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Hematology guideline

Aseem K Tiwari, Gunjan Bhardwaj, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Ravi C Dara, Ritesh Sachdev, Arun Raizada, Monisha Sethi
BACKGROUND: It is important to detect Latent Iron Deficiency (LID) to prevent development of an overt iron deficiency anemia. Early detection is difficult by using conventional hematological and biochemical parameters. Soluble transferrin receptor (sTfR) is presently the gold standard for diagnosing LID. We evaluated the utility of Reticulocyte Hemoglobin Equivalent (Ret-He), a newer hematological parameter, to predict LID in blood donors as compared to sTfR. METHODS: This was a randomized prospective study performed on 501 donor samples over a period of three-months...
August 12, 2018: Vox Sanguinis
Hibah Osman, Sudip Shrestha, Sarah Temin, Zipporah V Ali, Rumalie A Corvera, Henry D Ddungu, Liliana De Lima, Maria Del Pilar Estevez-Diz, Frank D Ferris, Nahla Gafer, Harmala K Gupta, Susan Horton, Graciela Jacob, Ruinuo Jia, Frank L Lu, Daniela Mosoiu, Christina Puchalski, Carole Seigel, Olaitan Soyannwo, James F Cleary
Purpose The purpose of this new resource-stratified guideline is to provide expert guidance to clinicians and policymakers on implementing palliative care of patients with cancer and their caregivers in resource-constrained settings and is intended to complement the Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update of 2016. Methods ASCO convened a multidisciplinary, multinational panel of experts in medical oncology, family medicine, radiation oncology, hematology/oncology, palliative and/or hospice care, pain and/or symptom management, patient advocacy, public health, and health economics...
July 2018: Journal of Global Oncology
Sylvain Robinet, François Parisot
Preliminary evaluation of qualitative and semi-quantitative clinical laboratory measurements is a prerequisite for the accreditation of clinical laboratories, according to the French committee of accreditation guidelines following the European reference standard EN ISO 15189. Numerous papers have been published regarding biochemistry, hematology or immunology. However, data are still lacking for molecular biology. We report our experience and present the performance characteristics of Allplex™ STI Essential real time PCR assay for the detection of seven pathogens, among which some are systematically responsible of sexually-transmitted infections...
August 1, 2018: Annales de Biologie Clinique
Arun K Mishra, Amrita Mishra, Pragya, Pronobesh Chattopadhyay
The objective of the study is to access the safety of Calendula essential oil by studying acute and sub-chronic dermal toxicity. The dermal toxicities of Calendula essential oil were evaluated in accordance with OECD guidelines number 402 and 411 respectively. The animals were exposed to Calendula officinalis (CO) essential oil dose of 20 mL/kg body weight for acute dermal toxicity, whereas for dermal sub-chronic toxicity study, rats were exposed to CO oil 2.5, 5 and 10 mL/kg body weight, respectively, for 7 times in a week for 90 days...
July 31, 2018: Regulatory Toxicology and Pharmacology: RTP
Kerstin A Kessel, Evelyn Klein, Carolin C Hack, Stephanie E Combs
INTRODUCTION: Recently, complementary and alternative medicine (CAM) has moved more into the focus, and cancer societies such as the German Cancer Society (Deutsche Krebsgesellschaft, DKG) have established working groups to develop a guideline for CAM. The present work aims to evaluate the acceptance of CAM in the whole radiation oncology community. METHODS: We conducted an online survey on CAM and sent the modified questionnaire that was successfully distributed to all members of the Research Group on Gynecological Oncology (Arbeitsgemeinschaft Gynakologische Onkologie, AGO) of the DKG in 2014 to the members of the German Society of Radiation Oncology (Deutsche Gesellschaft für Radioonkologie und Strahlentherapie, DEGRO)...
August 2, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Axel Matzdorff, Bernhard Wörmann
Immune thrombocytopenia (ITP) is a heterogeneous disease. Diagnosis of primary ITP continues to be based on the exclusion of all known causes for secondary ITP. The new ITP classification distinguishes three categories. First line treatment consists of either dexamethasone or prednisone. The most effective options in second line treatment are splenectomy or thrombopoietin receptor agonists. The medical societies for hematology and oncology of the German-speaking countries have recently updated their guidelines on ITP...
August 2018: Deutsche Medizinische Wochenschrift
Giulia la Martire, Christine Robin, Nadia Oubaya, Raphaël Lepeule, Florence Beckerich, Mathieu Leclerc, Walid Barhoumi, Andréa Toma, Cécile Pautas, Sébastien Maury, Wiem Akrout, Catherine Cordonnier-Jourdin, Vincent Fihman, Mario Venditti, Catherine Cordonnier
Febrile neutropenia (FN) is the main reason for antibiotic prescription in hematology wards where, on the other hand, antibiotic stewardship (AS) is poorly explored. The objectives of the present study were to evaluate (1) the impact of an AS intervention on antibiotic consumption and (2) the applicability and acceptance rate of the intervention and its clinical impact. A persuasive AS intervention based on European Conference on Infection in Leukaemia (ECIL) guidelines for FN was implemented in a high-risk hematology ward in a tertiary referral public university hospital...
July 26, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Saad Bakrim, Youssef Motiaa, Mohamed Benajiba, Ali Ouarour, Azlarab Masrar
Introduction: Among the most useful biological examinations in common medical practice, blood count is the most prescribed. The reference intervals of the hematological parameters of this examination are of major importance for clinical orientations and therapeutic decisions. In Morocco, the reference values used by the laboratories of medical biology and used by doctors are ones collected from Caucasian and European individuals. These values could be different in the Moroccan population...
2018: Pan African Medical Journal
Hakan Parlar, Hüseyin Şaşkın
OBJECTIVE: In this study, we investigated the role of two of the recent biomarkers of inflammation on the development of acute kidney injury in the early postoperative period of isolated coronary artery bypass grafting. METHODS: Three hundred and eleven patients, who underwent isolated coronary artery bypass grafting with cardiopulmonary bypass by the same surgery team in our clinic between May 2010 and October 2014, who had a preoperative serum creatinine level lower than 1...
May 2018: Brazilian Journal of Cardiovascular Surgery
Trevor N Christ, Jeryl J Villadolid, Anish Choksi, Monica Malec, Randall W Knoebel
Background: Pain is both common and undertreated in the hematology/oncology population despite national guidelines and a focus from The Joint Commission. Objective: Herein, we describe the features of a pain clinical decision support tool (PCDST) embedded into the electronic medical record (EMR) and report its impact on oncology inpatients at risk for uncontrolled pain. Methods: The PCDST was developed to identify patients with potentially uncontrolled pain, defined as a pain score ≥4. Clinical pharmacists were encouraged to use the tool to determine whether interventions were needed to better control pain...
July 2018: Hospital Pharmacy
Maria Bastaki, Michel Aubanel, Mark Bauter, Thierry Cachet, Jan Demyttenaere, Maodo Malick Diop, Christie L Harman, Shim-Mo Hayashi, Gerhard Krammer, Xiaodong Li, Craig Llewellyn, Odete Mendes, Kevin J Renskers, Jürgen Schnabel, Benjamin P C Smith, Sean V Taylor
β-Myrcene is a flavoring substance that occurs naturally in a large variety of foods. At the request of the European Food Safety Authority (EFSA) for additional toxicological data on β-myrcene, groups of Sprague Dawley rats (10/sex/group) were administered diets containing 0, 700, 2100, or 4200 ppm of β-myrcene designed to provide nominal doses of 0, 50, 150, or 300 mg/kg bw/day in a 90-day GLP-compliant study. Based on body weights, feed consumption, and substance stability data, final estimated daily intakes of β-myrcene were calculated to be 20...
July 4, 2018: Food and Chemical Toxicology
José Carlos Jaime-Pérez, Goel Treviño-Reyna, Patrizia Aguilar-Calderón, Olga G Cantú-Rodríguez, Luis Javier Marfil-Rivera, David Gómez-Almaguer
OBJECTIVES: To demonstrate the importance of regional efforts to register features and report frequency of hematology diseases in the context of incomplete national registries. METHODS: Frequencies and salient characteristics of hematologic diseases in Northeast Mexico were documented in a reference center at a tertiary care university hospital during the decade 2005-2015. Disease categories were grouped by age, sex and diagnosis. Age group distribution followed WHO guidelines in years as children (0-17), adults (18-64) and elders (+65)...
July 16, 2018: Hematology (Amsterdam, Netherlands)
Xue Xu, Mei-Ying Liang, Sha Dou, Jian-Liu Wang, Xiao-Hui Zhang
PROBLEM: Evaluate the response rate of glucocorticoid (GC) and/or immunoglobulin (IVIg) therapy in severe thrombocytopenia of immune thrombocytopenia (ITP) pregnant patients and the influence on maternal and neonatal outcomes. METHOD OF STUDY: This is a prospective observational cohort study. Pregnant ITP patients with platelet count less than 30 × 109 /L and their newborn infants participated in this research. Over a 3-year period, 87 patients were allocated to 4 groups: group 1 (n = 18) were treated by oral prednisone, group 2 (n = 20) with IVIg, group 3 (n = 22) with prednisone/methlyprednisone plus IVIg, and group 4 were non-treatment controls (n = 27)...
July 16, 2018: American Journal of Reproductive Immunology: AJRI
Jeremiah Oshiomame Unuofin, Gloria Aderonke Otunola, Anthony Jide Afolayan
OBJECTIVE: This study investigated the acute and subacute toxicity of whole-plant aqueous extract of Vernonia mespilifolia Less. (AEVM) in rats for evaluating its safety profile. METHODS: AEVM for the acute (2000 and 5000 mg/kg) and subacute (200, 400 and 600 mg/kg) toxicity studies was administered orally to rats according the guidelines 425 and 407 of Organization for Economic Cooperation and Development, respectively. Food and water intake as well as body and organ weight of animals were recorded...
July 4, 2018: Journal of Integrative Medicine
Dilan Paranagama, Philomena Colucci, Kristin A Evans, Machaon Bonafede, Shreekant Parasuraman
Background: Patients with polycythemia vera (PV) have a higher mortality risk compared with the general population, primarily driven by cardiovascular disease, thrombotic events (TEs), and hematologic transformations. The goal of risk-adapted therapy in PV is prevention of TEs. Current treatment recommendations indicate that high-risk patients (aged ≥ 60 years and/or with history of TEs) should be managed with cytoreductive medications, phlebotomy, and low-dose aspirin. This noninterventional study was conducted to describe real-world cytoreductive medication treatment in adult patients with PV, stratified by risk, in the United States...
2018: Experimental Hematology & Oncology
Sarah Perreault, Dayna McManus, Anthony Anderson, Tiffany Lin, Michael Ruggero, Jeffrey E Topal
Background Voriconazole is an azole antifungal utilized for prophylaxis and treatment of invasive fungal infections in hematologic patients. Previous studies have revealed decreased efficacy and increased toxicity with subtherapeutic <1 mcg/mL and supratherapeutic > 4 mcg/mL levels. A voriconazole dose modification guideline was introduced in July 2014 based on a retrospective analysis. Objective The primary objective was to evaluate the voriconazole dose modification guideline. Secondary objectives were to identify patient-specific characteristics that contribute to inadequate levels, adverse effects, and breakthrough invasive fungal infections...
January 1, 2018: Journal of Oncology Pharmacy Practice
Jakob Daniel Rudzki
IO treatments (immuno-oncology treatments) have become reality and are now daily practice or, in some cases, a daily challenge. New recommendations are being made with the prime purpose of increasing alertness and awareness as well as emphasizing standard operating strategies to deal with immune-related adverse events (ir-AEs) in patients treated with immune checkpoint inhibitors (ICI). This brief review refers to systemic reviews, guidelines and meta-analyses, randomized controlled trials and case series published from 2000 to the present...
2018: Memo
Bashu Dev Pardhe, Shreena Shakya, Anjeela Bhetwal, Jennifer Mathias, Puspa Raj Khanal, Roshan Pandit, Jyotsna Shakya, Hari Om Joshi, Sujan Babu Marahatta
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabolic co-morbidities. Hence, this study aims to recognize various risk factors including metabolic components and blood parameters to predict the possible incidence of the disease...
July 6, 2018: BMC Gastroenterology
Anupam Sachdeva, Vinod Gunasekaran, Payal Malhotra, Dinesh Bhurani, Satya Prakash Yadav, Nita Radhakrishnan, Manas Kalra, Sunil Bhat, Ruchira Misra, Pramod Jog
JUSTIFICATION: Practitioners and people need information about the therapeutic potential of umbilical cord blood stem cells and pros and cons of storing cord blood in public versus private banks. PROCESS: Indian Academy of Pediatrics conducted a consultative meeting on umbilical cord blood banking on 25th June 2016 in Pune, attended by experts in the field of hematopoietic stem cell transplantation working across India. Review of scientific literature was also performed...
June 15, 2018: Indian Pediatrics
Jorrit W van As, Henk van den Berg, Elvira C van Dalen
BACKGROUND: Platinum-based therapy, including cisplatin, carboplatin or oxaliplatin, or a combination of these, is used to treat a variety of paediatric malignancies. Unfortunately, one of the most important adverse effects is the occurrence of hearing loss or ototoxicity. In an effort to prevent this ototoxicity, different platinum infusion durations have been studied. This review is the second update of a previously published Cochrane review. OBJECTIVES: To assess the effects of different durations of platinum infusion to prevent hearing loss or tinnitus, or both, in children with cancer...
July 5, 2018: Cochrane Database of Systematic Reviews
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