keyword
https://read.qxmd.com/read/38534495/mendelian-randomisation-analysis-of-causal-association-between-lifestyle-health-factors-and-keratoconus
#1
JOURNAL ARTICLE
Jiaxuan Cheng, Lanting Yang, Yishan Ye, Lvfu He, Shihao Chen, Junjie Wang
Keratoconus (KC), a leading cause of vision impairment, has an unclear aetiology. This study used Mendelian randomization (MR) to explore the causal links between various factors (smoking, asthma, Down syndrome, inflammatory bowel disease, atopic dermatitis, and serum 25-hydroxyvitamin D levels) and KC. A two-sample MR design, grounded in genome-wide association study (GWAS) summary statistics, was adopted using data from FinnGen, UK Biobank, and other GWAS-related articles. The inverse-variance weighted (IVW) method was employed, complemented by the Wald ratio method for factors with only one single-nucleotide polymorphism (SNP)...
February 26, 2024: Bioengineering
https://read.qxmd.com/read/38529005/characterization-of-corneal-biomechanics-using-corvis-st-device-in-different-grades-of-myopia-in-a-sample-of-middle-eastern-ethnicity
#2
JOURNAL ARTICLE
Esraa El-Mayah, Ahmed Saad Albalkini, Omar A Barrada
PURPOSE: To characterize corneal biomechanical properties using the CORVIS-ST device in myopic individuals. METHODS: This prospective cross-sectional study included patients with myopia. Our study included 154 eyes of 154 myopic patients aged between 18 and 40 years, with stable refraction for at least 2 years. A full ophthalmological examination and corneal tomography were performed using a Pentacam HR device. Corneal biomechanical parameters were assessed using the CORVIS-ST device in mild, moderate, severe, and extreme myopia groups...
2024: Clinical Ophthalmology
https://read.qxmd.com/read/38524314/corneal-stress-strain-index-in-myopic-indian-population
#3
JOURNAL ARTICLE
Vaishal P Kenia, Raj V Kenia, Pradnya Bendre, Onkar H Pirdankar
AIM: The purpose is to study the corneal stress-strain index (SSI) in myopic refractive error among Indian subjects. METHODS: A retrospective study where young myopic subjects aged between 11 and 35 years who had undergone corneal biomechanics assessment using Corvis ST between January 2017 and December 2021 were enrolled. Subjects with central corneal thickness (CCT) <500 μ, intraocular pressure (IOP) >21 mmHg, history of any systemic and ocular disease or any previous ocular surgery, high astigmatism, corneal disease such as keratoconus were excluded...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38502381/corneal-biomechanics-and-their-association-with-severity-of-lens-dislocation-in-marfan-syndrome
#4
JOURNAL ARTICLE
Guangming Jin, Minjie Zou, Longhui Li, Zhenzhen Liu, Charlotte Young, Haotian Qi, Danying Zheng
PURPOSE: To investigate corneal biomechanical properties and its associations with the severity of lens dislocation in patients with Marfan syndrome. METHODS: A total of 30 patients with Marfan syndrome and 30 age-, sex- and axial length (AL)-matched controls were recruited. Corneal biomechanical parameters of both groups were measured by CorVis ST and were compared between groups. Potential associations between corneal biomechanical parameters and severity of lens dislocation were also investigated...
March 19, 2024: International Ophthalmology
https://read.qxmd.com/read/38493602/cornet-autonomous-feature-learning-in-raw-corvis-st-data-for-keratoconus-diagnosis-via-residual-cnn-approach
#5
JOURNAL ARTICLE
PeiPei Zhang, LanTing Yang, YiCheng Mao, XinYu Zhang, JiaXuan Cheng, YuanYuan Miao, FangJun Bao, ShiHao Chen, QinXiang Zheng, JunJie Wang
PURPOSE: To ascertain whether the integration of raw Corvis ST data with an end-to-end CNN can enhance the diagnosis of keratoconus (KC). METHOD: The Corvis ST is a non-contact device for in vivo measurement of corneal biomechanics. The CorNet was trained and validated on a dataset consisting of 1786 Corvis ST raw data from 1112 normal eyes and 674 KC eyes. Each raw data consists of the anterior and posterior corneal surface elevation during air-puff induced dynamic deformation...
March 13, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38492897/a-special-issue-dedicated-to-the-2022-meeting-of-the-french-society-for-nanomedicine
#6
EDITORIAL
Lucie Sancey, Yohann Corvis, Sylvie Begin-Colin, Nicolas Tsapis
No abstract text is available yet for this article.
March 14, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38441857/effect-of-intraorbital-mechanical-compression-on-retinal-microvascular-perfusion-in-quiescent-thyroid-associated-ophthalmopathy-based-on-ocular-biomechanics-measured-by-corvis-st
#7
JOURNAL ARTICLE
Wei Fang, Ziyun Zhou, Zhenbin Qian, Mengdi Wang, Fangjun Bao, Lijun Shen
INTRODUCTION: To analyze the correlation between orbital compliance and retinal vessel density (VD) based on dynamic Scheimpflug analyzer (Corvis ST) and optical coherence tomographic angiography (OCT-A). METHODS: In this prospective observational study, 65 eyes of 44 patients with thyroid-associated ophthalmopathy (TAO) in quiescent stage were included (15 males and 29 females). The whole eye movement (WEM) was detected by Corvis ST. The superficial capillary plexus VD (SCP-VD) and deep capillary plexus VD (DCP-VD) were obtained by scanning the 3 × 3 mm area around the fovea using OCT-A, while the peripapillary vessel density (ppVD) was obtained by scanning the 4...
March 5, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38410632/scheimpflug-based-corneal-biomechanical-analysis-as-a-predictor-of-glaucoma-in-eyes-with-high-myopia
#8
JOURNAL ARTICLE
Pedro M L Baptista, André S Ferreira, Nisa P Silva, Ana R M Figueiredo, Isabel C Sampaio, Rita V F Reis, Renato Ambrósio, Pedro M A M Menéres, João N M Beirão, Maria J F S Menéres
PURPOSE: To address if corneal biomechanical behavior has a predictive value for the presence of glaucomatous optical neuropathy in eyes with high myopia. PATIENTS AND METHODS: This observational cross-sectional study included 209 eyes from 108 consecutive patients, divided into four groups: high myopia and primary open-angle glaucoma (POAG) - HMG, n = 53; high myopia without POAG - HMNG, n = 53; non-myopic with POAG - POAG, n = 50; non-myopic and non-POAG- NMNG, n = 53...
2024: Clinical Ophthalmology
https://read.qxmd.com/read/38403983/the-statistical-fragility-of-marrow-stimulation-for-cartilage-defects-of-the-knee-a-systematic-review-of-randomized-controlled-trials
#9
JOURNAL ARTICLE
Avanish Yendluri, Ara Alexanian, Rohit R Chari, John J Corvi, Nikan K Namiri, Junho Song, Michael J Alaia, Xinning Li, Robert L Parisien
OBJECTIVE: Marrow stimulation is used to address knee cartilage defects. In this study, we used the fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ) to evaluate statistical fragility of outcomes reported in randomized controlled trials (RCTs) evaluating marrow stimulation. DESIGN: PubMed, Embase, and MEDLINE were queried for recent RCTs (January 1, 2010-September 5, 2023) assessing marrow stimulation for cartilage defects of the knee...
February 25, 2024: Cartilage
https://read.qxmd.com/read/38402288/corneal-stress%C3%A2-strain-index-in-relation-to-retinal-nerve-fibre-layer-thickness-among-healthy-young-adults
#10
JOURNAL ARTICLE
Min-Xin Liu, Dan-Lin Li, Zhi-Jian Yin, Yue-Zu Li, Ya-Jie Zheng, Yu Qin, Rong Ma, Gang Liang, Chen-Wei Pan
BACKGROUND/OBJECTIVES: To determine the relationship between corneal stress-strain index (SSI) and retinal nerve fibre layer (RNFL) thickness. SUBJECTS/METHODS: 1645 healthy university students from a university-based study contributed to the analysis. The RNFL thickness was measured by high-definition optical coherence tomography (HD-OCT), axial length (AL) was measured by IOL Master, and corneal biomechanics including SSI, biomechanical corrected intraocular pressure (bIOP), and central corneal thickness (CCT) were measured by Corvis ST...
February 24, 2024: Eye
https://read.qxmd.com/read/38382278/biometric-and-corneal-characteristics-in-marfan-syndrome-with-ectopia-lentis
#11
JOURNAL ARTICLE
L Izquierdo, I Gomez, C Moctezuma, M Mannis, M A Henriquez
PURPOSE: To describe the biometric and corneal characteristics of patients with Marfan Syndrome (MFS) and ectopia lentis. STUDY DESIGN: Observational, descriptive, prospective study. Subjects Individuals with MFS with ectopia lentis (EL). METHODS: Fourty-four eyes of 23 patients underwent Scheimpflug analysis using the Pentacam (Oculus, Wetzlar, Germany), axial length (AL) using the IOL master 700 (Carl Zeiss AG, Oberkochen, Germany), endothelial cell count (ECC) using the CEM-350 (NIDEK, Maihama, Japan) and corneal biomechanics evaluation with the Ocular Response Analyzer: ORA (Reichert Ophthalmic Instruments, Buffalo, New York, USA) and Corvis (Oculus, Wetzlar, Germany)...
February 20, 2024: Journal Français D'ophtalmologie
https://read.qxmd.com/read/38361411/evaluating-the-daily-modulation-of-fadd-and-related-molecular-markers-in-different-brain-regions-in-male-rats
#12
JOURNAL ARTICLE
Fernando Yáñez-Gómez, Laura Gálvez-Melero, Sandra Ledesma-Corvi, Cristian Bis-Humbert, Elena Hernández-Hernández, Glòria Salort, Rubén García-Cabrerizo, M Julia García-Fuster
Fas-Associated protein with Death Domain (FADD), a key molecule controlling cell fate by balancing apoptotic versus non-apoptotic functions, is dysregulated in post-mortem brains of subjects with psychopathologies, in animal models capturing certain aspects of these disorders, and by several pharmacological agents. Since persistent disruptions in normal functioning of daily rhythms are linked with these conditions, oscillations over time of key biomarkers, such as FADD, could play a crucial role in balancing the clinical outcome...
February 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38342901/distribution-and-determinants-of-corneal-volume-among-healthy-young-chinese-adults-a-cross-sectional-study
#13
JOURNAL ARTICLE
Gang Liang, Jia-Yan Kai, Dan-Lin Li, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Ya-Jie Zheng, Yu Qin, Chen-Wei Pan
BACKGROUND: Several studies have previously reported the normal values of corneal volume (CV) in various populations, whereas little is known about the CV distribution in healthy young Chinese adults. Our study aimed to investigate the distribution of CV and its relationships with other ocular biometric parameters among healthy young Chinese adults. METHODS: A total of 1645 eyes from 1645 students at Dali University in Yunnan Province, China, were analyzed. Pentacam was used to measure CV...
February 12, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38334467/altered-corneal-biomechanics-according-to-the-biomechanical-e-staging-in-pellucid-marginal-degeneration
#14
JOURNAL ARTICLE
Burak Mergen, Haris Sideroudi, Berthold Seitz, Elias Flockerzi
PURPOSE: The purpose of this study was to investigate corneal biomechanics in pellucid marginal degeneration (PMD) compared with healthy controls using Corvis ST (Oculus, Germany) by using the new biomechanical E-staging (based on the Corvis Biomechanical Factor, the linearized Corvis Biomechanical Index) together with tomographic parameters. METHODS: Corneal biomechanical and topographic data of 75 eyes of 75 patients with PMD and 75 eyes of 75 age-matched and sex-matched healthy controls were investigated...
February 6, 2024: Cornea
https://read.qxmd.com/read/38324098/comparison-of-corneal-biomechanical-parameters-in-healthy-corneas-with-symmetric-and-asymmetric-bow-tie-topographic-pattern-with-inferior-and-superior-steepening
#15
JOURNAL ARTICLE
Mohammad-Reza Sedaghat, Hadi Ostadi-Moghaddam, Hamed Momeni-Moghaddam, Soulmaz Motaei, Cynthia J Roberts, Michael W Belin, Samin Oladi Abbas Abadi
PURPOSE: To compare the corneal biomechanical parameters in healthy corneas with symmetric and asymmetric bow-tie topographic patterns. METHODS: In this cross-sectional study, 144 eyes were divided based on inferior-superior asymmetry value (I-S) into symmetric (zero I-S: - 0.50 to + 0.50 D) and asymmetric bow-tie topographic patterns with inferior (positive I-S: + 0.51 to + 1.4 D) or superior (negative I-S: - 2...
February 7, 2024: International Ophthalmology
https://read.qxmd.com/read/38309382/novel-rapid-treatment-options-for-adolescent-depression
#16
JOURNAL ARTICLE
Sandra Ledesma-Corvi, Jordi Jornet-Plaza, Laura Gálvez-Melero, M Julia García-Fuster
There is an urgent need for novel fast-acting antidepressants for adolescent treatment-resistant depression and/or suicidal risk, since the selective serotonin reuptake inhibitors that are clinically approved for that age (i.e., fluoxetine or escitalopram) take weeks to work. In this context, one of the main research lines of our group is to characterize at the preclinical level novel approaches for rapid-acting antidepressants for adolescence. The present review summarizes the potential use in adolescence of non-pharmacological options, such as neuromodulators (electroconvulsive therapy and other innovative types of brain stimulation), as well as pharmacological options, including consciousness-altering drugs (mainly ketamine but also classical psychedelics) and cannabinoids (i...
February 2, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38299478/step-by-step-standardization-of-the-bottom-up-semi-automated-nanocrystallization-of-pharmaceuticals-a-quality-by-design-and-design-of-experiments-joint-approach
#17
JOURNAL ARTICLE
Luis Castillo Henríquez, Badr Bahloul, Khair Alhareth, Feras Oyoun, Markéta Frejková, Libor Kostka, Tomáš Etrych, Luc Kalshoven, Alain Guillaume, Nathalie Mignet, Yohann Corvis
Nanosized drug crystals have been reported with enhanced apparent solubility, bioavailability, and therapeutic efficacy compared to microcrystal materials, which are not suitable for parenteral administration. However, nanocrystal design and development by bottom-up approaches are challenging, especially considering the non-standardized process parameters in the injection step. This work aims to present a systematic step-by-step approach through Quality-by-Design (QbD) and Design of Experiments (DoE) for synthesizing drug nanocrystals by a semi-automated nanoprecipitation method...
February 1, 2024: Small
https://read.qxmd.com/read/38285248/biomechanical-properties-measured-with-dynamic-scheimpflug-analyzer-in-central-serous-chorioretinopathy
#18
JOURNAL ARTICLE
Shuichiro Aoki, Ryo Asaoka, Keiko Azuma, Kohdai Kitamoto, Kohei Ueda, Tatsuya Inoue, Ryo Obata
PURPOSE: Recent evidence suggests that venous congestion at the vortex vein significantly contributes to the development of central serous chorioretinopathy (CSCR), and sclera is observed to be thicker in affected eyes. This study aims to investigate whether eyes with CSCR exhibit stiff corneas, measured using Corneal Visualization Scheimflug Technology (Corvis ST), which may serve as an indicator of scleral stiffness. METHODS: This retrospective case-control study comprises 52 eyes from 33 patients diagnosed with CSCR and 52 eyes from 32 normal controls without CSCR...
January 29, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38281439/improving-early-detection-of-keratoconus-by-non-contact-tonometry-a-computational-study-and-new-biomarkers-proposal
#19
JOURNAL ARTICLE
Elena Redaelli, Michael Nana, Begoña Calvo, José Félix Rodríguez Matas, Giulia Luraghi, Jos Rozema, Jorge Grasa
Keratoconus is a progressive ocular disorder affecting the corneal tissue, leading to irregular astigmatism and decreased visual acuity. The architectural organization of corneal tissue is altered in keratoconus, however, data from ex vivo testing of biomechanical properties of keratoconic corneas are limited and it is unclear how their results relate to true mechanical properties in vivo. This study explores the mechanical properties of keratoconic corneas through numerical simulations of non-contact tonometry (NCT) reproducing the clinical test of the Corvis ST device...
January 24, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38261848/patients-with-first-time-or-recurrent-patellar-dislocation-have-a-similar-high-rate-and-extent-of-articular-cartilage-injury-observed-on-magnetic-resonance-imaging
#20
JOURNAL ARTICLE
Andres R Perez, Carlo Coladonato, John Hayden Sonnier, Samuel T Saucedo, John P Avendano, John Corvi, Mike Campbell, Fotios P Tjoumakaris, Steven B Cohen, Michael C Ciccotti, Kevin B Freedman
PURPOSE: To use magnetic resonance imaging (MRI) scans to compare the prevalence of articular cartilage damage in patients with a single patellar dislocation versus those with multiple dislocations and to compare the locations and severity of chondral injury between the groups. METHODS: Patients with patellar dislocation between January 2017 and July 2021 were retrospectively identified. Patients with a documented history of patellar dislocation and an MRI scan of the affected knee were included...
February 2024: Arthroscopy, sports medicine, and rehabilitation
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