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David Holmes

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https://www.readbyqxmd.com/read/29458082/beyond-pain-nurses-assessment-of-patient-suffering-dignity-and-dying-in-the-intensive-care-unit
#1
Amanda Su, Lindsay Lief, David Berlin, Zara Cooper, Daniel Ouyang, John Holmes, Renee Maciejewski, Paul K Maciejewski, Holly G Prigerson
CONTEXT: Deaths in the Intensive Care Unit (ICU) are increasingly common in the United States, yet little is known about patients' experiences at the end-of-life in the ICU. OBJECTIVES: The objective of this study was to determine nurse assessment of symptoms experienced, and care received by ICU patients in their final week, and their associations with nurse-perceived suffering and dignity. METHODS: From September 2015 to March 2017, nurses who cared for 200 ICU patients who died were interviewed about physical and psychosocial dimensions of patients' experiences...
February 16, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29454226/dysphagia-and-laryngeal-pathology-in-post-surgical-cardiothoracic-patients
#2
Anna Miles, Naomi McLellan, Rochelle Machan, David Vokes, Alexandra Hunting, Mary McFarlane, Jennifer Holmes, Kelly Lynn
PURPOSE: Cardiothoracic surgery is known to result in dysphagia and laryngeal injury. While prevalence has been explored, extent, trajectory and longevity of symptoms are poorly understood. This retrospective, observational study explored dysphagia and laryngeal injury in patients following cardiothoracic surgery referred for instrumental swallowing assessment. METHODS: Clinical notes and endoscopic recordings of 106 patients (age range 18-87yrs; mean 63yrs; SD 15yrs) (including 190 endoscopes) at one large tertiary centre were reviewed by two speech-language pathologists and a laryngologist...
February 9, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29451313/drivers-and-mechanisms-of-tree-mortality-in-moist-tropical-forests
#3
REVIEW
Nate McDowell, Craig D Allen, Kristina Anderson-Teixeira, Paulo Brando, Roel Brienen, Jeff Chambers, Brad Christoffersen, Stuart Davies, Chris Doughty, Alvaro Duque, Fernando Espirito-Santo, Rosie Fisher, Clarissa G Fontes, David Galbraith, Devin Goodsman, Charlotte Grossiord, Henrik Hartmann, Jennifer Holm, Daniel J Johnson, Abd Rahman Kassim, Michael Keller, Charlie Koven, Lara Kueppers, Tomo'omi Kumagai, Yadvinder Malhi, Sean M McMahon, Maurizio Mencuccini, Patrick Meir, Paul Moorcroft, Helene C Muller-Landau, Oliver L Phillips, Thomas Powell, Carlos A Sierra, John Sperry, Jeff Warren, Chonggang Xu, Xiangtao Xu
Tree mortality rates appear to be increasing in moist tropical forests (MTFs) with significant carbon cycle consequences. Here, we review the state of knowledge regarding MTF tree mortality, create a conceptual framework with testable hypotheses regarding the drivers, mechanisms and interactions that may underlie increasing MTF mortality rates, and identify the next steps for improved understanding and reduced prediction. Increasing mortality rates are associated with rising temperature and vapor pressure deficit, liana abundance, drought, wind events, fire and, possibly, CO 2 fertilization-induced increases in stand thinning or acceleration of trees reaching larger, more vulnerable heights...
February 16, 2018: New Phytologist
https://www.readbyqxmd.com/read/29449963/the-nsight1-randomized-controlled-trial-rapid-whole-genome-sequencing-for-accelerated-etiologic-diagnosis-in-critically-ill-infants
#4
Josh E Petrikin, Julie A Cakici, Michelle M Clark, Laurel K Willig, Nathaly M Sweeney, Emily G Farrow, Carol J Saunders, Isabelle Thiffault, Neil A Miller, Lee Zellmer, Suzanne M Herd, Anne M Holmes, Serge Batalov, Narayanan Veeraraghavan, Laurie D Smith, David P Dimmock, J Steven Leeder, Stephen F Kingsmore
Genetic disorders are a leading cause of morbidity and mortality in infants in neonatal and pediatric intensive care units (NICU/PICU). While genomic sequencing is useful for genetic disease diagnosis, results are usually reported too late to guide inpatient management. We performed an investigator-initiated, partially blinded, pragmatic, randomized, controlled trial to test the hypothesis that rapid whole-genome sequencing (rWGS) increased the proportion of NICU/PICU infants receiving a genetic diagnosis within 28 days...
2018: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/29449805/screen-position-preference-offers-a-new-direction-for-action-observation-research-preliminary-findings-using-tms
#5
Martin Riach, David J Wright, Zoë C Franklin, Paul S Holmes
Action observation has been suggested to be an effective adjunct to physical practice in motor (re)learning settings. However, optimal viewing conditions for interventions are yet to be established. Single-pulse transcranial magnetic stimulation (TMS) was used to investigate the effect of two different screen positions and participants' screen position viewing preference on the amplitude of motor evoked potentials (MEPs) during observation of a ball pinch action. Twenty-four participants observed four blocked conditions that contained either a dynamic index finger-thumb ball pinch or a static hand holding a ball in a similar position on a horizontally or vertically positioned screen...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29445174/a-spatial-gradient-of-bacterial-diversity-in-the-human-oral-cavity-shaped-by-salivary-flow
#6
Diana M Proctor, Julia A Fukuyama, Peter M Loomer, Gary C Armitage, Stacey A Lee, Nicole M Davis, Mark I Ryder, Susan P Holmes, David A Relman
Spatial and temporal patterns in microbial communities provide insights into the forces that shape them, their functions and roles in health and disease. Here, we used spatial and ecological statistics to analyze the role that saliva plays in structuring bacterial communities of the human mouth using >9000 dental and mucosal samples. We show that regardless of tissue type (teeth, alveolar mucosa, keratinized gingiva, or buccal mucosa), surface-associated bacterial communities vary along an ecological gradient from the front to the back of the mouth, and that on exposed tooth surfaces, the gradient is pronounced on lingual compared to buccal surfaces...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29431053/nanoparticle-mediated-cell-capture-enables-rapid-endothelialization-of-a-novel-bare-metal-stent
#7
Brandon J Tefft, Susheil Uthamaraj, Adriana Harbuzariu, Jonathan Harburn, Tyra A Witt, Brant Newman, Peter J Psaltis, Ota Hlinomaz, David R Holmes, Rajiv Gulati, Robert D Simari, Dan Dragomir-Daescu, Gurpreet S Sandhu
Incomplete endothelialization of intracoronary stents has been associated with stent thrombosis and recurrent symptoms, whereas prolonged use of dual antiplatelet therapy increases bleeding related adverse events. Facilitated endothelialization has the potential to improve clinical outcomes in patients who are unable to tolerate dual antiplatelet therapy. The objective of this study is to demonstrate the feasibility of magnetic cell capture to rapidly endothelialize intracoronary stents in a large animal model...
February 12, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29412688/laba-ics-in-copd-patients-with-cv-disease-or-risk-a-factorial-analysis-of-the-summit-trial
#8
Bartolome R Celli, Julie A Anderson, Robert Brook, Peter M A Calverley, Courtney Crim, Andrew P Holmes, Fernando J Martinez, David E Newby, Julie Yates, Jørgen Vestbo
No abstract text is available yet for this article.
February 7, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29409976/a-randomized-double-blind-placebo-controlled-trial-of-escitalopram-in-patients-with-asthma-and-major-depressive-disorder
#9
E Sherwood Brown, Nasreen Sayed, Erin Van Enkevort, Alexandra Kulikova, Alyson Nakamura, David A Khan, Elena I Ivleva, Prabha Sunderajan, Bruce G Bender, Traci Holmes
BACKGROUND: Depression is common in asthma and is associated with poor outcomes. However, antidepressant therapy in depressed asthma patients has been the topic of little research. OBJECTIVE: This study examined the impact of antidepressant treatment with escitalopram vs. placebo on the Hamilton Rating Scale for Depression (HRSD), Inventory of Depressive Symptomatology-Self Report (IDS-SR), Asthma Control Questionnaire (ACQ), and oral corticosteroid use in asthma patients with major depressive disorder (MDD)...
January 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29407183/prognostic-impact-of-a-suboptimal-number-of-analyzed-metaphases-in-normal-karyotype-lower-risk-mds
#10
Louise de Swart, Alex Smith, Detlef Haase, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Guillermo Sanz, Reinhard Stauder, Moshe Mittelman, Eva Hellström-Lindberg, Luca Malcovati, Saskia Langemeijer, Mette Skov-Holm, Krzysztof Mądry, Ulrich Germing, Antonio Medina Almeida, Aurelia Tatic, Aleksandar Savic, Njetočka Gredelj Šimec, Corine van Marrewijk, Agnes Guerci-Bresler, Laurence Sanhes, Elisa Luño, Dominic Culligan, Odile Beyne-Rauzy, Sonja Burgstaller, Nicole Blijlevens, David Bowen, Theo de Witte
Conventional karyotype is one of the most relevant prognostic factors in MDS. However, about 50% of patients with MDS have a normal karyotype. Usually, 20-25 normal metaphases (nMP) are considered to be optimal to exclude small abnormal clones which might be associated with poor prognosis. This study evaluated the impact of examining a suboptimal number of metaphases in patients recruited to the EUMDS Registry with low and intermediate-1 risk according to IPSS. Only 179/1049 (17%) of patients with a normal karyotype had a suboptimal number of nMP, defined as less than 20 metaphases analyzed...
January 31, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29404599/association-of-rooming-in-with-outcomes-for-neonatal-abstinence-syndrome-a-systematic-review-and-meta-analysis
#11
Kathryn Dee L MacMillan, Cassandra P Rendon, Kanak Verma, Natalie Riblet, David B Washer, Alison Volpe Holmes
Importance: Rising incidence of neonatal abstinence syndrome (NAS) is straining perinatal care systems. Newborns with NAS traditionally receive care in neonatal intensive care units (NICUs), but rooming-in with mother and family has been proposed to reduce the use of pharmacotherapy, length of stay (LOS), and cost. Objective: To systematically review and meta-analyze if rooming-in is associated with improved outcomes for newborns with NAS. Data Sources: MEDLINE, CINAHL, The Cochrane Library, and clinicaltrials...
February 5, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29393712/role-of-a-standardized-prism-under-cover-test-in-the-assessment-of-dissociated-vertical-deviation
#12
Lindsay D Klaehn, Sarah R Hatt, David A Leske, Jonathan M Holmes
BACKGROUND: Dissociated vertical deviation (DVD) is commonly measured using a prism and alternate cover test (PACT), but some providers use a prism under cover test (PUCT). The aim of this study was to compare a standardized PUCT measurement with a PACT measurement, for assessing the magnitude of DVD. METHODS: Thirty-six patients with a clinical diagnosis of DVD underwent measurement of the angle of deviation with the PACT, fixing with the habitually fixing eye, and with PUCT, fixing both right and left eyes...
February 2, 2018: Strabismus
https://www.readbyqxmd.com/read/29388531/consumption-of-processed-food-dietary-patterns-in-four-african-populations
#13
Michelle D Holmes, Shona Dalal, Vikash Sewram, Megan B Diamond, Sally N Adebamowo, Ikeoluwapo O Ajayi, Clement Adebamowo, Faraja S Chiwanga, Marina Njelekela, Carien Laurence, Jimmy Volmink, Francis Bajunirwe, Joan Nankya-Mutyoba, David Guwatudde, Todd G Reid, Walter C Willett, Hans-Olov Adami, Teresa T Fung
OBJECTIVE: To identify predominant dietary patterns in four African populations and examine their association with obesity. DESIGN: Cross-sectional study. Setting/Subjects We used data from the Africa/Harvard School of Public Health Partnership for Cohort Research and Training (PaCT) pilot study established to investigate the feasibility of a multi-country longitudinal study of non-communicable chronic disease in sub-Saharan Africa. We applied principal component analysis to dietary intake data collected from an FFQ developed for PaCT to ascertain dietary patterns in Tanzania, South Africa, and peri-urban and rural Uganda...
February 1, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29370193/inhibition-of-%C3%AE-glucosidase-%C3%AE-amylase-and-aldose-reductase-by-potato-polyphenolic-compounds
#14
Diganta Kalita, David G Holm, Daniel V LaBarbera, J Mark Petrash, Sastry S Jayanty
Diabetes mellitus is a chronic disease that is becoming a serious global health problem. Diabetes has been considered to be one of the major risks of cataract and retinopathy. Synthetic and natural product inhibitors of carbohydrate degrading enzymes are able to reduce type 2 diabetes and its complications. For a long time, potatoes have been portrayed as unhealthy for diabetic patients by some nutritionist due to their high starch content. However, purple and red potato cultivars have received considerable attention from consumers because they have high levels of polyphenolic compounds that have potent antioxidant activities...
2018: PloS One
https://www.readbyqxmd.com/read/29363582/commonalities-and-differences-in-the-substrates-underlying-consolidation-of-first-and-second-order-conditioned-fear
#15
Belinda P P Lay, R Frederick Westbrook, David L Glanzman, Nathan M Holmes
Consolidation of newly formed fear memories requires a series of molecular events within the basolateral complex of the amygdala (BLA). Once consolidated, new information can be assimilated into these established associative networks to form higher-order associations. Much is known about the molecular events involved in consolidating newly acquired fear memories but little is known about the events that consolidate a secondary fear memory. Here, we show that, within the male rat BLA, DNA methylation and gene transcription are crucial for consolidating both the primary and secondary fear memories...
January 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29362794/association-between-left-atrial-appendage-occlusion-and-readmission-for-thromboembolism-among-patients-with-atrial-fibrillation-undergoing-concomitant-cardiac-surgery
#16
COMPARATIVE STUDY
Daniel J Friedman, Jonathan P Piccini, Tongrong Wang, Jiayin Zheng, S Chris Malaisrie, David R Holmes, Rakesh M Suri, Michael J Mack, Vinay Badhwar, Jeffrey P Jacobs, Jeffrey G Gaca, Shein-Chung Chow, Eric D Peterson, J Matthew Brennan
Importance: The left atrial appendage is a key site of thrombus formation in atrial fibrillation (AF) and can be occluded or removed at the time of cardiac surgery. There is limited evidence regarding the effectiveness of surgical left atrial appendage occlusion (S-LAAO) for reducing the risk of thromboembolism. Objective: To evaluate the association of S-LAAO vs no receipt of S-LAAO with the risk of thromboembolism among older patients undergoing cardiac surgery...
January 23, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29361936/vaginal-dysbiosis-increases-risk-of-preterm-fetal-membrane-rupture-neonatal-sepsis-and-is-exacerbated-by-erythromycin
#17
Richard G Brown, Julian R Marchesi, Yun S Lee, Ann Smith, Benjamin Lehne, Lindsay M Kindinger, Vasso Terzidou, Elaine Holmes, Jeremy K Nicholson, Phillip R Bennett, David A MacIntyre
BACKGROUND: Preterm prelabour rupture of the fetal membranes (PPROM) precedes 30% of preterm births and is a risk factor for early onset neonatal sepsis. As PPROM is strongly associated with ascending vaginal infection, prophylactic antibiotics are widely used. The evolution of vaginal microbiota compositions associated with PPROM and the impact of antibiotics on bacterial compositions are unknown. METHODS: We prospectively assessed vaginal microbiota prior to and following PPROM using MiSeq-based sequencing of 16S rRNA gene amplicons and examined the impact of erythromycin prophylaxis on bacterial load and community structures...
January 24, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29359388/three-dimensional-prototyping-for-procedural-simulation-of-transcatheter-mitral-valve-replacement-in-patients-with-mitral-annular-calcification
#18
Abdallah El Sabbagh, Mackram F Eleid, Jane M Matsumoto, Nandan S Anavekar, Mohammed A Al-Hijji, Sameh M Said, Vuyisile T Nkomo, David R Holmes, Charanjit S Rihal, Thomas A Foley
INTRODUCTION: Three-dimensional (3D) prototyping is a novel technology which can be used to plan and guide complex procedures such as transcatheter mitral valve replacement (TMVR). METHODS: Eight patients with severe mitral annular calcification (MAC) underwent TMVR. 3D digital models with digital balloon expandable valves were created from pre-procedure CT scans using dedicated software. Five models were printed. These models were used to assess prosthesis sizing, anchoring, expansion, paravalvular gaps, left ventricular outflow tract (LVOT) obstruction, and other potential procedure pitfalls...
January 23, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29351451/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction
#19
Merry L Lindsey, Roberto Bolli, John M Canty, Xiao-Jun Du, Nikolaos G Frangogiannis, Stefan Frantz, Robert G Gourdie, Jeffrey W Holmes, Steven P Jones, Robert Kloner, David J Lefer, Ronglih Liao, Elizabeth Murphy, Peipei Ping, Karin Przyklenk, Fabio A Recchia, Lisa Schwartz Longacre, Crystal May Ripplinger, Jennifer E Van Eyk, Gerd Heusch
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction...
January 12, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29350626/high-mobility-in-sub-0-75-sub-ga-sub-0-25-sub-as-quantum-wells-in-an-inas-phonon-lattice
#20
Chong Chen, Stuart N Holmes, Ian Farrer, Harvey E Beere, David A Ritchie
InGaAs based devices are great complements to silicon for CMOS, as they provide an increased carrier saturation velocity, lower operating voltage and reduced power dissipation. In this work we show that In0.75Ga0.25As quantum wells with a high mobility, 15 000 to 20 000 cm2/V.s at ambient temperature, show an InAs-like phonon with an energy of 28.8 meV, frequency of 232 cm-1 that dominates the polar-optical mode scattering from ∼ 70 K to 300 K. The optical phonon frequency is insensitive to the carrier density modulated with a surface gate or LED illumination...
January 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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