keyword
https://read.qxmd.com/read/38531998/is-there-an-advantage-to-delayed-molar-implant-placement-in-those-with-chronic-apical-periodontitis
#21
JOURNAL ARTICLE
Rabab Ahmad
DESIGN: This paper is a single-centre, double-blinded, prospective randomised control trial, comparing immediate vs delayed implant placement clinically and radiographically in patients with chronic periodontitis, specifically assessing the molar region. Seventy-four patients were recruited to the study over a one-year period, all of whom returned for follow up throughout the study. STUDY SELECTION: The study adhered to the principles outlined in the Declaration of Helsinki and obtained ethical approval from the affiliated University Hospital of Qingdao...
March 26, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38531480/biological-effects-and-phytochemical-study-of-the-underground-part-of-iris-scariosa-willd-ex-link-extract-a-new-source-of-bioactive-constituents
#22
JOURNAL ARTICLE
Botagoz A Omarova, Elvira E Shults, Kairat S Zhakipbekov, Аssima О Abekova, Margarita Yu Ishmuratova, Tatyana N Petrova, Elmira B Kartbayeva
The expected toxicity and resistance of chemotherapeutic agents necessitate and encourage for the use of natural chemotherapeutic sources of plant origin in the clinical stage of cancer therapy. Plants of the genus Iris (Iridaceae) used by local populations for the treatment of cancer, bacterial and viral infections. In this study, an ethanol extract of rhizomes of I. scariosa was prepared and tested for the cytotoxicity using the MTT assay. The extract exhibited the most potent cytotoxicity against the breast cancer cell line MCF7 (IC50  = 9...
March 24, 2024: Fitoterapia
https://read.qxmd.com/read/38531016/akt-driven-tgf-%C3%AE-and-dkk1-secretion-impairs-f508del-cf-airway-epithelium-polarity
#23
JOURNAL ARTICLE
Tahir Idris, Michael Bachmann, Marc Bacchetta, Bernhard Wehrle-Haller, Marc Chanson, Mehdi Badaoui
Epithelial polarity is fundamental in maintaining barrier integrity and tissue protection. In cystic fibrosis (CF), apicobasal polarity of the airway epithelium is altered, resulting in increased apical fibronectin deposition and enhanced susceptibility to bacterial infections. Here, we evaluated the effect of highly effective modulator treatment (HEMT) on fibronectin apical deposition and investigated the intracellular mechanisms triggering the defect in polarity of the CF airway epithelium. To this end, primary cultures of CF (F508del variant) human airway epithelial cells (HAECs) and a HAEC line, Calu-3, knocked-down (KD) for CFTR (CFTR KD) were compared to control counterparts, grown at an air-liquid interface (ALI)...
March 26, 2024: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38531008/establishment-of-a-human-organoid-based-evaluation-system-for-assessing-interspecies-infection-risk-of-animal-borne-coronaviruses
#24
JOURNAL ARTICLE
Qianchun Gong, Rendi Jiang, Lina Ji, Haofeng Lin, Meiqin Liu, Xiaofang Tang, Yong Yang, Wei Han, Jing Chen, Zishuo Guo, Qi Wang, Qian Li, Xi Wang, Tingting Jiang, Shizhe Xie, Xinglou Yang, Peng Zhou, Zhengli Shi, Xinhua Lin
The COVID-19 pandemic presents a major threat to global public health. Several lines of evidence have shown that the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), along with two other highly pathogenic coronaviruses, SARS-CoV and Middle East Respiratory Syndrome (MERS-CoV) originated from bats. To prevent and control future coronavirus outbreaks, it is necessary to investigate the interspecies infection and pathogenicity risks of animal-related coronaviruses. Currently used infection models, including in vitro cell lines and in vivo animal models, fail to fully mimic the primary infection in human tissues...
December 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38530969/characterization-of-the-diversity-of-type-iv-secretion-system-encoding-plasmids-in-acinetobacter
#25
JOURNAL ARTICLE
Farah Nasser, Avery Gaudreau, Shareefah Lubega, Arvin Zaker, Xuhua Xia, Arvind S Mer, Vanessa M D'Costa
The multi-drug resistant pathogen Acinetobacter baumannii has gained global attention as an important clinical challenge. Owing to its ability to survive on surfaces, its capacity for horizontal gene transfer, and its resistance to front-line antibiotics, A. baumannii has established itself as a successful pathogen. Bacterial conjugation is a central mechanism for pathogen evolution. The epidemic multidrug-resistant A. baumannii ACICU harbours a plasmid encoding a Type IV Secretion System (T4SS) with homology to the E...
December 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38530888/normalizing-granuloma-vasculature-and-matrix-improves-drug-delivery-and-reduces-bacterial-burden-in-tuberculosis-infected-rabbits
#26
JOURNAL ARTICLE
Meenal Datta, Laura E Via, Véronique Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin S Kumar, Sonu Subudhi, Lei Xu, Clifton E Barry, Rakesh K Jain
Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and implemented for immuno-modulation, other host targets-such as nonimmune stromal components found in pulmonary granulomas-may prove equally viable. Building on our previous work characterizing and normalizing the aberrant granuloma-associated vasculature, here we demonstrate that FDA-approved therapies (bevacizumab and losartan, respectively) can be repurposed as HDTs to normalize blood vessels and extracellular matrix (ECM), improve drug delivery, and reduce bacterial loads in TB granulomas...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38530258/common-oral-conditions-a-review
#27
JOURNAL ARTICLE
Eric T Stoopler, Alessandro Villa, Mohammed Bindakhil, David L Ojeda Díaz, Thomas P Sollecito
IMPORTANCE: Dry mouth, oral candidiasis, and recurrent aphthous ulcers are 3 of the most common oral conditions that may be associated with patient discomfort, decreased quality of life, and morbidity. OBSERVATIONS: In a meta-analysis of 26 population-based cohort and cross-sectional studies, the global prevalence of dry mouth symptoms was 23% (95% CI, 18% to 28%), placing individuals at risk of oral candidiasis, dental caries, dysgeusia, masticatory/speech impairment, and oropharyngeal dysphagia...
March 26, 2024: JAMA
https://read.qxmd.com/read/38530156/standardized-order-set-for-the-management-of-infective-endocarditis
#28
JOURNAL ARTICLE
Kerneisha Murphy, Emily Eiswirth
BACKGROUND: Infective endocarditis (IE) is a potentially life-threatening infection that affects the inner lining of the heart, particularly the heart valves. Patients with preexisting heart conditions, damaged heart valves, or a history of intravenous drug use are at a higher risk of acquiring IE. LOCAL PROBLEM: A rural acute care facility reported that 68.75% of patients who had a methicillin-resistant Staphylococcus aureus infection were diagnosed with IE. Review of medical records showed that 65% of patients with IE did not have antibiotic start/stop dates and 51% were discharged before the 6-week completion date...
March 26, 2024: Journal of the American Association of Nurse Practitioners
https://read.qxmd.com/read/38530074/certolizumab-pegol-in-the-treatment-of-axial-spondyloarthritis
#29
REVIEW
Elizabeth Anderson, Secia Beier, Julianna Desmarais
Axial spondyloarthritis is a chronic, immune-mediated systemic inflammatory disease encompassing ankylosing spondylitis and nonradiographic axial spondyloarthritis. TNF inhibitors are the preferred second line therapy for patients with active axial spondyloarthritis. Certolizumab pegol is a TNF inhibitor approved for treatment of both. Three large phase III trials (RAPID-axSpA, C-axSpAnd and C-OPTIMISE) and one large phase IV trial (CIMAX) establish its clinical efficacy in treatment of active disease and maintenance of remission for both diseases...
March 26, 2024: Immunotherapy
https://read.qxmd.com/read/38530030/expression-of-the-mspdbl2-antigen-in-a-discrete-subset-of-plasmodium-falciparum-schizonts-is-regulated-by-gdv1-but-may-not-be-linked-to-sexual-commitment
#30
JOURNAL ARTICLE
Aline Freville, Lindsay B Stewart, Kevin K A Tetteh, Moritz Treeck, Alfred Cortes, Till S Voss, Sarah J Tarr, David A Baker, David J Conway
UNLABELLED: The Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential relationship of MSPDBL2 to sexual commitment is examined, as variable mspdbl2 transcript levels and proportions of MSPDBL2-positive mature schizonts in clinical isolates have previously correlated with levels of many sexual stage parasite gene transcripts, although not with the master regulator ap2-g ...
March 26, 2024: MBio
https://read.qxmd.com/read/38529519/evaluation-of-the-functionality-in-an-emergency-department-setting-of-an-intravenous-protection-device-to-prevent-self-injection
#31
Kara Bragg, Michael Albus, Bradley Bragg, Rachelle M Beste, Leslie V Simon
BACKGROUND: The United States has an opioid abuse crisis that has been increasing exponentially since 2013. In 2021, there were 220 deaths each day from opioid overdoses in the United States alone. Patients suffering from addiction often present to the emergency department (ED) anticipating that an intravenous (IV) catheter will be placed. This catheter is then accessible for patients to self-inject illicit drugs while under medical care or elope from the facility with the IV in place to self-inject...
2024: Medical Devices: Evidence and Research
https://read.qxmd.com/read/38529474/pad-mediated-citrullination-is-a-novel-candidate-diagnostic-marker-and-druggable-target-for-hpv-associated-cervical-cancer
#32
JOURNAL ARTICLE
Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Valentina Dell'Oste
Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in multiple diseases, including cancer. Given that high-risk (hr) human papillomaviruses (HPVs) are the etiological agents of cervical cancer, in this study, we sought to determine whether PAD-mediated protein citrullination would play a functional role in the HPV-driven transformation of epithelial cells...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38529055/severe-atelectasis-due-to-aspirated-valproic-acid-tablet
#33
Tomomi Tanigaki, Takunori Ogawa, Sakika Nomura, Koki Ito, Yuhei Kurata, Akira Matsukida, Morio Ishihara, Aihide Yoshino, Akihiko Kawana, Yoshifumi Kimizuka
A 60-year-old man treated with valproic acid (VPA) for epilepsy developed atelectasis and respiratory failure after an accidentally aspirated VPA tablet-induced mucus hypersecretion. Following bronchoscopic removal of the aspirated tablet, his respiratory status improved and massive sputum production did not recur. We hypothesized that the aspirated VPA tablet increased the expression of mucin-related genes, thereby increasing mucus production. Our in vitro experiments using a human respiratory epithelial cell line revealed that VPA directly upregulates the airway mucin-related genes...
2024: Case Reports in Pulmonology
https://read.qxmd.com/read/38529000/development-of-a-medical-device-in-response-to-a-fatal-self-injection-of-non-prescribed-opioids-a-case-report
#34
Kara Bragg, Michael Albus, Leslie V Simon, Bradley Bragg, Rachelle Beste
Patients who inject drugs (PWID) pose unique challenges in their medical care due to risks of increased infection and overdose. There are no known commercially available devices to prevent patients from self-injecting non-prescribed substances into vascular access devices (VADs). A patient in the emergency department (ED) of a midsized suburban hospital self-injected an opioid in the ED restroom after the placement of a vascular catheter by the nursing staff as part of her ED care. Despite precautions taken for a patient with a known opioid use disorder (OUD) and a history of self-injecting non-prescribed substances into VADs, the patient suffered a self-induced fatal overdose...
March 2024: Curēus
https://read.qxmd.com/read/38527452/type-i-interferon-induced-by-adenovirus-or-adenoviral-vector-infection-regulates-the-cytokine-response-to-lps-in-a-macrophage-type-specific-manner
#35
JOURNAL ARTICLE
Mareike D Maler, Sophie Zwick, Carsten Kallfass, Peggy Engelhard, Hexin Shi, Laura Hellig, Pang Zhengyang, Annika Hardt, Gernot Zissel, Zsolt Ruzsics, Willi Jahnen-Dechent, Stefan F Martin, Peter Jess Nielsen, Daiana Stolz, Justyna Lopatecka, Sarah Bastyans, Bruce Beutler, Wolfgang W Schamel, György Fejer, Marina Alexandra Freudenberg
In mice, adenovirus (Ad)-elicited IFN-ab mediates the overproduction of LPS stimulated cytokines such as TNFa and IL-6. We found that Ad infection also mediates the overproduction of IFN-ab itself and enables its production in splenic marginal zone macrophages, which don't produce IFN-ab in response to LPS alone. We show the importance of the scavenger receptor MARCO for Ad uptake and cytokine overproduction in vivo, and the differential contribution of infection and rIFN-b to LPS-induced cytokine response in macrophage subsets...
March 25, 2024: Journal of Innate Immunity
https://read.qxmd.com/read/38527059/chitosan-nanoparticles-improve-the-effectivity-of-miltefosine-against-acanthamoeba
#36
JOURNAL ARTICLE
Alireza Latifi, Fariba Esmaeili, Mehdi Mohebali, Setayesh Yasami-Khiabani, Mostafa Rezaeian, Mohammad Soleimani, Elham Kazemirad, Amir Amani
BACKGROUND: Acanthamoeba keratitis (AK) is a corneal sight-threatening infection caused by the free-living amoebae of the genus Acanthamoeba. Early and appropriate treatment significantly impacts visual outcomes. Mucoadhesive polymers such as chitosan are a potential strategy to prolong the residence time and bioavailability of the encapsulated drugs in the cornea. Regarding the recent administration of miltefosine (MF) for treating resistant AK, in the present study, we synthesized miltefosine-loaded chitosan nanoparticles (MF-CS-NPs) and evaluated them against Acanthamoeba...
March 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38526917/vonoprazan-amoxicillin-dual-therapy-with-different-amoxicillin-dosages-for-treatment-naive-patients-of-helicobacter-pylori-infection-in-china-a-prospective-randomized-controlled-study
#37
JOURNAL ARTICLE
Zhu Liu, Dongjie Sun, Luan Kou, Li Jia, Jiaorong Hao, Jihai Zhou, Wenwen Zheng, Fengyu Gao, Xin Chen
BACKGROUND: The vonoprazan (VPZ)-amoxicillin (AMO) dual therapy (VA) demonstrates a satisfactory eradication rate for Helicobacter pylori (H. pylori). However, the optimal dosage of AMO in this regimen remains uncertain. The objective of this study is to investigate the efficacy of different doses of AMO in the VA regimen for first-line treatment of H. pylori infection. METHODS: A total of 192 treatment-naive H. pylori-infected patients were randomly assigned to one of three groups: low-dose VA (LD-VA: VPZ 20 mg b...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526879/synergistic-effects-of-ceftazidime-avibactam-combined-with-meropenem-in-a-murine-model-of-infection-with-kpc-producing-klebsiella-pneumoniae
#38
JOURNAL ARTICLE
Mei Zheng, Fu-Hao Li, Juan Liu, Wen-Jie Li, Ruo-Xi Yin, Da-Tong Cai, Diego O Andrey, Si-Lin Zheng, Ana C Gales, Wan-Jiang Zhang, Jian Sun, Xiao-Ping Liao, Yang Yu
OBJECTIVES: The emergence and expansion of carbapenem-resistant Klebsiella pneumoniae infections is a concern due to the lack of 'first-line' antibiotic treatment options. The ceftazidime/avibactam is an important clinical treatment for carbapenem-resistant K. pneumoniae infections but there is an increasing number of cases of treatment failure and drug resistance. Therefore, a potential solution is combination therapies that result in synergistic activity against K. pneumoniae carbapenemase: producing K...
March 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38526868/the-ecotin-like-peptidase-inhibitor-of-trypanosoma-cruzi-prevents-tmprss2-par2-tlr4-crosstalk-downmodulating-infection-and-inflammation
#39
JOURNAL ARTICLE
Tatiana F R Costa, Carolina M C Catta-Preta, Amy Goundry, Danielle B Carvalho, Nathalia S Rodrigues, Aislan C Vivarini, Mayra Fonseca de Abreu, Flavia C G Reis, Ana Paula C A Lima
Trypanosoma cruzi is the causative agent of Chagas disease, a chronic pathology that affects the heart and/or digestive system. This parasite invades and multiplies in virtually all nucleated cells, using a variety of host cell receptors for infection. T. cruzi has a gene that encodes an ecotin-like inhibitor of serine peptidases, ISP2. We generated ISP2-null mutants (Δisp2) in T. cruzi Dm28c using CRISPR/Cas9. Epimastigotes of Δisp2 grew normally in vitro but were more susceptible to lysis by human serum compared to parental and ISP2 add-back lines...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38526789/quantitative-and-standardized-pseudovirus-neutralization-assay-for-covid-19
#40
JOURNAL ARTICLE
Jerilyn R Izac, Edward J Kwee, Adolfas Gaigalas, Lili Wang
COVID-19 is a global pandemic caused by the highly infectious SARS-CoV-2 virus. Efforts to combat SARS-CoV-2 infection include mass vaccination and development of monoclonal and convalescent plasma therapeutics that require precise measurements of correlative, functional neutralizing antibodies that prevent virus infection. Developing rapid, safe, easy-to-use, and high-quality neutralization assays are essential for the success of the massive effort. Here, we developed a vesicular stomatitis virus-based neutralization assay that was capable of quantifying varying degrees of neutralization in patient serum samples...
2024: Methods in Molecular Biology
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