Olivier Morin, William C Chen, Farshad Nassiri, Matthew Susko, Stephen T Magill, Harish N Vasudevan, Ashley Wu, Martin Vallières, Efstathios D Gennatas, Gilmer Valdes, Melike Pekmezci, Paula Alcaide-Leon, Abrar Choudhury, Yannet Interian, Siavash Mortezavi, Kerem Turgutlu, Nancy Ann Oberheim Bush, Timothy D Solberg, Steve E Braunstein, Penny K Sneed, Arie Perry, Gelareh Zadeh, Michael W McDermott, Javier E Villanueva-Meyer, David R Raleigh
Background: We investigated prognostic models based on clinical, radiologic, and radiomic feature to preoperatively identify meningiomas at risk for poor outcomes. Methods: Retrospective review was performed for 303 patients who underwent resection of 314 meningiomas (57% World Health Organization grade I, 35% grade II, and 8% grade III) at two independent institutions, which comprised primary and external datasets. For each patient in the primary dataset, 16 radiologic and 172 radiomic features were extracted from preoperative magnetic resonance images, and prognostic features for grade, local failure (LF) or overall survival (OS) were identified using the Kaplan-Meier method, log-rank tests and recursive partitioning analysis...
May 2019: Neuro-oncology advances