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https://www.readbyqxmd.com/read/30118684/combined-oral-contraceptive-interference-with-the-ability-of-ulipristal-acetate-to-delay-ovulation-a-prospective-cohort-study
#1
Alison B Edelman, Jeffrey T Jensen, Sara McCrimmon, Marci Messerle-Forbes, Andrea O'Donnell, Jon Hennebold
OBJECTIVE: To determine if a combined oral contraceptive (COC) initiated shortly after ulipristal acetate (UPA) administration interferes with its mechanism of action. STUDY DESIGN: Healthy, reproductive-age women of normal BMI with proven ovulation (serum progesterone >3ng/mL) were enrolled for 3 cycles (Cycle 1, UPA only; Cycle 2 washout; Cycle 3 UPA plus COC). During Cycles 1 and 3, subjects were monitored with transvaginal ultrasound and blood sampling for progesterone and LH every other day until a dominant follicle measuring >15 mm was visualized...
August 14, 2018: Contraception
https://www.readbyqxmd.com/read/30092174/timing-is-crucial-some-critical-thoughts-on-using-lh-tests-to-determine-women-s-current-fertility
#2
Janek S Lobmaier, Laura M Bachofner
Naturally cycling women reportedly go through a variety of psychological and behavioural changes over menstrual cycle. Evolutionary informed scholars have interpreted such changes as maximising reproductive success. However, concerns have been raised regarding this ovulatory shift hypothesis, since recent studies have yielded inconsistent findings. We suggest that the inconsistent findings regarding the ovulatory shift hypothesis may result from a too simplistic definition of the fertile window. Presently, most studies use LH tests to determine the fertile window...
August 7, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/30055147/seasonal-ovarian-development-in-relation-to-the-gonadotropins-steroids-aromatase-and-steroidogenic-factor-1-sf-1-in-the-banded-gourami-trichogaster-fasciata
#3
Rajkumar Guchhait, Ankit Chatterjee, Dilip Mukherjee, Kousik Pramanick
The endocrine regulation of gonadal development and annual variation of key sex steroids is the basic knowledge to understand the reproductive cycle of teleost fish. Present study was aimed to investigate the levels of gonadotropins in relation to the follicular development and plasma steroids during the reproductive cycle of female Trichogaster fasciata. Female fish were sampled and ovarian development is described histologically throughout the year in relation to the seasonal variations of gonadosomatic index (GSI); follicle stimulating hormone (FSH) and luteinizing hormone (LH); three key steroids for folliculogenesis and maturation i...
July 25, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/30044162/long-term-effects-of-combined-simvastatin-and-metformin-treatment-on-the-clinical-abnormalities-and-ovulation-dysfunction-in-single-young-women-with-polycystic-ovary-syndrome
#4
Emaduldin Seyam, Enas Hefzy
The aim of the current work was to investigate the value of the long term effects of combined use of simvastatin and metformin treatment for a year versus the effects of their individual treatment on the clinical, biochemical abnormalities, and ovulation dysfunction in young single women with polycystic ovary syndrome (PCOS). It was a randomized, double-blind controlled study. Where two hundreds (n = 200) single young women with PCOS were randomized into seventy (n = 70) women using simvastatin 20 mg daily combined with metformin 500 mg three times daily considered as group A (study group), and another 2 sixty five (n = 65) women groups using simvastatin and metformin individually as a single treatment use, and considered as groups (B & C), respectively...
July 25, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/30032022/an-fsh-booster-surge-for-resurgence-of-the-preovulatory-follicle-in-heifers
#5
REVIEW
O J Ginther
Emergence of wave 1 during an interovulatory interval (IOI) in heifers is stimulated by FSH surge 1. A minor FSH surge with absence of a dominant follicle in the associated follicular wave occurs immediately before FSH surge 1. This minor surge is termed an FSH booster surge owing to its occurrence temporally during a resurgence of a preovulatory follicle that has been decreasing or lagging in growth rate for several days. The beginning nadir, peak, and ending nadir of the FSH booster surge occur at means of 7, 4, and 3 d before ovulation...
June 28, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/30021630/probabilistic-cost-effectiveness-analysis-of-controlled-ovarian-stimulation-with-recombinant-fsh-plus-recombinant-lh-vs-human-menopausal-gonadotropin-for-women-undergoing-ivf
#6
F S Mennini, A Marcellusi, R Viti, C Bini, A Carosso, A Revelli, C Benedetto
BACKGROUND: The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF. The aim of this analysis was to estimate the cost-effectiveness of Controlled Ovarian Stimulation (COS) with recombinant FSH (rFSH) plus recombinant LH (rLH) in comparison with highly purified human menopausal gonadotropin (HP-hMG) in the woman undergoing in vitro fertilization (IVF) in Italy...
July 18, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30003441/non-steroidal-anti-inflammatory-drug-induces-luteinized-unruptured-follicle-syndrome-in-young-female-juvenile-idiopathic-arthritis-patients
#7
Renato B Tomioka, Gabriela R V Ferreira, Nadia E Aikawa, Gustavo A R Maciel, Paulo C Serafini, Adriana M Sallum, Lucia M A Campos, Claudia Goldestein-Schainberg, Eloisa Bonfá, Clovis A Silva
To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy controls. Twenty-three adolescent and young adult female JIA patients (ILAR criteria) and 11 female healthy subjects were studied by pelvic ultrasound monitoring for follicular development and ovulation in one menstrual cycle. LUF syndrome was prospectively investigated by pelvic ultrasound with a dominant ovarian follicle without signs of follicular rupture, with elevation of serum progesterone in the luteal phase of the menstrual cycle and luteinizing hormone (LH) detected in the urine...
July 12, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29960164/luteinizing-hormone-upregulates-nppc-and-downregulates-npr3-mrna-abundance-in-bovine-granulosa-cells-through-activation-of-the-egf-receptor
#8
Joabel T Dos Santos, Matheus P De Cesaro, Juliana G Ferst, Andressa M Pereira Dau, Paulo R A da Rosa, Bruno M Pasqual, Alfredo Q Antoniazzi, Bernardo G Gasperin, Vilceu Bordignon, Paulo B D Gonçalves
During folliculogenesis, the luteinizing hormone (LH) surge triggers dynamic events in granulosa cells that culminate with ovulation. The aim of this study was to evaluate if the epidermal growth factor receptor (EGFR) is required for ovulation in cattle, and if it regulates the expression of the natriuretic peptide (NP) system in granulosa cells after gonadotropin-releasing hormone (GnRH)/LH stimulation. It was observed that GnRH induces amphiregulin (AREG) and epiregulin (EREG) mRNA at 3 and 6 h after in vivo treatment, but the expression of these genes was not regulated by atrial (ANP) and C-type (CNP) NPs in granulosa cells cultured in vitro...
June 22, 2018: Theriogenology
https://www.readbyqxmd.com/read/29945206/igf3-serves-as-a-mediator-of-lh-in-zebrafish-ovulation
#9
Jianzhen Li, Caiyan Niu, Christopher H K Cheng
Both oocyte maturation and ovulation is triggered by the luteinizing hormone (LH) surge in vertebrates, but exactly how these processes are regulated by LH remains to be fully elucidated. Previously we found that Igf3, a fish-specific member of the igf family predominantly expressed in the gonads, could mediate the action of LH on oocyte maturation in zebrafish. Here, we further reveal the importance of Igf3 in mediating the action of LH on ovulation in zebrafish. All the four igf gene family members are expressed in the zebrafish ovary but only the igf3 transcript level is increased in hCG-induced ovulation in vivo...
June 25, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29939337/impact-of-perfluorooctane-sulfonate-on-reproductive-ability-of-female-mice-through-suppression-of-estrogen-receptor-%C3%AE-activated-kisspeptin-neurons
#10
Xiaoli Wang, Yingyang Bai, Chuanfeng Tang, Xinyuan Cao, Fei Chang, Ling Chen
Perfluorooctane sulfonate (PFOS) is used extensively in industrial and household applications. High exposure to PFOS has been associated with increased odds of irregular and long menstrual cycles in women. However, the underlying mechanisms remain to be elucidated. Herein, we show that adult female mice appeared prolongation of diestrus and reduction of corpora luteum within a week of oral administration of PFOS (10 mg/kg), which are associated with decreases in the levels of serum progesterone, LH and hypothalamic GnRH...
June 25, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29920869/involvement-of-the-luteinizing-hormone-surge-in-the-regulation-of-ovary-and-oviduct-clock-gene-expression-in-mice
#11
Momoko Kobayashi, Kaya Watanabe, Ritsuko Matsumura, Nozomi Anayama, Akio Miyamoto, Hitoshi Miyazaki, Koyomi Miyazaki, Takashi Shimizu, Makoto Akashi
Circadian dysfunction perturbs the female reproductive cycle. In particular, mice lacking the clock gene Bmal1 show severe infertility, implying that BMAL1 plays roles in ovulation and luteinization. Here, we examined temporal changes in clock gene expression in the ovary and oviduct before and during gonadotropin-induced follicular growth, ovulation, and luteinization in sexually immature mice. While the oviduct did not show a drastic change in clock gene expression, Bmal1 expression in the ovary was higher than that in control mice during the period from 4 to 16 hr after human chorionic gonadotropin (hCG) administration...
June 19, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29904625/towards-the-clinical-evaluation-of-the-luteal-phase-in-fertile-women-a-preliminary-study-of-normative-urinary-hormone-profiles
#12
María Elena Alliende, José Antonio Arraztoa, Ulises Guajardo, Fernando Mellado
Objective: To describe and evaluate urinary hormone profiles in the luteal phase. Setting and Patients: Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center. Methods: Daily urinary hormonal assessment of luteinizing hormone, estrone glucuronide, and pregnanediol glucuronide. This was done during 3 or more cycles, with 78 completed cycles. Samples were analyzed by both crude levels and levels adjusted for the hormone excretion rate...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29899026/dominant-neuropeptide-cotransmission-in-kisspeptin-gaba-regulation-of-gnrh-neuron-firing-driving-ovulation
#13
Richard Piet, Bruna Kalil, Tim McLennan, Robert Porteous, Katja Czieselsky, Allan E Herbison
A population of kisspeptin-GABA coexpressing neurons located in the rostral periventricular area of the third ventricle (RP3V) is believed to activate gonadotropin-releasing hormone (GnRH) neurons to generate the luteinizing hormone (LH) surge triggering ovulation. Selective optogenetic activation of RP3V kisspeptin (RP3VKISS ) neurons in female mice for >30 s and ≥10 Hz in either a continuous or bursting mode was found to reliably generate a delayed and long-lasting activation of GnRH neuron firing in brain slices...
July 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29894213/low-glycosylated-forms-of-both-fsh-and-lh-play-major-roles-in-the-natural-ovarian-stimulation
#14
Leif Wide, Karin Eriksson
BACKGROUND: The natural ovarian stimulation is mediated by four gonadotrophin glycoforms: FSHtri with three, FSHtetra with four, LHdi with two, and LHtri with three N-glycans. The aim of the study was to determine the serum concentrations of the four glycoforms and their contents of anionic monosaccharides (AMS), i.e. sialic acid (SA) and sulfonated N-acetylgalactosamine (SU) residues throughout the menstrual cycle. METHODS: Serum samples were collected from 78 healthy women with regular menstrual cycles...
June 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29881719/hormonal-predictors-of-abnormal-luteal-phases-in-normally-cycling-women
#15
Saman H Abdulla, Thomas P Bouchard, Rene A Leiva, Phil Boyle, Jean Iwaz, René Ecochard
Objective: Explore potential relationships between preovulatory, periovulatory, and luteal-phase characteristics in normally cycling women. Design: Observational study. Setting: Eight European natural family planning clinics. Patient(s): Ninety-nine women contributing 266 menstrual cycles. Intervention(s): The participants collected first morning urine samples that were analyzed for estrone-3 glucuronide (E1G), pregnanediol-3- alpha-glucuronide (PDG), follicle stimulating hormone (FSH), and luteinizing hormone (LH)...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29808249/beta-endorphin-in-serum-and-follicular-fluid-of-pcos-and-non-pcos-women
#16
Nikolai Jaschke, Fabian Lunger, Ludwig Wildt, Beata Seeber
PURPOSE: To compare the concentrations of beta endorphin in serum and follicular fluid (FF) of PCOS- and non-PCOS women. Secondarily, to investigate associations between beta endorphin and other parameters. METHODS: Fifty-nine women undergoing in vitro fertilization (IVF) were included in the study. Sixteen were stratified to the PCOS group using the Rotterdam criteria. The remaining 43 women served as controls. Follicular fluid was collected during oocyte retrieval and peripheral blood sampling was performed on the same day...
July 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29807533/progestin-primed-milder-stimulation-with-clomiphene-citrate-yields-fewer-oocytes-and-suboptimal-pregnancy-outcomes-compared-with-the-standard-progestin-primed-ovarian-stimulation-in-infertile-women-with-polycystic-ovarian-syndrome
#17
Hongjuan Ye, Hui Tian, Wen He, Qifeng Lyu, Yanping Kuang, Qiuju Chen, Lihua Sun
BACKGROUND: Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed ovarian stimulation (PPOS) is effective and safe in patients with different ovarian reserves. The current data are lacking regarding how to individualize the gonadotropin dose and regimen for women with polycystic ovarian syndrome (PCOS). A retrospective cohort trial was performed to evaluate the efficacy of progestin-primed milder stimulation with clomiphene citrate (CC) compared to the standard progestin-primed ovarian stimulation (PPOS) protocol for infertile women with PCOS...
May 28, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29778367/role-of-gonadotropin-releasing-hormone-agonists-human-chorionic-gonadotropin-hcg-progesterone-and-estrogen-in-luteal-phase-support-after-hcg-triggering-and-when-in-pregnancy-hormonal-support-can-be-stopped
#18
REVIEW
Dominique de Ziegler, Paul Pirtea, Claus Yding Andersen, Jean Marc Ayoubi
Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG-used for triggering ovulation-vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778272/development-of-the-waveless-bovine-model
#19
F Jimenez-Krassel, J L H Ireland, C Kronemeyer, A Wilson-Alvarado, J J Ireland
Development of a bovine model without ovarian follicular waves (waveless) and transient increases in gonadotropin secretion during estrous cycles may lead to new methods to more consistently regulate ovulatory follicle growth thereby improving efficiency of embryo transfer. We hypothesized that the GnRH antagonist acyline would inhibit gonadotropin secretion thereby blocking follicular waves, ovarian function and ovulation during estrous cycles of cattle. To test this hypothesis, beef heifers (n = 5 per group) were treated twice daily with vehicle (control) or 25 or 50 μg/kg acyline beginning 12 h after GnRH-induced ovulation and ending 21 days later...
May 15, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29749274/can-apps-and-calendar-methods-predict-ovulation-with-accuracy
#20
Sarah Johnson, Lorrae Marriott, Michael Zinaman
OBJECTIVE: The accuracy of prediction of ovulation by cycle apps and published calendar methods was determined by comparing to true probability of ovulation. METHODS: A total of 949 volunteers collected urine samples for one entire menstrual cycle. Luteinizing hormone was measured to assign surge day, enabling probability of ovulation to be determined across different cycle lengths. Cycle-tracking apps were downloaded. As none provided their methodology, four published calendar-based methods were also examined: standard days, rhythm, alternative rhythm and simple calendar method...
May 25, 2018: Current Medical Research and Opinion
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