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Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Renato Ambrósio, Cynthia J Roberts, Abbas-Ali Yekta, Zeynab Danesh, Sven Reisdorf, Mehdi Khabazkhoob, Hamid-Reza Heidari, Javad Sadeghi
PURPOSE: To compare the long-term changes in corneal biomechanics, topography, and tomography before and 4 years after corneal cross-linking (CXL) with the Dresden protocol and correlate these changes with visual acuity. METHODS: In this longitudinal study, 18 eyes of 18 patients with progressive keratoconus who were treated with CXL were included. All patients received a standard ophthalmological examination and were examined by Placido disc-based topography, Scheimpflug tomography, and biomechanical assessments with the Corvis ST (OCULUS Optikgeräte GmbH, Wetzlar, Germany) and Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Buffalo, NY) before and 4 years after CXL...
December 1, 2018: Journal of Refractive Surgery
Johannes Steinberg, Marlene Siebert, Toam Katz, Andreas Frings, Juliane Mehlan, Vasyl Druchkiv, Jens Bühren, Stephan J Linke
PURPOSE: To analyze the potential benefit of the newly developed Tomography and Biomechanical Index (TBI) for early keratoconus screening. METHODS: In this retrospective study, the discriminatory power of the corneal tomography Belin/Ambrósio Enhanced Ectasia Display (BAD-D) index and the newly developed Corvis Biomechanical Index (CBI) and TBI to differentiate between normal eyes, manifest keratoconus eyes (KCE), very asymmetric keratoconus eyes with ectasia (VAE-E), and their fellow eyes with either regular topography (VAE-NT) or regular topography and tomography (VAE-NTT) were analyzed by applying the t test (for normal distribution), Wilcoxon matched-pairs test (if not normally distributed), and receiver operating characteristic curve (ROC)...
December 1, 2018: Journal of Refractive Surgery
Pratik Kataria, Prema Padmanabhan, Aparna Gopalakrishnan, Vasanthi Padmanaban, Sanjay Mahadik, Renato Ambrósio
PURPOSE: To test the predictive accuracy of the Belin-Ambrósio deviation index (BAD-D), the stiffness parameter A1 (SPA1 ), the Corvis biomechanical index (CBI), and the tomographic and biomechanical index (TBI) assessments for distinguishing subclinical and mild keratoconic eyes from normal eyes. SETTING: Medical Research Foundation, Sankara Nethralaya, Chennai, India. DESIGN: Retrospective case series. METHOD: In this cross-sectional clinical study, the following 3 groups of eyes were analyzed: very asymmetric ectasia with normal topography (very asymmetric-normal topography), mild keratoconus, and normal control...
December 7, 2018: Journal of Cataract and Refractive Surgery
Mattia Dimitri, Fabio Staderini, Margherita Brancadoro, Francesco Frosini, Andrea Coratti, Lorenzo Capineri, Andrea Corvi, Fabio Cianchi, Guido Biffi Gentili
PURPOSE: Bleeding from parenchyma transection during a robotic hepatic surgery remains the most critical point affecting postoperative recovery and long-term survival. Various robotic devices with different types of energies have been proposed; however, each of these lack in steerability, efficacy, or accuracy. The aim of this work is to evaluate the feasibility and performance of a new steerable microwave resection device intended for minimizing intraoperative blood loss during laparoscopic and robotic liver resections...
November 28, 2018: International Journal of Hyperthermia
Henry B Wallace, Stuti L Misra, Sunny S Li, James McKelvie
IMPORTANCE: Intraocular pressure is often reduced following cataract surgery. Postoperative changes in corneal stiffness are likely to be at least partly responsible for any reduction in IOP measured with applanation tonometry. BACKGROUND: To determine the effect of cataract surgery and corneal incision size on corneal biomechanics. DESIGN: Prospective randomised trial PARTICIPANTS: One-hundred prospectively enrolled patients qualifying for cataract surgery METHODS: Participants were randomised to clear corneal incisions with a 2...
November 25, 2018: Clinical & Experimental Ophthalmology
Brice Martin Couillaud, Philippe Espeau, Nathalie Mignet, Yohann Corvis
The solid form screening of active principal ingredients is a challenge for the pharmaceutical drug development since more than 80% of the marketed drugs are formulated in the solid form. A broad and comprehensive study of the various solid forms of the matter is needed to enhance its translation to clinic. Therefore, the most suitable solid form has to be taken into consideration regarding ex- and in-vivo stability, targeting, solubility, dissolution rate, and bioavailability. In this review, techniques of solid form screening are reported, including differences in the solid forms such as polymorphs, solvates, salts, co-crystals and amorphous particles...
November 20, 2018: ChemMedChem
Hun Lee, David Sung Yong Kang, Byoung Jin Ha, Jin Young Choi, Eung Kweon Kim, Kyoung Yul Seo, Tae Im Kim
PURPOSE: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. MATERIALS AND METHODS: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigations including corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction spherical equivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant's age, MRSE, IOP, and mean keratometric values) by piecewise regression analysis, association of biomechanical parameters with variables by Spearman's correlation and stepwise multiple regression analyses, and reference intervals (RI) by the bootstrap method...
November 2018: Yonsei Medical Journal
Hai Doan Do, Brice Martin Couillaud, Bich-Thuy Doan, Yohann Corvis, Nathalie Mignet
Nucleic acids (NAs) have been considered as promising therapeutic agents for various types of diseases. However, their clinical applications still face many limitations due to their charge, high molecular weight, instability in biological environment and low levels of transfection. To overcome these drawbacks, therapeutic NAs should be carried in a stable nanocarrier, which can be viral or non-viral vectors, and released at specific target site. Various controllable gene release strategies are currently being evaluated with interesting results...
October 12, 2018: Advanced Drug Delivery Reviews
Tommy C Y Chan, Yu Meng Wang, Marco Yu, Vishal Jhanji
PURPOSE: To investigate and compare the diagnostic ability of corneal tomography and biomechanical and combined parameters for detection of corneal ectasia. METHODS: Consecutive patients with subclinical keratoconus (SCKC) and age-matched controls were included. Only one eye from each patient was selected for analysis. The final D value from the Belin/Ambrósio Enhanced Ectasia Display (BAD) was obtained from the Pentacam (Oculus Optikgeräte, Wetzlar, Germany)...
September 1, 2018: Journal of Refractive Surgery
Federico Corvi, Marco Pellegrini, Maria Belotti, Carlo Bianchi, Giovanni Staurenghi
PURPOSE: To evaluate the feasibility in the clinical practice of a fast and simple mesopic microperimetry examination comparing the retinal sensitivity in eyes with drusen and reticular pseudodrusen by scotopic and mesopic testing. METHODS: In eyes with only drusen and only reticular pseudodrusen, retinal sensitivity was assessed by mesopic testing and after 35 minutes of dark adaptation by scotopic testing using 2 grids of 6 and 10 stimulus points. RESULTS: Fifteen eyes with drusen and 14 eyes with reticular pseudodrusen were enrolled with mean best-corrected visual acuity of 20/20...
August 30, 2018: Retina
Michele Lanza, Michele Rinaldi, Ugo Antonello Gironi Carnevale, Silvio di Staso, Mario Bifani Sconocchia, Ciro Costagliola
BACKGROUND: To evaluate differences of intraocular pressure (IOP) measurements performed with Goldmann applanation tonometer (GAT), dynamic contour tonometer (DCT), rebound tonometry (RT), Ocular Response Analyzer (ORA) and Corvis ST (CST) in eyes screened for refractive surgery. METHODS: One eye, only the right one, of 146 patients was included in this study. Each participant was submitted to a corneal analysis with Scheimpflug camera and IOP evaluation with GAT, DCT, RT, ORA and CST...
September 3, 2018: BMC Ophthalmology
Ramin Salouti, Ali Agha Alishiri, Reza Gharebaghi, Mostafa Naderi, Khosrow Jadidi, Ahmad Shojaei-Baghini, Mohammadreza Talebnejad, Zahra Nasiri, Seyedmorteza Hosseini, Fatemeh Heidary
AIM: To explore the relationship between different parameters of Ocular Response Analyzer (ORA) and Corvis ST (CST) in a sample of healthy Iranian school-aged children and the relationship between parameters of these 2 instruments against intraocular pressure (IOP), measured by the Goldmann applanation tonometer (GAT-IOP), age and gender, and find possible correlation between ORA and CST with GAT. METHODS: This cross-sectional study included 90 healthy children...
2018: International Journal of Ophthalmology
Juan M Spera, Francisco Guaimas, María M Corvi, Juan E Ugalde
Brucellaceae are a group of pathogenic intracellular bacteria with the ability to modulate the host response, both at the individual cell level and systemically. One of the hallmarks of the virulence process is the capacity of the bacteria to downregulate the adaptive and acquired host immune response through a plethora of virulence factors that directly impact several key signaling cascades. PrpA is one of those virulence factors that alters, via its polyclonal B-cell activity, the humoral and cellular immune responses of the host, ultimately favoring the establishment of a chronic infection...
November 2018: Infection and Immunity
Iben Bach Damgaard, Mohamed Reffat, Jesper Hjortdal
Worldwide, femtosecond Laser Assisted In-situ Keratomileusis (LASIK) is a well known and commonly used refractive technique, although Small Incision Lenticule Extraction (SMILE) has become increasingly popular since it was introduced in 2011. In LASIK, a corneal flap is cut with a microkeratome or femtosecond laser, followed by thinning of the stromal bed with excimer laser ablation. In SMILE, a minor intrastromal lenticule is cut with a femtosecond laser and subsequently removed through a small incision, leaving the anterior and strongest part of the cornea almost intact...
2018: Open Ophthalmology Journal
Gianni Dal Negro, Chantra Eskes, Susanne Belz, Caroline Bertein, Magda Chlebus, Marco Corvaro, Raffaella Corvi, Stephane Dhalluin, Marlies Halder, Jim Harvey, Martina Hermann, Simone Hoffmann-Dörr, Karin Kilian, Denis Lambrigts, Charles Laroche, Susanna Louhimies, Catherine Mahony, Irene Manou, Pauline McNamee, Pilar Prieto, Kirsty Reid, Erwin Roggen, Katrin Schutte, Catrina Stirling, Sylvie Uhlrich, Renate Weissenhorn, Maurice Whelan
EU regulations call for the use of alternative methods to animal testing. During the last decade, an increasing number of alternative approaches have been formally adopted. In parallel, new 3Rs-relevant technologies and mechanistic approaches have increasingly contributed to hazard identification and risk assessment evolution. In this changing landscape, an EPAA meeting reviewed the challenges that different industry sectors face in the implementation of alternative methods following a science-driven approach...
November 2018: Regulatory Toxicology and Pharmacology: RTP
Padmamalini Mahendradas, Mathew Francis, Ruchi Vala, Poornachandra B Gowda, Ankush Kawali, Rohit Shetty, Abhijit Sinha Roy
PURPOSE: To quantify biomechanical change associated with autoimmune diseases using Corvis ST deformation data. METHODS: Cross-sectional, observational, case control study of 76 patients with systemic autoimmune disease and 21 control subjects. All patients underwent detailed ophthalmic examination with Corvis-ST (Oculus Optikgerate Gmbh, Germany) measurements for biomechanical properties of the eye. Corneal deformation and also deformation caused by the extracorneal tissue were recorded...
August 7, 2018: Ocular Immunology and Inflammation
Ting Liu, Ting Yu, Lina Liu, Kaijian Chen, Ji Bai
Purpose: To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods: Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients with 510  μ m-560  μ m central corneal thickness (CCT) and a refractive spherical equivalent of -3.00 D to -8.00 D were included. It was designed randomly to undergo SMILE with a 110  μ m cap thickness in one eye and 150  μ m cap thickness in the other...
2018: Journal of Ophthalmology
Yohann Corvis, Simona Manta, Caroline Thebault, Olivier Couture, Hélène Dhotel, Jean-Philippe Michel, Johanne Seguin, Michel Bessodes, Philippe Espeau, Chantal Pichon, Cyrille Richard, Nathalie Mignet
Amphiphilic triblock (Atri) copolymers made of perfluorinated alkyl chain linked to hydrocarbon chain and methoxy-poly(ethylene glycol) of three different molecular weights were synthesized. In vitro evaluation demonstrated that these new compounds were noncytotoxic. Characterization and interaction of each triblock copolymer with a branched polyamine myristoyl lipid (2-{3[bis-(3-amino-propyl)-amino]-propylamino}- N-ditetradecyl carbamoyl methyl-acetamide, DMAPAP) were studied by the Langmuir film method and thermal analysis...
August 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Khosrow Jadidi, Saman Mohazzab-Torabi, Shiva Pirhadi, Mostafa Naderi, Abbasali Yekta, Sara Sardari, Mehdi Khabazkhoob
PURPOSE: This study compares the corneal biomechanical properties, as measured with Corvis ST, in three groups of cases with delayed-onset mustard gas keratopathy (DMGK), chronic corneal scarring (CCS), and those with normal corneas. METHODS: Forty-five eyes were enrolled in the DMGK, CCS, and normal groups (15 eyes each). All patients were examined with the slitlamp and Corvis ST. Extracted corneal biomechanical parameters included first and second applanation time (AT1, AT2), first and second applanation length (AL1, AL2), first and second applanation velocity (AV1, AV2), deformation amplitude (DA), highest concavity time, peak distance, highest concavity radius (HCR), central corneal thickness, corrected intraocular pressure (IOP), and noncorrected IOP...
July 12, 2018: Eye & Contact Lens
Sara Catalán-López, Luis Cadarso-Suárez, Mónica López-Ratón, Carmen Cadarso-Suárez
SIGNIFICANCE: Before the appearance of evident keratoconus, corneal biomechanical changes may be detectable. Here, these properties are analyzed to detect any difference that could help in the early recognition of keratoconus to allow patients to benefit from early treatments and to avoid refractive procedures in these corneas. PURPOSE: The purpose of this study was to compare corneal biomechanical characteristics as determined by Corvis Scheimpflug Technology tonometry between normal eyes and asymmetric keratoconic eyes...
July 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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