keyword
https://read.qxmd.com/read/38521533/comparing-blastocyst-euploid-rates-between-the-progestin-primed-and-gonadotrophin-releasing-hormone-antagonist-protocols-in-aneuploidy-genetic-testing-a-randomised-trial-protocol
#1
JOURNAL ARTICLE
He Li, Min Yu, Wenbi Zhang, Junling Chen, Hua Chen, Xiang Lu, Lu Li, Ernest H Y Ng, Xiaoxi Sun
INTRODUCTION: Progestin can inhibit the pituitary luteinising hormone (LH) surge during ovarian stimulation for in vitro fertilisation (IVF) and studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF. More and more centres are using PPOS because this regimen appears simpler and cheaper. This study aims to compare the euploidy rate of blastocysts following the PPOS protocol and the gonadotropin-releasing hormone antagonist protocol in women undergoing preimplantation genetic testing for aneuploidy (PGT-A)...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38510925/neurotensin-induces-sustainable-activation-of-the-erbb-erk1-2-pathway-which-is-required-for-developmental-competence-of-oocytes-in-mice
#2
JOURNAL ARTICLE
Asako Okamoto, Tomoya Nakanishi, Shingo Tonai, Masayuki Shimada, Yasuhisa Yamashita
PURPOSE: LH induces the expression of EGF-like factors and their shedding enzyme (ADAM17) in granulosa cells (GCs), which is essential for ovulation via activation of the ErbB-ERK1/2 pathway in cumulus cells (CCs). Neurotensin (NTS) is reported as a novel regulator of ovulation, whereas the NTS-induced maturation mechanism in oocytes remains unclear. In this study, we focused on the role of NTS in the expression of EGF-like factors and ErbBs, and ADAM17 activity, during oocyte maturation and ovulation in mice...
2024: Reproductive Medicine and Biology
https://read.qxmd.com/read/38485977/follicular-challenge-test-to-predict-suboptimal-response-to-gonadotropin-releasing-hormone-agonist-trigger-in-elective-oocyte-cryopreservation-cycles
#3
JOURNAL ARTICLE
Sarit Avraham, Michal Youngster, Gil Yerushalmi, Yekaterina Belov, Itai Gat, Alon Kedem, Odelia Yaakov, Yariv Gidoni, Jonathan Barkat, Ohad Baruchin, Ariel Hourvitz
This prospective study aimed to test the ability of follicular GnRH agonist challenge test (FACT) to predict suboptimal response to GnRH agonist trigger, assessed by LH levels post ovulation trigger in non-medical oocyte cryopreservation program. The study included 91 women that underwent non-medical fertility preservation. On day two to menstrual cycle, blood tests were drawn (basal Estradiol, basal FSH, basal LH, Progesterone) and ultrasound (US) was performed. On that evening, the women were instructed to inject 0...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38482566/elagolix-represents-a-less-invasive-and-cheaper-option-than-injectable-gnrh-antagonist-for-ovulation-suppression-in-ivf
#4
JOURNAL ARTICLE
Marco Mouanness, Zaher Merhi
BACKGROUND: The injectable GnRH antagonists have traditionally been used for ovulation suppression during controlled ovarian hyperstimulation in IVF, leading to increased painful daily injections and cost. The use of the oral GnRH antagonist elagolix for ovulation suppression in IVF has not been studied. METHODS: A retrospective cohort study of patients undergoing IVF received either oral elagolix 50 mg every other day or ganirelix/cetrotide injection daily for ovulation suppression during controlled ovarian hyperstimulation...
March 14, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38476786/effect-of-short-agonist-stop-sas-protocol-in-a-patient-having-an-allergic-reaction-from-conventional-ovarian-stimulating-hormone
#5
Al Hera Ansari, Akash More, Shilpa Dutta, Namrata Choudhary, Jarul Shrivastava, Rokaiya Shaikh
The case study examined a 32-year-old female and her 35-year-old partner who had experienced infertility attributed to the wife's irregular ovulation. Despite the male partner demonstrating normal reproductive parameters, he had a medical history involving hypertension. The woman also had a history of hypertension and chikungunya, which was accompanied by fever and joint pain in 2019. Due to the woman's allergic reaction to traditional ovulation stimulatory medications, the approach to assisted reproductive technologies (ART) had shifted towards employing the short agonist stop (SAS) regimen...
February 2024: Curēus
https://read.qxmd.com/read/38470466/neonatal-aromatase-inhibition-blocked-defeminization-of-avpv-kiss1-neurons-and-lh-surge-generating-system-in-male-rats
#6
JOURNAL ARTICLE
Koki Yamada, Tetsuya Mano, Safiullah Hazim, Marina Takizawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
The neuroendocrine system that controls the pre-ovulatory surge of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH), which triggers ovulation in female mammals, is sexually differentiated in rodents. A transient increase in circulating testosterone levels in male rats within a few hours of birth is primarily responsible for the defeminization of anteroventral periventricular nucleus (AVPV) kisspeptin neurons, which are critical regulators of the GnRH/LH surge. The present study aimed to determine if neonatal estradiol-17β (E2) converted from testosterone by aromatase primarily causes the defeminization of AVPV kisspeptin neurons and the surge of GnRH/LH in male rodents...
March 12, 2024: Endocrinology
https://read.qxmd.com/read/38460874/effect-of-200-%C3%AE-g-of-gonadorelin-hydrochloride-at-the-first-gnrh-of-a-cidr-synch-program-on-ovulation-rate-and-pregnancies-per-ai-in-holstein-heifers
#7
JOURNAL ARTICLE
D B Melo, W M Coelho, T C Marques, S Salman, I M Macedo, T Castro, M C G Menezes, H F Monteiro, R F Cotterman, A J Conley, F S Lima
The initial ovulatory response during synchronization programs is often low in dairy heifers, largely due to follicular dynamics and hormonal dynamics. Specifically, the progesterone concentration (P4) at the time of the first GnRH treatment in a breeding program can influence the LH response, often resulting in a suboptimal ovulatory response. The objective of this study was to determine the effect of the highest label dose 200 μg (100 μg vs. 200 μg) of GnRH (50 μg gonadorelin hydrochloride per mL; Factrel®; Zoetis Inc...
March 7, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38458359/ulipristal-upa-effects-on-rat-ovaries-unraveling-follicle-dynamics-ovulation-inhibition-and-safety-implications-for-prolonged-use
#8
JOURNAL ARTICLE
Mana Hirano, Osamu Wada-Hiraike, Motoko Fukui, Seiji Shibata, Mari Uehara, Aiko Nagumo, Yoko Urata, Kenbun Sone, Miyuki Harada, Kaori Koga, Yutaka Osuga
Ulipristal (UPA), a selective progesterone receptor modulator, has both agonistic and antagonistic effects on progesterone receptors. UPA suppresses ovulation by inhibiting the luteinizing hormone (LH) surge from the pituitary gland; however, the direct effect of UPA on ovarian tissue remains poorly studied. In the present study, we examined the effects of UPA on the ovaries of rats. Rats were treated for 28 days with UPA, and the effects of UPA on ovarian tissue were examined histologically and the expression of antioxidant genes and cell death markers were also investigated...
March 6, 2024: Reproductive Toxicology
https://read.qxmd.com/read/38452353/risk-factors-for-poor-oocyte-yield-and-oocyte-immaturity-after-gnrh-agonist-triggering
#9
JOURNAL ARTICLE
S Gambini, C Sonigo, G Robin, I Cedrin-Durnerin, C Vinolas, C Sifer, Y Boumerdassi, A Mayeur, V Gallot, M Grynberg, M Peigné
STUDY QUESTION: What are the potential risk factors for poor oocyte recuperation rate (ORR) and oocyte immaturity after GnRH agonist (GnRHa) ovulation triggering? SUMMARY ANSWER: Lower ovarian reserve and LH levels after GnRHa triggering are risk factors of poor ORR. Higher BMI and anti-Müllerian hormone (AMH) levels are risk factors of poor oocyte maturation rate (OMR). WHAT IS KNOWN ALREADY: The use of GnRHa to trigger ovulation is increasing...
March 7, 2024: Human Reproduction
https://read.qxmd.com/read/38406771/effects-of-combined-metformin-and-cabergoline-versus-metformin-alone-on-ovarian-and-hormonal-activities-in-iraqi-patients-with-pcos-and-hyperprolactinemia-a-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Inas Naser Hamad, Sinaa Abdul Amir Kadhim, Hayder Adnan Fawzi, Shoroq Mohammed Al-Temimi, Bassim Mohammad, Asma Swadi
Polycystic ovary syndrome (PCOS) is one of the most prevalent metabolic diseases during female reproductive life, often associated with insulin resistance and hyperprolactinemia. The efficacy of metformin and cabergoline for managing PCOS remains debated in the literature. This three-arm interventional study in Iraq assessed the effects of these drugs on body mass index (BMI), hormonal balance, and uterine artery blood flow in 75 women with PCOS and hyperprolactinemia. Participants were randomized into three groups: metformin (500 mg twice daily), cabergoline (0...
November 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38404024/kisspeptin-and-neurokinin-b-neuroendocrine-pathways-in-the-control-of-human-ovulation
#11
REVIEW
Richard A Anderson
The roles of initially kisspeptin and subsequently neurokinin B pathways in the regulation of human reproduction through the control of GnRH secretion were first identified 20 years ago, as essential for the onset of puberty in both boys and girls. Within that short time we already now have the first licence for clinical use for a neurokinin antagonist in a related indication, for menopausal vasomotor symptoms. Between these two markers of the start and end of the reproductive lifespan, it is clear that these pathways underlie many of the aspects of the hypothalamic regulation of reproduction which had hitherto been enigmatic...
February 25, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38398749/different-lengths-of-diet-supplementation-with-10-flaxseed-alter-the-hormonal-profile-and-the-follicular-fluid-fatty-acid-content-of-fattening-gilts
#12
JOURNAL ARTICLE
Martina Lecová, Diana Babjáková, Drahomíra Sopková, Zuzana Andrejčáková, Zdenka Hertelyová, Vladimír Petrilla, Magdaléna Polláková, Radoslava Vlčková
The effect of 10% dietary flaxseed fed for 3 and 6 weeks on serum hormone levels of fattening gilts, the fatty acid (FA) follicular fluid (FF) composition of small and large antral follicles, and the steroidogenesis and IGF-I secretion by isolated small antral follicles and their response to regulatory hormones (LH, FSH, IGF-I) was studied using immunoassay and gas chromatography analyses. Both supplemental periods increased levels of P4 and IGF-I in blood serum. A shorter period inhibited steroidogenesis (P4, T, E2) and IGF-I secretion by small antral follicles, which was associated with decreased levels of monounsaturated FAs (MUFA) and preferred n-6 polyunsaturated FA (PUFA) metabolism...
February 8, 2024: Life
https://read.qxmd.com/read/38378533/measurement-of-luteinizing-hormone-surge-in-vaginal-discharge-a-potential-biomarker-that-enables-simple-non-invasive-prediction-of-the-periovulatory-period
#13
JOURNAL ARTICLE
Moto Takeshita, Keita Saito, Yuya Suzuki, Wataru Yoshimasa, Risako Hayashi, Yoko Chiba
BACKGROUND: Predicting the periovulatory period is very important for conception. Current approaches to predicting the periovulatory period include monitoring of basal body temperature and urine luteinizing hormone (LH) concentration; however, these methods are time-consuming. Here, we examined the potential of using vaginal discharge (VD) as a non-invasive means of sample collection for determining the LH surge that indicates ovulation. METHODS: Urine and VD samples were collected from 35 healthy women aged 20-39 years...
February 20, 2024: BMC Women's Health
https://read.qxmd.com/read/38368516/comparison-in-vitro-fertilization-outcomes-between-doustim-and-minimal-stimulation-protocols-in-poor-ovarian-responders-a-randomized-clinical-trial
#14
JOURNAL ARTICLE
Nasrin Saharkhiz, Saghar Salehpoor, Sedigheh Hosseini, Leila Nazari, Samaneh Sheibani, Tahereh Doohandeh
BACKGROUND: Various protocols have been approved to improve the response rate leading to successful fertilization in poor ovarian responders (PORs). The application of double ovarian stimulation (DuoStim) in the follicular and luteal phases of the same ovarian cycle has been shown as an intriguing option to achieve more oocyte retrievals in the shortest time. The aim of the current study is to compare the outcomes of different protocols, minimal stimulation (MS) and Duostim. MATERIALS AND METHODS: This randomized clinical trial was performed on 42 in vitro fertilization (IVF) candidates with POR diagnosis...
February 2, 2024: International Journal of Fertility & Sterility
https://read.qxmd.com/read/38361634/analysis-of-cell-cell-interaction-between-mural-granulosa-cells-and-cumulus-granulosa-cells-during-ovulation-using-single-cell-rna-sequencing-data-of-mouse-ovary
#15
JOURNAL ARTICLE
Yuichiro Shirafuta, Isao Tamura, Amon Shiroshita, Taishi Fujimura, Ryo Maekawa, Toshiaki Taketani, Norihiro Sugino
PURPOSE: We investigated the interactions between mural granulosa cells (MGCs) and cumulus granulosa cells (CGCs) during ovulation after the LH surge. METHODS: We performed clustering, pseudotime, and interactome analyses utilizing reported single-cell RNA sequencing data of mouse ovary at 6 h after eCG-hCG injection. RESULTS: Clustering analysis classified granulosa cells into two distinct populations, MGCs and CGCs. Pseudotime analysis divided granulosa cells into before and after the LH surge, and further divided them into two branches, the ovulatory MGCs and the ovulatory CGCs...
2024: Reproductive Medicine and Biology
https://read.qxmd.com/read/38357937/cumulative-live-birth-rate-of-in%C3%A2-vitro-fertilization-cycle-via-progestin-primed-ovarian-stimulation-versus-gonadotropin-releasing-hormone-antagonist-protocol-in-infertile-women-with-normal-ovarian-reserve-an-open-label-randomized-controlled-trial
#16
JOURNAL ARTICLE
Hongjuan Ye, Liya Shi, Xinxin Quan, Min Hou, Huilan Ma, Songguo Xue, Zhao Yu, Qiuju Chen, Lihua Sun
This study aimed to evaluate the cumulative live birth rate (cLBR) of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) protocol for in vitro fertilization (IVF) cycle in infertile women with normal ovarian reserve (NOR). Infertile women with NOR who underwent their first IVF cycle were enrolled in an open-label randomized controlled trial. Patients were randomly assigned 1:1 to receive a freeze-all strategy with delayed embryo transfer (PPOS group, n = 174) and fresh embryo transfer first (GnRH-ant group, n = 174)...
December 2024: Human Fertility: Journal of the British Fertility Society
https://read.qxmd.com/read/38346724/parallel-expression-patterns-of-nr4a-nuclear-receptor-family-genes-in-the-pituitary-gland-of-proestrus-rats
#17
JOURNAL ARTICLE
Ryota Terashima, Daiki Nagao, Masato Ikeo, Keisuke Morioka, Titaree Laoharatchatathanin, Shiro Kurusu, Mitsumori Kawaminami
The NR4A nuclear receptor family (NR4As), encompassing NR4A1, NR4A2, and NR4A3, exerts pivotal roles in cellular processes through intricate expression patterns and interactions. Despite the influence of some NR4As on anterior pituitary functions regulated by the hypothalamus, their physiological expression patterns remain unclear. In our prior work, we demonstrated the specific upregulation of NR4A3 in the rat anterior pituitary gland during the proestrus afternoon, coinciding with a gonadotropin surge. In this study, we investigated changes in pituitary Nr4a gene expression throughout the estrous cycle in rats and a gonadotropin surge-induced model...
February 9, 2024: Journal of Reproduction and Development
https://read.qxmd.com/read/38342135/participation-of-follicular-superoxides-inflammatory-modulators-and-endocrine-factors-in-zebrafish-danio-rerio-ovulation-cross-talk-between-pka-and-mapk-signaling-in-pgr-regulation-of-ovulatory-markers
#18
JOURNAL ARTICLE
Soumyajyoti Ghosh, Subhasri Biswas, Urmi Mukherjee, Sampurna Karmakar, Sudipta Maitra
The ovulatory response involves diverse molecular determinants, the interplay between which remains less investigated in fish. This study explores the temporal changes in the follicular microenvironment, regulatory factors, and underlying signaling events during ovulation in female zebrafish subjected to 14L:10D at 28 ± 1 °C in vivo vis-à-vis in hCG-stimulated full-grown (FG) follicles in vitro. Congruent with reduced GSH levels, SOD, and GPx activity, a graded increase in follicular free radicals, Nox4, and p38 MAPK phosphorylation in the morning hour groups (05:00 and 06:30) correlates positively with the ovulatory surge in inflammatory mediators (Tnf-α, Il-1β, Il-6, Nos2, and Cox-2)...
February 9, 2024: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/38312373/expression-of-relaxin-family-peptide-receptors-1-and-3-in-the-ovarian-follicle-of-japanese-quail
#19
JOURNAL ARTICLE
Khoi X Hoang, Mei Matsuzaki, Tetsuya Kohsaka, Tomohiro Sasanami
In our previous studies, we demonstrated that the primary source of relaxin 3 (RLN3) in Japanese quail is ovarian granulosa cells. Although several relaxin family peptide (RXFP) receptors have been sequenced, the intricacies of these receptors in avian species remain insufficiently clarified. Therefore, we assessed the expression of RXFP receptors, RXFP1 and 3, in Japanese quail. Using RT-PCR, we found that both RXFP1 and 3 were ubiquitously expressed. The expression level of RXFP1 is significantly higher in the ovarian theca layer, indicating that it is the primary receptor for RLN3 in the ovary...
2024: Journal of Poultry Science
https://read.qxmd.com/read/38295019/progestin-primed-ovarian-stimulation
#20
JOURNAL ARTICLE
Juan Giles, Fabio Cruz, Juan A Garcia-Velasco
PURPOSE OF REVIEW: The use of progestins as pituitary suppressors has increased progressively, along with more detailed indications for their use, thereby consolidating an alternative approach to the personalization of ovarian stimulation. RECENT FINDINGS: Based on the ability of progesterone to inhibit ovulation, progestins have been used in ovarian stimulation (OS) follicular protocols to prevent a luteinizing hormone surge in patients undergoing in vitro fertilization (IVF), as an alternative to gonadotropin-releasing hormone (GnRH) analogue administration...
January 31, 2024: Current Opinion in Obstetrics & Gynecology
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