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tDCS AND obesity

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https://www.readbyqxmd.com/read/29497108/human-milk-oligosaccharides-protect-against-the-development-of-autoimmune-diabetes-in-nod-mice
#1
Ling Xiao, Belinda Van't Land, Phillip A Engen, Ankur Naqib, Stefan J Green, Angie Nato, Thea Leusink-Muis, Johan Garssen, Ali Keshavarzian, Bernd Stahl, Gert Folkerts
Development of Type 1 diabetes (T1D) is influenced by non-genetic factors, such as optimal microbiome development during early life that "programs" the immune system. Exclusive and prolonged breastfeeding is an independent protective factor against the development of T1D, likely via bioactive components. Human Milk Oligosaccharides (HMOS) are microbiota modulators, known to regulate immune responses directly. Here we show that early life provision (only for a period of six weeks) of 1% authentic HMOS (consisting of both long-chain, as well as short-chain structures), delayed and suppressed T1D development in non-obese diabetic mice and reduced development of severe pancreatic insulitis in later life...
March 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432784/cognitive-and-neuromodulation-strategies-for-unhealthy-eating-and-obesity-systematic-review-and-discussion-of-neurocognitive-mechanisms
#2
REVIEW
Laura Forcano, Fernanda Mata, Rafael de la Torre, Antonio Verdejo-Garcia
We systematically reviewed research on cognitive training and neuromodulation interventions for reducing food craving/intake, unhealthy diet and weight, and discussed their mechanisms of action. We reviewed 50 studies involving six cognitive trainings: Approach and Attentional Bias Modification, Implementation Intentions, Response Inhibition, Episodic Future Thinking and Working Memory; and four neuromodulation approaches: Transcranial Magnetic Stimulation (TMS), transcranial Direct Current Stimulation (tDCS), Deep Brain Stimulation (DBS) and Neurofeedback...
February 9, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29414579/molecular-and-elemental-effects-underlying-the-biochemical-action-of-transcranial-direct-current-stimulation-tdcs-in-appetite-control
#3
Artur D Surowka, Agata Ziomber, Mateusz Czyzycki, Alessandro Migliori, Kaja Kasper, Magdalena Szczerbowska-Boruchowska
Recent studies highlight that obesity may alter the electric activity in brain areas triggering appetite and craving. Transcranial direct current brain stimulation (tDCS) has recently emerged as a safe alternative for treating food addiction via modulating cortical excitability without any high-risk surgical procedure to be utilized. As for anodal-type tDCS (atDCS), we observe increased excitability and spontaneous firing of the cortical neurons, whilst for the cathodal-type tDCS (ctDCS) a significant decrease is induced...
April 15, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29384550/combined-brain-fe-cu-zn-and-neurometabolite-analysis-a-new-methodology-for-unraveling-the-efficacy-of-transcranial-direct-current-stimulation-tdcs-in-appetite-control
#4
Agata Ziomber, Artur Dawid Surowka, Lucyna Antkiewicz-Michaluk, Irena Romanska, Pawel Wrobel, Magdalena Szczerbowska-Boruchowska
Obesity is a chronic, multifactorial origin disease that has recently become one of the most frequent lifestyle disorders. Unfortunately, current obesity treatments seem to be ineffective. At present, transcranial direct current brain stimulation (tDCS) represents a promising novel treatment methodology that seems to be efficient, well-tolerated and safe for a patient. Unfortunately, the biochemical action of tDCS remains unknown, which prevents its widespread use in the clinical arena, although neurobiochemical changes in brain signaling and metal metabolism are frequently reported...
March 1, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29046305/neuromodulation-directed-at-the-prefrontal-cortex-of-subjects-with-obesity-reduces-snack-food-intake-and-hunger-in-a-randomized-trial
#5
RANDOMIZED CONTROLLED TRIAL
Sascha Heinitz, Martin Reinhardt, Paolo Piaggi, Christopher M Weise, Enrique Diaz, Emma J Stinson, Colleen Venti, Susanne B Votruba, Eric M Wassermann, Miguel Alonso-Alonso, Jonathan Krakoff, Marci E Gluck
Background: Obesity is associated with reduced activation in the left dorsolateral prefrontal cortex (DLPFC), a region of the brain that plays a key role in the support of self-regulatory aspects of eating behavior and inhibitory control. Transcranial direct current stimulation (tDCS) is a noninvasive technique used to modulate brain activity. Objectives: We tested whether repeated anodal tDCS targeted at the left DLPFC (compared with sham tDCS) has an immediate effect on eating behavior during ad libitum food intake, resulting in weight change, and whether it might influence longer-term food intake-related appetite ratings in individuals with obesity...
December 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28716588/cathodal-transcranial-direct-current-stimulation-of-the-extrastriate-visual-cortex-modulates-implicit-anti-fat-bias-in-male-but-not-female-participants
#6
Valentina Cazzato, Stergios Makris, Cosimo Urgesi
Explicit negative attitudes toward obese individuals are well documented and seem to modulate the activity of perceptual areas, such as the Extrastriate Body Area (EBA) in the lateral occipito-temporal cortex, which is critical for body-shape perception. Nevertheless, it is still unclear whether EBA serves a role in implicit weight-stereotypical bias, thus reflecting stereotypical trait attribution on the basis of perceptual cues. Here, we used an Implicit Association Test (IAT) to investigate whether applying transcranial direct current stimulation (tDCS) over bilateral extrastriate visual cortex reduces pre-existing implicit weight stereotypical associations (i...
July 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28676735/non-invasive-prefrontal-frontal-brain-stimulation-is-not-effective-in-modulating-food-reappraisal-abilities-or-calorie-consumption-in-obese-females
#7
Felicitas Grundeis, Cristin Brand, Saurabh Kumar, Michael Rullmann, Jan Mehnert, Burkhard Pleger
Background/Objectives: Previous studies suggest that non-invasive transcranial direct current stimulation (tDCS) applied to the prefrontal cortex modulates food choices and calorie intake in obese humans. Participants/Methods: In the present fully randomized, placebo-controlled, within-subject and double-blinded study, we applied single sessions of anodal, cathodal, and sham tDCS to the left dorsolateral prefrontal cortex (DLPFC) and contralateral frontal operculum in 25 hungry obese women and investigated possible influences on food reappraisal abilities as well as calorie intake...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28663570/brain-stimulation-in-obesity
#8
REVIEW
C H Göbel, V M Tronnier, T F Münte
Obesity is taking up epidemic proportions worldwide with significant impacts on the health of both the affected individual and on society as a whole. Treatment approaches consist of behavioural and pharmacological approaches, however, these are often found to be ineffective. In severe obesity, bariatric surgery is frequently performed. Unfortunately, 40% of patients show substantial weight gain over the long term or display the associated metabolic syndrome, making the development of novel therapies necessary...
December 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28572072/the-critical-role-of-cognitive-based-trait-differences-in-transcranial-direct-current-stimulation-tdcs-suppression-of-food-craving-and-eating-in-frank-obesity
#9
Mary Katherine Ray, Maria D Sylvester, Lauren Osborn, Joel Helms, Bulent Turan, Emilee E Burgess, Mary M Boggiano
Obesity remains a major public health concern and novel treatments are needed. Transcranial direct current stimulation (tDCS) is a neuromodulation technique shown to reduce food craving and consumption, especially when targeting the dorsolateral prefrontal cortex (DLPFC) with a right anode/left cathode electrode montage. Despite the implications to treat frank (non-bingeeating) obesity, no study has tested the right anode/left cathode montage in this population. Additionally, most tDCS appetite studies have not controlled for differences in traits under DLPFC control that may influence how well one responds to tDCS...
September 1, 2017: Appetite
https://www.readbyqxmd.com/read/28396289/food-craving-food-choice-and-consumption-the-role-of-impulsivity-and-sham-controlled-tdcs-stimulation-of-the-right-dlpfc
#10
Claudio Georgii, Philipp Goldhofer, Adrian Meule, Anna Richard, Jens Blechert
BACKGROUND: Impulsivity has been found to be associated with overeating and obesity. Transcranial direct current stimulation (tDCS) may enhance inhibitory control while reducing food craving and intake. Thus, the aim of the present study was to investigate whether tDCS stimulation modifies food choice, craving and consumption as a function of trait impulsivity. METHODS: Forty-two predominantly healthy-weight women received active tDCS stimulation to the right dorsolateral prefrontal cortex and sham stimulation in a within participant design...
August 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28288802/non-invasive-brain-stimulation-for-food-cravings-consumption-and-disorders-of-eating-a-review-of-methods-findings-and-controversies
#11
REVIEW
Peter A Hall, Corita M Vincent, Amer M Burhan
OBJECTIVE: To describe the state of the human research literature pertaining to the use of non-invasive brain stimulation (NIBS) procedures for modulating food cravings, food consumption, and treating disorders of eating (i.e., obesity, bulimia nervosa, and anorexia nervosa). METHODS: A narrative review of methods, empirical findings, and current areas of controversy. Both single-session experimental and multi-session therapeutic modalities are considered, separately for repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) technologies...
March 11, 2017: Appetite
https://www.readbyqxmd.com/read/27498606/long-term-effects-of-repeated-prefrontal-cortex-transcranial-direct-current-stimulation-tdcs-on-food-craving-in-normal-and-overweight-young-adults
#12
RANDOMIZED CONTROLLED TRIAL
M Ljubisavljevic, K Maxood, J Bjekic, J Oommen, N Nagelkerke
BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) plays an important role in the regulation of food intake. Several previous studies demonstrated that a single session of transcranial direct current stimulation (tDCS) of the DLPFC reduces food craving and caloric intake. OBJECTIVES: We hypothesized that repeated tDCS of the right DLPFC cortex may exert long-term changes in food craving in young, healthy adults and that these changes may differ between normal and overweight subjects...
November 2016: Brain Stimulation
https://www.readbyqxmd.com/read/26972354/repeated-transcranial-direct-current-stimulation-reduces-food-craving-in-wistar-rats
#13
I C Macedo, C de Oliveira, R Vercelino, A Souza, G Laste, L F Medeiros, V L Scarabelot, E A Nunes, J Kuo, F Fregni, W Caumo, I L S Torres
It has been suggested that food craving-an intense desire to consume a specific food (particularly foods high in sugar and fat)-can lead to obesity. This behavior has also been associated with abuse of other substances, such as drugs. Both drugs and food cause dependence by acting on brain circuitry involved in reward, motivation, and decision-making processes. The dorsolateral prefrontal cortex (DLPFC) can be activated following evocation and is implicated in alterations in food behavior and craving. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique capable of modulates brain activity significantly, has emerged as a promising treatment to inhibit craving...
August 1, 2016: Appetite
https://www.readbyqxmd.com/read/26590516/transcranial-direct-current-stimulation-reduces-food-craving-and-measures-of-hyperphagia-behavior-in-participants-with-prader-willi-syndrome
#14
RANDOMIZED CONTROLLED TRIAL
Gabriela L Bravo, Albert B Poje, Iago Perissinotti, Bianca F Marcondes, Mauricio F Villamar, Ann M Manzardo, Laura Luque, Jean F LePage, Diane Stafford, Felipe Fregni, Merlin G Butler
Prader-Willi syndrome (PWS) is a neurodevelopmental genetic disorder characterized by intellectual disabilities and insatiable appetite with compulsive eating leading to severe obesity with detrimental health consequences. Transcranial direct current stimulation (tDCS) has been shown to modulate decision-making and cue-induced food craving in healthy adults. We conducted a pilot double blind, sham-controlled, multicenter study of tDCS modulation of food drive and craving in 10 adult PWS participants, 11 adult obese (OB) and 11 adult healthy-weight control (HWC) subjects...
March 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/26530931/neuromodulation-targeted-to-the-prefrontal-cortex-induces-changes-in-energy-intake-and-weight-loss-in-obesity
#15
RANDOMIZED CONTROLLED TRIAL
Marci E Gluck, Miguel Alonso-Alonso, Paolo Piaggi, Christopher M Weise, Reiner Jumpertz-von Schwartzenberg, Martin Reinhardt, Eric M Wassermann, Colleen A Venti, Susanne B Votruba, Jonathan Krakoff
OBJECTIVE: Obesity is associated with decreased activity in the prefrontal cortex. Transcranial direct current stimulation (tDCS) modifies cortical excitability and may facilitate improved control of eating. The energy intake (EI) and body weight in subjects who received cathodal versus sham (study 1) and subsequent anodal versus sham (study 2) tDCS aimed at the left dorsolateral prefrontal cortex (LDLPFC) were measured. METHODS: Nine (3m, 6f) healthy volunteers with obesity (94 ± 15 kg [M ± SD]; 42 ± 8 y) were admitted as inpatients for 9 days to participate in a double-blind, randomized, placebo-controlled crossover experiment...
November 2015: Obesity
https://www.readbyqxmd.com/read/26110109/neuroimaging-and-neuromodulation-approaches-to-study-eating-behavior-and-prevent-and-treat-eating-disorders-and-obesity
#16
REVIEW
D Val-Laillet, E Aarts, B Weber, M Ferrari, V Quaresima, L E Stoeckel, M Alonso-Alonso, M Audette, C H Malbert, E Stice
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain...
2015: NeuroImage: Clinical
https://www.readbyqxmd.com/read/25769391/arteriovenous-grafts-are-associated-with-earlier-catheter-removal-and-fewer-catheter-days-in-the-united-states-renal-data-system-population
#17
COMPARATIVE STUDY
Andrew E Leake, Theodore H Yuo, Timothy Wu, Larry Fish, Ellen D Dillavou, Rabih A Chaer, Steven A Leers, Michel S Makaroun
OBJECTIVE: Arteriovenous fistulas (AVFs) are associated with improved long-term outcomes but longer maturation times and higher primary failure rates compared with arteriovenous grafts (AVGs). The Fistula First Breakthrough Initiative has recently emphasized tunneled dialysis catheter (TDC) avoidance. We sought to characterize the relationship of AVFs and AVGs to the use of TDCs as well as secondary procedures. METHODS: Using the United States Renal Data System (USRDS) database, we identified incident hemodialysis (HD) patients in 2005 that started HD with a TDC and survived at least 1 year...
July 2015: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/25576052/blunted-brain-energy-consumption-relates-to-insula-atrophy-and-impaired-glucose-tolerance-in-obesity
#18
Kamila Jauch-Chara, Ferdinand Binkofski, Michaela Loebig, Kathrin Reetz, Gianna Jahn, Uwe H Melchert, Ulrich Schweiger, Kerstin M Oltmanns
Brain energy consumption induced by electrical stimulation increases systemic glucose tolerance in normal-weight men. In obesity, fundamental reductions in brain energy levels, gray matter density, and cortical metabolism, as well as chronically impaired glucose tolerance, suggest that disturbed neuroenergetic regulation may be involved in the development of overweight and obesity. Here, we induced neuronal excitation by anodal transcranial direct current stimulation versus sham, examined cerebral energy consumption with (31)P magnetic resonance spectroscopy, and determined systemic glucose uptake by euglycemic-hyperinsulinemic glucose clamp in 15 normal-weight and 15 obese participants...
June 2015: Diabetes
https://www.readbyqxmd.com/read/24656950/the-effects-of-prefrontal-cortex-transcranial-direct-current-stimulation-tdcs-on-food-craving-and-temporal-discounting-in-women-with-frequent-food-cravings
#19
Maria Kekic, Jessica McClelland, Iain Campbell, Steffen Nestler, Katya Rubia, Anthony S David, Ulrike Schmidt
Bulimia nervosa, binge-eating disorder, and some forms of obesity are characterised by compulsive overeating that is often precipitated by food craving. Transcranial direct current stimulation (tDCS) has been used to suppress food cravings, but there is insufficient evidence to support its application in clinical practice. Furthermore, the potential moderating role of impulsivity has not been considered. This study used a randomised within-subjects crossover design to examine whether a 20-minute session of sham-controlled bilateral tDCS to the dorsolateral prefrontal cortex (anode right/cathode left) would transiently modify food cravings and temporal discounting (TD; a measure of choice impulsivity) in 17 healthy women with frequent food cravings...
July 2014: Appetite
https://www.readbyqxmd.com/read/24159560/computational-modeling-of-transcranial-direct-current-stimulation-tdcs-in-obesity-impact-of-head-fat-and-dose-guidelines
#20
Dennis Q Truong, Greta Magerowski, George L Blackburn, Marom Bikson, Miguel Alonso-Alonso
Recent studies show that acute neuromodulation of the prefrontal cortex with transcranial direct current stimulation (tDCS) can decrease food craving, attentional bias to food, and actual food intake. These data suggest potential clinical applications for tDCS in the field of obesity. However, optimal stimulation parameters in obese individuals are uncertain. One fundamental concern is whether a thick, low-conductivity layer of subcutaneous fat around the head can affect current density distribution and require dose adjustments during tDCS administration...
2013: NeuroImage: Clinical
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