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Congenital AND Infect*

E Eisenhuber, C Schaefer-Prokop, G Mostbeck
Lung cancer is a histologically, immunologically and therefore morphologically and functionally very heterogeneous group of neoplasms with the highest cancer mortality worldwide. Therefore, the range of diseases mimicking lung cancer is also very broad and includes congenital, infectious and inflammatory changes as well as other benign space-occupying lesions and other primary and secondary pulmonary neoplasms. The difficulty in radiology lies in the ability to diagnose lung cancer with a high degree of certainty...
December 14, 2018: Der Radiologe
Lorenza Romani, Stefania Pane, Carlo Severini, Michela Menegon, Gianluca Foglietta, Stefania Bernardi, Hyppolite K Tchidjou, Andrea Onetti Muda, Paolo Palma, Lorenza Putignani
BACKGROUND: Congenital malaria is usually defined as the detection of asexual forms of Plasmodium spp. in a blood sample of a neonate during perinatal age if there is no possibility of postpartum infection by a mosquito bite. The incidence of congenital malaria is highly variable and seems related to several factors, such as different diagnostic methods for Plasmodium spp. detection, and area in which the epidemiologic analyses are performed. In non-endemic countries, cases of congenital malaria are rare...
December 14, 2018: Malaria Journal
W W Diao, Y Y Zhu, X L Zhu, W Y Li, X M Chen
Objective: To summarize the clinical characteristics of congenital pyriform fistula with acute suppurative thyroiditis as the initial presentation. Method: A total of 71 patients with congenital pyriform sinus fistula were treated, of which 33 cases had acute suppurative thyroiditis as the first symptom. For the patients with congenital pyriform sinus fistula who have acute suppurative thyroiditis as the first symptom, infection should be controlled first. Full drainage should be done when necessary, and the lesion should be completely excised during the stable period...
October 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Juan A González-Sánchez, Giovanni F Ramírez-Arroyo
Chikungunya fever (CHIKF) is a re-emerging mosquito-borne disease caused by a virus endemic to Africa and Asia. Due to the ease with which its vectors propagate, the virus has spread to India and Europe, and more recently it arrived to the Caribbean, eventually extending into North, Central, and South America. According to the World Health Organization (WHO), the most common clinical manifestations are abrupt fever, polyarthralgia, headache, maculopapular rash, myalgia, and nausea/vomiting. Severe joint pain and stiffness have been known to incapacitate some patients from a few days to several months after infection...
December 2018: Puerto Rico Health Sciences Journal
Hanne Thang Vestergaard, Marianne Kragh Thomsen, Lene Nielsen, Inge Panum
Congenital cytomegalovirus (cCMV) is the most common infectious cause of congenital malformations in Denmark. The disease is not notifiable, and there are no national data. A regional Danish prospective study from the 1970s found a cCMV incidence of 0.4%. We propose three algorithms for microbiological diagnosing: 1) Testing of pregnant women should only be -applied, when symptoms compatible with CMV infection are present, and no other diagnoses are found. 2) In children less than three weeks of age urine is the -preferred sample...
December 10, 2018: Ugeskrift for Laeger
Tiphaine Gaillard, Manon Boxberger, Marylin Madamet, Bruno Pradines
According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child. The administration of intermittent preventive treatment (IPTp) with sulfadoxine-pyrimethamine (SP) at each antenatal care visit as early as 13 weeks of gestation until the time of delivery is a strategy that is currently recommended by WHO for the prevention of malaria in pregnancy. However, the emergence and the spread of the resistance to SP in Africa raise the question of the short-term effectiveness of the strategy...
December 14, 2018: Malaria Journal
Sameena Shah, Rabab Zehra Jafri, Khalil Mobin, Rabeea Mirza, Kashmira Nanji, Fatima Jahangir, Sufian Jawed Patel, Muzamil Shabana Ejaz, Iman Qaiser, Hira Iftikhar, Komal Aziz, Wajiha Khan, Humza S Maqbool, Hassaan Ahmed
BACKGROUND: Nocturnal enuresis (NE) is a common symptom in children worldwide. International Children's Continence Society (ICCS) defines enuresis as either mono-symptomatic, NE with lower urinary tract symptoms and NE with co-morbid conditions. The objectives of this study were to determine the frequencies and types of NE and associated symptoms and conditions in children aged 5 to 16 years based on ICCS criteria. METHODS: A multi-center cross sectional study was conducted between November 2012 and December 2013 in the primary care clinics of four hospitals in Karachi...
December 14, 2018: BMC Family Practice
Jennifer R Charlton, Louis Boohaker, David Askenazi, Patrick D Brophy, Mamta Fuloria, Jason Gien, Russell Griffin, Sangeeta Hingorani, Susan Ingraham, Ayesa Mian, Robin K Ohls, Shantanu Rastogi, Christopher J Rhee, Mary Revenis, Subrata Sarkar, Michelle Starr, Alison L Kent
BACKGROUND: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d). METHODS: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Late AKI was defined as occurring >7 days after birth according to the KDIGO criteria. Models were constructed to assess the association between late AKI and death or length of stay...
December 13, 2018: Pediatric Research
Michael M McVoy, Edgar Tenorio, Lawrence M Kauvar
Hyperimmune globulin (HIG) has shown efficacy against human cytomegalovirus (HCMV) for both transplant and congenital transmission indications. Replicating that activity with a monoclonal antibody (mAb) offers the potential for improved consistency in manufacturing, lower infusion volume, and improved pharmacokinetics, as well as reduced risk of off-target reactivity leading to toxicity. HCMV pathology is linked to its broad cell tropism. The glycoprotein B (gB) envelope protein is important for infections in all cell types...
December 11, 2018: International Journal of Molecular Sciences
Lizhou Zhang, Wei Ji, Shuang Lyu, Luhua Qiao, Guangxiang Luo
Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as an important human viral pathogen, causing congenital malformation including microcephaly among infants born to mothers infected with the virus during pregnancy. Phylogenetic analysis suggested that ZIKV can be classified into African and Asian lineages. In this study, we have developed a stable plasmid-based reverse genetic system for robust production of both ZIKV prototype African-lineage MR766 and clinical Asian-lineage FSS13025 strains using a tetracycline (Tet)-controlled gene expression vector...
December 9, 2018: Viruses
Diego Simón, Alvaro Fajardo, Pilar Moreno, Gonzalo Moratorio, Juan Cristina
Zika virus (ZIKV) is an emerging pathogen member of the Flaviviridae family. ZIKV has spread rapidly in the Latin American region, causing hundreds of thousands of cases of ZIKV disease, as well as microcephaly in congenital infections. Detailed studies on the pattern of evolution of ZIKV strains have been extremely important to our understanding of viral survival, fitness, and evasion of the host's immune system. For these reasons, we performed a comprehensive phylogenetic analysis of ZIKV strains recently isolated in the Americas...
December 8, 2018: Viruses
Emel Aksoy, Ahmet Kursat Azkur
Schmallenberg virus (SBV), discovered in 2011 in Germany, is associated with clinical manifestations of fever, diarrhea, reduced milk yield, abortions and congenital malformations in ruminants. Despite many studies performed for SBV, there is no detailed research on in vitro apoptotic effect of SBV. This study is aimed to determine apoptosis pathways and role of pro-apoptotic and anti-apoptotic molecules in Vero cells infected with SBV. The study results showed that SBV induced apoptosis via both extrinsic and intrinsic pathways by activating both caspase-8 and caspase-9, respectively...
December 12, 2018: Journal of Veterinary Medical Science
Xin Chen, Wansheng Peng, Zhen Zhang, Qian Zhao, Yan Zhou, Li Chen, Jiahua Pan
OBJECTIVE: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100. METHODS: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Neda A Moatamed
Urine is a major repository of biometabolites, some proteins, and DNA. Within the past few decades, it has become increasingly apparent that certain infectious, neoplastic, and congenital diseases can be investigated using urine samples for diagnostic and prognostic purposes. In this chapter, a number of pertinent urine analytes and methods of banking urine samples for future analyses are discussed.
2019: Methods in Molecular Biology
Shah Faisal, Hasnain Jan, Muhammad Haroon, Muhammad Taimur Khan, Farman Ullah Jan, Tanveer Iqbal, Ayyaz Khan, Muhammad Shakeel
Toxoplasmosis is a very common and asymptomatic infection caused by Toxoplasma gondii. Pregnant women can develop serious complications if the infection passes to the developing fetus. Primary infection in the pregnant women during the gestation period will result in the development of severe systemic disease with temporary parasitemia and will affect the developing fetus. Several clinical complications can be observed in the congenitally infected children which include mild disease to serious health defects such as mental retardation...
December 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Edyta Maj, Katarzyna Wójtowicz, Aleksandra, Podlecka-Piȩtowska, Marek Prokopienko, Andrzej Marchel, Olgierd Rowiński, Monika Bekiesińska-Figatowska
The development of magnetic resonance imaging (MRI) has led to an increasingly frequent detection of changes in the spinal cord. The most common intramedullary lesions are: demyelinating; vascular; inflammatory; infectious; and congenital, largely called tumor-like lesions. Spinal cord tumors are relatively rare, as compared with brain tumors. The hardest task is to conclude whether the spinal cord lesion is a tumor or a tumor-like lesion. This review is intended to help evaluate the spinal cord and gives an overview of the tumor-like lesions occurring in the spinal cord along with their characteristic...
December 11, 2018: Acta Radiologica
Yael Gernez, Mary Grace Baker, Paul J Maglione
Primary immunodeficiency (PID) diseases result from genetic defects of the immune system that increase a patient's susceptibility to infections. The types of infections that occur in patients with PID diseases are dictated largely by the nature of the immunodeficiency, which can be defined by dysfunction of cellular or humoral defenses. An increasing number of PID diseases, including those with both cellular and humoral defects, have antibody deficiency as a major feature, and as a result can benefit from immunoglobulin replacement therapy...
December 2018: Transfusion
Sean Price
Physicians fight Texas' stubborn rates of congenital infections. Syphillis, CMV, and HIV are the top three.
July 1, 2018: Texas Medicine
Nathieli B Bottari, Micheli M Pillat, Maria R C Schetinger, Karine P Reichert, Vanessa Machado, Charles E Assmann, Henning Ulrich, Anielen Dutra, Vera M Morsch, Taís Vidal, Ivana B M Da Cruz, Cinthia Melazzo, Aleksandro Schafer Da Silva
The effects of Toxoplasma gondii during embryonic development have not been explored despite the predilection of this parasite for neurons and glial cells. Here, we investigated the activation of the purinergic system and proinflammatory responses during congenital infection by T. gondii. Moreover, neuroprotective and neuromodulatory properties of resveratrol (RSV), a polyphenolic natural compound, were studied in infected neuronal progenitor cells (NPCs). For this study, NPCs were isolated from the telencephalon of infected mouse embryos and subjected to neurosphere culture in the presence of EGF and FGF2...
December 8, 2018: Purinergic Signalling
Concetta Marsico, Immaculada Aban, Huichien Kuo, Scott H James, Pablo J Sanchez, Amina Ahmed, Ravit Arav-Boger, Marian G Michaels, Negar Ashouri, Janet A Englund, Benjamin Estrada, Richard F Jacobs, Jose R Romero, Sunil K Sood, Suzanne Whitworth, Penelope M Jester, Richard J Whitley, David W Kimberlin
Background: Viral loads (VLs) frequently are followed during treatment of symptomatic congenital cytomegalovirus disease, but their predictive value is unclear. Methods: Post-hoc analysis of two antiviral studies was performed. Seventy-three subjects were treated for 6 weeks and 47 subjects for 6 months. Whole blood VL was determined by real-time polymerase chain reaction before and during therapy. Results: Higher baseline VL was associated with central nervous system involvement (3...
December 7, 2018: Journal of Infectious Diseases
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