keyword
https://read.qxmd.com/read/38522078/impaired-neuronal-macroautophagy-in-the-prelimbic-cortex-contributes-to-comorbid-anxiety-like-behaviors-in-rats-with-chronic-neuropathic-pain
#1
JOURNAL ARTICLE
Su Fu, Haojie Sun, Jiaxin Wang, Shuaixin Gao, Liu Zhu, Kun Cui, Shimeng Liu, Xuetao Qi, Rui Guan, Xiaocen Fan, Qingying Liu, Wen Chen, Li Su, Shuang Cui, Feifei Liao, Fengyu Liu, Catherine C L Wong, Ming Yi, You Wan
A large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanisms are not fully understood. Here, we reported that impaired neuronal macroautophagy in the prelimbic cortical (PrL) subregion of the mPFC paralleled the occurrence of anxiety-like behaviors in rats with chronic spared nerve injury (SNI). Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos+ neuronal subpopulation in the PrL...
March 24, 2024: Autophagy
https://read.qxmd.com/read/38507554/involvement-of-spinal-neuroplastin-65-in-neuropathic-pain-by-gabaa-receptor-%C3%AE-2-subunit-regulation
#2
JOURNAL ARTICLE
Li Xu, Yu Wang, Yang Jiao, Yulin Huang, Rui Xu, Xiaoping Gu, Wei Zhang, Zhengliang Ma
BACKGROUND: Neuropathic pain (NP) is a highly challenging condition with complex pathological mechanisms, and the spinal gamma aminobutyric acid A receptor receptor plays a crucial role in its progression. Recent studies have revealed a potential interaction between neuroplastin 65 (NP65) and gamma aminobutyric acid A receptor α2 subunit (GABAAR-α2) on the cell surface. We hypothesize that NP65 is involved in the pathogenesis of NP by regulating the level of GABAAR-α2...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38500267/the-effective-perospirone-augmentation-with-clonazepam-for-treatment-resistant-burning-mouth-syndrome-a-case-report
#3
Motoko Watanabe, Chihiro Takao, Chizuko Maeda, Gayatri Nayanar, Risa Tominaga, Yasuyuki Kimura, Trang Thi Huyen Tu, Takahiko Nagamine, Akira Toyofuku
Burning mouth syndrome (BMS) is characterized by burning sensations in the oral region without corresponding abnormalities and is often accompanied by uncomfortable sensations. Herein, we present cases of BMS in which the remaining uncomfortable sensations improved with perospirone augmentation with clonazepam. Case 1: A 61-year-old man complained of a burning pain in his tongue, a sensation of dryness and discomfort as if his tongue was sticking to a palatal plate. With the diagnosis of BMS, psychopharmacotherapy was initiated with amitriptyline...
March 18, 2024: Neuropsychopharmacology Reports
https://read.qxmd.com/read/38494618/xdemvy-tm-lotilaner-ophthalmic-solution-0-25-topical-solution-for-the-treatment-of-demodex-blepharitis
#4
JOURNAL ARTICLE
Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits
XdemvyTM (lotilaner ophthalmic solution) 0.25% topical solution was recently approved for the treatment of Demodex blepharitis in adults aged ≥18 years. As an antiparasitic agent, lotilaner selectively inhibits gamma-aminobutyric acid chloride channels specific to the parasite and induces spastic paralysis, leading to death of Demodex blepharitis mites. In two randomized, double-masked, vehicle-controlled, multi-center, phase-3 clinical trials (Saturn-1 and Satuirn-2), lotilaner 0.25% topical solution was investigated for the treatment of Demodex blepharitis...
2024: Skinmed
https://read.qxmd.com/read/38491439/daoyin-therapy-in-chronic-neck-pain-study-protocol-for-a-randomized-controlled-trial
#5
JOURNAL ARTICLE
Xiangxu Chen, Mingze Zhu, Wei Li, Daan Wang, Jing Liu
BACKGROUND: Daoyin therapy (DT), an ancient therapeutic approach with a history spanning thousands of years, has traditionally been employed to address musculoskeletal pain and psychosomatic disorders. However, the application of DT for chronic neck pain (CNP) has received limited attention in the existing literature, and systematic randomized clinical trials (RCTs) in this context remain scarce. This manuscript outlines an RCT protocol designed to investigate whether DT is more effective at alleviating CNP in adult individuals compared to other interventions...
March 15, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38479183/specific-transcription-factors-ascl1-and-lhx6-attenuate-diabetic-neuropathic-pain-by-modulating-spinal-neuroinflammation-and-microglial-activation-in-mice
#6
JOURNAL ARTICLE
Sung-Min Hwang, Md Mahbubur Rahman, Eun Jin Go, Yong Ho Kim, Chul-Kyu Park
Gamma-aminobutyric acid (GABA) neuronal system-related transcription factors (TFs) play a critical role in GABA production, and GABA modulates diabetic neuropathic pain (DNP). The present study investigated the therapeutic effects of intrathecal delivery of two TFs achaete-scute homolog 1 (Ascl1) and LIM homeobox protein 6 (Lhx6) in a mouse model of DNP and elucidated their underlying mechanisms. GABA-related specific TFs, including Ascl1, Lhx6, distal-less homeobox 1, distal-less homeobox 5, the Nkx2.1 homeobox gene, and the Nkx2...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38476603/apigenin-a-natural-molecule-at-the-intersection-of-sleep-and-aging
#7
REVIEW
Daniel J Kramer, Adiv A Johnson
NAD+ , a pivotal coenzyme central to metabolism, exhibits a characteristic decline with age. In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that inhibits the NAD+ -consuming glycoprotein CD38. In animal models, apigenin positively impacts both sleep and longevity. For example, apigenin improves learning and memory in older mice, reduces tumor proliferation in a mouse xenograft model of triple-negative breast cancer, and induces sedative effects in mice and rats. Moreover, apigenin elongates survival in fly models of neurodegenerative disease and apigenin glycosides increase lifespan in worms...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38444825/updating-perspectives-on-spinal-cord-function-motor-coordination-timing-relational-processing-and-memory-below-the-brain
#8
REVIEW
James W Grau, Kelsey E Hudson, David T Johnston, Sienna R Partipilo
Those studying neural systems within the brain have historically assumed that lower-level processes in the spinal cord act in a mechanical manner, to relay afferent signals and execute motor commands. From this view, abstracting temporal and environmental relations is the province of the brain. Here we review work conducted over the last 50 years that challenges this perspective, demonstrating that mechanisms within the spinal cord can organize coordinated behavior (stepping), induce a lasting change in how pain (nociceptive) signals are processed, abstract stimulus-stimulus (Pavlovian) and response-outcome (instrumental) relations, and infer whether stimuli occur in a random or regular manner...
2024: Frontiers in Systems Neuroscience
https://read.qxmd.com/read/38438259/hypothalamic-paraventricular-stimulation-inhibits-nociceptive-wdr-trigeminocervical-complex-cells-via-oxytocinergic-transmission
#9
JOURNAL ARTICLE
Miguel Condés-Lara, Guadalupe Martínez-Lorenzana, Antonio Espinosa de Los Monteros-Zúñiga, Gustavo López-Córdoba, Aketzalli Córdova-Quiroga, Shakty A Flores-Bojorquez, Abimael González-Hernández
Oxytocinergic transmission blocks nociception at the peripheral, spinal, and supraspinal levels through the oxytocin receptor (OTR). Indeed, a neuronal pathway from the hypothalamic paraventricular nucleus (PVN) to the spinal cord and trigeminal nucleus caudalis (Sp5c) has been described. Hence, although the trigeminocervical complex (TCC), an anatomical area spanning the Sp5c, C1, and C2 regions, plays a role in some pain disorders associated with craniofacial structures ( e.g. , migraine), the role of oxytocinergic transmission in modulating nociception at this level has been poorly explored...
March 4, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38417539/bdnf-in-neuropathic-pain-the-culprit-that-cannot-be-apprehended
#10
REVIEW
Peter A Smith
In males but not in females, brain derived neurotrophic factor (BDNF) plays an obligatory role in the onset and maintenance of neuropathic pain. Afferent terminals of injured peripheral nerves release colony stimulating factor (CSF-1) and other mediators into the dorsal horn. These transform the phenotype of dorsal horn microglia such that they express P2X4 purinoceptors. Activation of these receptors by neuron-derived ATP promotes BDNF release. This microglial-derived BDNF increases synaptic activation of excitatory dorsal horn neurons and decreases that of inhibitory neurons...
February 26, 2024: Neuroscience
https://read.qxmd.com/read/38340499/thrombospondin-4-a-mediator-and-candidate-indicator-of-pain
#11
JOURNAL ARTICLE
Yanqiong Wu, Min Yang, Xueqin Xu, Yan Gao, Xiaohui Li, Yang Li, Shanchun Su, Xianqiao Xie, Zeyong Yang, Changbin Ke
Pain is the most common symptom for which patients seek medical attention. Existing treatments for pain control are largely ineffective due to the lack of an accurate way to objectively measure pain intensity and a poor understanding of the etiology of pain. Thrombospondin 4(TSP4), a member of the thrombospondin gene family, is expressed in neurons and astrocytes and induces pain by interacting with the calcium channel alpha-2-delta-1 subunit (Cavα2δ1). In the present study we show that TSP4 expression level correlates positively with pain intensity, suggesting that TSP4 could be a novel candidate of pain indicator...
February 6, 2024: European Journal of Cell Biology
https://read.qxmd.com/read/38331341/fucoxanthin-mitigates-valproic-acid-induced-autistic-behavior-through-modulation-of-the-akt-gsk-3%C3%AE-signaling-pathway
#12
JOURNAL ARTICLE
Piyush Anand, Arshbir Kaur, Shamsher Singh
This study aimed to investigate the effects of fucoxanthin, a natural compound found in seaweed, on various aspects of autism using a rat model induced by valproic acid (VPA). Pregnant rats were administered VPA (600 mg/kg) on gestational day 12.5, and male pups were orally administered fucoxanthin at 50, 100, or 200 mg/kg beginning on post-natal day (PND) 23-43. Behavioral assessments were conducted on PND 45-53, and on PND 54, the animals were sacrificed for further biochemical analyses (superoxide dismutase (SOD) and glutathione (GSH), nitric oxide (NO)) via UV spectroscopy...
February 6, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38329679/electroacupuncture-alleviates-hyperalgesia-and-anxiety-like-behaviors-in-pain-memory-model-rats-through-activation-of-gabaergic-neurons-and-gaba-receptor-in-the-rostral-anterior-cingulate-cortex
#13
JOURNAL ARTICLE
Jing Sun, Chi Zhang, Yifang Wang, Siqi Xiao, Haiju Sun, Zhiyuan Bian, Zui Shen, Xiaofen He, Jianqiao Fang, Xiaomei Shao
Recent studies have confirmed that pain memory is often accompanied by negative emotions. Electroacupuncture (EA) can block the retrieval of painful memories, thereby alleviating the associated negative behaviors. However, the underlying mechanism is poorly understood. This study revealed that the effect of EA on pain memory-induced negative behaviors is related to the mediation of GABAergic neuron activity and GABA receptor expression in the rostral anterior cingulate cortex (rACC). Previous studies have shown that the rACC is a crucial area for regulating nociceptive behaviors and negative emotions in pain memory models...
February 8, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38325715/pathophysiological-and-therapeutic-implications-of-neuropeptide-s-system-in-neurological-disorders
#14
REVIEW
Kamini R Shirsath, Vaishnavi K Patil, Sanjay N Awathale, Sameer N Goyal, Kartik T Nakhate
Neuropeptide S (NPS) is a 20 amino acids-containing neuroactive molecule discovered by the reverse pharmacology method. NPS is detected in specific brain regions like the brainstem, amygdala, and hypothalamus, while its receptor (NPSR) is ubiquitously expressed in the central nervous system (CNS). Besides CNS, NPS and NPSR are also expressed in the peripheral nervous system. NPSR is a G-protein coupled receptor that primarily uses Gq and Gs signaling pathways to mediate the actions of NPS. In animal models of Parkinsonism and Alzheimer's disease, NPS exerts a neuroprotective role...
February 5, 2024: Peptides
https://read.qxmd.com/read/38325276/health-related-quality-of-life-in-patients-with-newly-diagnosed-advanced-ovarian-cancer-treated-with-niraparib-vs-placebo-results-from-the-phase-3-randomized-prima-engot-ov26-gog-3012-trial
#15
JOURNAL ARTICLE
Bhavana Pothuri, Sileny Han, Dana M Chase, Florian Heitz, Robert A Burger, Lydia Gaba, Linda Van Le, Eva Guerra, David Bender, Jacob Korach, Noelle Cloven, Cristina Churruca, Philippe Follana, Paul DiSilvestro, Jean-François Baurain, Kris Jardon, Carmela Pisano, Ulla Peen, Johanna Mäenpää, Divya Gupta, Emeline Bacqué, Yong Li, Natalie Compton, Jenya Antonova, Bradley J Monk, Antonio González-Martín
OBJECTIVE: To assess patient-reported health-related quality of life (HRQoL) in patients with ovarian cancer (OC) who received niraparib as first-line maintenance therapy. METHODS: PRIMA/ENGOT-OV26/GOG-3012 (NCT02655016) enrolled patients with newly diagnosed advanced OC who responded to first-line platinum-based chemotherapy. Patients were randomized (2:1) to niraparib or placebo once daily in 28-day cycles until disease progression, intolerable toxicity, or death...
February 6, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38310082/recent-progress-in-understanding-the-intracellular-domain-s-gating-and-functional-roles-in-trimeric-ligand-gated-ion-channels
#16
JOURNAL ARTICLE
Yan Lu, Yi Yu Lin, Jin Wang
Ligand-gated ion channels are a large category of essential ion channels, whose superfamily members may modulate their state by binding to specific ligands, allowing specific ions to pass through the cell membrane. Purinergic ligand- gated ion channel(P2X)and ASIC (acid-sensitive ion channel) are representative members of trimeric ligand-gated ion channels. Recent studies have shown that structural differences in the intracellular domain of P2X receptors (P2XR) may determine the desensitization process. The lateral fenestrations of P2XR potentially serve as a pathway for ion conduction and play a decisive role in ion selectivity...
February 2, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/38287551/implication-of-intestinal-microbiota-in-the-etiopathogenesis-of-fibromyalgia-a-systematic-review
#17
REVIEW
Juan Francisco Palma-Ordóñez, Ana María Moreno-Fernández, Jorge Antolín Ramírez-Tejero, Elena Durán-González, Antonio Martínez-Lara, David Cotán
Fibromyalgia (FM) is a highly prevalent chronic disease. About 4.7% of the world's population suffers from generalized pain and hypersensitivity, in addition to a wide range of physical and psychological symptoms. The etiopathogenesis of this disease is multifactorial, which makes its diagnosis and treatment challenging. Recently, the increase in the number of studies on microbiota has provided new data that can help to understand the onset and development of FM. An updated systematic review of the causes of FM has been carried out in this work...
January 2024: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/38283799/why-can-modulation-of-%C3%AE-6-containing-gaba-a-receptors-reduce-the-symptoms-of-multiple-neuropsychiatric-disorders
#18
JOURNAL ARTICLE
Werner Sieghart
α6-containing GABAA receptors (α6GABAA Rs) are strongly expressed in cerebellar granule cells, where they mediate a correctly timed and precise coordination of all muscle groups that execute behavior and protect the brain from information overflow. Recently, it was demonstrated that positive modulators with a high selectivity for α6GABAA Rs (α6-modulators) can reduce the symptoms of multiple neuropsychiatric disorders in respective animal models to an extent comparable with established clinical therapeutics...
January 2024: Archives of pharmacology and therapeutics
https://read.qxmd.com/read/38276272/bidirectional-regulation-of-gaba-a-reversal-potential-in-the-adult-brain-physiological-and-pathological-implications
#19
REVIEW
Haram R Kim, Marco Martina
In physiological conditions, the intracellular chloride concentration is much lower than the extracellular. As GABAA channels are permeable to anions, the reversal potential of GABAA is very close to that of Cl- , which is the most abundant free anion in the intra- and extracellular spaces. Intracellular chloride is regulated by the activity ratio of NKCC1 and KCC2, two chloride-cation cotransporters that import and export Cl- , respectively. Due to the closeness between GABAA reversal potential and the value of the resting membrane potential in most neurons, small changes in intracellular chloride have a major functional impact, which makes GABAA a uniquely flexible signaling system...
January 19, 2024: Life
https://read.qxmd.com/read/38273253/migraine-a-borderland-disease-to-epilepsy-near-it-but-not-of-it
#20
REVIEW
Jakob Paungarttner, Martina Quartana, Lucrezia Patti, Barbora Sklenárová, Fatemeh Farham, Inés Hernando Jiménez, M Gokcen Soylu, Irina Maria Vlad, Semih Tasdelen, Teresa Mateu, Oreste Marsico, Federica Reina, Viktoria Tischler, Christian Lampl
BACKGROUND: Migraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and socioeconomic burden. The link between these disorders has been of interest for decades and innovations concerning diagnosing and treatment enable new insights into their relationship. FINDINGS: Although appearing to be distinct at first glance, both diseases exhibit a noteworthy comorbidity, shared pathophysiological pathways, and significant overlaps in characteristics like clinical manifestation or prophylactic treatment...
January 26, 2024: Journal of Headache and Pain
keyword
keyword
169253
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.