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Kasey Cargill, Sunder Sims-Lucas
The mammalian kidney is a complex organ that has several metabolically active cell types to aid in waste filtration, salt-water balance, and electrolyte homeostasis in the body. These functions are done primarily through the nephron, which relies on strict regulation of various metabolic pathways. Any deviations in the metabolic profile of nephrons or their precursor cells called nephron progenitors can lead to renal pathologies and abnormal development. Metabolism encompasses the mechanisms by which cells generate intermediate molecules and energy in the form of adenosine triphosphate (ATP)...
December 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Anna Lena Fisse, Kalliopi Pitarokoili, Jeremias Motte, Donata Gamber, Antonios Kerasnoudis, Ralf Gold, Min-Suk Yoon
OBJECTIVE: HRUS is increasingly being used in the diagnosis and evaluation of autoimmune neuropathies such as CIDP. Recently, studies focused not only on changes of nerves size, but also the fascicular structure and the echogenicity changes in CIDP. However, little is known about the alterations of echogenicity in the long-term course in CIDP. The aim of this study was to evaluate echogenicity in CIDP patients in a long-term follow-up period and to analyze the benefit of the evaluation of echogenicity compared to nerve size...
December 15, 2018: Journal of Neurology
Ana-Maria Orbai, Richard Holland, Ying Ying Leung, William Tillett, Niti Goel, Robin Christensen, Neil McHugh, Laure Gossec, Maarten de Wit, Pil Højgaard, Laura C Coates, Philip J Mease, Julie Birt, Lara Fallon, Oliver FitzGerald, Alexis Ogdie, Beverly Shea, Vibeke Strand, Kristina Callis Duffin, Peter Tugwell, Dorcas Beaton, Dafna D Gladman
OBJECTIVE: The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) psoriatic arthritis (PsA) working group is developing a Core Outcome Measurement Set for PsA clinical trials [randomized controlled trials (RCT) and longitudinal observational studies (LOS)] using the OMERACT Filter 2.1 instrument selection algorithm. Our objective was to assess the Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) for the measurement of the core domain PsA-specific health-related quality of life (HRQOL)...
December 15, 2018: Journal of Rheumatology
Tereza Rojko, Petra Bogovič, Stanka Lotrič-Furlan, Katarina Ogrinc, Tjaša Cerar-Kišek, Urška Glinšek Biškup, Miroslav Petrovec, Eva Ružić-Sabljić, Andrej Kastrin, Franc Strle
The aims of the study were to determine the frequency of borrelial infection in patients with peripheral facial palsy (PFP) and to compare clinical and laboratory characteristics of patients with borrelial PFP and patients with PFP of unknown etiology. Adult patients with PFP who presented at our department between January 2006 and December 2013 qualified for the study if they had undergone lumbar puncture and also been tested for the presence of borrelial IgM and IgG antibodies in serum and cerebrospinal fluid (CSF) in indirect chemiluminescence immunoassay...
December 6, 2018: Ticks and Tick-borne Diseases
Paula Silva Felicio, Barbara Alemar, Aline Silva Coelho, Gustavo Noriz Berardinelli, Matias Eliseo Melendez, André Van Helvoort Lengert, Rodrigo Depieri Miche Lli, Rui M Reis, Gabriela Carvalho Fernandes, Ingrid Petroni Ewald, Camila Matzenbacher Bittar, Cristina Brinckmann Oliveira Netto, Osvaldo Artigalas, Ana Peixoto, Manuela Pinheiro, Manuel R Teixeira, Fernando Regla Vargas, Anna Cláudia Evangelista Dos Santos, Miguel Angelo Martins Moreira, Patricia Ashton-Prolla, Edenir Inêz Palmero
Portuguese immigration to Brazil occurred in several waves and greatly contributed to the genetic composition of current Brazilian population. In this study, we evaluated the frequency of a Portuguese founder Alu insertion in BRCA2 exon 3 (c.156_157insAlu) among individuals fulfilling Hereditary Breast and Ovarian Cancer (HBOC) syndrome criteria in 1,380 unrelated families originated from three distinct Brazilian States. We identified the c.156_157insAlu BRCA2 mutation in nine (9/1,380; 0.65%) probands analised...
December 2018: Cancer Genetics
Alain Lescoat, Cécile Marie Yelnik, Guillaume Coiffier, Matthieu Wargny, Christophe Lamotte, Claire Cazalets, Nicolas Belhomme, Alice Ballerie, Pierre-Yves Hatron, David Launay, Aleth Perdriger, Vincent Sobanski, Eric Hachulla, Patrick Jégo
OBJECTIVE: to evaluate the association of ulnar artery occlusion (UAO) assessed by Doppler Ultrasonography (dUS) with the severity markers of systemic sclerosis (SSc) METHODS: 204 unselected patients fulfilling 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional multicenter study. All patients benefit from bilateral hand dUS evaluating the presence of UAO and clinical/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were conducted, grading the severity of UAO as "no UAO", "only one UAO" and "UAO on both hands" and assessing its association with clinical features of SSc...
December 15, 2018: Arthritis & Rheumatology
David Ferreira, Eswari Vilayur, Michael Gao, Christy Sankoorikal, Cino Bendinelli
BACKGROUND: Hungry bone syndrome (HBS) is one of the most serious complications following parathyroidectomy for severe hyperparathyroidism. There is a lack of literature informing the treatment and risk factors for this condition and the ideal pre-operative strategy for prevention. AIMS: The primary aims of this study were to examine the incidence of HBS with pre-operative calcitriol loading for 10 days and to determine the risk factors for HBS. The secondary aims were to determine the rate of intravenous calcium replacement in those with HBS and to assess whether cinacalcet removal has increased rates of parathyroidectomy in the ESKD population...
December 15, 2018: Internal Medicine Journal
Jo Daniels, John D Pauling, Christopher Eccleston
OBJECTIVES: Raynaud's phenomenon (RP) is a significant cause of morbidity. Vasodilator medications cause unwanted adverse effects, with behavioural and lifestyle changes forming the mainstay of self-management; this is difficult to implement successfully. The objectives of this study were to evaluate the efficacy of behaviour change interventions for RP and identify learning points for future treatment development. DESIGN: Systematic literature review and narrative synthesis of findings...
December 14, 2018: BMJ Open
Cristina Ehrmann, Birgit Prodinger, Gerold Stucki, Wenzhi Cai, Xia Zhang, Shan Liu, Shouguo Liu, Jianan Li, Jan D Reinhardt
OBJECTIVES: To examine metric properties and responsiveness of the International Classification of Functioning, Disability and Health (ICF) Generic Set when used in routine clinical practice to assess functioning. DESIGN: Prospective multicentre study. SETTING: 50 hospitals from 20 provinces of Mainland China. PARTICIPANTS: 4510 adult inpatients admitted to the departments of Pulmonology, Cardiology, Neurology, Orthopaedics, Cerebral Surgery or Rehabilitation Medicine...
December 14, 2018: BMJ Open
Dolores Sánchez-Rodríguez, Ester Marco, Anne-Marie Schott, Yves Rolland, Hubert Blain, Olga Vázquez-Ibar, Ferran Escalada, Xavier Duran, Josep M Muniesa, Cédric Annweiler
BACKGROUND: The European Society of Clinical Nutrition and Metabolism (ESPEN) has developed a consensus definition of malnutrition. This study aimed to determine the prevalence of malnutrition according to the ESPEN definition in otherwise healthy community-dwelling older women and to explore its value for predicting long-term mortality in this population. METHODS: This prospective population-based cohort study included 181 women (age ≥75 years) from a subsample of the EPIDémiologie de l'OStéoporose (EPIDOS) study participants from Toulouse...
December 1, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Heejin Yoo, Kyunga Kim, Yoon-Ho Choi, Jae J Kim, Sung Kim
BACKGROUND: Undifferentiated-type early gastric cancers account for a large proportion of gastric cancers in younger patients. Therefore, the clinical outcomes of endoscopic resection in younger patients are a major concern. We aimed to investigate the influence of age on lymph node metastasis and long-term survival after surgery for undifferentiated-type early gastric cancers. METHODS: We identified 4,236 patients who underwent surgery for undifferentiated-type early gastric cancers...
December 11, 2018: Surgery
Séverine Mangel, Laurent Durin, Geneviève Lombard
The anticipated organ donation approach aims to increase access to donor organs in France. It concerns patients with neurological injuries in a serious condition, for whom there are no treatment options, but who could be suitable for organ procurement if their condition were to evolve towards brain death. This approach requires meticulous preparation, fulfilment of the required conditions and close support for the family.
December 2018: Soins; la Revue de Référence Infirmière
Jenny Leopold, Yulia Popkova, Kathrin M Engel, Jürgen Schiller
Matrix-assisted laser desorption/ionization (MALDI) is one of the most successful "soft" ionization methods in the field of mass spectrometry and enables the analysis of a broad range of molecules, including lipids. Although the details of the ionization process are still unknown, the importance of the matrix is commonly accepted. Both, the development of and the search for useful matrices was, and still is, an empirical process, since properties like vacuum stability, high absorption at the laser wavelength, etc...
December 13, 2018: Biomolecules
Giulia Casu
AIM AND OBJECTIVES: To develop and initially validate the Positive Sexuality Scale (PSS) to assess adult female positive sexuality. BACKGROUND: While traditional approaches focus on negative sexual experiences and sexual dysfunctions, within the positive psychology framework positive sexuality is a subjective experience of happiness and fulfillment with one's sexual expression, which contributes to well-being. No measure exists that specifically measures adult female positive sexuality and can be confidently used with women of any fertility/childlessness status...
December 14, 2018: Journal of Clinical Nursing
Yong Liu, Yuanfeng Li, Damla Keskin, Linqi Shi
Poly(β-amino ester) (abbreviated as PBAE or PAE) refers to a polymer synthesized from an acrylate and an amine by Michael addition and has properties inherent to tertiary amines and esters, such as pH responsiveness and biodegradability. The versatility of building blocks provides a library of polymers with miscellaneous physicochemical and mechanical properties. When used alone or together with other materials, PBAEs can be fabricated into different formulations in order to fulfill various requirements in drug delivery (for instance, gene, anticancer drugs, and antimicrobials delivery) and natural complex mimicry (nanochaperones)...
December 14, 2018: Advanced Healthcare Materials
Cecilia Hultstrand Ahlin, Åsa Hörnsten, Anna-Britt Coe, Mikael Lilja, Senada Hajdarevic
AIMS AND OBJECTIVES: We aimed to explore patients' experiences of contact and interaction with healthcare professionals (HCPs) during the diagnostic process of melanoma. BACKGROUND: In Sweden, most patients with suspected skin lesions seek care at the primary level of services in the first instance. Previous research describe the diagnostic process as a complex journey with uncertainty. Nonetheless, the importance of contact and interaction between patient and HCPs during the diagnostic process is rarely explored...
December 14, 2018: Journal of Clinical Nursing
Hakan Köksal, Elisabeth Müller, Else Marit Inderberg, Øyvind Bruland, Sébastien Wälchli
Novel therapies to treat patients with solid cancers that have developed resistance to chemotherapy represent unmet needs of considerable dimensions. In the present review, we will address the attempts to develop Chimeric Antigen Receptor (CAR) targeted immunotherapy against osteosarcoma (OS). This aggressive cancer displays its peak incidence in children and young adults. The main cause of patient death is lung metastases with a 5-year survival as low as 5-10% in the primary metastatic setting and 30% in the relapse situation, respectively...
December 14, 2018: Scandinavian Journal of Immunology
Shanshan Wang, Daphne Sze Ki Cheung, Angela Y M Leung
OBJECTIVES: This paper provides an overview of the status of dementia care in Mainland China under the framework of the three-tier long-term care system proposed by the Chinese government, and gives the direction for service development. METHODS: Official documents, annual reports of related associations, and studies conducted in Mainland China from 2006 to 2017, published both in English and Chinese were reviewed. RESULTS: With the establishment of the three-tier long-term care system, the Government has invested a lot in long-term care, and improvements have been made...
December 13, 2018: Public Health Nursing
Elena Rogante, Salvatore Sarubbi, Dorian A Lamis, Valeria Canzonetta, Alice Sparagna, Valerio De Angelis, Denise Erbuto, Paolo Martelletti, Maurizio Pompili
BACKGROUND AND OBJECTIVES: Migraine headache is the seventh leading cause of disability worldwide causing adverse outcomes in many aspects of an individual's life. Many psychological aspects affect chronic migraine (CM): illness perception, anxiety, depressive symptoms, and job satisfaction. This observational study aimed to examine the association among illness perception, anxiety, depressive symptoms, and job satisfaction, connected to migraine and its features. METHODS: Ninety-eight individuals with CM treated with OnabotulinumtoxinA were recruited from the Regional Referral Headache Centre of Sant'Andrea Hospital in Rome...
December 13, 2018: Headache
Ashwani K Singal, Song Ong, Sanjaya Satpathy, Patrick S Kamath, Russel H Wiesner
Kidney injury is frequently seen in patients with end stage liver disease from cirrhosis and liver failure. Among select patients, simultaneous liver kidney (SLK) transplantation provides improved post-transplant graft and patient outcomes compared to liver transplantation alone. We conducted review of the existing literature on SLK transplant criteria and outcomes. Since the introduction of the model for end-stage disease score in 2002, there has been an increased use of simultaneous liver kidney transplantation...
December 10, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
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