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LH ovulation

V E Gomez-León, O J Ginther, E R Araujo, J D Guimarães, M C Wiltbank
Follicle diameter deviation has been identified as the pivotal morphological manifestation of follicle selection, however, many of the hormonal mechanisms leading to this key event and regulating variation between individual follicular waves remain undefined. This study compared circulating FSH, LH, and P4 with the follicular dynamics during three different physiological conditions. We hypothesized that these end-points would: 1) be similar for a spontaneous wave 2 vs one induced by follicular aspiration, 2) but would differ between wave 1 and 2, and 3) between conventional (F2 > 7...
September 11, 2018: Theriogenology
Maggie C Evans, Greg M Anderson
Optimal fertility in humans and animals relies on the availability of sufficient metabolic fuels, information about which is communicated to the brain via levels of the hormones leptin and insulin. The circadian clock system is also critical; this input is particularly evident in the precise timing of the female-specific surge of GnRH and LH secretion that triggers ovulation on the following day. Chronodisruption or metabolic imbalance can both impair reproductive activity, and these two disruptions exacerbate each other, such that they often occur simultaneously...
October 9, 2018: Endocrinology
Shogo Higaki, Ryotaro Miura, Tomoko Suda, L Mattias Andersson, Hironao Okada, Yi Zhang, Toshihiro Itoh, Fumikazu Miwakeichi, Koji Yoshioka
This study aimed to evaluate the effectiveness of estrous detection technique based on continuous measurements of vaginal temperature (VT) and conductivity (VC) with supervised machine learning in cattle. The VT and VC of 17 cows in tie-stalls were measured using our developed wearable vaginal sensor from Day 11 (Day 0 = ovulation day) to Day 11 of the subsequent estrous cycle at 15-min interval. After the maximum VT and VC were extracted hourly, their changes were expressed as residual VT (rVT = actual VT - mean VT for the same time on the previous 3 days) and as VC ratio (VCr = actual VC/mean VC for the same time on Day 11-13), respectively, and were used for analysis...
September 27, 2018: Theriogenology
Frederico da Silva Bitecourt, Carina Oliveira Dumont Horta, Karen Santos Lima, Bruno Bastos Godoi, Fernanda Luiza Menezes Bello, Cíntia Maria Rodrigues, Luana Pereira Leite Schetino, Kinulpe Honorato-Sampaio
SummaryPrevious studies have established a model of atresia in preovulatory follicles after stimulation of immature rats with equine chorionic gonadotropin (eCG). This gonadotropin recruits a follicular pool and the deprivation of preovulatory luteinizing hormone (LH) surge induces the atresia in preovulatory follicles. The present study investigated the occurrence of ovulation and provided some morphological features of granulosa cell (GC) apoptosis of atretic follicles at 0, 48, 72 and 120 h after eCG stimulation...
October 2, 2018: Zygote: the Biology of Gametes and Early Embryos
Emma D Deeks
Menopur® is a highly purified, urine-derived, human menopausal gonadotropin containing both follicle stimulating hormone (FSH) and luteinizing hormone (LH) activity. It is an effective option for controlled ovarian stimulation (COS) in assisted reproductive technology protocols and for ovulation induction (OI) in anovulatory infertility, and is associated with a different endocrine profile from that of recombinant (r) FSH in these settings (in terms of serum levels of FSH, androgens and/or estradiol). When used for COS in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), Menopur® was as good as rFSH in terms of pregnancy rates (despite being associated with a lower oocyte yield) and was found to improve some aspects of embryo quality in the IVF (but not ICSI) setting; using Menopur® in combination with highly purified urinary FSH resulted in similar reproductive outcomes as Menopur® alone...
September 28, 2018: Clinical Drug Investigation
Mohsen Ayrout, Florian Le Billan, Valérie Grange-Messent, Sakina Mhaouty-Kodja, Marc Lombès, Stéphanie Chauvin
Stress-induced reproductive dysfunction is frequently associated with increased glucocorticoid (GC) levels responsible for suppressed GnRH/LH secretion and impaired ovulation. Besides the major role of the hypothalamic kisspeptin system, other key regulators may be involved in such regulatory mechanisms. Herein, we identify dynorphin as a novel transcriptional target of GC. We demonstrate that only priming with high estrogen (E2) concentrations prevailing during the late prooestrus phase enables stress-like GC concentrations to specifically stimulate Pdyn (prodynorphin) expression both in vitro (GT1-7 mouse hypothalamic cell line) and ex vivo (ovariectomized E2-supplemented mouse brains)...
August 29, 2018: Psychoneuroendocrinology
Haney Samir, Kentaro Nagaoka, Gen Watanabe
The objective of the current study was to investigate the effect of subluteal progesterone environment on the efficacy of the ovarian responses in goats passively immunized against endogenous inhibin. Twelve cycling female Shiba goats were synchronized using two doses of prostaglandin F2α 11 days apart. After detection of ovulation (D0, by ultrasonography), goats were randomly assigned into 2 groups: (1) Subluteal P4 group (SLP; n = 6), treated with a previously once-used controlled intravaginal progesterone-releasing device (ou-CIDR) intravaginal from D 6 to D 12 concurrently with a luteolytic dose of PGF2α at D6 (2) Normal Luteal P4 group (NLP; n = 6), had neither ou-CIDR nor PGF2α...
November 2018: Theriogenology
Laura Riccetti, Samantha Sperduti, Clara Lazzaretti, Livio Casarini, Manuela Simoni
Pituitary gonadotropins, follicle-stimulating (FSH) and luteinizing hormone (LH) promote follicular recruitment and support antral follicle growth, maturation and selection, resulting in ovulation of the dominant follicle. FSH and LH biological functions are mediated by G protein-coupled receptors, FSHR and LHCGR, resulting in the activation of a number of signaling cascades, such as the cyclic AMP/protein kinase A (cAMP/PKA) pathway. Some in-vitro data are consistent with the dual, proliferative and pro-apoptotic role of cAMP, leaving unanswered questions on how cAMP/PKA signaling is linked to the follicle fate...
October 2018: Minerva Ginecologica
Sajja Devendra Siva Karthik, Alka Kriplani, Garima Kachhawa, Rajesh Khadgawat, Nutan Aggarwal, Neerja Bhatla
Context: Gonadotropin-releasing hormone (GnRH) antagonists in fixed or flexible regimens are used for prevention of premature luteinizing hormone (LH) surge, however, data comparing these regimens in stimulated intrauterine insemination (IUI) cycles are lacking. Aims: The aim of this study is to evaluate the effectiveness of GnRH antagonists in fixed and flexible regimens on the rate of premature luteinization (PL) and ovulation rate in sequential clomiphene-gonadotropin controlled ovulation-IUI cycles...
April 2018: Journal of Human Reproductive Sciences
F M Abreu, M A Coutinho da Silva, L H Cruppe, M L Mussard, G A Bridges, B R Harstine, G W Smith, T W Geary, M L Day
Objective was to investigate the effect of different progesterone (P4) concentrations during early follicular development on luteinizing hormone (LH) secretion and oocyte characteristics in beef cows. Primiparous cows (n = 24) were estrous pre-synchronized and follicular ablation was performed (d 0) 6 days following the time of ovulation. At the time of follicular ablation, cows were assigned to either: 1) high P4 treatment - HiP4; a new CIDR was inserted on d 0 to supplement P4 from the existing corpus luteum [CL], or 2) low P4 treatment - LoP4; a previously-used CIDR and two doses of PGF 8 to 12 h apart were given on d 0...
September 2018: Animal Reproduction Science
Juan E Romano, Duane H Keisler, Marcel Amstalden
The objectives of this investigation were to determine the effect of copulation on estrus duration, LH response and ovulation in Boer goats. A controlled randomized study, with two replicates, in which does were divided at each replicate in treatment (COP; n = 12) and control (CON; n = 12) groups was performed. All the does were pluriparous and estrus synchronized with CIDR (progesterone 300 mg) maintained in the vagina for seven days, and received 50 μg of GnRH at device insertion and 5 mg of natural prostaglandin F-2α im at CIDR removal...
November 2018: Theriogenology
Yun Wang, Yanping Kuang, Qiuju Chen, Renfei Cai
BACKGROUND: Progress in vitrification techniques has allowed reproductive physicians to consider new strategies for using progestin as an alternative to a GnRH analogue to improve in vitro fertilisation (IVF). However, the role of progestin in blocking luteinising hormone (LH) surges and its potential in clinical practice are unclear, especially for poor responders. We designed a prospective randomised controlled trial (RCT) to compare the efficacy of a gonadotropin-releasing hormone (GnRH) antagonist and progestin in blocking LH surges and premature ovulation in poor responders...
August 22, 2018: Trials
Justine Hugon-Rodin, Keisuke Yoshii, Najiba Lahlou, Jennifer Flandrin, Anne Gompel, Nicolas de Roux
Context: Mutations in the kisspeptin receptor 1 gene (KISS1R) have been reported in a few patients with normosmic congenital hypogonadotropic hypogonadism (nCHH) (OMIM #146110). Objectives: To describe a female with nCHH and a novel homozygous KISS1R mutation and to assess the role of kisspeptin pathway to induce an ovulation by gonadotropin-releasing hormone (GnRH) pulse therapy. Design, Setting and Intervention: Observational study of a patient including genetic, kisspeptin receptor functions and treatment efficiency using GnRH pump...
August 16, 2018: Journal of Clinical Endocrinology and Metabolism
Alison B Edelman, Jeffrey T Jensen, Sara McCrimmon, Marci Messerle-Forbes, Andrea O'Donnell, Jon D Hennebold
OBJECTIVE: To determine if a combined oral contraceptive (COC) initiated shortly after ulipristal acetate (UPA) administration interferes with its mechanism of action. STUDY DESIGN: Healthy, reproductive-age women of normal BMI with proven ovulation (serum progesterone >3 ng/ml) were enrolled for three cycles (Cycle 1, UPA only; Cycle 2 washout; Cycle 3 UPA plus COC). During Cycles 1 and 3, subjects were monitored with transvaginal ultrasound and blood sampling for progesterone and LH every other day until a dominant follicle measuring >15 mm was visualized...
August 14, 2018: Contraception
Janek S Lobmaier, Laura M Bachofner
Naturally cycling women reportedly go through a variety of psychological and behavioural changes over menstrual cycle. Evolutionary informed scholars have interpreted such changes as maximising reproductive success. However, concerns have been raised regarding this ovulatory shift hypothesis, since recent studies have yielded inconsistent findings. We suggest that the inconsistent findings regarding the ovulatory shift hypothesis may result from a too simplistic definition of the fertile window. Presently, most studies use LH tests to determine the fertile window...
August 7, 2018: Hormones and Behavior
Rajkumar Guchhait, Ankit Chatterjee, Dilip Mukherjee, Kousik Pramanick
The endocrine regulation of gonadal development and annual variation of key sex steroids is the basic knowledge to understand the reproductive cycle of teleost fish. Present study was aimed to investigate the levels of gonadotropins in relation to the follicular development and plasma steroids during the reproductive cycle of female Trichogaster fasciata. Female fish were sampled and ovarian development is described histologically throughout the year in relation to the seasonal variations of gonadosomatic index (GSI); follicle stimulating hormone (FSH) and luteinizing hormone (LH); three key steroids for folliculogenesis and maturation i...
November 1, 2018: General and Comparative Endocrinology
Emaduldin Seyam, Enas Hefzy
The aim of the current work was to investigate the value of the long term effects of combined use of simvastatin and metformin treatment for a year versus the effects of their individual treatment on the clinical, biochemical abnormalities, and ovulation dysfunction in young single women with polycystic ovary syndrome (PCOS). It was a randomized, double-blind controlled study. Where two hundreds (n = 200) single young women with PCOS were randomized into seventy (n = 70) women using simvastatin 20 mg daily combined with metformin 500 mg three times daily considered as group A (study group), and another 2 sixty five (n = 65) women groups using simvastatin and metformin individually as a single treatment use, and considered as groups (B & C), respectively...
July 25, 2018: Gynecological Endocrinology
O J Ginther
Emergence of wave 1 during an interovulatory interval (IOI) in heifers is stimulated by FSH surge 1. A minor FSH surge with absence of a dominant follicle in the associated follicular wave occurs immediately before FSH surge 1. This minor surge is termed an FSH booster surge owing to its occurrence temporally during a resurgence of a preovulatory follicle that has been decreasing or lagging in growth rate for several days. The beginning nadir, peak, and ending nadir of the FSH booster surge occur at means of 7, 4, and 3 d before ovulation...
October 2018: Domestic Animal Endocrinology
F S Mennini, A Marcellusi, R Viti, C Bini, A Carosso, A Revelli, C Benedetto
BACKGROUND: The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF. The aim of this analysis was to estimate the cost-effectiveness of Controlled Ovarian Stimulation (COS) with recombinant FSH (rFSH) plus recombinant LH (rLH) in comparison with highly purified human menopausal gonadotropin (HP-hMG) in the woman undergoing in vitro fertilization (IVF) in Italy...
July 18, 2018: Reproductive Biology and Endocrinology: RB&E
Renato B Tomioka, Gabriela R V Ferreira, Nadia E Aikawa, Gustavo A R Maciel, Paulo C Serafini, Adriana M Sallum, Lucia M A Campos, Claudia Goldestein-Schainberg, Eloisa Bonfá, Clovis A Silva
To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy controls. Twenty-three adolescent and young adult female JIA patients (ILAR criteria) and 11 female healthy subjects were studied by pelvic ultrasound monitoring for follicular development and ovulation in one menstrual cycle. LUF syndrome was prospectively investigated by pelvic ultrasound with a dominant ovarian follicle without signs of follicular rupture, with elevation of serum progesterone in the luteal phase of the menstrual cycle and luteinizing hormone (LH) detected in the urine...
July 12, 2018: Clinical Rheumatology
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