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Hematology guideline

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https://www.readbyqxmd.com/read/30537299/nucleated-red-blood-cells-as-a-novel-indicator-of-cd34-cell-content-in-umbilical-cord-blood
#1
David Galel, Clarence Crisostomo, Jennifer Ortega, Kirstin Peters, Sara Neveu, Carolina Davila, James Barlow
BACKGROUND: Umbilical cord blood (UCB) has become an important source of transplantable CD34+ hematopoietic progenitor cells. Cord blood banks (CBBs) can increase their efficiency by minimizing the processing of UCB units with low CD34+ content, which have a lower likelihood of transplant utilization. We sought to identify a readily available preprocessing metric that would correlate with CD34+ cell counts, without the cost of additional analysis. STUDY DESIGN AND METHODS: Data were compiled for 131 UCB units processed at the regional CBB...
December 7, 2018: Transfusion
https://www.readbyqxmd.com/read/30535059/diagnostic-accuracy-of-the-1-3-%C3%AE-d-glucan-test-for-pneumocystis-pneumonia-in-a-tertiary-university-hospital-in-denmark-a-retrospective-study
#2
Anne Line Engsbro, Sara Najat, Karin Meinike Jørgensen, Jørgen A L Kurtzhals, Maiken Cavling Arendrup
1,3-β-D-glucan (BG), a cell-wall component of most fungi including Pneumocystis (PC), is recommended by international guidelines for screening for pneumocystis pneumonia (PCP) in hematologic patients. We retrospectively validated the BG test in our tertiary university hospital. Forty-five patients (median age 53 years, 33% female) tested for PC by polymerase chain reaction (PCR) and/or immunoflourescence (IF)-microscopy with a stored blood sample within ±5 days of the PC test were tested by the Fungitell (cutoff <60 and >80 pg/ml)...
December 11, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/30528964/recent-advances-in-car-t-cell-toxicity-mechanisms-manifestations-and-management
#3
REVIEW
Jennifer N Brudno, James N Kochenderfer
Chimeric antigen receptor (CAR) T-cell therapy is an effective new treatment for hematologic malignancies. Two CAR T-cell products are now approved for clinical use by the U.S. FDA: tisagenlecleucel for pediatric acute lymphoblastic leukemia (ALL) and adult diffuse large B-cell lymphoma subtypes (DLBCL), and axicabtagene ciloleucel for DLBCL. CAR T-cell therapies are being developed for multiple myeloma, and clear evidence of clinical activity has been generated. A barrier to widespread use of CAR T-cell therapy is toxicity, primarily cytokine release syndrome (CRS) and neurologic toxicity...
November 14, 2018: Blood Reviews
https://www.readbyqxmd.com/read/30527521/mr-imaging-of-the-spine-urgent-and-emergent-indications
#4
Efrat Saraf Lavi, Amit Pal, Drew Bleicher, Kyungmin Kang, Charif Sidani
Spinal emergencies and urgent conditions must be recognized early so that the diagnosis can be quickly confirmed and treatment can be instituted to possibly prevent permanent loss of function. The American College of Radiology provides guidelines for recognition of patients presenting with myelopathy or acute low back pain who require further evaluation for suspicion of more serious problems and contribute to appropriate imaging utilization. Spinal emergencies include spinal cord compression secondary to vertebral fracture or space occupying lesion, spinal infection or abscess, vascular or hematologic damage, severe disc herniation, and spinal stenosis...
December 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/30523709/initial-diagnostic-work-up-of-acute-leukemia-asco-clinical-practice-guideline-endorsement-of-the-college-of-american-pathologists-and-american-society-of-hematology-guideline
#5
Valérie de Haas, Nofisat Ismaila, Anjali Advani, Daniel A Arber, Raetasha S Dabney, Dipti Patel-Donelly, Elizabeth Kitlas, Rob Pieters, Ching-Hon Pui, Kendra Sweet, Ling Zhang
PURPOSE: The College of American Pathologists (CAP) and the American Society of Hematology (ASH) developed an evidence-based guideline on the initial diagnostic work-up of acute leukemia (AL). Because of the relevance of this topic to the ASCO membership, ASCO reviewed the guideline and applied a set of procedures and policies for endorsing clinical practice guidelines that have been developed by other professional organizations. METHODS: The CAP-ASH guideline on initial diagnostic work-up of AL was reviewed for developmental rigor by methodologists...
December 3, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/30523626/merkel-cell-carcinoma-in-the-hiv-1-aids-patient
#6
Robert H Goldstein, James A DeCaprio
Merkel cell carcinoma (MCC) is a highly aggressive, primary neuroendocrine cancer of the skin. The majority of MCC cases are associated with the recently discovered Merkel cell polyomavirus (MCPyV), while the remaining are caused by ultraviolet (UV) light-induced mutations from excessive sunlight exposure. The risk of developing MCC is much higher in the white population relative to all other races. Approximately 10% of all patients with MCC have some form of immunosuppression including HIV-1/AIDS, chronic inflammatory conditions, solid organ transplantation, or hematological malignancies...
2019: Cancer Treatment and Research
https://www.readbyqxmd.com/read/30508848/gestational-diabetes-mellitus-in-a-tertiary-care-hospital-of-kolkata-india-prevalence-pathogenesis-and-potential-disease-biomarkers
#7
Jayita Basu, Chhanda Datta, Subhankar Chowdhury, Debasmita Mandal, Nandan Kumar Mondal, Amlan Ghosh
AIMS: Prevalence of gestational diabetes mellitus (GDM) may vary across a country like India. Risk factors and disease-pathogenesis were also not fully elucidated. This study aimed to examine prevalence of GDM among pregnant women visiting antenatal clinic of a tertiary-care hospital of Kolkata, India; possible mechanism of disease pathogenesis and potency of associated parameters as disease biomarkers were also explored. METHODS: 735 pregnant women were screened for GDM according to DIPSI (Diabetes in Pregnancy Study Group India) guideline and risk-factors were analyzed...
December 3, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30504359/evidence-based-management-of-immune-thrombocytopenia-ash-guideline-update
#8
REVIEW
Cindy E Neunert, Nichola Cooper
In 1996 and 2011, the American Society of Hematology (ASH) supported efforts to create guidelines for the diagnosis and management of patients with immune thrombocytopenia (ITP). These guidelines used different approaches to arrive at recommendations for testing and treatment. Despite differences in methodology, in both cases there was a paucity of randomized trials to inform recommendations. As data on the diagnosis and management of ITP expands, the ASH Committee on Quality is dedicated to maintaining updated guidelines representing recent evidence and guideline methodology...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504357/shifting-ground-and-gaps-in-transfusion-support-of-patients-with-hematological-malignancies
#9
REVIEW
Christine Cserti-Gazdewich
The transfusion support of hematological malignancies considers 2 dimensions: the quantity of what we order (in terms of triggers, doses, targets, and intervals), and the special qualities thereof (with respect to depths of matching and appropriate product modifications). Meanwhile, transfusion-related enhancements in the quantity and quality of life may not be dose dependent but rather tempered by unintended patient harms and system strains from overexposure. Evidence and guidelines concur in endorsing clinically noninferior conservative red blood cell (RBC) transfusion care strategies (eg, triggering at hemoglobin <7-8 g/dL and in single-unit doses for stable, nonbleeding inpatients)...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504338/management-of-thrombosis-in-children-and-neonates-practical-use-of-anticoagulants-in-children
#10
REVIEW
Paul Monagle, Fiona Newall
Venous thrombosis (VTE) in children and neonates presents numerous management challenges. Although increasing in frequency, VTE in children and neonates is still uncommon compared with adults. The epidemiology of VTE is vastly different in neonates vs children vs adolescents vs adults. In reality, pediatric thrombosis should be viewed as a multitude of rare diseases (eg, renal vein thrombosis, spontaneous thrombosis, catheter-related thrombosis, cerebral sinovenous thrombosis), all requiring different approaches to diagnosis and with different short- and long-term consequences, but linked by the use of common therapeutic agents...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504327/novel-insights-and-therapeutic-approaches-in-idiopathic-multicentric-castleman-disease
#11
REVIEW
David C Fajgenbaum
Castleman disease (CD) describes a heterogeneous group of hematologic disorders that share characteristic lymph node histopathology. Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy (MCD) with systemic inflammation, cytopenias, and life-threatening multiple organ dysfunction resulting from a cytokine storm often driven by interleukin 6 (IL-6). Uncontrolled human herpesvirus-8 (HHV-8) infection causes approximately 50% of MCD cases, whereas the etiology is unknown in the remaining HHV-8-negative/idiopathic MCD cases (iMCD)...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30502844/primary-thromboembolic-prevention-in-multiple-myeloma-patients-an-exploratory-meta-analysis-on-aspirin-use
#12
Giacomo Zoppellaro, Nicola Veronese, Serena Granziera, Laura Gobbi, Brendon Stubbs, Alexander T Cohen
BACKGROUND: Multiple myeloma (MM) is a common hematological disorder, often complicated by venous thromboembolism, especially during treatment with immunomodulatory drugs. Acetylsalicylic acid (ASA) has been extensively used as thromboprophylaxis but its rationale is unclear and the efficacy versus low-molecular weight heparins (LMWH) is still matter of debate. European and American guidelines suggest different approaches and the optimal antithrombotic strategy is yet to be established...
October 2018: Seminars in Hematology
https://www.readbyqxmd.com/read/30498607/gastrointestinal-malignancy-presenting-with-a-virchow-s-node-in-a-patient-with-rothmund-thomson-syndrome
#13
Kara Nadeau, Michele Brule
Rothmund-Thomson syndrome is a genetic disorder with characteristic findings in childhood as well as a predisposition to osteosarcoma, skin cancer, and hematological malignancy. We present the first reported case of duodenal malignancy in a patient with Rothmund-Thompson syndrome. An enlarged Virchow's node was noted and an advanced duodenal adenocarcinoma was diagnosed shortly thereafter. The features of Rothmund-Thomson syndrome are discussed, as well as current management and screening guidelines for duodenal adenocarcinoma...
2018: Case Reports in Genetics
https://www.readbyqxmd.com/read/30497666/chronic-effects-of-copper-and-zinc-on-the-fish-etroplus-suratensis-bloch-1790-by-continuous-flow-through-cft-bioassay
#14
N D Don Xavier, S Bijoy Nandan, P R Jayachandran, P R Anu, A M Midhun, D Mohan
Copper (Cu) and zinc (Zn) play a vital role in the growth and development, however increased uptake causes deleterious effects in normal functioning of organisms. We have demonstrated in this contribution the tolerance limit of Cu and Zn on Etroplus suratensis (pearl spot) by Continuous Flow Through (CFT) bioassay and the biomarker responses. The accumulation for Cu, Zn and selected trace metals (Cr, Cd, Ni and Pb) from field conditions, as well Geo-accumulation index (I geo) and Contamination factor (C.F) suggested moderate to heavy pollution in the Cochin estuarine system...
November 13, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/30487129/novel-insights-and-therapeutic-approaches-in-idiopathic-multicentric-castleman-disease
#15
REVIEW
David C Fajgenbaum
Castleman disease (CD) describes a heterogeneous group of hematologic disorders that share characteristic lymph node histopathology. Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy (MCD) with systemic inflammation, cytopenias, and life-threatening multiple organ dysfunction resulting from a cytokine storm often driven by interleukin 6 (IL-6). Uncontrolled human herpesvirus-8 (HHV-8) infection causes approximately 50% of MCD cases, whereas the etiology is unknown in the remaining HHV-8-negative/idiopathic MCD cases (iMCD)...
November 29, 2018: Blood
https://www.readbyqxmd.com/read/30482768/american-society-of-hematology-2018-guidelines-for-management-of-venous-thromboembolism-heparin-induced-thrombocytopenia
#16
REVIEW
Adam Cuker, Gowthami M Arepally, Beng H Chong, Douglas B Cines, Andreas Greinacher, Yves Gruel, Lori A Linkins, Stephen B Rodner, Sixten Selleng, Theodore E Warkentin, Ashleigh Wex, Reem A Mustafa, Rebecca L Morgan, Nancy Santesso
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction mediated by platelet-activating antibodies that target complexes of platelet factor 4 and heparin. Patients are at markedly increased risk of thromboembolism. OBJECTIVE: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about diagnosis and management of HIT. METHODS: ASH formed a multidisciplinary guideline panel balanced to minimize potential bias from conflicts of interest...
November 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/30482767/american-society-of-hematology-2018-guidelines-for-management-of-venous-thromboembolism-venous-thromboembolism-in-the-context-of-pregnancy
#17
REVIEW
Shannon M Bates, Anita Rajasekhar, Saskia Middeldorp, Claire McLintock, Marc A Rodger, Andra H James, Sara R Vazquez, Ian A Greer, John J Riva, Meha Bhatt, Nicole Schwab, Danielle Barrett, Andrea LaHaye, Bram Rochwerg
BACKGROUND: Venous thromboembolism (VTE) complicates ∼1.2 of every 1000 deliveries. Despite these low absolute risks, pregnancy-associated VTE is a leading cause of maternal morbidity and mortality. OBJECTIVE: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians and others in decisions about the prevention and management of pregnancy-associated VTE. METHODS: ASH formed a multidisciplinary guideline panel balanced to minimize potential bias from conflicts of interest...
November 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/30482766/american-society-of-hematology-2018-guidelines-for-management-of-venous-thromboembolism-treatment-of-pediatric-venous-thromboembolism
#18
REVIEW
Paul Monagle, Carlos A Cuello, Caitlin Augustine, Mariana Bonduel, Leonardo R Brandão, Tammy Capman, Anthony K C Chan, Sheila Hanson, Christoph Male, Joerg Meerpohl, Fiona Newall, Sarah H O'Brien, Leslie Raffini, Heleen van Ommen, John Wiernikowski, Suzan Williams, Meha Bhatt, John J Riva, Yetiani Roldan, Nicole Schwab, Reem A Mustafa, Sara K Vesely
BACKGROUND: Despite an increasing incidence of venous thromboembolism (VTE) in pediatric patients in tertiary care settings, relatively few pediatric physicians have experience with antithrombotic interventions. OBJECTIVE: These guidelines of the American Society of Hematology (ASH), based on the best available evidence, are intended to support patients, clinicians, and other health care professionals in their decisions about management of pediatric VTE. METHODS: ASH formed a multidisciplinary guideline panel that included 2 patient representatives and was balanced to minimize potential bias from conflicts of interest...
November 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/30482765/american-society-of-hematology-2018-guidelines-for-management-of-venous-thromboembolism-optimal-management-of-anticoagulation-therapy
#19
REVIEW
Daniel M Witt, Robby Nieuwlaat, Nathan P Clark, Jack Ansell, Anne Holbrook, Jane Skov, Nadine Shehab, Juliet Mock, Tarra Myers, Francesco Dentali, Mark A Crowther, Arnav Agarwal, Meha Bhatt, Rasha Khatib, John J Riva, Yuan Zhang, Gordon Guyatt
BACKGROUND: Clinicians confront numerous practical issues in optimizing the use of anticoagulants to treat venous thromboembolism (VTE). OBJECTIVE: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians and other health care professionals in their decisions about the use of anticoagulants in the management of VTE. These guidelines assume the choice of anticoagulant has already been made. METHODS: ASH formed a multidisciplinary guideline panel balanced to minimize potential bias from conflicts of interest...
November 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/30482764/american-society-of-hematology-2018-guidelines-for-management-of-venous-thromboembolism-diagnosis-of-venous-thromboembolism
#20
REVIEW
Wendy Lim, Grégoire Le Gal, Shannon M Bates, Marc Righini, Linda B Haramati, Eddy Lang, Jeffrey A Kline, Sonja Chasteen, Marcia Snyder, Payal Patel, Meha Bhatt, Parth Patel, Cody Braun, Housne Begum, Wojtek Wiercioch, Holger J Schünemann, Reem A Mustafa
BACKGROUND: Modern diagnostic strategies for venous thromboembolism (VTE) incorporate pretest probability (PTP; prevalence) assessment. The ability of diagnostic tests to correctly identify or exclude VTE is influenced by VTE prevalence and test accuracy characteristics. OBJECTIVE: These evidence-based guidelines are intended to support patients, clinicians, and health care professionals in VTE diagnosis. Diagnostic strategies were evaluated for pulmonary embolism (PE), deep vein thrombosis (DVT) of the lower and upper extremity, and recurrent VTE...
November 27, 2018: Blood Advances
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