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Low Ovarian reserv

Linyuan Wang, Peter F Rambau, Linda E Kelemen, Michael S Anglesio, Samuel Leung, Aline Talhouk, Martin Köbel
AIMS: Ovarian endometrioid carcinoma (EC) generally has a good prognosis. Adjuvant chemotherapy can be spared in low stage disease, but prognostic biomarkers are needed to refine the treatment threshold. Wnt/β-catenin signaling is commonly altered in EC. We examined immunohistochemical expression of nuclear β-catenin and CDX2, both are mediators of the Wnt pathway, as prognostic biomarkers for EC. METHODS AND RESULTS: We evaluated two ovarian EC cohorts, discovery set (N=183) and validation set (N=174), with ovarian cancer-specific survival (OCSS) as the primary end-point...
October 16, 2018: Histopathology
Omar Sefrioui, Aicha Madkour, Smahane Aboulmaouahib, Ismail Kaarouch, Noureddine Louanjli
Circulating anti-müllerian hormone (AMH) and antral follicle count (AFC) are the best predictors of IVF outcomes. However, in extreme low AMH range especially for young patients, AMH prediction power loose its specificity to give real idea of pregnancy chance with IVF treatments and good prognosis of an extremely reduced ovarian reserve and expected poor response. Indeed, this retrospective study was conducted to evaluate IVF outcomes in patients following IVF-ICSI program with extremely low AMH levels (≤0...
October 16, 2018: Gynecological Endocrinology
Iñaki González-Foruria, Francisca Martínez, Jorge Rodríguez-Purata, Marta Ballester, Verónica Alonso-Mosquera, Rosario Buxaderas, Ignacio Rodríguez, Buenaventura Coroleu
Anti-Müllerian hormone (AMH) is a useful biomarker to predict the ovarian response to controlled ovarian stimulation (COS) for IVF. However, currently there is a lack of evidence for the role of ovarian reserve markers when there is no need of COS. The aim of this study was to evaluate the usefulness of AMH to predict the outcomes of donor sperm insemination cycles in non-infertile women. A retrospective study including 139 healthy women, who underwent 348 intrauterine insemination (IUI) cycles with donor sperms under the stimulated or natural cycles, was conducted...
October 16, 2018: Gynecological Endocrinology
Yajie Chang, Jingjie Li, Xiaolan Li, Hong'e Liu, Xiaoyan Liang
BACKGROUND This study investigated the quality and quantity of eggs and embryos as well as the clinical pregnancy outcome in young infertile women with diminished ovarian reserve (DOR) after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). MATERIAL AND METHODS We retrospectively reviewed records of 4285 infertile women and divided them into 3 groups according to age and ovarian reserve: young women with normal ovarian reserve (n=1695), young women with DOR (n=1121), and older women with DOR (n=1469)...
October 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Amy L Winship, Sarah E Gazzard, Luise A Cullen-McEwen, John F Bertram, Karla J Hutt
The ovarian reserve of primordial follicle oocytes is formed during in utero development and represents the entire supply of oocytes available to sustain female fertility. Maternal undernutrition during pregnancy and lactation diminishes offspring ovarian reserve in rats. In mice, maternal oocyte maturation is also susceptible to undernutrition, causing impaired offspring cardiovascular function. We aimed to determine whether programming of the ovarian reserve is impacted in offspring when maternal undernutrition extends from preconception oocyte development through to weaning...
October 1, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Shiran Yakovi, Ido Izhaki, Moshe Ben-Ami, Johnny S Younis
The pathophysiology of the genuine empty follicle syndrome (EFS) is still debated. Ovarian aging has been contested as a cause of this condition. Our aim was to investigate the occurrence of the genuine EFS in cases of a low number of mature follicles in a prospective manner. Ninety-five infertile women were recruited and evaluated following conventional controlled ovarian stimulation (COS) with ≤ six follicles of ≥14 mm diameter on the day of hCG administration. Enrolled women were 37.5 ± 5...
October 10, 2018: Gynecological Endocrinology
M Candiani, J Ottolina, E Posadzka, S Ferrari, L M Castellano, I Tandoi, L Pagliardini, A Nocun, R Jach
STUDY QUESTION: Does CO2 laser vaporization offer better results in treating endometrioma in terms of ovarian reserve preservation compared to traditional cystectomy? SUMMARY ANSWER: Assessing both antral follicle count (AFC) and serum anti-Müllerian hormone (AMH) levels as measures of ovarian reserve, the results suggest that CO2 technology may be an alternative treatment for endometrioma, causing minimal damage to adjacent healthy ovarian tissue. WHAT IS KNOWN ALREADY: Excisional surgery has been questioned as an ideal surgical approach for endometriomas because it is associated with potential reduction of ovarian reserve...
October 9, 2018: Human Reproduction
Keisuke Koyama, Takeshi Koyama, Masahito Sugimoto
Ovarian reserve in cattle can be predicted by an indicator, the antral follicle count (AFC), which is easily determined via ovarian ultrasonography. However, the repeatability of AFC measurements in the same individual taken approximately 1 year apart after first parity remains unclear. This study, thus, aimed to clarify the between-lactation repeatability of AFC after first parity in dairy cows. We measured the AFC of the same individual cows consecutively across both first and second parity, both second and third parity, and both third and fourth parity in 31, 37, and 26 heads, respectively...
October 9, 2018: Journal of Reproduction and Development
Sobenna A George, Rebecca Williamson Lewis, David A Schirmer, Karen E Effinger, Jessica B Spencer, Ann C Mertens, Lillian R Meacham
PURPOSE: Current guidelines recommend screening at-risk childhood cancer survivors for ovarian dysfunction using follicle-stimulating hormone (FSH). However, FSH identifies diminished ovarian reserve (DOR), a component of ovarian dysfunction, in the later stages when fertility preservation is less likely to succeed. This analysis evaluates the utility of anti-Mullerian hormone (AMH) for the assessment of DOR in adolescent and young adult (AYA)-aged survivors of childhood cancer. METHODS: A retrospective chart review of 13- to 21-year-old female survivors who received gonadotoxic therapy and were ≥2 years off therapy was performed...
October 3, 2018: Journal of Adolescent and Young Adult Oncology
Rossana Di Paola, Simone Garzon, Sara Giuliani, Antonio Simone Laganà, Marco Noventa, Francesca Parissone, Carlotta Zorzi, Ricciarda Raffaelli, Fabio Ghezzi, Massimo Franchi, Stefano Zaffagnini
PURPOSE: To evaluate the potential application of a nomogram based on woman's age and ovarian reserve markers as a tool to optimize the follicle-stimulating hormone (FSH) starting dose in intrauterine insemination (IUI) cycles. METHODS: We conducted a retrospective analysis enrolling 179 infertile women undergoing controlled ovarian stimulation (COS), followed by IUI. Each woman received an FSH starting dose according to clinical decision. After collecting data about COS and IUI procedures, we calculated the FSH starting dose according to the nomogram...
November 2018: Archives of Gynecology and Obstetrics
Benjamin P Jones, Paul Serhal, Jara Ben Nagi
We read with interest the response to our commentary on social egg freezing (SEF), by Levin et al 2018. We are encouraged to have proponents to our belief that single women should consider freezing their oocytes before the exponential decline in their ovarian reserve. We concur that there is irrefutable evidence demonstrating the clinical implications, including low response to controlled ovarian stimulation, of the exponential age related decline in ovarian reserve from the age of 37 onwards. This article is protected by copyright...
September 19, 2018: Acta Obstetricia et Gynecologica Scandinavica
Konstantin Weber-Lassalle, Philipp Harter, Jan Hauke, Corinna Ernst, Stefan Kommoss, Frederik Marmé, Nana Weber-Lassalle, Katharina Prieske, Dimo Dietrich, Julika Borde, Esther Pohl-Rescigno, Alexander Reuss, Beyhan Ataseven, Christoph Engel, Julia C Stingl, Rita K Schmutzler, Eric Hahnen
The Li-Fraumeni cancer predisposition syndrome (LFS1) presents with a variety of tumor types and the TP53 gene is covered by most diagnostic cancer gene panels. We demonstrate that deleterious TP53 variants identified in blood-derived DNA of 523 patients with ovarian cancer (AGO-TR1 trial) were not causal for the patients' ovarian cancer in three out of six TP53-positive cases. In three out of six patients, deleterious TP53 mutations were identified with low variant fractions in blood-derived DNA but not in the tumor of the patient seeking advice...
September 14, 2018: Human Mutation
Ann-Lisbeth Liest, Ahmed Shaker Omran, Rasmus Mikiver, Per Rosenberg, Srinivas Uppugunduri
INTRODUCTION: Our primary objective was to test the hypothesis that human epididymal protein 4 (HE4) and risk of ovarian malignancy index (ROMA) outperform CA125 and risk of malignancy index (RMI) in categorizing a pelvic mass into high or low risk of malignancy in a Swedish population. Further, cut off values needed to be defined for HE4 and ROMA in pre- and postmenopausal women prior to introduction into clinical practice. A tertiary objective was to investigate the correlation between HE4 levels in serum and urine...
September 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
Emma Gargus, Rebecca Deans, Antoinette Anazodo, Teresa K Woodruff
Cancer treatments can damage the ovaries, causing primary ovarian insufficiency (POI), a condition associated with numerous sequelae that impact long-term quality of life. This article systematically reviews the literature on the prevalence, surveillance, and treatment of POI in survivors of pediatric and adolescent and young adult (AYA) cancers. A systematic review of the literature was conducted in January 2018 through a search of Medline, Embase, Web of Science, and SCOPUS, alongside the screening of relevant reference lists...
September 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Sandro C Esteves, Matheus Roque, Giuliano M Bedoschi, Alessandro Conforti, Peter Humaidan, Carlo Alviggi
Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. Indeed, clinical trials using the current standards to define POR failed to show evidence in favor of a particular treatment modality. Furthermore, critical factors for reproductive success, such as the age-dependent embryo aneuploidy rates and the intrinsic ovarian resistance to gonadotropin stimulation, are not taken into consideration by the current POR criteria...
2018: Frontiers in Endocrinology
Alisha Evans, Sheryl de Lacey, Kelton Tremellen
The aim of this study is to determine Australians' understanding of the decline in fertility with age, social determinants that influence their decision to start a family and attitudes towards ovarian reserve screening as a tool allowing personalised reproductive life planning. An online survey of 383 childless Australian men and women, aged 18-45 years, was conducted. Both sexes overestimated natural and in vitro fertilization (IVF)-assisted fertility potential with increasing age, with the magnitude of overestimation being more pronounced for men and IVF treatment compared with natural conception...
August 30, 2018: Australian Journal of Primary Health
Qiu-Yue Zhai, Wei Ge, Jun-Jie Wang, Xiao-Feng Sun, Jin-Mei Ma, Jing-Cai Liu, Yong Zhao, Yan-Zhong Feng, Paul W Dyce, Massimo De Felici, Wei Shen
Zinc oxide nanoparticles (nZnO) have been shown to have higher toxic effects likely due to their ion-shedding ability and low solubility under neutral conditions. In order to investigate whether exposure to nZnO during embryonic development affects ovary development, 12.5 day post coitum (dpc) fetal mouse ovaries were cultured in the presence of nZnO for 6 days. We found that the nanoparticles (NPs) accumulated within the oocyte cytoplasm in a dose dependent manner, caused DNA damage and apoptosis, and result in a significant decrease in oocyte numbers...
August 28, 2018: Aging
Juan Enrique Schwarze, Johana Canales, Javier Crosby, Carolina Ortega-Hrepich, Sonia Villa, Ricardo Pommer
The aim of this review is to determine if the use of DHEA increases the likelihood of success in patients with POR. We searched MEDLINE and EMBASE using the terms "DHEA and diminished ovarian reserve", "DHEA and poor response", "DHEA and premature ovarian aging". A fixed effects model was used and Peto's method to get the odds ratio (OR) with 95% confidence intervals (CI 95%). For quantitative variables, Cohen's method was used to present the standardized mean differences (SMD) with their corresponding confidence intervals...
August 20, 2018: JBRA Assisted Reproduction
Fangfang Zhu, Xinxin Xu, Beibei Shi, Linchai Zeng, Luhui Wang, Xueqing Wu, Haiyan Zhu
OBJECTIVE: To evaluate the prognostic impact of preoperative plasma lipid profile, glucose, and body mass index in patients with ovarian cancer. METHODS: A retrospective study was performed among women with ovarian cancer who underwent surgical resection between January 1, 2001, and December 1, 2015, at the First Affiliated Hospital of Wenzhou Medical University, China. Data were evaluated using Cox regression analyses, Kaplan-Meier survival analysis and landmark survival analysis...
November 2018: International Journal of Gynaecology and Obstetrics
Caroline R Juneau, Jason M Franasiak, Linnea R Goodman, Diego Marin, Katherine Scott, Scott J Morin, Shelby A Neal, Jeffrey E Juneau, Richard T Scott
OBJECTIVE: To study the prevalence of celiac disease in the infertile population undergoing in vitro fertilization (IVF) and assess outcomes. DESIGN: Prospective cohort study. SETTING: A single infertility center from January 2016 to March 2017. PATIENT(S): Women 18-45 years of age participating in IVF. INTERVENTION(S): Patients had serum tissue transglutaminase (tTG) and endomysial (EMA) IgA testing to screen for celiac disease and completed a 10-question "yes or no" survey to assess their medical history, previous testing, dietary habits, and pertinent symptoms...
August 2018: Fertility and Sterility
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