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Antibody rejection

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https://www.readbyqxmd.com/read/30333363/decreased-expression-of-microrna-107-in-b-lymphocytes-of-patients-with-antibody-mediated-renal-allograft-rejection
#1
Zhe-Wei Zhang, Ming Wang, Jun-Jie Hu, Gang Xu, Yong Zhang, Nan Zhang
MicroRNAs (miRNAs) are small noncoding RNA molecules that participate in normal B cell lineage development through posttranscriptional gene regulation. Antibody-mediated renal allograft rejection (ABMR) is emerging as one of the most common serious threats to renal transplant patients. In this study, we explored the role of miRNAs in the pathogenesis of ABMR. The differentially expressed miRNAs were identified by Affymetrix miRNA microarray analysis using B lymphocytes from 5 recipients and 5 volunteers. Based on quantitative RT-PCR, the expression levels of miR-107 were lower in the B lymphocytes from recipients than in those from volunteers...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/30333318/combining-sting-based-neoantigen-targeted-vaccine-with-checkpoint-modulators-enhances-antitumor-immunity-in-murine-pancreatic-cancer
#2
Heather L Kinkead, Alexander Hopkins, Eric Lutz, Annie A Wu, Mark Yarchoan, Kayla Cruz, Skylar Woolman, Teena Vithayathil, Laura H Glickman, Chudi O Ndubaku, Sarah M McWhirter, Thomas W Dubensky, Todd D Armstrong, Elizabeth M Jaffee, Neeha Zaidi
Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algorithm, NetMHC, to generate a neoantigen-targeted vaccine, PancVAX, which was administered together with the STING adjuvant ADU-V16 to mice bearing pancreatic adenocarcinoma (Panc02) cells. PancVAX activated a neoepitope-specific T cell repertoire within the tumor and caused transient tumor regression...
October 18, 2018: JCI Insight
https://www.readbyqxmd.com/read/30333303/exploring-the-cardiac-response-to-injury-in-heart-transplant-biopsies
#3
Philip F Halloran, Jeff Reeve, Arezu Z Aliabadi, Martin Cadeiras, Marisa G Crespo-Leiro, Mario Deng, Eugene C Depasquale, Johannes Goekler, Xavier Jouven, Daniel H Kim, Jon Kobashigawa, Alexandre Loupy, Peter Macdonald, Luciano Potena, Andreas Zuckermann, Michael D Parkes
BACKGROUND: Because injury is universal in organ transplantation, heart transplant endomyocardial biopsies present an opportunity to explore response to injury in heart parenchyma. Histology has limited ability to assess injury, potentially confusing it with rejection, whereas molecular changes have potential to distinguish injury from rejection. Building on previous studies of transcripts associated with T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), we explored transcripts reflecting injury...
October 18, 2018: JCI Insight
https://www.readbyqxmd.com/read/30321549/an-optimized-protocol-to-quantify-signaling-in-human-transitional-b-cells-by-phospho-flow-cytometry
#4
Nicholas A Zwang, Balaji B Ganesh, Kim T Cardenas, Anita S Chong, Patricia W Finn, David L Perkins
BACKGROUND AND PURPOSE: Phospho flow cytometry is a powerful technique to analyze signaling in rare cell populations. This technique, however, requires harsh conditions for cell fixation and permeabilization, which can denature surface antigens or antibody-conjugated fluorochromes. These are among several technical limitations which have been a barrier to quantify signaling in unique B cell subsets. One such immature subset, transitional B cells (TrBs), may play a role in suppressing solid organ transplant rejection, graft-versus-host disease, autoimmunity, and even the immune response to malignancy...
October 12, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/30321467/efficacy-of-therapeutic-plasma-exchange-on-angiotensin-ii-type-1-receptor-antibodies-on-two-kidney-transplant-recipients
#5
Chisa Yamada, Yihung Huang, Silas Norman, Abhijit Naik, Omar Moussa, Milagros Samaniego, Laura Cooling
BACKGROUND: Angiotensin II type-1 receptor antibody (AT1RAb) has been reported to cause antibody mediated rejection (AMR) in kidney transplant recipients possibly by contraction of renal arteries. We here report 2 kidney transplant recipients with elevated AT1RAbs and negative HLA donor specific antibodies (DSA) and anti-major histocompatibility complex class I chain-related gene A (MICA) Abs who received therapeutic plasma exchange (TPE) treatment followed by IVIG. CASE 1: Thirty-eight-year-old patient received second kidney transplant for end stage renal disease (ESRD) with chronic rejection...
October 15, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/30318177/implication-of-antibodies-against-human-leukocyte-antigen-in-simultaneous-presentation-of-fetal-and-neonatal-alloimmune-thrombocytopenia-and-neutropenia
#6
Idoia Gimferrer, Gayle Teramura, Mary Gallagher, Paul Warner, Hongxiu Ji, Shilpi Chabra
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal alloimmune neutropenia (NAN) are two rare complications of newborns caused by antibodies against paternal inherited antigens. Human platelet (HPA) and neutrophil antigens (HNA) are the common targets. Human leukocyte antigen (HLA) class I proteins are also expressed on platelets and neutrophils and anti-HLA antibodies have occasionally been implicated in these complications. We report a premature twin infant who presented with severe thrombocytopenia and neutropenia clinically compatible with FNAIT and NAN, from a mother with no identifiable HPA or HNA antibodies, but with very high levels of complement-fixing antibodies against paternal inherited HLA...
September 29, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/30316402/early-focal-segmental-glomerulosclerosis-as-a-cause-of-delayed-graft-function-with-combined-acute-antibody-rejection-a-case-report
#7
S Jung, K-M Park, J Hah, K C Hong, S-D Hwang, J Song
Focal segmental glomerulosclerosis (FSGS) is the most common form of post-transplant glomerulonephritis. We describe a case where a biopsy proved that early recurrence of FSGS on postoperative day 1 was the cause of delayed graft function. A 39-year-old man, on hemodialysis for 15 years due to polycystic kidney disease, received a cadaveric renal transplantation. On postoperative day 1, his hourly urine output decreased from 700-800 mL to 50 mL. The graft biopsy showed a mild acute kidney injury confusing nephrotic syndrome...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316396/acute-antibody-mediated-rejection-by-de-novo-anti-hla-dp%C3%AE-and-dp%C3%AE-antibodies-after-kidney-transplantation-a-case-report
#8
D Thammanichanond, W Parapiboon, T Mongkolsuk, S Worawichawong, C Tammakorn, P Kitpoka
The presence of isolated de novo anti-DP antibodies is uncommon, making it difficult to determine the impact of anti-DP antibodies on graft outcome. We describe a case of acute antibody-mediated rejection mediated by de novo donor-specific anti-HLA-DP antibodies. Furthermore, the generation of non-donor-specific anti-DP antibodies (NDSAs) detected in the patient's sera was investigated. An 18-year-old woman with pretransplant 0% panel-reactive antibody received kidney transplantation from a living donor. She experienced combined acute T-cell-mediated and antibody-mediated rejection at 15 months after transplantation...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316380/risk-factors-for-acute-rejection-after-deceased-donor-kidney-transplantation-in-china
#9
Q Fu, H Zhang, W Nie, R Deng, J Li, Y Xiong, Y Dai, L Liu, X Yuan, X He, C Wang
OBJECTIVES: This study aimed to identify the potential risk factors of acute rejection after deceased donor kidney transplantation in China. METHODS: Adult kidney transplantations from deceased donors in our center from February 2004 to December 2015 were enrolled for retrospective analysis. All deceased donations complied with China's Organ Donation Program. No organs from executed prisoners were used. The incidence of clinical and biopsy-proved acute rejection was assessed with the Kaplan-Meier method, and the Cox proportional hazard model was used for multivariate analysis...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316369/different-risk-factors-for-graft-survival-between-living-related-and-deceased-donor-kidney-transplantation
#10
H Zhang, Y Wei, L Liu, J Li, R Deng, Y Xiong, X Yuan, X He, Q Fu, C Wang
The aim of this study was to determine distinctive risk factors for graft survival of living-related and deceased donor kidney transplantation (KTx). METHODS: Consecutive 536 living-related and 524 deceased donor kidney transplant recipients from February 2014 to December 2015 in a single center were enrolled for retrospective analysis. Graft survival was assessed with the Kaplan-Meier method, and the Cox proportional hazard model was used to determine independent risk factors of allograft survival...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316365/clinical-significance-of-serum-visfatin-in-renal-transplant-recipients
#11
K-H Shu, H-F Chiu, M-J Wu, C-H Chen, T-M Yu
Chronic antibody-mediated rejection is the most common cause of late graft loss in renal transplant recipients. Visfatin is a pre-B cell colony-enhancing factor secreted by activated lymphocytes. We hypothesize that visfatin may play a role in the augmentation of B cell colonies and facilitate antibody-mediated rejection. Renal transplant recipients were randomly selected for the study. Fasting blood samples were obtained for the assay of visfatin. The participants were prospectively followed up for 3 years...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316363/class-ii-hla-eplet-mismatch-is-a-risk-factor-for-de-novo-donor-specific-antibody-development-and-antibody-mediated-rejection-in-kidney-transplantation-recipients
#12
H Kishikawa, T Kinoshita, M Hashimoto, S Fukae, A Taniguchi, K Yamanaka, M Nakagawa, K Nishimura
OBJECTIVES: We investigated the correlation between class II HLA epitope mismatch and antibody-mediated rejection (AMR) episodes in kidney transplant recipients. In patients with AMR, epitope mismatch was also examined for each class II HLA mismatch to determine development of de novo donor-specific antibodies (DSAs). METHODS: We conducted a retrospective study of 167 kidney recipients. The numbers of eplet mismatches were compared between those with (n = 12) and without (n = 155) AMR, and the numbers of eplet mismatches for each type of mismatch in class II HLA among the AMR patients was also compared...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316362/effect-of-early-immunosuppression-therapy-on-de-novo-anti-human-leukocyte-antigen-antibody-after-kidney-transplantation
#13
H Zhang, Q Fu, Y Zheng, J Li, S Wang, R Deng, G Huang, W Deng, H Huang, L Liu, C Wang
The aim of the study was to investigate the effect of immunosuppression therapy early after kidney transplantation, particularly exposure of mycophenolic acid (MPA) and calcineurin inhibitor (CNI), on posttransplantation de novo HLA antibody production. METHODS: A single-center retrospective cohort study was performed at the First Affiliated Hospital of Sun Yat-sen University, enrolling the kidney transplant or pancreas-kidney transplant recipients who had surgery between January 2010 and February 2016...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30314457/the-efficacy-and-safety-of-anti-interleukin-6-receptor-monoclonal-blockade-in-a-renal-transplant-patient-with-castleman-disease-early-post-transplant-outcome
#14
Masatoshi Matsunami, Yoshifumi Ubara, Keiichi Sumida, Yoichi Oshima, Masahiko Oguro, Kazuya Kinoshita, Kiho Tanaka, Yuki Nakamura, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Takuro Igawa, Yasuharu Sato, Yasuo Ishii
BACKGROUND: Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disease characterized by systemic inflammatory reactions associated with the dysregulated production of interleukin-6 (IL-6). In patients with MCD, renal involvement is uncommon, with only one report published regarding kidney transplantation (KTx) to treat end-stage renal disease (ESRD) secondary to MCD. Recent clinical observations have shown that IL-6 production is implicated in allograft rejection, while IL-6 receptor blockade (with tocilizumab [TCZ]) reduces alloantibody generation and thereby improves graft survival; however, the efficacy and safety of TCZ in MCD patients undergoing KTx is still unknown...
October 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30312536/diagnostic-application-of-kidney-allograft-derived-absolute-cell-free-dna-levels-during-transplant-dysfunction
#15
J B Whitlam, L Ling, A Skene, J Kanellis, F L Ierino, H R Slater, D L Bruno, D A Power
Graft-derived cell-free DNA (donor-derived cell-free DNA) is an emerging marker of kidney allograft injury. Studies examining the clinical validity of this biomarker have previously used the graft fraction, or proportion of total cell-free DNA that is graft-derived. The present study evaluated the diagnostic validity of absolute measurements of graft-derived cell-free DNA, as well as calculated graft fraction, for the diagnosis of graft dysfunction. Plasma graft-derived cell-free DNA, total cell-free DNA and graft fraction were correlated with biopsy diagnosis as well as individual Banff scores...
October 12, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30309322/rituximab-plasma-exchange-and-immunoglobulins-an-ineffective-treatment-for-chronic-active-antibody-mediated-rejection
#16
Gastón J Piñeiro, Erika De Sousa-Amorim, Manel Solé, José Ríos, Miguel Lozano, Frederic Cofán, Pedro Ventura-Aguiar, David Cucchiari, Ignacio Revuelta, Joan Cid, Eduard Palou, Josep M Campistol, Federico Oppenheimer, Jordi Rovira, Fritz Diekmann
BACKGROUND: Chronic active antibody-mediated rejection (c-aABMR) is an important cause of allograft failure and graft loss in long-term kidney transplants. METHODS: To determine the efficacy and safety of combined therapy with rituximab, plasma exchange (PE) and intravenous immunoglobulins (IVIG), a cohort of patients with transplant glomerulopathy (TG) that met criteria of active cABMR, according to BANFF'17 classification, was identified. RESULTS: We identified 62 patients with active c-aABMR and TG (cg ≥ 1)...
October 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30308576/donor-specific-cell-free-dna-as-a-biomarker-in-solid-organ-transplantation-a-systematic-review
#17
Simon R Knight, Adam Thorne, Maria Letizia Lo Faro
BACKGROUND: There is increasing interest in the use of noninvasive biomarkers to reduce the risks posed by invasive biopsy for monitoring of solid organ transplants (SOT). One such promising marker is the presence of donor-derived cell-free DNA (dd-cfDNA) in the urine or blood of transplant recipients. METHODS: We systematically reviewed the published literature investigating the use of cfDNA in monitoring of graft health following SOT. Electronic databases were searched for studies relating cfDNA fraction or levels to clinical outcomes, and data including measures of diagnostic test accuracy (DTA) were extracted...
October 11, 2018: Transplantation
https://www.readbyqxmd.com/read/30300438/long-term-effects-of-delayed-graft-function-duration-on-function-and-survival-of-deceased-donor-kidney-transplants
#18
Mateus Swarovsky Helfer, Jeferson de Castro Pompeo, Otávio Roberto Silva Costa, Alessandra Rosa Vicari, Adriana Reginato Ribeiro, Roberto Ceratti Manfro
INTRODUCTION: Delayed graft function (DGF) is a frequent complication after deceased donor kidney transplantation with an impact on the prognosis of the transplant. Despite this, long-term impact of DGF on graft function after deceased donor kidney transplantation has not been properly evaluated. OBJECTIVE: The main objective of this study was to evaluate risk factors for DGF and the impact of its occurrence and length on graft survival and function. METHODS: A retrospective cohort study was performed in 517 kidney transplant recipients who received a deceased donor organ between January 2008 and December 2013...
October 4, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/30300283/importance-of-hematopoietic-mixed-chimerism-for-induction-of-renal-allograft-tolerance-in-nonhuman-primates
#19
Cornelius C Thaiss, Tetsu Oura, Hajime Sasaki, Abbas Dehnadi, Masatoshi Matsunami, Ivy A Rosales, Benedict A Cosimi, Tatsuo Kawai
BACKGROUND: Although induction of durable mixed chimerism is required for murine skin allograft tolerance, renal allograft tolerance has been achieved after induction of only transient mixed chimerism in nonhuman primates (NHPs) and humans. To better define the level/duration of chimerism required for stable renal allograft tolerance, we retrospectively analyzed these parameters and compared them with transplant outcomes in NHP combined kidney and bone marrow transplant (CKBMT) recipients...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30296518/diagnosis-of-t-cell-mediated-kidney-rejection-in-formalin-fixed-paraffin-embedded-tissues-using-rna-seq-based-machine-learning-algorithms
#20
Peng Liu, George Tseng, Zijie Wang, B S Yuchen Huang, Parmjeet Randhawa
Molecular diagnosis is being increasingly used into transplant pathology to render more objective and quantitative determinations that also provide mechanistic and prognostic insights. This study performed RNA-Seq on biopsies from kidneys with stable function (STA) and biopsies with classical findings of T-cell mediated rejection (TCMR). Machine learning tools were used to develop prediction models for distinguishing TCMR and STA samples using the top genes identified by DSeq2. The prediction models were tested on 703 biopsies with Affymetrix chip gene expression profiles available in the public domain...
October 5, 2018: Human Pathology
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