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https://www.readbyqxmd.com/read/29648937/endothelial-wound-repair-of-the-organ-cultured-porcine-corneas
#1
Ingrida Smeringaiova, Stanislava Reinstein Merjava, Zbynek Stranak, Pavel Studeny, Jan Bednar, Katerina Jirsova
PURPOSE: To assess whether injured porcine endothelium of small and large corneoscleral disc differ in its reparative/regenerative capacity under various conditions of organ culture storage. MATERIAL AND METHODS: 166 paired porcine corneas were trephined to obtain tissues with diameter 12.0 mm and 17.5 mm (with area neighboring endothelial periphery). In tested discs, central endothelium was mechanically wounded. Density of live endothelial cells (LECD), percentage of dead cells (%DC), coefficient of variation and cell hexagonality were assessed in central and paracentral endothelium following 5- or 9-day incubation in medium with 2% or 10% fetal bovine serum...
July 2018: Current Eye Research
https://www.readbyqxmd.com/read/27843416/artemis-very-high-frequency-digital-ultrasound-guided-femtosecond-laser-recut-after-flap-complication
#2
Dan Z Reinstein, Zachary Dickeson, Timothy J Archer, Marine Gobbe
Incomplete flaps are a relatively uncommon complication of laser-assisted in situ keratomileusis (LASIK) that occur when creation of the corneal flap is interrupted. Further complications can arise if a second flap is created that intersects the original flap interface, resulting in tissue slivers that can lead to more complications and poor visual outcomes. We report the case of a 56-year-old man who underwent LASIK in which an incomplete flap occurred after 45% completion using a mechanical microkeratome with a 160 µm head...
2014: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/27824384/refractive-lenticule-transplantation-for-correction-of-iatrogenic-hyperopia-and-high-astigmatism-after-lasik
#3
Apostolos Lazaridis, Dan Z Reinstein, Timothy J Archer, Stephan Schulze, Walter Sekundo
PURPOSE: To design a technique for intrastromal transplantation of stromal lenticules with specific refractive power for correction of post-LASIK induced hyperopia and astigmatism. METHODS: A 28-year-old patient was referred for consultation after complicated LASIK for moderate myopia and astigmatism. The refractive error of the right eye was severely overcorrected due to data entry error. Post-LASIK refraction showed high astigmatism (right eye: +6.50 -9.00 @ 84°) and corrected distance visual acuity (CDVA) of 20/32...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/26856428/comparison-of-central-corneal-thickness-between-fourier-domain-oct-very-high-frequency-digital-ultrasound-and-scheimpflug-imaging-systems
#4
COMPARATIVE STUDY
Timothy E Yap, Timothy J Archer, Marine Gobbe, Dan Z Reinstein
PURPOSE: To compare corneal thickness measurements between three imaging systems. METHODS: In this retrospective study of 81 virgin and 58 post-laser refractive surgery corneas, central and minimum corneal thickness were measured using optical coherence tomography (OCT), very high-frequency digital ultrasound (VHF digital ultrasound), and a Scheimpflug imaging system. Agreement between methods was analyzed using mean differences (bias) (OCT - VHF digital ultrasound, OCT - Scheimpflug, VHF digital ultrasound - Scheimpflug) and Bland-Altman analysis with 95% limits of agreement (LoA)...
February 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/26603414/september-consultation-2
#5
COMMENT
Dan Reinstein
No abstract text is available yet for this article.
September 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26432113/corneal-sensitivity-after-small-incision-lenticule-extraction-and-laser-in-situ-keratomileusis
#6
COMPARATIVE STUDY
Dan Z Reinstein, Timothy J Archer, Marine Gobbe, Elena Bartoli
PURPOSE: To longitudinally evaluate corneal sensitivity after small-incision lenticule extraction and compare the results with those in previous studies. SETTING: London Vision Clinic, London, United Kingdom. DESIGN: Retrospective case series. METHODS: Consecutive myopic eyes treated with small-incision lenticule extraction using the Visumax femtosecond laser were studied. Corneal sensitivity was measured centrally and at 4 paracentral locations using a Cochet-Bonnet esthesiometer preoperatively and 1 day, 1 week, and 1, 3, 6, and 12 months postoperatively...
August 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26186562/comparison-of-corneal-epithelial-thickness-measurement-between-fourier-domain-oct-and-very-high-frequency-digital-ultrasound
#7
COMPARATIVE STUDY
Dan Z Reinstein, Timothy E Yap, Timothy J Archer, Marine Gobbe, Ronald H Silverman
PURPOSE: To compare measurements of corneal epithelial thickness using optical coherence tomography (OCT) and very high-frequency digital ultrasound (VHFDU). METHODS: Retrospective analysis of 189 virgin corneas and 175 post-laser refractive surgery (LRS) corneas that had corneal epithelial thickness measurement with RTVue Fourier-domain OCT (Optovue, Inc., Fremont, CA) (tear film included) and Artemis VHFDU (ArcScan Inc., Morrison, CO) (tear film excluded). Averages were calculated for the central 2-mm diameter zone and for two further concentric annuli of 1...
July 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/26158929/biomechanical-modeling-of-femtosecond-laser-keyhole-endokeratophakia-surgery
#8
Harald P Studer, Kishore R Pradhan, Dan Z Reinstein, Elena Businaro, Timothy J Archer, Marine Gobbe, Cynthia J Roberts
PURPOSE: To apply a finite element model to endokeratophakia and evaluate anterior and posterior corneal surface changes. METHODS: Spatial elevation data (Pentacam HR; Oculus, Wetzlar, Germany) were obtained for the front and back corneal surfaces of an eye prior to undergoing an endokeratophakia procedure. These were used to warp a spherical template finite element model of the cornea to create a patient-specific finite element mesh and the initial stress distribution was computed with an iterative approach...
July 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/25785529/lasik-induced-aberrations-comparing-corneal-and-whole-eye-measurements
#9
COMPARATIVE STUDY
Marine Gobbe, Dan Z Reinstein, Timothy J Archer
PURPOSE: To compare the change in aberrations produced by laser-assisted in situ keratomileusis (LASIK) measured by either front surface corneal aberrometry or Hartmann-Shack whole-eye aberrometry. METHODS: This was a retrospective case series from consecutive patients treated with LASIK at the London Vision Clinic, London, UK. Corneal and ocular wavefront data were collected before and after LASIK for myopia and hyperopia. To control for centration of corneal and whole-eye aberration measurements, only patients with pupil offset (measured as the distance between the corneal vertex and the entrance pupil center) of 0...
April 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/25735048/comparison-of-higher-order-aberration-induction-between-manual-microkeratome-and-femtosecond-laser-flap-creation
#10
COMPARATIVE STUDY
Camille Yvon, Timothy J Archer, Marine Gobbe, Dan Z Reinstein
PURPOSE: To compare the mean change in aberrations produced by a mechanical microkeratome and femtosecond laser. METHODS: This was a retrospective study of 62 consecutive near emmetropic eyes that underwent LASIK and satisfied the following criteria: negligible laser ablation (for spherical equivalent of 0.00 to +0.50 diopters and maximum meridian of +0.50 diopters), and preoperative and at least 3 months postoperative Placido-based corneal aberrometry (ATLAS; Carl Zeiss Meditec, Jena, Germany)...
February 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/25599543/stromal-surface-topography-guided-custom-ablation-as-a-repair-tool-for-corneal-irregular-astigmatism
#11
Dan Z Reinstein, Marine Gobbe, Timothy J Archer, Gerhard Youssefi, Hugo F S Sutton
PURPOSE: To illustrate the concept of using a stromal surface topography-guided procedure for therapeutic repair after a complication following primary laser refractive surgery. METHODS: One case example of therapeutic retreatment for short nasal flap after primary LASIK performed in September 2000 is presented. The Artemis very high-frequency digital ultrasound arc-scanner (Arc-Scan, Inc., Morrison, CO) was used to obtain layered corneal thickness including epithelial thickness profile...
January 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/24893355/lenticule-thickness-readout-for-small-incision-lenticule-extraction-compared-to-artemis-three-dimensional-very-high-frequency-digital-ultrasound-stromal-measurements
#12
Dan Z Reinstein, Timothy J Archer, Marine Gobbe
PURPOSE: To evaluate the accuracy of the lenticule thickness readout for small incision lenticule extraction (SMILE) with the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). METHODS: Artemis very high-frequency digital ultrasound (ArcScan, Inc., Morrison, CO) measurements were obtained before and 3 months after SMILE in 70 eyes of 37 patients. The Artemis measured lenticule thickness was calculated as the maximum difference in stromal thickness before and after treatment...
May 2014: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/24857439/comparison-of-ocular-biomechanical-response-parameters-in-myopic-and-hyperopic-eyes-using-dynamic-bidirectional-applanation-analysis
#13
COMPARATIVE STUDY
Cynthia J Roberts, Dan Z Reinstein, Timothy J Archer, Ashraf M Mahmoud, Marine Gobbe, Linden Lee
PURPOSE: To compare differences in the ocular biomechanical response in myopic and hyperopic eyes. SETTING: London Vision Clinic, London, United Kingdom, The Ohio State University, Columbus, OH, United States. DESIGN: Retrospective study. METHODS: The study population included myopic and hyperopic patients evaluated preoperatively for refractive surgery at the London Vision Clinic between June 2006 and May 2008. Biomechanical response parameters from the dynamic bidirectional applanation device (Ocular Response Analyzer) were analyzed using custom software for signal analysis, including corneal hysteresis (CH) and 10 other output parameters...
June 2014: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/24557351/epithelial-remodeling-as-basis-for-machine-based-identification-of-keratoconus
#14
Ronald H Silverman, Raksha Urs, Arindam Roychoudhury, Timothy J Archer, Marine Gobbe, Dan Z Reinstein
PURPOSE: To develop and evaluate automated computerized algorithms for differentiation of normal and keratoconus corneas based solely on epithelial and stromal thickness data. METHODS: Maps of the corneal epithelial and stromal thickness were generated from Artemis-1 very high-frequency ultrasound arc-scans of 130 normal and 74 keratoconic subjects diagnosed by combined topography and tomography examination. Keratoconus severity was graded based on anterior curvature, minimum corneal thickness, and refractive error...
March 13, 2014: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/24203809/femtosecond-laser-assisted-keyhole-endokeratophakia-correction-of-hyperopia-by-implantation-of-an-allogeneic-lenticule-obtained-by-smile-from-a-myopic-donor
#15
Kishore R Pradhan, Dan Z Reinstein, Glenn I Carp, Timothy J Archer, Marine Gobbe, Reeta Gurung
PURPOSE: To describe endokeratophakia in which a small incision lenticule extraction (SMILE) lenticule from a myopic patient is implanted into a recipient eye through a small incision to correct hyperopia. METHODS: A 23-year-old aphakic woman presented following cataract surgery to remove a childhood congenital cataract with hyperopia of +12.00 -1.50 × 155, corrected distance visual acuity of counting fingers, and exotropia. A SMILE procedure using the VisuMax femto-second laser (Carl Zeiss Meditec, Jena, Germany) was performed on a donor patient with high myopia and the extracted lenticule was stored (power -10...
November 2013: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/23909779/improved-effectiveness-of-transepithelial-ptk-versus-topography-guided-ablation-for-stromal-irregularities-masked-by-epithelial-compensation
#16
COMPARATIVE STUDY
Dan Z Reinstein, Timothy J Archer, Marine Gobbe
PURPOSE: To demonstrate improved effectiveness of transepithelial phototherapeutic keratectomy (PTK) where topography-guided ablation is degraded by epithelial compensation for localized irregularities. METHODS: Artemis very high-frequency digital ultrasound (ArcScan Inc., Morrison, CO) scanning was performed on five eyes (four patients) after LASIK in which a truncated nasal flap was created but the ablation was still performed, resulting in irregular astigmatism and double vision...
August 2013: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/23909778/coaxially-sighted-corneal-light-reflex-versus-entrance-pupil-center-centration-of-moderate-to-high-hyperopic-corneal-ablations-in-eyes-with-small-and-large-angle-kappa
#17
COMPARATIVE STUDY
Dan Z Reinstein, Marine Gobbe, Timothy J Archer
PURPOSE: To determine whether centering ablations on the coaxially sighted corneal light reflex (CSCLR) in eyes with large angle kappa leads to poor visual outcomes when compared to patients with eyes with negligible angle kappa that by default would be centered on the entrance pupil. In eyes with no angle kappa, the CSCLR coincides with the entrance pupil center, whereas eyes with large angle kappa possess an offset between the CSCLR and the entrance pupil center. METHODS: This study was a retrospective case series of consecutive patients treated by hyperopic LASIK using the MEL80 excimer laser (Carl Zeiss Meditec, Jena, Germany)...
August 2013: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/23820227/mathematical-model-to-compare-the-relative-tensile-strength-of-the-cornea-after-prk-lasik-and-small-incision-lenticule-extraction
#18
COMPARATIVE STUDY
Dan Z Reinstein, Timothy J Archer, J Bradley Randleman
PURPOSE: To develop a mathematical model to estimate the relative differences in postoperative stromal tensile strength following photorefractive keratectomy (PRK), LASIK, and small incision lenticule extraction (SMILE). METHODS: Using previously published data where in vitro corneal stromal tensile strength was determined as a function of depth, a mathematical model was built to calculate the relative remaining tensile strength by fitting the data with a fourth order polynomial function yielding a high correlation coefficient (R(2) = 0...
July 2013: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/23049806/high-prevalence-of-posterior-polymorphous-corneal-dystrophy-in-the-czech-republic-linkage-disequilibrium-mapping-and-dating-an-ancestral-mutation
#19
Petra Liskova, Rhian Gwilliam, Martin Filipec, Katerina Jirsova, Stanislava Reinstein Merjava, Panos Deloukas, Tom R Webb, Shomi S Bhattacharya, Neil D Ebenezer, Alex G Morris, Alison J Hardcastle
Posterior polymorphous corneal dystrophy (PPCD) is a rare autosomal dominant genetically heterogeneous disorder. Nineteen Czech PPCD pedigrees with 113 affected family members were identified, and 17 of these kindreds were genotyped for markers on chromosome 20p12.1- 20q12. Comparison of haplotypes in 81 affected members, 20 unaffected first degree relatives and 13 spouses, as well as 55 unrelated controls, supported the hypothesis of a shared ancestor in 12 families originating from one geographic location...
2012: PloS One
https://www.readbyqxmd.com/read/22947295/refractive-and-topographic-errors-in-topography-guided-ablation-produced-by-epithelial-compensation-predicted-by-3d-artemis-vhf-digital-ultrasound-stromal-and-epithelial-thickness-mapping
#20
Dan Z Reinstein, Timothy J Archer, Marine Gobbe
PURPOSE: To describe and quantify the errors inherent to topography-guided ablation of irregular corneas due to natural epithelial thickness compensatory remodeling. METHODS: Artemis very high-frequency (VHF) digital ultrasound scanning (ArcScan Inc) was performed on a cornea that had undergone radial keratotomy with inferior and superior trapezoidal keratotomies, resulting 27 years later in high irregular astigmatism (+6.50 -8.00 × 101) and severe loss of corrected distance visual acuity (CDVA) to 20/50...
September 2012: Journal of Refractive Surgery
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