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https://www.readbyqxmd.com/read/30341893/the-role-of-sphingosine-1-phosphate-in-coronary-artery-disease-and-ischemia-reperfusion-injury
#1
REVIEW
Aynaz Mihanfar, Hamid Reza Nejabati, Amir Fattahi, Zeinab Latifi, Masoud Pezeshkian, Abbas Afrasiabi, Naser Safaie, Ahmad Reza Jodati, Mohammad Nouri
Coronary artery disease (CAD) is a common cause of morbidity and mortality worldwide. Atherosclerotic plaques, as a hallmark of CAD, cause chronic narrowing of coronary arteries over time and could also result in acute myocardial infarction (AMI). The standard treatments for ameliorating AMI are reperfusion strategies, which paradoxically result in ischemic reperfusion (I/R) injury. Sphingosine 1 phosphate (S1P), as a potent lysophospholipid, plays an important role in various organs, including immune and cardiovascular systems...
October 20, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30326990/cross-sectional-study-on-asthma-insights-and-management-in-the-gulf-and-russia
#2
Ashraf Alzaabi, Majdy Idrees, Naser Behbehani, Musa R Khaitov, Kaan Tunceli, Eduardo Undaneta, Nancy Awad, Mohamed Safwat
BACKGROUND: Asthma is a chronic and complex lung disease that is not completely understood. It involves airway inflammation, reversible airflow obstruction, and bronchial hyperresponsiveness. The most common symptoms are recurrentwheezing, chest tightness, shortness of breath, and coughing. OBJECTIVE: The Asthma Insights and Management study gathered information on the burden of asthma in the Gulf region (United Arab Emirates, Kuwait, Saudi Arabia) and Russia. METHODS: This was a cross-sectional, multinational, noninterventional, two-phase study that collected data from patients ages greater than or equal to 12 years, through interviews and a survey questionnaire...
October 16, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/30317554/alteration-of-cellular-and-immune-related-properties-of-bone-marrow-mesenchymal-stem-cells-and-macrophages-by-k562-chronic-myeloid-leukemia-cell-derived-exosomes
#3
Nazli Jafarzadeh, Zohreh Safari, Majid Pornour, Naser Amirizadeh, Mehdi Forouzandeh Moghadam, Majid Sadeghizadeh
Leukemic cells can impact the bone marrow niche to create a tumor-favorable microenvironment using their secreted factors. Little knowledge is available about immunosuppressive and tumor-promoting properties of chronic myeloid leukemia derived exosomes in bone marrow stromal components. We report here that K562-derived exosomes can affect the gene expression, cytokine secretion, nitric oxide (NO) production, and redox potential of bone marrow mesenchymal stem cells (BM-MSCs) and macrophages. Human BM-MSCs and mouse macrophages were treated with K562-derived exosomes...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30316680/increased-expression-of-mir-301a-in-pbmcs-of-patients-with-relapsing-remitting-multiple-sclerosis-is-associated-with-reduced-nkrf-and-pias3-expression-levels-and-disease-activity
#4
Vahid Tavakolpour, Gelareh Shokri, Abdorreza Naser Moghadasi, Parisa Mozafari Nahavandi, Mehrdad Hashemi, Fatemeh Kouhkan
Most of the multiple sclerosis (MS) patients are initially diagnosed with relapsing remitting multiple sclerosis (RRMS). Th17 cells and macrophages have been shown to play critical roles in pathogenesis of MS and initiation of CNS tissue damage. MiR-301a have recently been exposed as an activator of STAT3 in Th17 cells as well as an activator of NF-κB in macrophages by targeting PIAS3 and NKRF correspondingly. However, the possible role of miR-301a in RRMS has not yet been elucidated. Herewith, for the first time, we have studied the expression of miR-301a, NKRF and PIAS3 by quantitative real-time PCR and western blotting method in peripheral blood mononuclear cells (PBMCs) of 71 RRMS patients, including two groups of patients in relapse phase (n = 44) and a group of remitting phase patients (n = 28) in comparison to healthy volunteers (n = 28)...
October 4, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/30316230/an-investigation-of-prescription-indicators-and-trends-among-general-practitioners-and-specialists-from-2005-to-2015-in-kerman-iran
#5
Ali Masoud, Somayeh Noori Hekmat, Reza Dehnavieh, Naser Haj-Akbari, Atousa Poursheikhali, Zhaleh Abdi
BACKGROUND: The World Health Organization (WHO) aims to promote strategies that ensure efficacy, safety, suitability, and cost-effectiveness of medicine prescription. Health systems should design effective mechanisms to monitor prescription and rational use of medicines at all healthcare settings. This study aimed to determine and analyze prescription patterns of general practitioners and specialists in Kerman/Iran from 2005 to 2015. METHODS: This is an explanatory mixed method study...
April 25, 2018: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/30315456/a-protocol-to-compare-methods-for-untargeted-metabolomics
#6
Lingjue Wang, Fuad J Naser, Jonathan L Spalding, Gary J Patti
There are thousands of published methods for profiling metabolites with liquid chromatography/mass spectrometry (LC/MS). While many have been evaluated and optimized for a small number of select metabolites, very few have been assessed on the basis of global metabolite coverage. Thus, when performing untargeted metabolomics, researchers often question which combination of extraction techniques, chromatographic separations, and mass spectrometers is best for global profiling. Method comparisons are complicated because thousands of LC/MS signals (so-called features) in a typical untargeted metabolomic experiment cannot be readily identified with current resources...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30305002/skin-cancer-preventive-behaviors-in-iranian-farmers-applying-protection-motivation-theory
#7
Babak Moeini, Elahe Ezati, Majid Barati, Forouzan Rezapur-Shahkolai, Naser Mohammad Gholi Mezerji, Maryam Afshari
Farmers are among the most common work groups at risk of skin cancer. The protection motivation theory has been widely accepted as a framework for predicting health related behaviors. This study was conducted to determine the role of factors preventing skin cancer among farmers in Eslamabad-e Gharb district, Iran, using the protection motivation theory. In this descriptive study, 280 farmers living in this district were studied from May to June 2017. Using cluster random sampling methods, health houses where farmers received health care were selected...
October 10, 2018: Workplace Health & Safety
https://www.readbyqxmd.com/read/30302726/fourth-update-on-the-iranian-national-registry-of-primary-immunodeficiencies-integration-of-molecular-diagnosis
#8
Hassan Abolhassani, Fatemeh Kiaee, Marzieh Tavakol, Zahra Chavoshzadeh, Seyed Alireza Mahdaviani, Tooba Momen, Reza Yazdani, Gholamreza Azizi, Sima Habibi, Mohammad Gharagozlou, Masoud Movahedi, Amir Ali Hamidieh, Nasrin Behniafard, Mohammamd Nabavi, Mohammad Hassan Bemanian, Saba Arshi, Rasol Molatefi, Roya Sherkat, Afshin Shirkani, Reza Amin, Soheila Aleyasin, Reza Faridhosseini, Farahzad Jabbari-Azad, Iraj Mohammadzadeh, Javad Ghaffari, Alireza Shafiei, Arash Kalantari, Mahboubeh Mansouri, Mehrnaz Mesdaghi, Delara Babaie, Hamid Ahanchian, Maryam Khoshkhui, Habib Soheili, Mohammad Hossein Eslamian, Taher Cheraghi, Abbas Dabbaghzadeh, Mahmoud Tavassoli, Rasoul Nasiri Kalmarzi, Seyed Hamidreza Mortazavi, Sara Kashef, Hossein Esmaeilzadeh, Javad Tafaroji, Abbas Khalili, Fariborz Zandieh, Mahnaz Sadeghi-Shabestari, Sepideh Darougar, Fatemeh Behmanesh, Hedayat Akbari, Mohammadreza Zandkarimi, Farhad Abolnezhadian, Abbas Fayezi, Mojgan Moghtaderi, Akefeh Ahmadiafshar, Behzad Shakerian, Vahid Sajedi, Behrang Taghvaei, Mojgan Safari, Marzieh Heidarzadeh, Babak Ghalebaghi, Seyed Mohammad Fathi, Behzad Darabi, Saeed Bazregari, Nasrin Bazargan, Morteza Fallahpour, Alireza Khayatzadeh, Naser Javahertrash, Bahram Bashardoust, Mohammadali Zamani, Azam Mohsenzadeh, Sarehsadat Ebrahimi, Samin Sharafian, Ahmad Vosughimotlagh, Mitra Tafakoridelbari, Maziar Rahimi, Parisa Ashournia, Anahita Razaghian, Arezou Rezaei, Setareh Mamishi, Nima Parvaneh, Nima Rezaei, Lennart Hammarström, Asghar Aghamohammadi
BACKGROUND: The number of inherited diseases and the spectrum of clinical manifestations of primary immunodeficiency disorders (PIDs) are ever-expanding. Molecular diagnosis using genomic approaches should be performed for all PID patients since it provides a resource to improve the management and to estimate the prognosis of patients with these rare immune disorders. METHOD: The current update of Iranian PID registry (IPIDR) contains the clinical phenotype of newly registered patients during last 5 years (2013-2018) and the result of molecular diagnosis in patients enrolled for targeted and next-generation sequencing...
October 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/30301711/incidence-and-epidemiological-features-of-acute-pancreatitis-among-adult-inhabitants-in-qatar
#9
Abdel-Naser Elzouki, Omar Alsaed, Abazar Saeed, Ahmed Ayash, Fahmi Yousef Khan
BACKGROUND/AIMS: Acute pancreatitis (AP) is one of the most common gastrointestinal causes of hospital admission in Qatar. The aim of the present study was to investigate the epidemiological features and demographic characteristics of patients with AP and to estimate the annual incidence rates of this disease among adult inhabitants in Qatar. MATERIALS AND METHODS: This retrospective study was conducted using the data collected by reviewing records of patients with AP admitted to the medical and surgical wards of Hamad GeneralHospital and Alkhor Hospital, Qatar from January 2007 to December 2012...
October 9, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/30301636/a-potential-clinical-significance-of-dab2ip-and-spry2-transcript-variants-in-prostate-cancer
#10
Niusha Samadaian, Pouya Salehipour, Mohsen Ayati, Naser Rakhshani, Ali Najafi, Mandana Afsharpad, Fatemeh Yazarlou, Mohammad Hossein Modarressi
Deregulation of key signaling pathways is one of the primary phenomena in carcinogenesis. DAB2IP and SPRY2 are regulatory elements, which act as feedback inhibitors of receptor tyrosine kinases signaling in mitogen-activated protein kinase pathway. These elements have also been implicated in the pathophysiology of cancer. Therefore, this study is aimed to investigate the expression of all known splice variants of DAB2IP and SPRY2 in prostate tissue. Fresh Prostate tissue samples (50 prostate cancer/ matched normal tissue and 30 BPH) were collected and total RNA was extracted followed by cDNA synthesis...
September 29, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30298022/psychiatric-disorders-in-refugees-and-internally-displaced-persons-after-forced-displacement-a-systematic-review
#11
Naser Morina, Aemal Akhtar, Jürgen Barth, Ulrich Schnyder
Background: Protracted armed conflicts not only shape political, legal, and socio-economic structures, but also have a lasting impact on people's human migration. In 2017, the United Nations High Commissioner for Refugees reported an unprecedented number of 65.6 million individuals who were displaced worldwide as a result of armed conflicts. To date, however, little is known about these people's mental health status. Therefore, we conducted a systematic review of the prevalence of psychiatric disorders among forcibly displaced populations in settings of armed conflicts...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30297685/attenuation-of-morphine-withdrawal-syndrome-by-prosopis-farcta-extract-and-its-bioactive-component-luteolin-in-comparison-with-clonidine-in-rats
#12
Ardeshir Moayeri, Maryam Azimi, Elahe Karimi, Ali Aidy, Naser Abbasi
BACKGROUND Today, the plant Prosopis farcta is frequently used for traditional medicinal purposes. The aim of this study was the identification of luteolin in P. farcta extract (PFE) and to evaluate its effect on morphine discontinuation syndrome in rats. MATERIAL AND METHODS Using high-performance liquid chromatography (HPCL), luteolin was evaluated in PFE. The frequency of behavioral symptoms of morphine withdrawal (jumping, rearing, and teeth chattering) induced by naloxone challenge were illustrated in morphine-dependent rats receiving PFE, luteolin, saline, or clonidine...
October 9, 2018: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/30285775/hospitalization-for-mental-health-related-ambulatory-care-sensitive-conditions-what-are-the-trends-for-first-nations-in-british-columbia
#13
Josée G Lavoie, Amanda Ward, Sabrina T Wong, Naser Ibrahim, Darrien Morton, John D O'Neil, Michael Green
BACKGROUND: Indigenous peoples globally experience a disproportionate burden of mental illness due to forced policies and practices of colonization and cultural disruption. The objective of this study was to provide a baseline profile of hospitalization rates for mental health-related Ambulatory Care Sensitive Conditions among First-Nations living both on and off reserve in British Columbia, Canada, and explore the relationship between local access to health services and mental health-related hospitalization rates...
October 3, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/30284475/three-dimensional-nanofiberous-plla-pcl-scaffold-improved-biochemical-and-molecular-markers-hips-cell-derived-insulin-producing-islet-like-cells
#14
Naser Mobarra, Masoud Soleimani, Reza Pakzad, Seyed Ehsan Enderami, Parvin Pasalar
Nanofibrous scaffolds are considered as a new strategy for Type 1 diabetes mellitus therapy. We used a hybrid of poly-l-lactic acid (PLLA) and polycaprolactone (PCL) as three-dimensional (3D) culture models for differentiation of human induced pluripotent stem cells (hiPSCs) to beta islet-like cluster cell compared with routine culture (2D). Morphological changes of cells were checked by microscope. mRNA endodermal SOX-17 on day 7 and pancreatic gene markers Pdx1, glucagon and Glut2 were evaluated on day 23 by qPCR...
October 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/30283207/comment-on-an-intrauterine-gestational-sac-surrounded-by-thin-myometrium-at-fundus
#15
COMMENT
Ibrahim A Abdelazim, Bassam Nussair, Gulmira Zhurabekova, Shikanova Svetlana, Mohannad Abu-Faza, Waheeb Naser
No abstract text is available yet for this article.
July 2018: Journal of Medical Ultrasound
https://www.readbyqxmd.com/read/30281149/genomic-and-transcriptomic-characterisation-of-undifferentiated-pleomorphic-sarcoma-of-bone
#16
Naser M Ali, Stefania Niada, Anna T Brini, Mark R Morris, Sathishkumar Kurusamy, Abdullah Alholle, David Huen, Cristina R Antonescu, Franck Tirode, Vaiyapuri Sumathi, Farida Latif
Undifferentiated pleomorphic sarcoma of bone (UPSb), is a rare primary bone sarcoma that lacks a specific line of differentiation. There is very little information about the genetic alterations leading to tumourigenesis or malignant transformation. Distinguishing between UPSb and other malignant bone sarcomas, including dedifferentiated chondrosarcoma and osteosarcoma, can be challenging due to overlapping features. To explore the genomic and transcriptomic landscape of UPSb tumours, whole-exome sequencing (WES) and RNA Sequencing (RNA-Seq) were performed on UPSb tumours...
October 3, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/30276841/schistosomiasis-bilharziasis-and-male-infertility
#17
Mohamed Badawy Abdel-Naser, Andreas Altenburg, Christos C Zouboulis, Uwe Wollina
Schistosomiasis (bilharziasis) is an endemic parasitic disease of a major source of morbidity and mortality for developing countries. It is caused by different species of blood flukes (trematode worms) of the genus Schistosoma, the most important of which are S. haematobium which infests the genitourinary tract and S. mansoni and S. japonicum which infest the gastrointestinal tract. The incidence of schistosome-induced male infertility is not known and probably underestimated being overshadowed by the more severe and often fatal urinary and gastrointestinal complications...
October 1, 2018: Andrologia
https://www.readbyqxmd.com/read/30269105/the-standardized-extract-of-nigella-sativa-and-its-major-ingredient-thymoquinone-ameliorates-angiotensin-ii-induced-hypertension-in-rats
#18
Lili Enayatfard, Reza Mohebbati, Saeed Niazmand, Mahmoud Hosseini, Mohammad Naser Shafei
Background This study investigated the effect of hydroalcoholic extract of Nigella sativa (N. sativa) and its active component, thymoquinone (TQ) on hypertension induced by angiotensin II (AngII), the main product of renin-angiotensin system (RAS). Methods Seven animal groups (n=7 for each group) were used as follows: (1) control, (2) AngII (300 ng/kg), (3) AngII+losartan (Los; 10 mg/kg), (4) TQ (40 mg/kg)+AngII, and (5-7) three doses of N. sativa (200, 400, and 600 mg/kg)+AngII. Los and AngII were injected intravenously; TQ and extracts were injected intraperitoneally...
October 1, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30266521/addressing-cancer-immunotherapy-research-in-iran-adoptive-cell-therapy-on-the-horizon
#19
REVIEW
Fatemeh Khatami, Monireh Torabi-Rahvar, Jafar Kiani, Mahmood Naderi, Naser Ahmadbeigi
Recent advances in immunotherapeutic modalities have profoundly changed the prospect of cancer treatment. These modalities mainly focus on modulating the immune response toward tumor cells by using monoclonal antibodies, cancer vaccines, adoptive cell transfer or combination of these methods. In the last few years, Iranian scientists have conducted several projects in these arenas. Here, we provide an overview of these studies and analyze the quality and trend of publications in each sub-specialty of the field...
September 26, 2018: Cytotherapy
https://www.readbyqxmd.com/read/30260046/msln-mesothelin-antxr1-tem8-and-muc3a-are-the-potent-antigenic-targets-for-car-t-cell-therapy-of-gastric-adenocarcinoma
#20
Masoud Sotoudeh, Seyed Iman Shirvani, Shahin Merat, Naser Ahmadbeigi, Mahmood Naderi
Gastric adenocarcinoma is usually diagnosed in late stages, necessitating the use of different therapeutic modalities. Currently, antibody-based therapies have also been approved through with limited clinical efficacy. Reinforcing antibody-based immunotherapy by using chimeric antigen receptor (CAR) T cells may enhance the approach. However, the cells can cause severe on-target and off-tumor toxicities owing to their higher sensitivity to low-level antigen expressions. To address the need for safe and reliable targets, we made a bioinformatics pipeline by which we screened overexpressed genes in the disease for off-tumor sites in many normal tissues...
September 27, 2018: Journal of Cellular Biochemistry
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