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Fuzheng Zhao, Feng Ju, Kailong Huang, Yanping Mao, Xu-Xiang Zhang, Hongqiang Ren, Tong Zhang
Due to complexity and variety of pharmaceutical wastewater composition, little is known as for functionally important microflora of pharmaceutical wastewater treatment plants (pWWTPs). We compared bacterial composition and diversity of pWWTPs (27 sludge samples collected from 12 full-scale pWWTPs) with those of other industrial (iWWTPs) (27 samples) and municipal wastewater treatment plants (mWWTPs) (27 samples) through meta-analysis based on 16S rRNA gene amplicon sequencing, and identified putatively important organisms and their ecological correlations...
October 9, 2018: Science of the Total Environment
Myxuan Huynh, Loredana Gabriela Marcu, Eileen Giles, Michala Short, Donna Matthews, Eva Bezak
INTRODUCTION: The most common solid tumours that develop in children are cancers of the central nervous system. Due to the increased rate of survival over the past decades, greater focus has been placed on the minimisation of long term side effects. In childhood cancer survivors, over 60% report one or more radiation-related late toxicities while half of these adverse events are graded as life-threatening or severe. Proton therapy enables high conformity with the planning target volume and a reduction in dose to areas beyond the target...
October 9, 2018: Cancer Treatment Reviews
Bassam Haddad, Guillaume Lefèvre, Alexandra Rousseau, Thomas Robert, Samir Saheb, Cedric Rafat, Marie Bornes, Camille Petit-Hoang, Frédéric Richard, Edouard Lecarpentier, Vassilis Tsatsaris, Jean Guibourdenche, Anthony Corchia, Eric Rondeau, Tabassome Simon, Alexandre Hertig
OBJECTIVE: Severe preeclampsia may require the delivery of the placenta to avoid life-threatening complications for the mother. Before 26 weeks of gestation, this often results in perinatal death. A decrease in soluble fms-like tyrosine kinase 1 (sFlt1), an anti-angiogenic factor central to the pathophysiology of the maternal syndrome, has been reported after LDL- apheresis. The present study tested whether LDL-apheresis could be used to allow women with early and severe preeclampsia to reach a gestational age where the baby had a viable chance of survival...
September 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Lawrence M Wei, Dylan P Thibault, J Scott Rankin, Mohamad Alkhouli, Harold G Roberts, Sreekanth Vemulapalli, Babatunde Yerokun, Niv Ad, Hartzell V Schaff, Nicholas G Smedira, Hiroo Takayama, Patrick M McCarthy, Vinod H Thourani, Gorav Ailawadi, Jeffrey P Jacobs, Vinay Badhwar
BACKGROUND: The primary surgical therapy for hypertrophic cardiomyopathy (HCM) with obstruction is septal myectomy (SM). The current outcomes of SM with and without concomitant mitral operations in the United States was examined using The Society of Thoracic Surgeons (STS) database. METHODS: From July 2014 through June 2017, 4,274 SM operations were performed. Emergent status, endocarditis, aortic stenosis, and planned aortic valve operations were excluded. In the final cohort of 2,382 patients, 1,581 (66...
October 13, 2018: Annals of Thoracic Surgery
Graham Devereux, Seonaidh Cotton, Shona Fielding, Nicola McMeekin, Peter J Barnes, Andrew Briggs, Graham Burns, Rekha Chaudhuri, Henry Chrystyn, Lisa Davies, Anthony De Soyza, Simon Gompertz, John Haughney, Karen Innes, Joanna Kaniewska, Amanda Lee, Alyn Morice, John Norrie, Anita Sullivan, Andrew Wilson, David Price
Importance: Chronic obstructive pulmonary disease (COPD) is a major global health issue and theophylline is used extensively. Preclinical investigations have demonstrated that low plasma concentrations (1-5 mg/L) of theophylline enhance antiinflammatory effects of corticosteroids in COPD. Objective: To investigate the effectiveness of adding low-dose theophylline to inhaled corticosteroids in COPD. Design, Setting, and Participants: The TWICS (theophylline with inhaled corticosteroids) trial was a pragmatic, double-blind, placebo-controlled, randomized clinical trial that enrolled patients with COPD between February 6, 2014, and August 31, 2016...
October 16, 2018: JAMA: the Journal of the American Medical Association
Carolyn A Fahey, Prosper F Njau, William H Dow, Ntuli Kapologwe, Sandra I McCoy
OBJECTIVE: Food insecurity (FI) impedes antiretroviral therapy (ART) adherence. We previously demonstrated that short-term cash and food incentives increased ART possession and retention in HIV services in Tanzania. To elucidate potential pathways that led to these achievements, we examined whether incentives also improved FI. DESIGN: Three-arm randomized controlled trial. METHODS: From 2013 to 2015, 805 food-insecure adult ART initiates (≤90 days) at three clinics were randomized to receive cash or food transfers (∼$11/month for ≤6 months, conditional on visit attendance) or standard-of-care (SOC) services...
October 15, 2018: AIDS
Elin Bolle Strand, Anne Marit Mengshoel, Leiv Sandvik, Ingrid B Helland, Semhar Abraham, Lise Solberg Nes
Background and aims Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is challenging to live with, often accompanied by pervasive fatigue and pain, accompanied by decreased quality of life (QoL) as well as anxiety and/or depression. Associations between higher pain, lower QoL and higher anxiety and depression have been shown in patients with various chronic pain disorders. Few studies have however examined such associations in a sample of patients with ME/CFS. The aims of the current study were to examine the impact of pain levels and compare levels of pain, health related QoL, anxiety and depression between patients with ME/CFS and healthy controls...
October 16, 2018: Scandinavian Journal of Pain
Ismail Evren, Ahmet Hacıislamoğlu, Mithat Ekşi, Abdullah Hizir Yavuzsan, Firat Baytekin, Yunus Çolakoğlu, Didem Canoğlu, Volkan Tugcu
OBJECTIVE: Parameters predictive of biochemical or clinical recurrence after Radical Prostatectomy (RP) were determined as pre-treatment PSA value, pathologic tumor stage, tumor grade and presence of Positive Surgical Margin (PSM), extracapsular extension and seminal vesicle invasion and the status of pelvic lymph nodes. The aim of our study is to evaluate the effect of additional features in patients undergoing RP in our clinic. MATERIALS AND METHODS: We studied 556 RP operations performed between 2009 and 2016 for prostate cancer at this clinic...
September 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Dan Chen, Yalian Ji
BACKGROUND: This study aimed to investigate the clinical features of neonatal sepsis caused by Citrobacter freundii as well as the current status and treatment strategy of multi-drug resistance for infection with this bacterium. METHODS: Nine newborns were diagnosed with C. freundii sepsis between January 2014 and December 2017,we collated and analysed a range of data of the nine patients, including general information,laboratory tests during infection,blood culture and treatments...
October 16, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Saoussen Bacha, Hela Cherif, Della Rabaa, Sonia Habibech, Sana Cheikhrouhou, Hager Racil, Naouel Chaouch, Mohamed Lamine Megdiche, Abdellatif Chabbou
BACKGROUND: The prognosis of patients with non-small cell lung cancer (NSCLC) with brain metastasis (BM) is dark. The aim of our study was to analyze the prognostic factors after the onset of BM and to evaluate the current management of BM. METHODS: We conducted a retrospective study that included 100 patients diagnosed with primary NSCLC with BM. Survival was analysed using Kaplan Meier curve.Univariate survival analysis was performed to assess the prognostic value of sex, age, gender, performance status, histologic type, tumor size, BM features and treatment modality of primary lung tumor and BM...
March 2018: La Tunisie Médicale
Göran Rådegran
Pulmonary arterial hypertension (PAH) is a progressive vascular disease, due to vasoconstriction and remodelling of pulmonary arteries. Survival has from diagnosis, if untreated, been found to be 1 to 2.8 years, depending on whether related to rheumatic disease or not. The ESC/ERS risk stratification tool provides a new approach to evaluate the clinical status of PAH patients. It supports a refined treatment strategy, based on risk assessment at diagnosis and early follow-up, with the aim to identify patients early and initiate, as well as adjust treatment individually, striving for the patients to remain in, or improve to low risk status, whereby survival is markedly improved...
October 15, 2018: Läkartidningen
Anna M Modest, Lauren A Wise, Matthew P Fox, Jennifer Weuve, Alan S Penzias, Michele R Hacker
STUDY QUESTION: Does inverse probability weighting (IPW) provide a more valid estimate of the cumulative incidence of live birth after multiple cycles of IVF? SUMMARY ANSWER: IPW can provide a more accurate estimate of treatment success for counseling and decision-making regarding IVF. WHAT IS KNOWN ALREADY: Different approaches have been used to define and calculate IVF success; however, many of these approaches have limitations and potentially violate statistical assumptions...
October 15, 2018: Human Reproduction
Jason D Chodakowski, Daniel Mark Courtney
PURPOSE OF REVIEW: We provide a timely update on treatment care issues facing clinicians and patients with acute pulmonary embolism accompanied by either right ventricular strain (sub-massive pulmonary embolism) or shock (massive pulmonary embolism). RECENT FINDINGS: Care and research changes over the last several years have resulted in four important trends: more consensus and accuracy in the way acute pulmonary embolism severity is described and communicated among acute care clinicians and researchers, increased availability and use of risk prediction scoring systems, increased use of advanced invasive therapy in the setting of severe right ventricular dysfunction, and emergence of multidisciplinary pulmonary embolism response teams to guide standard care decision-making...
October 12, 2018: Current Opinion in Critical Care
Abdelhafeiz Mahamoud, Yousif Awad, Hussam Ali Osman, Atif El Agib, Rubens Riscala Madi, Saul J Semiao-Santos, Abdallah El Harith
PURPOSE: Based on world-wide evaluation, the direct agglutination test (DAT) is now generally acknowledged as one of the leading diagnostics for visceral leishmaniasis (VL). To enhance more routine and mass application, but simultaneously ensure safety to both user and environment, further improvements need to be introduced. METHODOLOGY: In the current format, a two-sixfold titre decrease was observed due to using formaldehyde as an antigen preservative in DAT. Successful formaldehyde preservative exclusion was achieved by increasing its concentration to 3 % (wt/vol) for conserving promastigote status after β-mercaptoethanol (β-ME) treatment and repeating exposure of the parasite to the fixative after Coomassie Brilliant Blue staining...
October 16, 2018: Journal of Medical Microbiology
Syed I Khalid, Adam Carlton, Roberta P Glick
OBJECTIVES: Previous reports of a higher incidence and risk of stroke in minorities were associated primarily with race and ethnicity, yet the relationship between socio-economic status (SES) and racial disparities in stroke is less well known. We have investigated the effects of SES on the incidence of stroke type and its severity in minorities. METHODS: The clinical and demographic data on 140 patients diagnosed with a stroke in the North Lawndale neighbourhood of Chicago, one of the city's poorest communities, were collected prospectively over a 13-month period and then were retrospectively analysed...
2018: Brain Injury: [BI]
Chang Gang Yang, Shou Xi Chai
Bundled straw covering (BSC), using corn whole straw for partial coverage planting, is a novel dryland cultivation technique. To examine the effects of BSC on the thermal-moisture status and winter wheat yield under typical arid and semiarid conditions in the Loess Plateau of Northwest China, soil temperature, soil water content and consumption, grain yield and water-use efficiency were compared for four treatments, including no-tillage with straw mulch (NTS), whole field plastic mulching with soil covering on the top of the plastic mulch and bunch-seeding (PFM), open field cultivation (CK) and BSC during three growing seasons from 2013 to 2016...
October 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Hong-Kai Wang, Wen-Hao Xu, Chun-Guang Ma, Liang-Ping Zhou, Guo-Hai Shi, Hai-Liang Zhang, Ding-Wei Ye
OBJECTIVES: To investigate the role of tumor growth velocity in defining tumor progression in metastatic renal cell carcinoma patients treated with the vascular endothelial growth factor tyrosine kinase inhibitor, sorafenib. METHODS: A modified calculation for tumor growth velocity was introduced to evaluate the tumor growth velocity, before and after sorafenib withdrawal. Known prognostic factors together with tumor growth velocity before drug withdrawal and tumor growth velocity after drug withdrawal were compared using a χ2 -test from a contingency table, and partial likelihood test from a Cox regression model for overall survival...
October 16, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
B Delahunt, J R Srigley, M J Judge, M B Amin, A Billis, P Camparo, A J Evans, S Fleming, D Griffiths, A Lopez-Beltran, G Martignoni, H Moch, J N Nacey, M Zhou
AIMS: The International Collaboration on Cancer Reporting (ICCR) has provided detailed datasets based upon the published reporting protocols of the Royal College of Pathologists, The Royal College of Pathologists of Australasia and the College of American Pathologists. METHODS AND RESULTS: The dataset for carcinomas of renal tubular origin treated by nephrectomy was developed to provide a minimum structured reporting template suitable for international use and incorporated recommendations from the 2012 Vancouver Consensus Conference of the International Society of Urological Pathology and the fourth edition of the World Health Organization Bluebook on tumours of the urinary and male genital systems published in 2016...
October 16, 2018: Histopathology
Terence Fu, Christopher J Chin, Wei Xu, Jiahua Che, Shao Hui Huang, Eric Monteiro, Yazeed Alghonaim, Jolie Ringash, Ian J Witterick
OBJECTIVES/HYPOTHESIS: Treatment of non-squamous cell carcinoma sinonasal malignancies (NSCCSMs) typically involves surgery and radiotherapy (RT), but optimal sequencing remains controversial. STUDY DESIGN: Retrospective chart review. METHODS: Patients with NSCCSM treated with combined surgery and RT between 2000 and 2011 were identified. Margin control, overall survival, disease-free survival, local recurrence-free survival, and regional recurrence-free survival were compared between neoadjuvant and adjuvant RT groups...
October 16, 2018: Laryngoscope
Ilya Likhterov, Meng Ru, Cindy Ganz, Mark L Urken, Raymond Chai, Devin Okay, Jerry Liu, Robert Stewart, Bruce Culliney, Daisy Palacios, Cathy L Lazarus
OBJECTIVES/HYPOTHESIS: This study examined saliva weight over time and its association with diet and patient-rated swallowing, dry mouth, sticky saliva, and dysgeusia quality of life in head and neck cancer (HNCA) patients treated with surgery plus adjuvant chemoradiotherapy (CRT), or primary CRT. STUDY DESIGN: Prospective cohort study in an outpatient HNCA center setting. METHODS: Patients were seen pretreatment, and 1, 3, 6, 12, 24, and 36 + months post-treatment...
October 16, 2018: Laryngoscope
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