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chloride channel and vascular

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https://www.readbyqxmd.com/read/30312171/clca4-inhibits-cell-proliferation-and-invasion-of-hepatocellular-carcinoma-by-suppressing-epithelial-mesenchymal-transition-via-pi3k-akt-signaling
#1
Zhao Liu, Mi Chen, Lin-Ka Xie, Ting Liu, Zhen-Wei Zou, Yong Li, Peng Chen, Xin Peng, Charlie Ma, Wen-Jie Zhang, Pin-Dong Li
Calcium activated Chloride Channel A4 (CLCA4), as a tumor suppressor, was reported to contribute to the progression of several malignant tumors, yet little is known about the significance of CLCA4 in invasion and prognosis of hepatocellular carcinoma (HCC). CLCA4 expression was negatively correlated with tumor size, vascular invasion and TNM stage. Kaplan-Meier analysis showed that CLCA4 was an independent predictor for overall survival (OS) and time to recurrence (TTR). In addition, CLCA4 status could act as prognostic predictor in different risk of subgroups...
October 11, 2018: Aging
https://www.readbyqxmd.com/read/30289819/targeted-sequencing-identifies-a-missense-variant-in-the-best3-gene-associated-with-antihypertensive-response-to-hydrochlorothiazide
#2
Sonal Singh, Zhiying Wang, Mohamed H Shahin, Taimour Y Langaee, Yan Gong, Stephen T Turner, Arlene B Chapman, John G Gums, Caitrin W McDonough, Kent R Bailey, Amber L Beitelshees, Rhonda M Cooper-DeHoff, Steve Scherer, Eric Boerwinkle, Julie A Johnson
Chromosome 12q15 was identified in Genetic Epidemiology of Response Assessment (GERA) and replicated in Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) for its association with blood pressure (BP) response to hydrochlorothiazide (HCTZ). However, the functional variant is unknown and we aimed to identify the likely functional variants through targeted sequencing. The chromosome 12q15 region was sequenced in 397 best and worst responders to HCTZ in PEAR (N=199) and GERA (N=198) hypertensive study participants...
October 4, 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30248350/celosia-argentea-l-amaranthaceae-a-vasodilator-species-from-the-brazilian-cerrado-an-ethnopharmacological-report
#3
Sara Emilia Lima Tolouei, Cleide Adriane Signor Tirloni, Rhanany Alan Calloi Palozi, Maysa Isernhagen Schaedler, Lucas Pires Guarnier, Aniely Oliveira Silva, Valter Paes de Almeida, Jane Manfron Budel, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Vanessa Samúdio Dos Santos, Denise Brentan Silva, Paulo Roberto Dalsenter, Arquimedes Gasparotto Junior
ETHNOPHARMACOLOGICAL RELEVANCE: Celosia argentea L. (Amaranthaceae), popularly known as "crista de galo", is used in folk medicine due to its diuretic and hypotensive effects. However, there are no reports in the literature regarding its pharmacological effects on the cardiovascular system as well as no data proving the safety of this species. AIM: To perform a detailed ethnopharmacological investigation of the ethanol soluble fraction from C. argentea (ESCA) using male and female Wistar rats...
September 21, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30244120/the-toxic-effects-of-monosodium-glutamate-msg-the-involvement-of-nitric-oxide-prostanoids-and-potassium-channels-in-the-reactivity-of-thoracic-arteries-in-msg-obese-rats
#4
Michał Majewski, Adam Jurgoński, Bartosz Fotschki, Jerzy Juśkiewicz
We investigated the potential effects of monosodium glutamate (MSG)-induced obesity with regards to nitric oxide and prostanoid production, as well as potassium channel function, in rat thoracic arteries. Newborn male Wistar rats were injected intraperitoneally with typically reported MSG (4.0 mg/g) once daily for 4 consecutive days. At 90 days postnatal, the rats were sacrificed and the thoracic aortas were evaluated for vascular responses and for prostanoid production. Nitric oxide was studied with calcium ionophore (A23187), acetylcholine (ACh) and sodium nitroprusside (SNP)...
September 19, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30123054/high-chloride-channel-accessory-1-expression-predicts-poor-prognoses-in-patients-with-rectal-cancer-receiving-chemoradiotherapy
#5
Tzu-Ju Chen, Hong-Lin He, Yow-Ling Shiue, Ching-Chieh Yang, Li-Ching Lin, Yu-Feng Tian, Shang-Hung Chen
Background: Concurrent chemoradiotherapy (CCRT) has now become the standard of treatments for advanced rectal cancer before surgery. To search the biological molecules with prognostic and therapeutic potential of CCRT could be beneficial for these patients. Recently, aberrant expression of chloride channels has been linked to radio-resistance in glioblastoma; however, its clinical implication has not been well-studied in rectal cancers. Therefore, we examined the clinical significance of targetable drivers associated with chloride channel activity in patients with rectal cancer receiving CCRT...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/30089032/intraluminal-pressure-triggers-myogenic-response-via-activation-of-calcium-spark-and-calcium-activated-chloride-channel-in-rat-renal-afferent-arteriole
#6
Kay-Pong Yip, Lavanya Balasubramanian, Chen Kan, Lei Wang, Ruisheng Liu, Luisa Ribeiro-Silva, James S K Sham
Myogenic contraction of renal arterioles is an important regulatory mechanism for renal blood flow autoregulation. We have previously demonstrated that integrin-mediated mechanical force increases the occurrence of Ca2+ sparks in freshly isolated renal vascular smooth muscle cells (VSMCs). To further test whether generation of Ca2+ sparks is a downstream signal of mechanotransduction in pressure induced myogenic constriction, the relationship between Ca2+ spark frequency and transmural perfusion pressure was investigated in intact VSMCs of pressurized rat afferent arterioles...
August 8, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29998199/sugar-glass-fugitive-ink-loaded-with-calcium-chloride-for-the-rapid-casting-of-alginate-scaffold-designs
#7
Gabrielle Gauvin-Rossignol, Philippe Legros, Jean Ruel, Marc-André Fortin, André Bégin-Drolet
Alginate-based hydrogels are widely used for the development of biomedical scaffolds in regenerative medicine. The use of sugar glass as a sacrificial template for fluidic channels fabrication within alginate scaffolds remains a challenge because of the premature dissolution of sugar by the water contained in the alginate as well as the relatively slow internal gelation rate of the alginate. Here, a new and simple method, based on a sugar glass fugitive ink loaded with calcium chloride to build sacrificial molds, is presented...
July 2018: Heliyon
https://www.readbyqxmd.com/read/29972266/aggravated-intestinal-apoptosis-by-clc-3-deletion-is-lethal-to-mice-endotoxemia
#8
Lin-Yan Huang, Yu-Jie Li, Peng-Peng Li, Hong-Chun Li, Ping Ma
Our previous study found that ClC-3 chloride channel functioned differently in the vascular and intestinal inflammation, the loss of ClC-3 reduced vascular inflammation but exacerbated intestinal inflammation. To furtherly clarify the role of ClC-3 chloride channels in systemic inflammation, we used LPS-induced endotoxemia model to investigate the response of wild-type and ClC-3 knockout mice to systemic inflammation. The results showed that in the LPS-induced endotoxemia model, the mortality of mice with ClC-3 deletion was significantly higher than that of wild-type mice...
September 2018: Cell Biology International
https://www.readbyqxmd.com/read/29748816/epicatechin-s-cardiovascular-protective-effects-are-mediated-via-opioid-receptors-and-nitric-oxide
#9
Kirsty MacRae, Kylie Connolly, Rebecca Vella, Andrew Fenning
PURPOSE: Cardiovascular disease is the leading cause of mortality globally. Epicatechin has previously been shown to improve vascular responses and possess cardioprotective properties. However, the mechanisms underpinning these cardiotropic outcomes remain unknown. The aim of this study was to further identify epicatechin's mechanism of action in the cardiovasculature. METHODS: The effects of epicatechin on isolated rat conduit arteries, resistance vessels and cardiac electrophysiology were investigated on resting tension and precontracted vessels and cardiac action potential parameters, both in the presence and in the absence of various antagonists...
May 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29200904/taurine-relaxes-human-radial-artery-through-potassium-channel-opening-action
#10
Kemal Gokhan Ulusoy, Erkan Kaya, Kubilay Karabacak, Melik Seyrek, İbrahim Duvan, Vedat Yildirim, Oguzhan Yildiz
The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10 mM)-induced contractions was investigated...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29093568/experimental-preeclampsia-in-rats-affects-vascular-gene-expression-patterns
#11
Simone V Lip, Anne Marijn van der Graaf, Marjon J Wiegman, Sicco A Scherjon, Mark V Boekschoten, Torsten Plösch, Marijke M Faas
Normal pregnancy requires adaptations of the maternal vasculature. During preeclampsia these adaptations are not well established, which may be related to maternal hypertension and proteinuria. The effects of preeclampsia on the maternal vasculature are not yet fully understood. We aimed to evaluate gene expression in aortas of pregnant rats with experimental preeclampsia using a genome wide microarray. Aortas were isolated from pregnant Wistar outbred rats with low-dose LPS-induced preeclampsia (ExpPE), healthy pregnant (Pr), non-pregnant and low-dose LPS-infused non-pregnant rats...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28603045/arctigenin-improves-vascular-tone-and-decreases-inflammation-in-human-saphenous-vein
#12
Armond Daci, Burim Neziri, Shaip Krasniqi, Raif Cavolli, Rame Alaj, Giuseppe Danilo Norata, Giangiacomo Beretta
The goal of this study was to test the effects of bioactive phenylpropanoid dibenzylbutyrolactone lignan arctigenin (ATG) in vascular tone. Human bypass graft vessel, from a saphenous vein (SV), were set up in organ bath system and contracted with potassium chloride (KCl, 40mM). Two concentration-response curves of noradrenaline (NE) (10nM-100μM) separated with an incubation period of 30min without (Control) or with ATG (3-100μM) were established. Inhibitors of nitric oxide, prostaglandins, K+ related channels or calcium influx were used to delineate the molecular mechanisms beyond ATG effects...
September 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28552745/a-critical-role-for-cystathionine-%C3%AE-synthase-in-hydrogen-sulfide-mediated-hypoxic-relaxation-of-the-coronary-artery
#13
J Donovan, P S Wong, R E Roberts, M J Garle, S P H Alexander, W R Dunn, V Ralevic
Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide (H2 S) is reported to be an oxygen sensor/transducer in the vasculature. The present study aimed to identify and characterise the role of H2 S in the hypoxic response of the coronary artery, and to define the H2 S synthetic enzymes involved. Immunoblotting and immunohistochemistry showed expression of all three H2 S-producing enzymes, cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST), in porcine coronary artery...
August 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28493701/substituted-2-acylaminocycloalkylthiophene-3-carboxylic-acid-arylamides-as-inhibitors-of-the-calcium-activated-chloride-channel-transmembrane-protein-16a-tmem16a
#14
Eric C Truong, Puay W Phuan, Amanda L Reggi, Loretta Ferrera, Luis J V Galietta, Sarah E Levy, Alannah C Moises, Onur Cil, Elena Diez-Cecilia, Sujin Lee, Alan S Verkman, Marc O Anderson
Transmembrane protein 16A (TMEM16A), also called anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mammalian cells, including epithelia, vascular smooth muscle tissue, electrically excitable cells, and some tumors. TMEM16A inhibitors have been proposed for treatment of disorders of epithelial fluid and mucus secretion, hypertension, asthma, and possibly cancer. Herein we report, by screening, the discovery of 2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides (AACTs) as inhibitors of TMEM16A and analysis of 48 synthesized analogs (10ab-10bw) of the original AACT compound (10aa)...
June 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28478457/relaxing-effect-of-tsu-68-an-antiangiogenic-agent-on-mouse-airway-smooth-muscle
#15
Honghao Tan, Jun Lei, Lu Xue, Congli Cai, Qing-Hua Liu, Jinhua Shen
BACKGROUND/AIMS: Recently, some small-molecule compounds that were designed for cancer therapy have acquired new roles in the treatment of pulmonary diseases. However, drug screening aimed at abnormal muscle contraction is still limited. TSU-68 is a potent, orally administered, small-molecule agent that can reduce the vascular endothelial growth factor (VEGF)-induced Ca2+ increase in endothelial cells. We questioned whether TSU-68 could also affect calcium influx and relax airway smooth muscle (ASM) cells...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28350105/inflammatory-role-of-high-salt-level-in-tumor-microenvironment-review
#16
REVIEW
Suneetha Amara, Venkataswarup Tiriveedhi
Chronic inflammation is known to play a critical role in cancer development and progression. High salt is known to mediate several chronic inflammatory diseases including hypertension, myocardial infarction, neurological ischemic attack, autoimmune diseases and cancers. High salt level is shown to induce angiogenesis and immune-dysfunction, both of which play a direct role in cancer proliferation. Furthermore, salt has been suggested to enhance Warburg-like metabolic phenotype in cancer cells and at the same time also induce pro-tumor MΦ2-macrophage phenotype...
May 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28320851/tmem16a-contributes-to-endothelial-dysfunction-by-facilitating-nox2-nadph-oxidase-derived-reactive-oxygen-species-generation-in-hypertension
#17
Ming-Ming Ma, Min Gao, Kai-Min Guo, Mi Wang, Xiang-Yu Li, Xue-Lin Zeng, Lu Sun, Xiao-Fei Lv, Yan-Hua Du, Guan-Lei Wang, Jia-Guo Zhou, Yong-Yuan Guan
Ca2+ -activated Cl- channels play a crucial role in various physiological processes. However, the role of TMEM16A in vascular endothelial dysfunction during hypertension is unclear. In this study, we investigated the specific involvement of TMEM16A in regulating endothelial function and blood pressure and the underlying mechanism. Reverse transcription-polymerase chain reaction, Western blotting, coimmunoprecipitation, confocal imaging, patch-clamp recordings, and TMEM16A endothelial-specific transgenic and knockout mice were used...
May 2017: Hypertension
https://www.readbyqxmd.com/read/28320373/nelumbo-nucifera-leaves-extracts-inhibit-mouse-airway-smooth-muscle-contraction
#18
Xiao Yang, Lu Xue, Qingyang Zhao, Congli Cai, Qing-Hua Liu, Jinhua Shen
BACKGROUND: Alkaloids extracted from lotus leaves (AELL) can relax vascular smooth muscle. However, whether AELL has a similar relaxant role on airway smooth muscle (ASM) remains unknown. This study aimed to explore the relaxant property of AELL on ASM and the underlying mechanism. METHODS: Alkaloids were extracted from dried lotus leaves using the high temperature rotary evaporation extraction method. The effects of AELL on mouse ASM tension were studied using force measuring and patch-clamp techniques...
March 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28228405/inhibition-of-romk-blocks-macula-densa-tubuloglomerular-feedback-yet-causes-renal-vasoconstriction-in-anesthetized-rats
#19
Magali Araujo, William J Welch, Xiaoyan Zhou, Kathleen Sullivan, Shawn Walsh, Alexander Pasternak, Christopher S Wilcox
The Na+ -K+ -2Cl- cotransporter (NKCC2) on the loop of Henle is the site of action of furosemide. Because outer medullary potassium channel (ROMK) inhibitors prevent reabsorption by NKCC2, we tested the hypothesis that ROMK inhibition with a novel selective ROMK inhibitor (compound C) blocks tubuloglomerular feedback (TGF) and reduces vascular resistance. Loop perfusion of either ROMK inhibitor or furosemide caused dose-dependent blunting of TGF, but the response to furosemide was 10-fold more sensitive (IC50  = 10-6 M for furosemide and IC50 = 10-5 M for compound C)...
June 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28214884/transient-receptor-potential-melastatin-4-trpm4-contributes-to-high-salt-diet-mediated-early-stage-endothelial-injury
#20
Xiao-Qing Ding, Tao Ban, Zeng-Yan Liu, Jie Lou, Liang-Liang Tang, Jia-Xin Wang, Wen-Feng Chu, Dan Zhao, Bin-Lin Song, Zhi-Ren Zhang
BACKGROUND/AIMS: The present study investigated whether the transient receptor potential melastatin 4 (TRPM4) channel plays a role in high salt diet (HSD)-induced endothelial injuries. METHODS: Western blotting and immunofluorescence were used to examine TRPM4 expression in the mesenteric endothelium of Dahl salt-sensitive (SS) rats fed a HSD. The MTT, TUNEL, and transwell assays were used to evaluate the cell viability, cell apoptosis, and cell migration, respectively, of human umbilical vein endothelial cells (HUVECs)...
2017: Cellular Physiology and Biochemistry
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