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David Holmes

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https://www.readbyqxmd.com/read/29674941/cosmology-and-fundamental-physics-with-the-euclid-satellite
#1
REVIEW
Luca Amendola, Stephen Appleby, Anastasios Avgoustidis, David Bacon, Tessa Baker, Marco Baldi, Nicola Bartolo, Alain Blanchard, Camille Bonvin, Stefano Borgani, Enzo Branchini, Clare Burrage, Stefano Camera, Carmelita Carbone, Luciano Casarini, Mark Cropper, Claudia de Rham, Jörg P Dietrich, Cinzia Di Porto, Ruth Durrer, Anne Ealet, Pedro G Ferreira, Fabio Finelli, Juan García-Bellido, Tommaso Giannantonio, Luigi Guzzo, Alan Heavens, Lavinia Heisenberg, Catherine Heymans, Henk Hoekstra, Lukas Hollenstein, Rory Holmes, Zhiqi Hwang, Knud Jahnke, Thomas D Kitching, Tomi Koivisto, Martin Kunz, Giuseppe La Vacca, Eric Linder, Marisa March, Valerio Marra, Carlos Martins, Elisabetta Majerotto, Dida Markovic, David Marsh, Federico Marulli, Richard Massey, Yannick Mellier, Francesco Montanari, David F Mota, Nelson J Nunes, Will Percival, Valeria Pettorino, Cristiano Porciani, Claudia Quercellini, Justin Read, Massimiliano Rinaldi, Domenico Sapone, Ignacy Sawicki, Roberto Scaramella, Constantinos Skordis, Fergus Simpson, Andy Taylor, Shaun Thomas, Roberto Trotta, Licia Verde, Filippo Vernizzi, Adrian Vollmer, Yun Wang, Jochen Weller, Tom Zlosnik
Euclid is a European Space Agency medium-class mission selected for launch in 2020 within the cosmic vision 2015-2025 program. The main goal of Euclid is to understand the origin of the accelerated expansion of the universe. Euclid will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky. Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research...
2018: Living Reviews in Relativity
https://www.readbyqxmd.com/read/29629902/humanized-mouse-model-of-rasmussen-s-encephalitis-supports-the-immune-mediated-hypothesis
#2
Hania Kebir, Lionel Carmant, François Fontaine, Kathie Béland, Ciprian M Bosoi, Nathalie T Sanon, Jorge I Alvarez, Sébastien Desgent, Camille L Pittet, David Hébert, Marie-Josée Langlois, Rose-Marie Rébillard, Dang K Nguyen, Cécile Cieuta-Walti, Gregory L Holmes, Howard P Goodkin, John R Mytinger, Mary B Connolly, Alexandre Prat, Elie Haddad
Rasmussen's encephalitis (RE) is a chronic inflammatory brain disorder that causes frequent seizures and unilateral hemispheric atrophy with progressive neurological deficits. Hemispherectomy remains the only treatment that leads to seizure freedom for this refractory epileptic syndrome. The absence of an animal model of disease has been a major obstacle hampering the development of effective therapies. Here, we describe an experimental mouse model that shares several clinical and pathological features with the human disease...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29617585/outpatient-talc-administration-by-indwelling-pleural-catheter-for-malignant-effusion
#3
RANDOMIZED CONTROLLED TRIAL
Rahul Bhatnagar, Emma K Keenan, Anna J Morley, Brennan C Kahan, Andrew E Stanton, Mohammed Haris, Richard N Harrison, Rehan A Mustafa, Lesley J Bishop, Liju Ahmed, Alex West, Jayne Holme, Matthew Evison, Mohammed Munavvar, Pasupathy Sivasothy, Jurgen Herre, David Cooper, Mark Roberts, Anur Guhan, Clare Hooper, James Walters, Tarek S Saba, Biswajit Chakrabarti, Samal Gunatilake, Ioannis Psallidas, Steven P Walker, Anna C Bibby, Sarah Smith, Louise J Stadon, Natalie J Zahan-Evans, Y C Gary Lee, John E Harvey, Najib M Rahman, Robert F Miller, Nick A Maskell
BACKGROUND: Malignant pleural effusion affects more than 750,000 persons each year across Europe and the United States. Pleurodesis with the administration of talc in hospitalized patients is the most common treatment, but indwelling pleural catheters placed for drainage offer an ambulatory alternative. We examined whether talc administered through an indwelling pleural catheter was more effective at inducing pleurodesis than the use of an indwelling pleural catheter alone. METHODS: Over a period of 4 years, we recruited patients with malignant pleural effusion at 18 centers in the United Kingdom...
April 5, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29614256/interactions-of-staphyloxanthin-and-enterobactin-with-myeloperoxidase-and-reactive-chlorine-species
#4
Melanie S Coker, Louisa V Forbes, Matthew Plowman-Holmes, David R Murdoch, Christine C Winterbourn, Anthony J Kettle
When neutrophils engulf bacteria, myeloperoxidase converts hydrogen peroxide to hypochlorous acid, which is toxic to all micro-organisms. It has been suggested that some pathogens have virulence factors that target myeloperoxidase to dampen the oxidative reactions of neutrophils. These virulence factors include staphyloxanthin, the golden pigment of Staphylococcus aureus, and enterobactin - a siderophore released by gram-negative bacteria. We investigated the potential of staphyloxanthin and enterobactin to shield bacteria from hypochlorous acid and related chloramines...
March 31, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29607448/silicone-wristbands-compared-with-traditional-polycyclic-aromatic-hydrocarbon-exposure-assessment-methods
#5
Holly M Dixon, Richard P Scott, Darrell Holmes, Lehyla Calero, Laurel D Kincl, Katrina M Waters, David E Camann, Antonia M Calafat, Julie B Herbstman, Kim A Anderson
Currently there is a lack of inexpensive, easy-to-use technology to evaluate human exposure to environmental chemicals, including polycyclic aromatic hydrocarbons (PAHs). This is the first study in which silicone wristbands were deployed alongside two traditional personal PAH exposure assessment methods: active air monitoring with samplers (i.e., polyurethane foam (PUF) and filter) housed in backpacks, and biological sampling with urine. We demonstrate that wristbands worn for 48 h in a non-occupational setting recover semivolatile PAHs, and we compare levels of PAHs in wristbands to PAHs in PUFs-filters and to hydroxy-PAH (OH-PAH) biomarkers in urine...
April 2, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29599300/concentrations-of-trace-elements-and-clinical-outcomes-in-hemodialysis-patients-a-prospective-cohort-study
#6
Marcello Tonelli, Natasha Wiebe, Aminu Bello, Catherine J Field, John S Gill, Brenda R Hemmelgarn, Daniel T Holmes, Kailash Jindal, Scott W Klarenbach, Braden J Manns, Ravi Thadhani, David Kinniburgh
BACKGROUND AND OBJECTIVES: Deficiency of essential trace elements and excess of potentially toxic trace elements are common in patients on hemodialysis. Whether these abnormalities are associated with poor outcomes is unknown but worth investigating, because they are potentially treatable. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We did a prospective longitudinal study of 1278 patients on incident hemodialysis, assessing blood concentrations of 25 trace elements at baseline...
March 29, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29599024/plastic-recycling-in-the-nordics-a-value-chain-market-analysis
#7
Leonidas Milios, Lena Holm Christensen, David McKinnon, Camilla Christensen, Marie Katrine Rasch, Mikael Hallstrøm Eriksen
There is low utilisation of plastic waste in the Nordic region and only a fraction of plastic materials go back into production processes through reuse and recycling practices. This paper aims to increase knowledge concerning factors that inhibit demand for recycled plastics, and to identify critical barriers for plastic recycling across the regional plastics value chain. A literature review and targeted interviews with key actors across the plastics value chain enabled the mapping of interactions between the major actors and identified hotspots that act as barriers to the flow of plastic materials...
March 26, 2018: Waste Management
https://www.readbyqxmd.com/read/29590334/a-rare-missense-mutation-in-myh6-associates-with-non-syndromic-coarctation-of-the-aorta
#8
Thorsteinn Bjornsson, Rosa B Thorolfsdottir, Gardar Sveinbjornsson, Patrick Sulem, Gudmundur L Norddahl, Anna Helgadottir, Solveig Gretarsdottir, Audur Magnusdottir, Ragnar Danielsen, Emil L Sigurdsson, Berglind Adalsteinsdottir, Sverrir I Gunnarsson, Ingileif Jonsdottir, David O Arnar, Hrodmar Helgason, Tomas Gudbjartsson, Daniel F Gudbjartsson, Unnur Thorsteinsdottir, Hilma Holm, Kari Stefansson
Aims: Coarctation of the aorta (CoA) accounts for 4-8% of congenital heart defects (CHDs) and confers substantial morbidity despite treatment. It is increasingly recognized as a highly heritable condition. The aim of the study was to search for sequence variants that affect the risk of CoA. Methods and results: We performed a genome-wide association study of CoA among Icelanders (120 cases and 355 166 controls) based on imputed variants identified through whole-genome sequencing...
March 24, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29580630/feasibility-of-performing-radiofrequency-catheter-ablation-and-endomyocardial-biopsy-in-the-same-setting
#9
J William Schleifer, Kevin K Manocha, Samuel J Asirvatham, Peter A Noseworthy, Rajiv Gulati, Paul A Friedman, Malini Madhavan, Thomas M Munger, Leslie T Cooper, Guy S Reeder, David R Holmes, Suraj Kapa
In patients with unexplained cardiomyopathy, electroanatomical mapping can identify abnormal tissue to target during electrophysiology-guided endomyocardial biopsy (EP-guided EMB). The objective of this study is to determine whether catheter ablation performed in the same setting as EP-guided EMB increases procedural risk. Sixty-seven patients (mean age 54.4 ± 13.8, 57% male) undergoing EP-guided EMB were included. Radiofrequency catheter ablation was performed in 17 patients (25%) for ventricular arrhythmias and in 2 (3%) for typical atrial flutter...
March 5, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29572506/health-related-quality-of-life-in-lower-risk-mds-patients-compared-with-age-and-sex-matched-reference-populations-a-european-leukemianet-study
#10
Reinhard Stauder, Ge Yu, Karin A Koinig, Tim Bagguley, Pierre Fenaux, Argiris Symeonidis, Guillermo Sanz, Jaroslav Cermak, Moshe Mittelman, Eva Hellström-Lindberg, Saskia Langemeijer, Mette Skov Holm, Krzysztof Mądry, Luca Malcovati, Aurelia Tatic, Ulrich Germing, Aleksandar Savic, Corine van Marrewijk, Agnès Guerci-Bresler, Elisa Luño, Jackie Droste, Fabio Efficace, Alex Smith, David Bowen, Theo de Witte
In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49...
March 6, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29567993/unexplored-therapeutic-opportunities-in-the-human-genome
#11
Tudor I Oprea, Cristian G Bologa, Søren Brunak, Allen Campbell, Gregory N Gan, Anna Gaulton, Shawn M Gomez, Rajarshi Guha, Anne Hersey, Jayme Holmes, Ajit Jadhav, Lars Juhl Jensen, Gary L Johnson, Anneli Karlson, Andrew R Leach, Avi Ma'ayan, Anna Malovannaya, Subramani Mani, Steven L Mathias, Michael T McManus, Terrence F Meehan, Christian von Mering, Daniel Muthas, Dac-Trung Nguyen, John P Overington, George Papadatos, Jun Qin, Christian Reich, Bryan L Roth, Stephan C Schürer, Anton Simeonov, Larry A Sklar, Noel Southall, Susumu Tomita, Ilinca Tudose, Oleg Ursu, Dušica Vidovic, Anna Waller, David Westergaard, Jeremy J Yang, Gergely Zahoránszky-Köhalmi
This corrects the article DOI: 10.1038/nrd.2018.14.
March 23, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29566805/inclusion-of-functional-status-measures-in-the-risk-adjustment-of-30-day-mortality-after-transcatheter-aortic-valve-replacement-a-report-from-the-society-of-thoracic-surgeons-american-college-of-cardiology-tvt-registry
#12
Suzanne V Arnold, Sean M O'Brien, Sreekanth Vemulapalli, David J Cohen, Amanda Stebbins, J Matthew Brennan, David M Shahian, Fred L Grover, David R Holmes, Vinod H Thourani, Eric D Peterson, Fred H Edwards
OBJECTIVES: The aim of this study was to develop and validate a risk adjustment model for 30-day mortality after transcatheter aortic valve replacement (TAVR) that accounted for both standard clinical factors and pre-procedural health status and frailty. BACKGROUND: Assessment of risk for TAVR is important both for patient selection and provider comparisons. Prior efforts for risk adjustment have focused on in-hospital mortality, which is easily obtainable but can be biased because of early discharge of ill patients...
March 26, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29565417/pediatric-clinical-exome-genome-sequencing-and-the-engagement-process-encouraging-active-conversation-with-the-older-child-and-adolescent-points-to-consider-a-statement-of-the-american-college-of-medical-genetics-and-genomics-acmg
#13
Lynn W Bush, Louis E Bartoshesky, Karen L David, Benjamin Wilfond, Janet L Williams, Ingrid A Holm
Disclaimer: This article is designed primarily as an educational resource for medical geneticists and other health care providers to help them provide quality patient care. Adherence to the information contained in this article does not necessarily assure a successful medical outcome. This information and any associated recommendations should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, each provider should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient...
March 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29561903/phylogenetic-analyses-and-antimicrobial-resistance-profiles-of-campylobacter-spp-from-diarrhoeal-patients-and-chickens-in-botswana
#14
Stefan P W de Vries, Moses Vurayai, Mark Holmes, Srishti Gupta, Michael Bateman, David Goldfarb, Duncan J Maskell, Maitshwarelo Ignatius Matsheka, Andrew J Grant
Campylobacter spp. are a leading cause of bacterial enteritis worldwide, including countries in Africa, and have been identified by the World Health Organisation (WHO) as one of the high priority antimicrobial resistant pathogens. However, at present there is little knowledge on the prevalence, molecular epidemiology or antimicrobial susceptibility of Campylobacter spp. isolates in Botswana, both in patients and in the zoonotic context. Some data indicate that ~14% of diarrhoeal disease cases in a paediatric setting can be ascribed to Campylobacter spp...
2018: PloS One
https://www.readbyqxmd.com/read/29561740/methods-for-the-comparison-of-differential-item-functioning-across-assessments
#15
W Holmes Finch, Maria Hernandez Finch, Brian F French, David E McIntosh, Lauren Moss
An important aspect of the educational and psychological evaluation of individuals is the selection of scales with appropriate evidence of reliability and validity for inferences and uses of the scores for the population of interest. One key aspect of validity is the degree to which a scale fairly assesses the construct(s) of interest for members of different subgroups within the population. Typically, this issue is addressed statistically through assessment of differential item functioning (DIF) of individual items, or differential test functioning (DTF) of sets of items within the same measure...
2018: Journal of Applied Measurement
https://www.readbyqxmd.com/read/29557102/pre-hospital-management-of-decompression-illness-expert-review-of-key-principles-and-controversies
#16
Simon J Mitchell, Michael H Bennett, Phillip Bryson, Frank K Butler, David J Doolette, James R Holm, Jacek Kot, Pierre Lafère
Guidelines for the pre-hospital management of decompression illness (DCI) had not been formally revised since the 2004 Divers Alert Network/Undersea and Hyperbaric Medical Society workshop held in Sydney, entitled "Management of mild or marginal decompression illness in remote locations". A contemporary review was initiated by the Diver's Alert Network and undertaken by a multinational committee with members from Australasia, the USA and Europe. The process began with literature reviews by designated committee members on: the diagnosis of DCI; first aid strategies for DCI; remote triage of possible DCI victims by diving medicine experts; evacuation of DCI victims; effect of delay to recompression in DCI; pitfalls in management when DCI victims present at hospitals without diving medicine expertise and in-water recompression...
March 31, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29556351/perfluorocarbon-enhanced-glasgow-oxygen-level-dependent-gold-magnetic-resonance-metabolic-imaging-identifies-the-penumbra-following-acute-ischemic-stroke
#17
Graeme A Deuchar, David Brennan, William M Holmes, Martin Shaw, I Mhairi Macrae, Celestine Santosh
The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients. Our solution involves two complementary novel MRI techniques (Glasgow Oxygen Level Dependant (GOLD) Metabolic Imaging), which when combined with a perfluorocarbon (PFC) based oxygen carrier and hyperoxia can identify penumbra due to dynamic changes related to continued metabolism within this tissue compartment. Our aims were (i) to investigate whether PFC offers similar enhancement of the second technique (Lactate Change) as previously demonstrated for the T2 *OC technique (ii) to demonstrate both GOLD metabolic imaging techniques working concurrently to identify penumbra, following administration of Oxycyte® (O-PFC) with hyperoxia...
2018: Theranostics
https://www.readbyqxmd.com/read/29548719/bioequivalence-of-dapagliflozin-metformin-extended-release-fixed-combination-drug-product-and-single-component-dapagliflozin-and-metformin-extended-release-tablets-in-healthy-russian-subjects
#18
Yunona Khomitskaya, Nadezhda Tikhonova, Konstantin Gudkov, Svetlana Erofeeva, Victoria Holmes, Brian Dayton, Nigel Davies, David W Boulton, Weifeng Tang
PURPOSE: Fixed-combination drug products (FCDPs) combining dapagliflozin and metformin extended release (XR) may provide patients with type 2 diabetes mellitus with an alternative antihyperglycemic treatment, which could improve adherence by reducing tablet burden. This study evaluated the bioequivalence of dapagliflozin/metformin XR FCDP versus the co-administration of the individual monotherapy tablets currently available for use in the Russian Federation. METHODS: Healthy subjects aged 18 to 45 years were enrolled in this randomized, open-label, 2-period crossover study, conducted in a single Russian center...
March 13, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29542934/elastogranular-mechanics-buckling-jamming-and-structure-formation
#19
David J Schunter, Martin Brandenbourger, Sophia Perriseau, Douglas P Holmes
Confinement of a slender body into a granular array induces stress localization in the geometrically nonlinear structure, and jamming, reordering, and vertical dislodging of the surrounding granular medium. By varying the initial packing density of grains and the length of a confined elastica, we identify the critical length necessary to induce jamming, and demonstrate how folds couple with the granular medium to localize along grain boundaries. Above the jamming threshold, the characteristic length of elastica deformation is shown to diverge in a manner that is coupled with the motion and rearrangement of the grains, suggesting the ordering of the granular array governs the deformation of the slender structure...
February 16, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29531966/lesion-modeling-characterization-and-visualization-for-image-guided-cardiac-ablation-therapy-monitoring
#20
Cristian A Linte, Jon J Camp, Maryam E Rettmann, Dieter Haemmerich, Mehmet K Aktas, David T Huang, Douglas L Packer, David R Holmes
In spite of significant efforts to improve image-guided ablation therapy, a large number of patients undergoing ablation therapy to treat cardiac arrhythmic conditions require repeat procedures. The delivery of insufficient thermal dose is a significant contributor to incomplete tissue ablation, in turn leading to the arrhythmia recurrence. Ongoing research efforts aim to better characterize and visualize RF delivery to monitor the induced tissue damage during therapy. Here, we propose a method that entails modeling and visualization of the lesions in real-time...
April 2018: Journal of Medical Imaging
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