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Zarqa Ali, Charlotte Suppli Ulrik, Tove Agner, Simon Francis Thomsen
Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardio-vascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines...
August 15, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
Christian Antonio Tuwahatu, Chi Chung Yeung, Yun Wah Lam, Vellaisamy Arul Lenus Roy
The development of polymeric materials as drug delivery systems has advanced from systems that rely on classical passive targeting to carriers that can sustain the precisely controlled release of payloads upon physicochemical triggers in desired microenvironment. Molecularly imprinted polymers (MIP), materials designed to capture specific molecules based on their molecular shape and charge distribution, are attractive candidates for fulfilling these purposes. In particular, drug-imprinted polymers coupled with active targeting mechanisms have been explored as potential drug delivery systems...
August 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Douglas A Ruff, David H Brainard, Marlene R Cohen
The way that humans and animals perceive the lightness of an object depends on its physical luminance as well as its surrounding context. While neuronal responses throughout the visual pathway are modulated by context, the relationship between neuronal responses and lightness perception is poorly understood. We searched for a neuronal mechanism of lightness by recording responses of neuronal populations in monkey primary visual cortex (V1) and area V4 to stimuli that produce a lightness illusion in humans, in which the lightness of a disk depends on the context in which it is embedded...
August 15, 2018: Journal of Neurophysiology
Janaina Silva Martins Humberto, Jefferson Veronezi Pavanin, Maria José Alves da Rocha, Ana Carolina Fragoso Motta
The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines...
August 13, 2018: Brazilian Oral Research
Somin Lee, Jihoon Ko, Dohyun Park, Seung-Ryeol Lee, Minhwan Chung, Younggyun Lee, Noo Li Jeon
Microphysiological systems have emerged in the last decade to provide an alternative to in vivo models in basic science and pharmaceutical research. In the field of vascular biology, in particular, there has been a lack of a suitable in vitro model exhibiting a three-dimensional structure and the physiological function of vasculature integrated with organ-on-a-chip models. The rapid development of organ-on-a-chip technology is well positioned to fulfill unmet needs. Recently, functional integration of vasculature with diverse microphysiological systems has been increasing...
August 15, 2018: Lab on a Chip
Ramesh Chandrababu, Eilean Lazarus Rathinasamy, C Suresh, Jyothi Ramesh
BACKGROUND: Anxiety, fear and other unpleasant emotional experiences are common among patients before and after cardiovascular interventional procedures. The higher anxiety may affect prognosis and recovery of patients. AIM: To appraise the evidence concerning the effect of reflexology on the anxiety in patients undergoing cardiovascular interventional procedures. DESIGN: A systematic review and meta-analysis. DATA SOURCES: The MEDLINE, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane Central Register of Controlled Trials (Cochrane Library), EMBASE, PsycINFO and Web of Science were searched between 2001 - 2017...
August 14, 2018: Journal of Advanced Nursing
Chieko Kawakita, Masaru Kinomura, Yoshie Gon, Chika Okita, Katsuyoshi Katayama, Mana Nishikawa, Noriaki Shimada, Kenji Notohara, Masaki Fukushima, Kenichiro Asano
A 40-year-old male was hospitalized with renal impairment and severe hypercalcemia. His concentration of serum IgG4 was high, but serum whole PTH, 1-25(OH)2 vitamin D3 and PTHrP were not elevated. Computed tomography showed swelling of the bilateral lacrimal glands and systemic lymphadenopathy. The histological findings of lacrimal gland biopsy fulfilled the diagnostic criteria of IgG4-related ophthalmic disease (IgG4ROD). Bone scintigraphy showed increased ectopic uptake in the stomach, heart, lungs, and kidneys...
August 14, 2018: CEN Case Reports
Anna Weiss, Carrie K Chu, Heather Lin, Yu Shen, Simona F Shaitelman, Patrick Bryan Garvey, Isabelle Bedrosian, Gildy V Babiera
PURPOSE: Modern treatments are prolonging life for metastatic breast cancer patients. Reconstruction in these patients is controversial. The purpose of this study was to characterize de novo metastatic breast cancer patients who undergo mastectomy and reconstruction and to report complication and survival rates. METHODS: We queried the National Cancer Database for de novo metastatic breast cancer patients, who underwent systemic therapy and mastectomy with reconstruction (R) or without reconstruction (NR) between 2004 and 2013...
August 14, 2018: Annals of Surgical Oncology
Jana Fischereit, K Heinke Schlünzen
A thermally comfortable design of outdoor spaces favors social interaction and outdoor activities and thus contributes to the overall well-being of urban dwellers. To assess such a design, obstacle-resolving models (ORM) combined with thermal indices may be used. This paper reviews existing thermal indices to identify those suitable for thermal comfort assessment with ORMs. For the identification, 11 criteria and six index features are derived from literature analysis focusing on the characteristics of human environmental heat exchange, of outdoor urban environments, and of ORMs...
August 14, 2018: International Journal of Biometeorology
M Schmelzle, F Krenzien, W Schöning, J Pratschke
BACKGROUND AND OBJECTIVES: The treatment of hepatocellular carcinoma (HCC) includes surgical, interventional and systemic approaches. This review highlights the importance of surgical treatment approaches in the multimodal treatment of HCC, based on the currently available literature, corresponding German guidelines as well as current developments in organ donation in Germany. RESULTS: Curative treatment options for HCC include liver transplantation, partial liver resection, and local ablative procedures depending on the lesion size...
August 14, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
K Oechsle
Improvement in the quality of life of patients with life-threatening illnesses or incurable progressive diseases, including patients with cancer and also several internal medical diseases, represents the major aim of palliative care. Basic principles are to also address the needs of the family caregiver and a comprehensive understanding of physical symptoms and psychosocial as well as spiritual aspects. Treatment planning for physical symptoms, e.g., pain, dyspnea and nausea, in patients in need of palliative care has to include the subjective symptom distress of the patient, factors that can be treated causally and the treatment limitations resulting from the underlying life-threatening or incurable disease...
August 14, 2018: Der Internist
Xu Cong Ruan, Wai Loong Wong, Hui Qing Yeong, Yong Kuei Timothy Lim
INTRODUCTION: Endometrial carcinoma is the most common gynaecological malignancy. Studies have shown that laparoscopic total hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection was advantageous compared to laparotomy in reducing length of stay and intraoperative blood loss. However, these studies had a predominantly Caucasian population. A comparison study was conducted among the Singapore population to investigate the differences in oncological and surgical outcomes between these two methods...
July 2018: Singapore Medical Journal
Butuo Zhu, Hui Li, Jiangqi Wen, Kirankumar S Mysore, Xianbing Wang, Yanxi Pei, Lifang Niu, Hao Lin
The C function gene AGAMOUS ( AG ) encodes for a MADS-box transcription factor required for floral organ identity and floral meristem (FM) determinacy in angiosperms. Unlike Arabidopsis, most legume plants possess two AG homologs arose by an ancient genome duplication event. Recently, two euAGAMOUS genes, MtAGa and MtAGb , were characterized and shown to fulfill the C function activity in the model legume Medicago truncatula . Here, we reported the isolation and characterization of a new mtaga allele by screening the Medicago Tnt1 insertion mutant collection...
2018: Frontiers in Plant Science
Mark A van Heumen, Martine H Hollander, Maria G van Pampus, Jeroen van Dillen, Claire A I Stramrood
Objective: To analyze the predictive value of antepartum vulnerability factors, such as social support, coping, history of psychiatric disease, and fear of childbirth, and intrapartum events on the development of symptoms of postpartum posttraumatic stress disorder (PP-PTSD) in women with a traumatic childbirth experience. Materials and methods: Women with at least one self-reported traumatic childbirth experience in or after 2005 were invited to participate through various social media platforms in March 2016...
2018: Frontiers in Psychiatry
Qazi Mumtaz Ahmad, Akmal Laeeq Chishti, Nayyab Waseem
OBJECTIVE: To find out the effect of melatonin as adjunct therapy on outcome of admitted newborns presenting with hypoxic ischaemic encephalopathy. METHODS: This randomized controlled trial was conducted at King Edward Medical University, Lahore, Pakistan, from October 2016 to March 2017, and comprised newborns with gestational age of 34 weeks or higher who fulfilled the definition of hypoxic ischaemic encephalopathy and presented within 12 hours of birth. The severity of hypoxic ischaemic encephalopathy was assessed by Thompson score...
August 2018: JPMA. the Journal of the Pakistan Medical Association
Jan Walter, Sebastian Haller, Chantal Quinten, Tommi Kärki, Benedikt Zacher, Tim Eckmanns, Muna Abu Sin, Diamantis Plachouras, Pete Kinross, Carl Suetens, Ecdc Pps Study Group
An aim of the ECDC point prevalence survey (PPS) in European Union/European Economic Area acute care hospitals was to acquire standardised healthcare-associated infections (HAI) data. We analysed one of the most common HAIs in the ECDC PPS, healthcare-associated pneumonia (HAP). Standardised HAI case definitions were provided and countries were advised to recruit nationally representative subsets of hospitals. We calculated 95% confidence intervals (CIs) around prevalence estimates and adjusted for clustering at hospital level...
August 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Saskia Bolz, Andreas Totzeck, Kerstin Amann, Mark Stettner, Christoph Kleinschnitz, Tim Hagenacker
BACKGROUND: We present a patient fulfilling the electrophysiological criteria for definite chronic inflammatory demyelinating polyneuropathy (CIDP), antibody-positive myasthenia gravis (MG), and membranous glomerulonephritis (MGN) confirmed by biopsy. To our knowledge, this is the first case of the concomitant appearance of these three autoimmune diseases in a single patient. CASE REPRESENTATION: A 42-year-old Caucasian male presented with rapidly progressive gait disturbance, distal weakness of the lower extremities, ascending hypoesthesia, impaired fine motor skills, and beginning cranial nerve palsy showing dysarthrophonia, facial paralysis, and eye movement abnormalities and was diagnosed as rapid onset (atypical) CIDP...
August 14, 2018: BMC Neurology
Jaap J Tolk, Rob P A Janssen, Tsjitske M Haanstra, Sita M A Bierma-Zeinstra, Max Reijman
BACKGROUND: One out of five patients is unsatisfied to some extent after total knee arthroplasty (TKA). Unmet expectations are the main driver of post-operative dissatisfaction. Improved pre-operative education on realistic expectations for long-term outcome after TKA potentially leads to higher post-operative satisfaction. The effect of expectation modification on post-operative satisfaction in TKA patients has not yet been studied. The primary objective of the presented study is to examine whether an educational module on long-term recovery after TKA will improve patient satisfaction compared to usual pre-operative education...
August 14, 2018: Trials
Sarah J Gutman, Benedict T Costello, Stavroula Papapostolou, Aleksandr Voskoboinik, Leah Iles, Johnson Ja, James L Hare, Andris Ellims, Peter M Kistler, Thomas H Marwick, Andrew J Taylor
Aims: In patients with non-ischaemic cardiomyopathy (NICM), the mortality benefit of a primary prevention implantable cardioverter-defibrillator (ICD) has been challenged. Left ventricular (LV) scar identified by cardiac magnetic resonance (CMR) imaging is associated with a high risk of malignant arrhythmia in NICM. We aimed to determine the impact of LV scar on the mortality benefit from a primary prevention ICD in NICM. Methods and results: We recruited 452 consecutive heart failure patients [New York Heart Association (NYHA) Class II/III] with NICM and LV ejection fraction ≤35% from a state-wide CMR service...
August 10, 2018: European Heart Journal
Lisa K Stamp, Peter T Chapman, Murray Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth
Objectives: To determine factors that predict inadequate serum urate (SU) lowering response in a randomized controlled trial of allopurinol dose escalation (DE) in gout. Methods: Participants undergoing allopurinol DE were classified as: complete response (CR)-reached target SU at month 9 and 12 of the DE phase or if still dose escalating at month 9 reached target SU by month 12; partial response (PR)-reached target at some stage but not fulfilling criteria for CR; or inadequate response (IR)-did not reach target SU at any time...
August 9, 2018: Rheumatology
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