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Gianni Dal Negro, Chantra Eskes, Susanne Belz, Caroline Bertein, Magda Chlebus, Marco Corvaro, Raffaella Corvi, Stephane Dhalluin, Marlies Halder, Jim Harvey, Martina Herman, Simone Hoffmann-Dörr, Karin Kilian, Denis Lambrigts, Charles Laroche, Susanna Louhimies, Catherine Mahony, Irene Manou, Pauline McNamee, Pilar Prieto, Kirsty Reid, Erwin Roggen, Katrin Schutte, Catrina Stirling, Sylvie Uhlrich, Renate Weissenhorn, Maurice Whelan
EU regulations call for the use of alternative methods to animal testing. During the last decade, an increasing number of alternative approaches have been formally adopted. In parallel, new 3Rs-relevant technologies and mechanistic approaches have increasingly contributed to hazard identification and risk assessment evolution. In this changing landscape, an EPAA meeting reviewed the challenges that different industry sectors face in the implementation of alternative methods following a science-driven approach...
August 8, 2018: Regulatory Toxicology and Pharmacology: RTP
Padmamalini Mahendradas, Mathew Francis, Ruchi Vala, Poornachandra B Gowda, Ankush Kawali, Rohit Shetty, Abhijit Sinha Roy
PURPOSE: To quantify biomechanical change associated with autoimmune diseases using Corvis ST deformation data. METHODS: Cross-sectional, observational, case control study of 76 patients with systemic autoimmune disease and 21 control subjects. All patients underwent detailed ophthalmic examination with Corvis-ST (Oculus Optikgerate Gmbh, Germany) measurements for biomechanical properties of the eye. Corneal deformation and also deformation caused by the extracorneal tissue were recorded...
August 7, 2018: Ocular Immunology and Inflammation
Ting Liu, Ting Yu, Lina Liu, Kaijian Chen, Ji Bai
Purpose: To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods: Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients with 510  μ m-560  μ m central corneal thickness (CCT) and a refractive spherical equivalent of -3.00 D to -8.00 D were included. It was designed randomly to undergo SMILE with a 110  μ m cap thickness in one eye and 150  μ m cap thickness in the other...
2018: Journal of Ophthalmology
Yohann Corvis, Simona Manta, Caroline Thebault, Olivier Couture, Hélène Dhotel, Jean-Philippe Michel, Johanne Seguin, Michel Bessodes, Philippe Espeau, Chantal Pichon, Cyrille Richard, Nathalie Mignet
Amphiphilic triblock (Atri) copolymers made of perfluorinated alkyl chain linked to hydrocarbon chain and methoxy-poly(ethylene glycol) of three different molecular weights were synthesized. In vitro evaluation demonstrated that these new compounds were noncytotoxic. Characterization and interaction of each triblock copolymer with a branched polyamine myristoyl lipid (2-{3[bis-(3-amino-propyl)-amino]-propylamino}- N-ditetradecyl carbamoyl methyl-acetamide, DMAPAP) were studied by the Langmuir film method and thermal analysis...
August 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Khosrow Jadidi, Saman Mohazzab-Torabi, Shiva Pirhadi, Mostafa Naderi, Abbasali Yekta, Sara Sardari, Mehdi Khabazkhoob
PURPOSE: This study compares the corneal biomechanical properties, as measured with Corvis ST, in three groups of cases with delayed-onset mustard gas keratopathy (DMGK), chronic corneal scarring (CCS), and those with normal corneas. METHODS: Forty-five eyes were enrolled in the DMGK, CCS, and normal groups (15 eyes each). All patients were examined with the slitlamp and Corvis ST. Extracted corneal biomechanical parameters included first and second applanation time (AT1, AT2), first and second applanation length (AL1, AL2), first and second applanation velocity (AV1, AV2), deformation amplitude (DA), highest concavity time, peak distance, highest concavity radius (HCR), central corneal thickness, corrected intraocular pressure (IOP), and noncorrected IOP...
July 12, 2018: Eye & Contact Lens
Sara Catalán-López, Luis Cadarso-Suárez, Mónica López-Ratón, Carmen Cadarso-Suárez
SIGNIFICANCE: Before the appearance of evident keratoconus, corneal biomechanical changes may be detectable. Here, these properties are analyzed to detect any difference that could help in the early recognition of keratoconus to allow patients to benefit from early treatments and to avoid refractive procedures in these corneas. PURPOSE: The purpose of this study was to compare corneal biomechanical characteristics as determined by Corvis Scheimpflug Technology tonometry between normal eyes and asymmetric keratoconic eyes...
July 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
S Brettl, P Franko Zeitz, T A Fuchsluger
BACKGROUND: The in vivo analysis of corneal biomechanics in patients with keratoconus is especially of interest with respect to diagnosis, follow-up and monitoring of the disease. OBJECTIVE: For a better understanding it is necessary to describe the potential of dynamic Scheimpflug measurements for the detection and interpretation of biomechanical changes in keratoconus. MATERIAL AND METHODS: The current state of analyzing biomechanical changes in keratoconus with the Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) is described...
June 22, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Ashkan Eliasy, Kai-Jung Chen, Riccardo Vinciguerra, Osama Maklad, Paolo Vinciguerra, Renato Ambrósio, Cynthia J Roberts, Ahmed Elsheikh
The purpose of this study was to assess the validity of the Corvis ST (Oculus; Wetzlar, Germany) biomechanical correction algorithm (bIOP) in determining intraocular pressure (IOP) using experiments on ex-vivo human eyes. Five ex-vivo human ocular globes (age 69 ± 3 years) were obtained and tested within 3-5 days post mortem. Using a custom-built inflation rig, the internal pressure of the eyes was controlled mechanically and measured using the CorVis ST (CVS-IOP). The CVS-IOP measurements were then corrected to produce bIOP, which was developed for being less affected by variations in corneal biomechanical parameters, including tissue thickness and material properties...
June 15, 2018: Experimental Eye Research
Francesco Esposito, Marco Freddolini, Massimiliano Marcucci, Leonardo Latella, Andrea Corvi
BACKGROUND: Crutch use is prescribed early in the rehabilitation process following total hip replacement (THR) surgery to improve safety and promote return to active living. RESEARCH QUESTION: Purpose of this study was to understand mid-term effects of crutch length setup on quiet standing and walking two months post-op when crutch use was no longer required. METHODS: Thirty patients were evaluated 2 months post-surgery when they had been walking without crutch for a month...
June 5, 2018: Gait & Posture
Thomas A Fuchsluger, Susanne Brettl, Gerd Geerling, Wolfgang Kaisers, Philipp Franko Zeitz
AIMS: To examine corneal biomechanics in healthy and keratoconic eyes, with or without crosslinking obtained by ultrahigh-speed Scheimpflug measurements (Corvis ST). METHODS: One hundred and seventeen eyes were studied in three groups: group 1 (n=39) contained keratoconic eyes without crosslinking. Group 2 (CXL; n=28) comprised keratoconic eyes after crosslinking. These were compared with a control group (n=50 matched healthy eyes). In addition, 10 keratoconus patients, before and after CXL treatment, respectively, were examined...
June 5, 2018: British Journal of Ophthalmology
Marco Pellegrini, Federico Corvi, Alessandro Invernizzi, Vittoria Ravera, Matteo G Cereda, Giovanni Staurenghi
PURPOSE: To describe the imaging features of choroidal melanoma using swept-source optical coherence tomography angiography (SS-OCT-A) and to evaluate its ability to display tumor intrinsic vasculature. METHODS: Consecutive patients diagnosed with choroidal melanoma underwent a complete ophthalmic evaluation, including best-corrected visual acuity, color fundus photography, B-scan ultrasound, fluorescein angiography, indocyanine green angiography, and SS-OCT-A (PLEX Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA)...
May 8, 2018: Retina
Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Renato Ambrósio, Hamid-Reza Heidari, Nasim Maddah, Zeynab Danesh, Fatemeh Sabzi
PURPOSE: To assess the diagnostic capability of corneal shape and biomechanical parameters for distinguishing normal eyes from frank keratoconus (KCN). METHODS: This is a retrospective analysis of eyes of 137 control subjects and 145 patients with KCN, with one of their eyes randomly selected as the study eye. Corneal biomechanical parameters were assessed using the Corvis ST (Oculus Optikgeräte GmbH) and Oculus Response Analyzer (Reichert Ophthalmic Instruments)...
August 2018: Cornea
Shotaro Asano, Kosuke Nakajima, Kana Kure, Keiko Azuma, Kimiko Shimizu, Hiroshi Murata, Tatsuya Inoue, Ryo Obata, Ryo Asaoka
The aim of the current study is to investigate corneal biomechanical properties in detail using Ocular Response Analyzer (ORA) and Corvis ST (CST) tonometry and to analyze the association between corneal biomechanical properties and the frequency of intravitreal anti-vascular endothelial growth factor (VEGF) injections (FIV ) in AS eyes with choroidal neovascularization (CNV). Twenty-eight eyes of 15 patients with AS were enrolled. Mean age of AS patients was 67.9 ± 9.8 years. ORA and CST measurements were carried out, in addition to comprehensive ophthalmic examinations...
May 25, 2018: Scientific Reports
Elisabetta Tonet, Elisa Maietti, Giorgio Chiaranda, Francesco Vitali, Matteo Serenelli, Giulia Bugani, Gianni Mazzoni, Rossella Ruggiero, Jonathan Myers, Giovanni Quinto Villani, Ursula Corvi, Giovanni Pasanisi, Simone Biscaglia, Rita Pavasini, Giulia Ricci Lucchi, Gianluigi Sella, Roberto Ferrari, Stefano Volpato, Gianluca Campo, Giovanni Grazzi
BACKGROUND: Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) and they represent independent risk factors for disability, morbidity, hospital readmission and mortality. Regular physical exercise represents a means for improving functional capacity. Nevertheless, its clinical benefit has been less investigated in elderly patients in the early phase after ACS. The HULK trial aims to investigate the clinical benefit of an early, tailored low-cost physical activity intervention in comparison to standard of care in elderly ACS patients with reduced physical performance...
May 21, 2018: BMC Cardiovascular Disorders
R Herber, N Terai, K R Pillunat, F Raiskup, L E Pillunat, E Spörl
BACKGROUND: Topographic and tomographic parameters alone are often not sufficient for early detection of corneal changes. Pathological alterations in the microstructure of the cornea occur before changes in topography and tomography can be detected. Biomechanical parameters show a strong correlation with microscopic structural changes. OBJECTIVE: The aim of the study was to gain information about the microscopic structure and consistency of the cornea by measuring biomechanical parameters...
May 16, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Kai-Jung Chen, Akram Joda, Riccardo Vinciguerra, Ashkan Eliasy, Shervin Mir Mohi Sefat, Daniel Kook, Brendan Geraghty, Cynthia J Roberts, Ahmed Elsheikh
PURPOSE: To compare a biomechanically corrected intraocular pressure (bIOP) algorithm provided by the dynamic Scheimpflug analyzer (Corvis ST) with Goldmann applanation tonometry IOP (Goldmann IOP) and standard dynamic Scheimpflug analyzer IOP measurements before and after laser in situ keratomileusis (LASIK) and refractive lenticule extraction small-incision lenticule extraction (SMILE) surgeries. SETTING: Smile Eye Clinic, Munich, Germany, and University of Liverpool, Liverpool, United Kingdom...
May 2018: Journal of Cataract and Refractive Surgery
Lena Smirnova, Nicole Kleinstreuer, Raffaella Corvi, Andre Levchenko, Suzanne C Fitzpatrick, Thomas Hartung
A biological system is more than the sum of its parts - it accomplishes many functions via synergy. Deconstructing the system down to the molecular mechanism level necessitates the complement of reconstructing functions on all levels, i.e., in our conceptualization of biology and its perturbations, our experimental models and computer modelling. Toxicology contains the somewhat arbitrary subclass "systemic toxicities"; however, there is no relevant toxic insult or general disease that is not systemic...
2018: ALTEX
Mohammad Jannesari, Mahmoud Kadkhodaei, Peiman Mosaddegh, Henryk Kasprzak, Mahmoud Jabbarvand Behrouz
PURPOSE: The assessment of corneal biomechanics is essential for studying ophthalmological operations, such as refractive surgeries, and for more accurate estimation of intraocular pressure. The chief aim of the current study is to characterize corneal and fatty tissues in order to construct a model to predict eye globe behavior during dynamic tonometry tests. METHODS: In the present study, images from corneal deformation, acquired from Corvis ST tonometer, were processed...
2018: Acta of Bioengineering and Biomechanics
Robert Koprowski, Sławomir Wilczyński
Introduction: The paper presents a commentary on the method of analysis of corneal vibrations occurring during eye pressure measurements with air-puff tonometers, for example, Corvis. The presented definition and measurement method allow for the analysis of image sequences of eye responses-cornea deformation. In particular, the outer corneal contour and sclera fragments are analysed, and 3D reconstruction is performed. Methods: On this basis, well-known parameters such as eyeball reaction or corneal response are determined...
2018: Journal of Healthcare Engineering
Chiara Preziosa, Federico Corvi, Marco Pellegrini, Sara Bochicchio, Ana P Rosar, Giovanni Staurenghi
BACKGROUND/PURPOSE: To document by optical coherence tomography angiography, the onset of a choroidal neovascularization (CNV) secondary to traumatic choroidal rupture and describe its changes after an intravitreal injection of bevacizumab. METHODS: Case report. RESULTS: A 20-year-old woman presented referring vision loss after a blunt ocular trauma in her left eye. The patient underwent a complete ophthalmic examination. Best-corrected visual acuity was 20/200...
March 16, 2018: Retinal Cases & Brief Reports
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