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Bernhard Wilhelm Ullrich, Philipp Schenk, Ulrich J Spiegl, Thomas Mendel, Gunther Olaf Hofmann
STUDY DESIGN: A retrospective, longitudinal cohort study. OBJECTIVE: The purpose of this study was to examine whether Hounsfield units (HUs), as an alternative bone mineral density measurement to dual-energy X-ray absorptiometry and quantitative computed tomography, which lead to additional radiation exposure for patients, has an effect on the maintenance of reduction in bisegmental Cobb angle (CA) and cage subsidence in patients who receive bisegmental spine stabilization after traumatic thoracolumbar spine fractures...
October 19, 2018: European Spine Journal
Zhiliang He, Min Jia, Youjia Yu, Chao Yuan, Jian Wang
Stem cells transplantation has shown considerable promise in intervertebral disc repair and low-back pain release. Cartilage endplate stem cells (CESCs) also showed potential for nucleus pulposus (NP) regeneration in a rabbit disc degeneration model, the precise mechanism was unclear. Here we investigated the effects of CESCs on NP cells (NPCs) proliferation and the mechanism in vitro. CESCs and NPCs were isolated from surgical specimens of degenerative human lumbar disc. NPCs were co-cultured with CESCs at a 1:1 ratio or cultured in CESCs conditioned medium (CESCs-CM)...
October 16, 2018: Biochemical and Biophysical Research Communications
David Christopher Kieser, Derek Thomas Cawley, Takashi Fujishiro, Celeste Tavolaro, Simon Mazas, Louis Boissiere, Ibrahim Obeid, Vincent Pointillart, Jean Marc Vital, Olivier Gille
Study Design: Retrospective, longitudinal observational study. Purpose: To describe the natural history of anterior bone loss (ABL) in cervical disc arthroplasty (CDA) and introduce a classification system for its assessment. Overview of Literature: ABL has recently been recognized as a complication of CDA, but its cause and clinical effects remain unknown. Methods: Patients with non-keeled CDA (146) were retrospectively reviewed...
October 18, 2018: Asian Spine Journal
Qi Liu, Xiaomeng Wang, Yue Hua, Ganggang Kong, Xiuhua Wu, Zhiping Huang, Zucheng Huang, Junhao Liu, Zhou Yang, Qingan Zhu
STUDY DESIGN: An experimental animal study of osteoporosis and intervertebral disc degeneration. OBJECTIVES: The aim of this study was to clarify the effects of estrogen deficiency and supplement on cervical intervertebral disc degeneration (IDD) induced by bilateral facetectomy in rats. SUMMARY OF BACKGROUND DATA: The relationship between intervertebral disc degeneration (IDD) and osteoporosis (OP) are still controversy with the wide prevalence in aged people...
October 15, 2018: Spine
Weera Chaiyamongkol, Apipop Kritsaneephaiboon, Piyawat Bintachitt, Sitthiphong Suwannaphisit, Boonsin Tangtrakulwanich
Study Design: Biomechanical study. Purpose: To investigate the relative stiffness of a new posterior pelvic fixation for unstable vertical fractures of the sacrum. Overview of Literature: The reported operative fixation techniques for vertical sacral fractures include iliosacral screw, sacral bar fixations, transiliac plating, and local plate osteosynthesis. Clinical as well as biomechanical studies have demonstrated that these conventional techniques are insufficient to stabilize the vertically unstable sacral fractures...
October 16, 2018: Asian Spine Journal
Julien Galley, Federico Balagué
Purpose: Thirty years ago, we reported that parallel aspect of the L5-S1 disc on a lateral view of the spine might be considered to be an initial stage of disk degeneration. The current study represents an attempt to increase the validity of parallel sign on conventional radiograph using MR real T1 mapping. Methods: Forty-four young asymptomatic volunteers (mean age 21.6 ± 2.3) underwent lumbar spine MRI, twice the same day, morning and afternoon. Dedicated sequences using the inversion-recovery technique were used to calculate the T1 relaxation time...
September 27, 2018: Journal of the Belgian Society of Radiology
Olutoyin A Olutoye, Stephanie M Cruz, Adesola C Akinkuotu, Fariha Sheikh, Irving J Zamora, Ling Yu, Adekunle M Adesina, Oluyinka O Olutoye
BACKGROUND: Studies demonstrating an association between anesthesia and brain cell death (neuroapoptosis) in young animals were performed without accompanying surgery. This study tests the hypothesis that fetal surgery decreases anesthesia-induced neuroapoptosis. MATERIALS AND METHODS: Seventy-day-pregnant ewes received 2% isoflurane for 1 h (low dose [LD]) or 4% for 3 h (high dose [HD]) with or without fetal surgery (S). Unexposed fetuses served as controls (C)...
October 12, 2018: Fetal Diagnosis and Therapy
Guanghui Chen, Mengchen Yin, Weibo Liu, Jian Wang, Jing Wang, Xin Gao, Guangjian Bai, Ge Liu, Yiwei Hu, Yang Wang, Chao Liu, Li Cheng, Jianru Xiao, Tielong Liu
BACKGROUND: Reconstruction of thoracolumbar structural stability is a formidable challenge for spine surgeons after vertebral body tumor resection. Various disadvantages of the currently used expandable or non-expandable cages have limited their clinical applications. OBJECTIVE: To develop a novel prosthesis for clinical use and assess its preliminary clinical outcome in reconstruction of thoracolumbar structural stability after spinal tumor resection. METHODS: Based on the data obtained from a retrospective analysis of the morphological characteristics of the thoracolumbar vertebrae and endplates in previously published articles, we modified the nano hydroxyapatite/polyamide-66 (n-HA/PA66) strut into a novel height adjustable vertebral body...
October 8, 2018: World Neurosurgery
Ramon Margalef, Marc Sisquella, Marc Bosque, Clara Romeu, Orlando Mayoral, Sonia Monterde, Mercedes Priego, Rafael Guerra-Perez, Nicolau Ortiz, Josep Tomas, Manel M Santafe
Myofascial pain syndrome is one of the most common forms of muscle pain. In this syndrome pain is originated by the so-called trigger points, which consists of a set of palpable contraction knots in the muscle. It has been proposed that a high spontaneous neurotransmission may be involved in the generation of these contraction knots. To confirm this hypothesis, we exposed mouse muscles to an anticholinesterasic agent to increase the neurotransmision in the synaptic cleft in two different conditions, in vivo and ex vivo experiments...
October 11, 2018: Journal of Applied Physiology
Marco Brayda-Bruno, Domenico Albano, Guglielmo Cannella, Fabio Galbusera, Alberto Zerbi
PURPOSE: The aims of the study were to introduce a classification scheme for endplate lesions based on T2-weighted magnetic resonance imaging and to detect possible associations between endplate lesions and other variables such as age, sex, disc degeneration and Modic changes in a large population. METHODS: MRI images of 996 low back pain patients were collected. All intervertebral spaces were classified as "normal", "wavy/irregular", "notched", "Schmorl's node" and "fracture"...
October 10, 2018: European Spine Journal
Yì Xiáng J Wáng, Min Deng, Lai-Chang He, Nazmi Che-Nordin, Fernando Ruiz Santiago
Despite years' research, the radiographic criteria for osteoporotic vertebral fracture and its grading remain debated. The importance of identifying vertebral endplate/cortex fracture (ECF) is being recognised; however, evaluation of osteoporotic ECF requires training and experience. This article aims to serve as a teaching material for radiologists/physicians or researchers to evaluate osteoporotic ECF. Emphasis is particularly dedicated to identifying ECF that may not be associated with apparent vertebral body collapse...
October 2018: Journal of Orthopaedic Translation
Carlos Ruiz Wills, Baptiste Foata, Miguel Á González Ballester, Jaro Karppinen, Jérôme Noailly
Altered cell nutrition in the intervertebral disk (IVD) is considered a main cause for disk degeneration (DD). The cartilage endplate (CEP) provides a major path for the diffusion of nutrients from the peripheral vasculature to the IVD nucleus pulposus (NP). In DD, sclerosis of the adjacent bony endplate is suggested to be responsible for decreased diffusion and disk cell nutrition. Yet, experimental evidence does not support this hypothesis. Hence, we evaluated how moderate CEP composition changes related to tissue degeneration can affect disk nutrition and cell viability...
2018: Frontiers in Physiology
Emiliano Trias, Peter H King, Ying Si, Yuri Kwon, Valentina Varela, Sofía Ibarburu, Mariángeles Kovacs, Ivan C Moura, Joseph S Beckman, Olivier Hermine, Luis Barbeito
Neuroinflammation is a recognized pathogenic mechanism underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS), but the inflammatory mechanisms influencing peripheral motor axon degeneration remain largely unknown. A recent report showed a pathogenic role for c-Kit-expressing mast cells mediating inflammation and neuromuscular junction denervation in muscles from SOD1G93A rats. Here, we have explored whether mast cells infiltrate skeletal muscles in autopsied muscles from ALS patients. We report that degranulating mast cells were abundant in the quadriceps muscles from ALS subjects but not in controls...
October 4, 2018: JCI Insight
Zhenjun Zhang, Guy R Fogel, Zhenhua Liao, Yitao Sun, Xuejun Sun, Weiqiang Liu
BACKGROUND: Lumbar spinal fusion in the interbody space is augmented with interbody fusion cages to provide structural support while arthrodesis occurs. Subsidence is a serious complication of interbody fusion. However, the biomechanical influence of anterior longitudinal ligament (ALL) and pedicle screws on subsidence has not been fully understood. OBJECTIVE: To investigate biomechanical effects of the hyperlordotic cages in different surgical conditions using finite element analysis...
2018: Bio-medical Materials and Engineering
William C Tally, H Thomas Temple, T Y Subhawong, Timothy Ganey
Background: When conservative treatments fail to alleviate the discomfort of abnormal motion, spinal fusion has been shown to provide symptomatic treatment for spinal instability, stenosis, spondylolisthesis, and symptomatic degenerative disc disease. The trend and rates of fusion over the past few years have been dramatic in the United States. Accompanying that higher incidence has been the shifting from traditional open surgery to minimally invasive techniques to reduce scar tissue formation, extent of muscle stripping, and muscle retraction which all have been shown to adversely affect outcomes...
January 2018: International Journal of Spine Surgery
Ana Manuela de Azevedo, Ana Paula Losada, Andrés Barreiro, Sonia Vázquez, María Isabel Quiroga
Skeletal anomalies affect animal welfare and cause important economic problems in aquaculture. Despite the high frequency of skeletal problems in reared Solea senegalensis, there is lack of information regarding the histological features of normal and deformed vertebrae in this flatfish. The aim of this study was to describe the histopathological and radiographical appearance of vertebral body anomalies. Sixty-seven juvenile fish were radiographically examined 104 or 105 days after hatching. Through radiographic images, vertebral segments were selected and processed for histopathological examination from 7 normal and 7 affected fish...
October 3, 2018: Veterinary Pathology
Michael Conti Mica, Leonard I Voronov, Gerard Carandang, Robert M Havey, Bartosz Wojewnik, Avinash G Patwardhan
Background: A novel expandable lumbar interbody fusion cage has been developed which allows for a broad endplate footprint similar to an anterior lumbar interbody fusion; however, it is deployed from a minimally invasive transforaminal unilateral approach. The perceived benefit is a stable circumferential fusion from a single approach that maintains the anterior tension band of the anterior longitudinal ligament. The purpose of this biomechanics laboratory study was to evaluate the biomechanical stability of an expandable lumbar interbody cage inserted using a transforaminal approach and deployed in situ compared to a traditional lumbar interbody cage inserted using an anterior approach (control device)...
August 2018: International Journal of Spine Surgery
Pierce D Nunley, David A Cavanaugh, Eubulus J Kerr, Phillip Andrew Utter, Peter G Campbell, Kelly A Frank, Kyle E Marshall, Marcus B Stone
Background: Heterotopic ossification (HO) is a known risk following cervical total disc replacement (CTDR) surgery, but the cause and effect of HO are not well understood. Reported HO rates vary, and few studies are specifically designed to report HO. The effects on outcomes, and the risk factors for the development of HO have been hypothesized and reported in small-population, retrospective analyses, using univariate statistics. Methods: Posthoc, multiple-phase analysis of radiographic, clinical, and demographic data for CTDR as it relates to HO was performed...
June 2018: International Journal of Spine Surgery
Sarah Klatzkow, Matthew D Johnson, Michele James, Sheila Carrera-Justiz
An 8-year-old neutered male miniature Poodle presented for evaluation of a suspected T3-L3 lesion with cervical component following vehicular trauma. Magnetic resonance imaging and computed tomography revealed a T2-T3 luxation with right displacement of T3. A T2 caudal endplate fracture was present as well as multifocal noncompressive bulges of cervical intervertebral discs. Conservative management failed and ventral stabilization of C7-T4 was performed via a median sternotomy. Paired String-of-Pearls plates were placed on the ventral aspect of vertebrae...
2018: Case reports in veterinary medicine
Eduardo de Paula Estephan, Antonio Alberto Zambon, Paulo Eurípedes Marchiori, André Macedo Serafim da Silva, Vitor Marques Caldas, Cristiane Araújo Martins Moreno, Umbertina Conti Reed, Rita Horvath, Ana Töpf, Hanns Lochmüller, Edmar Zanoteli
Mutations in RAPSN are an important cause of congenital myasthenic syndrome (CMS), leading to endplate acetylcholine receptor deficiency. We present three RAPSN early-onset CMS patients (from a Brazilian cohort of 61 CMS patients). Patient 1 and patient 2 harbor the mutation p.N88K in homozygosity, while patient 3 harbors p.N88K in compound heterozygosity with another pathogenic variant (p.V165M; c.493G ≥ A). At onset, patient 3 presented with more severe symptoms compared to the other two, showing generalized weakness and repeated episodes of respiratory failure in the first years of life...
September 5, 2018: Neuromuscular Disorders: NMD
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