral follicles, whilst decreasing the percentage of corpora lutea compared to control ovaries...
November 27, 2018: Progress in Biophysics and Molecular Biology
Yvonne O'Brien, Caroline Kelleher, Mary Wingfield
RESEARCH QUESTION: Significant medical benefits could be derived from universal AMH screening for women in their mid to late twenties. We aimed to investigate the psychological and emotional responses of women to being informed of their anti-Mullerian hormone (AMH) result with a view to informing the possible introduction of universal AMH screening. MATERIALS AND METHODS: This was a prospective qualitative study using semi-structured in-depth interviews of women attending a reproductive medicine clinic who had ovarian reserve testing performed via measurement of serum AMH levels, as part of their gynecological investigations...
November 29, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
Xing Ke, Lisong Shen
Epithelial ovarian cancer (EOC) is one of the major malignant cancers with high rates of early metastasis in which regulatory T cells (Tregs) play an important role. Tregs suppress immune responses and promote the development of tumours in patients with EOC. However, the underlying mechanisms remain unclear. In this study, we found higher levels of CD4+ CD25high CD127low Tregs in patients with EOC than in patients with benign ovarian tumours and healthy donors. The immune inhibitory effect of Tregs functions by maintaining high levels of immunosuppressive cytokines in EOC...
November 28, 2018: Scandinavian Journal of Immunology
Michael von Wolff
Natural Cycle IVF (NC-IVF) with and without modifications is being increasingly performed. NC-IVF and conventional gonadotropin-stimulated IVF (cIVF) should not be understood as competing treatments, but as complementary treatments with different target groups and to some extent other indications. NC-IVF is particularly interesting for couples who wish to save money, wish a treatment with as few risks as possible and for women who would like to avoid selection and cryopreservation of embryos. NC-IVF therefore contributes to the concept of individualized and patient-oriented therapy...
November 9, 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
Oliver Klein, Frederic Kanter, Hagen Kulbe, Paul Jank, Carsten Denkert, Grit Nebrich, Wolfgang D Schmitt, Zhiyang Wu, Catarina A Kunze, Jalid Sehouli, Silvia Darb-Esfahani, Ioana Braicu, Jan Lellmann, Herbert Thiele, Eliane T Taube
PURPOSE: Precise histological classification of epithelial ovarian cancer (EOC) has immanent diagnostic and therapeutic consequences, but remains challenging in histological routine. The aim of this pilot study was to examine the potential of MALDI-Imaging mass spectrometry in combination with machine learning methods to classify EOC histological subtypes from tissue microarray. EXPERIMENTAL DESIGN: Formalin-fixed-paraffin-embedded tissue of 20 patients with ovarian clear-cell, 14 low-grade serous, 19 high-grade serous ovarian carcinomas and 14 serous borderline tumors were analysed using MALDI-Imaging...
November 24, 2018: Proteomics. Clinical Applications
Adam F Summers, Shelby L Rosasco, Eric J Scholljegerdes
Profitability of beef cattle producers can be directly tied to the productive lifespan of a cow. Management decisions influencing heifer nutrition and reproduction play a key role in establishing heifer fertility and longevity. Altering feeding strategies to utilize compensatory growth has been reported to have a positive influence on fertility during the first breeding season; however, there are discrepancies in the literature as to the impact this strategy may have on the proportion of heifers attaining puberty prior to entering their first breeding season...
November 20, 2018: Journal of Animal Science
Diana Zamora-Gutiérrez, Adrian Guzmán, Cyndi G Hernández-Coronado, Héctor Castillo-Juárez, Francisco Fierro, Carlos G Gutiérrez, Rafael Bojalil, Ana Ma Rosales-Torres
In the present study we investigated the temporal relationship between angiogenic and anti-angiogenic vascular endothelial growth factor isoforms (VEGFxxxa and VEGFxxxb respectively), the receptors VEGFR1 and VEGFR2, their soluble forms, and the kinases and the splicing factors regulating the synthesis of VEGF isoforms in healthy and atretic antral follicles. The results show a higher (P<0.05) mRNA expression of VEGF120a, VEGF164a and VEGF120b in healthy than in atretic follicles, but the mRNA expression of VEGF164b was not detected...
November 15, 2018: Molecular Reproduction and Development
Ming-Chao Huang, Shu-Ling Tzeng, Chun-I Lee, Hsiu-Hui Chen, Chun-Chia Huang, Tsung-Hsien Lee, Maw-Sheng Lee
This retrospective analysis compared the efficiency of the gonadotropin- releasing hormone (GnRH) antagonist (GnRH-ant) protocol and the GnRH agonist long (GnRH-a) protocol for patients with diminished ovarian reserve (DOR). A total of 1,233 patients with DOR (anti-Mullerian hormone <1.1 ng/mL) were recruited for this retrospective case-control study. They were divided into two groups according to female age. Younger patients were assigned to POSEIDON group3 (PG3: age ≤35 years); older patients were assigned to POSEIDON group 4 (PG4: age >35 years)...
2018: PloS One
Carlo Alviggi, Alessandro Conforti, Sandro C Esteves, Roberta Vallone, Roberta Venturella, Sonia Staiano, Emanuele Castaldo, Claus Yding Andersen, Giuseppe De Placido
Hypo-responsiveness to controlled ovarian stimulation is an undervalued topic in reproductive medicine. This phenomenon manifests as a low follicles output rate (FORT) with a discrepancy between the relatively low number of pre-ovulatory follicles which develop following ovarian stimulation as compared to the number of antral follicles available at the start of stimulation. The pathophysiology mechanisms explaining the ovarian resistance to gonadotropin stimulation are not fully understood, but the fact that both hypo-responders and normal responders share similar phenotypic characteristics suggests a genotype-based mechanism...
2018: Frontiers in Endocrinology
Jussara Maria Gonçalves, Carolina Amália Barcellos Silva, Elena Riet Correa Rivero, Mabel Mariela Rodríguez Cordeiro
Over the past years, studies have described that users of antipsychotics are less likely to develop cancer than the population in general due to cytotoxic properties of this class of drugs on cancer cells. For this reason, Pimozide has been widely studied as a potential anticancer treatment, and satisfactory results in Melanoma, Central Nervous System Tumors, Osteosarcoma, Neuroblastoma, Myeloproliferative Neoplasms, Breast, Lung, Prostate, Ovarian, Colorectal, Pancreatic, and Hepatocellular Carcinoma have been showed...
November 1, 2018: Clinical and Experimental Pharmacology & Physiology
Tuan Zea Tan, Valerie Heong, Jieru Ye, Diana Lim, Jeffrey Low, Mahesh Choolani, Clare Scott, David Shao Peng Tan, Ruby Yun-Ju Huang
The evaluation of intra-tumour heterogeneity (ITH) from a transcriptomic point of view is limited. Single-cell cancer studies reveal significant genomic and transcriptomic ITH within a tumour and it is no longer adequate to employ single-subtype assignment as this does not acknowledge the ITH that exists. Molecular assessment of subtype heterogeneity (MASH) was developed to comprehensively report on the composition of all transcriptomic subtypes within a tumour lesion. Using MASH on 3,431 ovarian cancer samples, correlation and association analyses with survival, metastasis, and clinical outcomes were performed to assess the impact of subtype composition as a surrogate for ITH...
October 30, 2018: Journal of Pathology
María Jesús López Martín, Désirée García, Rita Vassena, Amelia Rodríguez
RESEARCH QUESTION: Is higher antral follicle count (AFC) in healthy young women associated with higher oocyte developmental competence? DESIGN: Retrospective study of 1985 first oocyte donation cycles, corresponding to 3210 fresh embryo transfers in oocyte recipients, conducted between January 2010 and May 2014. RESULTS: Donors with higher AFC who underwent ovarian stimulation, produced both more cumulus-oocyte complexes (COC) (B coefficient = 0...
December 2018: Reproductive Biomedicine Online
Juan José Hidalgo, Francisco Ros, María Aubá, Tania Errasti, Begoña Olartecoechea, Álvaro Ruiz-Zambrana, Juan Luis Alcázar
OBJECTIVES: To perform the external validation of the three-step strategy proposed by the International Ovarian Tumor Analysis Group to evaluate its diagnostic performance for classifying adnexal masses as benign or malignant, when ultrasound is performed by non-expert sonographers. As secondary objective, to assess the diagnostic performance of an alternative strategy using Simple Rules Risk as second step instead of Simple Rules. METHODS: Prospective observational study conducted from September 2015 to August 2017 in two university hospitals including a consecutive series of patients diagnosed as having an adnexal mass...
October 24, 2018: Ultrasound in Obstetrics & Gynecology
Linyuan Wang, Peter F Rambau, Linda E Kelemen, Michael S Anglesio, Samuel Leung, Aline Talhouk, Martin Köbel
AIMS: Ovarian endometrioid carcinoma (EC) generally has a good prognosis. Adjuvant chemotherapy can be spared in low stage disease, but prognostic biomarkers are needed to refine the treatment threshold. Wnt/β-catenin signaling is commonly altered in EC. We examined immunohistochemical expression of nuclear β-catenin and CDX2, both are mediators of the Wnt pathway, as prognostic biomarkers for EC. METHODS AND RESULTS: We evaluated two ovarian EC cohorts, discovery set (N=183) and validation set (N=174), with ovarian cancer-specific survival (OCSS) as the primary end-point...
October 16, 2018: Histopathology
Omar Sefrioui, Aicha Madkour, Smahane Aboulmaouahib, Ismail Kaarouch, Noureddine Louanjli
Circulating anti-müllerian hormone (AMH) and antral follicle count (AFC) are the best predictors of IVF outcomes. However, in extreme low AMH range especially for young patients, AMH prediction power loose its specificity to give real idea of pregnancy chance with IVF treatments and good prognosis of an extremely reduced ovarian reserve and expected poor response. Indeed, this retrospective study was conducted to evaluate IVF outcomes in patients following IVF-ICSI program with extremely low AMH levels (≤0...
October 16, 2018: Gynecological Endocrinology
Iñaki González-Foruria, Francisca Martínez, Jorge Rodríguez-Purata, Marta Ballester, Verónica Alonso-Mosquera, Rosario Buxaderas, Ignacio Rodríguez, Buenaventura Coroleu
Anti-Müllerian hormone (AMH) is a useful biomarker to predict the ovarian response to controlled ovarian stimulation (COS) for IVF. However, currently there is a lack of evidence for the role of ovarian reserve markers when there is no need of COS. The aim of this study was to evaluate the usefulness of AMH to predict the outcomes of donor sperm insemination cycles in non-infertile women. A retrospective study including 139 healthy women, who underwent 348 intrauterine insemination (IUI) cycles with donor sperms under the stimulated or natural cycles, was conducted...
October 16, 2018: Gynecological Endocrinology
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