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Ion Lascurain-Aguirrebeña, Di J Newham, Xabat Casado-Zumeta, Aitana Lertxundi, Duncan J Critchley
BACKGROUND: Neck pain is prevalent, costly and disabling. Cervical mobilisations are frequently used to treat it but their effectiveness has been questioned by several systematic reviews. Evidence suggests that better outcomes are achieved with mobilisations when they are applied to specific patient subgroups. A criteria for patients suitable for neck mobilisations has been proposed, but the effectiveness on this patient subgroup has not been tested. OBJECTIVE: To assess the effectiveness of cervical mobilisations applied to a subgroup of patients with neck pain who fulfil specific criteria...
October 13, 2018: Musculoskeletal Science & Practice
Ramadoss Ramu, Vivek Arya, Satyapal Taneja, Mohammad Ali
Adult onset Still's disease (AOSD) is a rare inflammatory disorder of unknown etiology. It is a diagnosis of exclusion. We report a case of post-splenectomised man, presented with high grade fever, joint pain and body ache. Since Overwhelming Post Splenectomy Infection (OPSI) was the initial probable diagnosis, empirical antibiotic therapy was initiated. Evaluation to find a septic focus, autoimmune diseases ad malignancies was carried out which showed negative results. Since alternative diagnoses were excluded and the Yamaguchi's criteria for AOSD was fulfilled, the patient was treated with IV steroids which resulted in rapid resolution of his symptoms...
January 2018: Journal of the Association of Physicians of India
Parminder Singh
Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Bone diseases such as rickets in children, osteomalacia and osteoporosis in adults are related with vitamin D insufficiency...
January 2018: Journal of the Association of Physicians of India
Tinashe Chiurugwi, Stuart Kemp, Wayne Powell, Lee T Hickey
This review explores how speed breeding protocols that hasten plant growth and development could be applied to shorten breeding cycles and accelerate research activities in orphan crops. There is a growing need for the agri-food sector to sustainably produce larger quantities of higher-quality food, feed and fuel using fewer resources, within the context of changing agroclimatic conditions. Meeting this challenge will require the accelerated development and dissemination of improved plant varieties and substantial improvement of agricultural practices...
October 19, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Floriana Burgio, Natalie Rimmer, Uwe Pieles, Johanna Buschmann, Marina Beaufils-Hugot
For the fabrication of appropriate bone tissue engineered constructs, several prerequisites should be fulfilled. It should offer long-term stability, allow proper cell attachment and proliferation, furthermore be osteoinductive and easy to be vascularized. Having these requirements as background, we fabricated a novel porous 3D-printed hydroxyapatite (HA) scaffold and treated it with oxygen plasma (OPT). MG-63 pre-osteoblast-seeded bone constructs allowed good cell attachment and proliferation, even better when cultivated in a perfusion flow bioreactor...
October 19, 2018: Biology Open
Tanja Schallschmidt, Sandra Lebek, Delsi Altenhofen, Mareike Damen, Yvonne Schulte, Birgit Knebel, Ralf Herwig, Axel Rasche, Torben Stermann, Anne Kamitz, Nicole Hallahan, Markus Jähnert, Heike Vogel, Annette Schürmann, Alexandra Chadt, Hadi Al-Hasani
To identify novel disease genes for type 2 diabetes (T2D) we generated two backcross populations of obese and diabetes-susceptible New Zealand Obese (NZO/HI) with the two lean mouse strains 129P2/OlaHsd and C3HeB/FeJ. Subsequent whole-genome linkage scans revealed 30 novel quantitative trait loci (QTL) for T2D-associated traits. The strongest association with blood glucose (12 cM, LOD 13.3) and plasma insulin (17 cM, LOD 4.8) was detected on proximal chromosome 7 (designated Nbg7p , NZO blood glucose on proximal chromosome 7) exclusively in the NZOxC3H crossbreeding, suggesting that the causal gene is contributed by the C3H genome...
October 19, 2018: Genetics
Stefania Clemente, Caterina Oliviero, Giuseppe Palma, Vittoria D'Avino, Raffaele Liuzzi, Manuel Conson, Roberto Pacelli, Laura Cella
BACKGROUND: Technological advances in Hodgkin lymphoma (HL) radiation therapy (RT) by high conformal treatments potentially increase control over organs-at-risk (OARs) dose distribution. However, plan optimization remains a time-consuming task with great operator dependent variability. Purpose of the present study was to devise a fully automated pipeline based on the Pinnacle3 Auto-Planning (AP) algorithm for treating female supradiaphragmatic HL (SHL) patients. METHODS: CT-scans of 10 female patients with SHL were considered...
October 19, 2018: Radiation Oncology
Yong Hu, Dong Shi, Ye Hu, Hongwei Zhao, Xingdong Sun
A new method of ultrasonic chemical mechanical polishing (CMP) combined with ultrasonic lapping is introduced to improve the machining performance of carbide silicon (SiC). To fulfill the method, an ultrasonic assisted machining apparatus is designed and manufactured. Comparative experiments with and without ultrasonic assisted vibration are conducted. According to the experimental results, the material removal rate (MRR) and surface generation are investigated. The results show that both ultrasonic lapping and ultrasonic CMP can decrease the two-body abrasion and reduce the peak-to-valley (PV) value of surface roughness, the effect of ultrasonic in lapping can contribute to the higher MRR and better surface quality for the following CMP...
October 18, 2018: Materials
Catalina Filote, Irina Volf, Sílvia C R Santos, Cidália M S Botelho
In the context of developing the circular economy that enables a more sustainable use of the available resources and minimum waste generation, marine macroalgae have attracted the attention of researchers and industry due to its potential as a renewable resource. The current work aims to contribute to the design of a complete biorefinery processing, using Fucus spiralis seaweed (brown division) as starting material, and to determine the potential of the derived waste as biosorbent of heavy metals in aqueous solution...
January 15, 2019: Science of the Total Environment
Andrea F Kroll de Senna, Camila Giugliani, Juliana C A Lago, Agnes M B L Bizon, Ana C M Martins, Ceres A V Oliveira, Elsa R J Giugliani
OBJECTIVE: To evaluate the construct validity and the internal consistency of the Maternal Breastfeeding Evaluation Scale tool, aiming at its application in the Brazilian population. METHODS: Cross-sectional study that applied the tool to 287 Brazilian women 30 days after childbirth. Main component analysis with varimax rotation was used for the factor analysis, verifying the number of subscales and the maintenance or extraction of the components. Four hypotheses were tested using the unpaired Student's t-test for construct validation...
October 16, 2018: Jornal de Pediatria
Harshal Deshmukh, Maria Papageorgiou, Eric S Kilpatrick, Stephen L Atkin, Thozhukat Sathyapalan
OBJECTIVE: The aim of this study was to develop a simple phenotypic algorithm that can capture the underlying clinical and hormonal abnormalities to help in the diagnosis and risk stratification of PCOS. METHODS: The study consisted of 111 women with PCOS fulfilling the Rotterdam diagnostic criteria and 67 women without PCOS. A Firth's penalised logistic regression model was used for independent variable section. Model optimism, discrimination and calibration were assessed using bootstrapping, area under the curve (AUC) and Hosmer-Lemeshow statistics, respectively...
October 19, 2018: Clinical Endocrinology
A B de Castro, Natalia Dyba, Elizabeth D Cortez, Genecar G Pe Benito
BACKGROUND: Collaborative Online International Learning (COIL) is a pedagogical approach using digital technology to provide experiential international learning without travel abroad. Through web-based, cross-country intellectual exchange, COIL helps prepare nursing students for increasingly diverse and multicultural health care work environments globally. PROBLEM: Opportunities to engage in multicultural learning experiences have traditionally relied on intensive study abroad trips, which can be prohibitive for students with limited fiscal resources or who are place-bound...
October 18, 2018: Nurse Educator
Maria R Depaoli, Jesse C Hay, Wolfgang F Graier, Roland Malli
The endoplasmic reticulum (ER) is a functionally and morphologically complex cellular organelle largely responsible for a variety of crucial functions, including protein folding, maturation and degradation. Furthermore, the ER plays an essential role in lipid biosynthesis, dynamic Ca2+ storage, and detoxification. Malfunctions in ER-related processes are responsible for the genesis and progression of many diseases, such as heart failure, cancer, neurodegeneration and metabolic disorders. To fulfill many of its vital functions, the ER relies on a sufficient energy supply in the form of adenosine-5'-triphosphate (ATP), the main cellular energy source...
October 19, 2018: Biological Reviews of the Cambridge Philosophical Society
M Golino, F R Spera, L Manfredonia, A De Vita, A Di Franco, P Lamendola, A Villano, V Melita, E Mencarelli, G A Lanza, F Crea
OBJECTIVE: About one-third of patients undergoing percutaneous coronary interventions (PCIs) for flow-limiting coronary stenosis continue to develop signs of myocardial ischemia (MI) during exercise stress test [EST], despite successful coronary revascularization. Coronary microvascular dysfunction is a likely major cause of the persistence of EST-induced MI in these patients. PATIENTS AND METHODS: We studied 15 patients (14 men, age 67±5 years) fulfilling the following strict inclusion criteria: (1) recent PCI (<6 months), with drug-eluting stent, of coronary artery stenoses for stable angina, with evidence of full success (no residual stenosis >20% in any vessel); (2) persistence of ST-segment depression induction during EST...
October 2018: European Review for Medical and Pharmacological Sciences
Prasan Deep Rath, Der-Yuan Chen, Jieruo Gu, Vivian W Y Lee, Nizar Abdulateef Al Ani, Khalid Shirazy, Lyndon Llamado
Although anti-tumor necrosis factor (TNF) agents have greatly improved the management of rheumatic diseases, their cost limits access to many patients throughout the world. As a result, patients and clinicians have turned to biosimilars to provide similar efficacy at a lower cost. Many of the regulatory guidelines in the Asia Pacific region are largely based on those of the European Medicines Agency and the World Health Organization; however, there are variations between countries. Additionally, in some countries, intended copies are available that were approved prior to the development of guidelines and have not fulfilled the requirements of a biosimilar...
October 18, 2018: International Journal of Rheumatic Diseases
Joshua A Cuoco, Christopher M Busch, Cara M Rogers, Evin L Guilliams, Brendan J Klein, Gregory A Howes, Eric A Marvin
Background The Accreditation Council for Graduate Medical Education and the American Osteopathic Association recently agreed to establish a single graduate medical education system for the United States allopathic and osteopathic resident physicians by 2020. Consequential to this merger, new standards will be implemented for academic and research requirements within medical schools as well as residency programs. In the United States, osteopathic medicine is considered to be a parallel profession to allopathic medicine...
August 9, 2018: Curēus
Adeel A Siddiqui, Muhammad Jamil, Ghulam M Kaimkhani, Malik Wasim, Muhammad Soughat Katto, Uzair Yaqoob, Mariyam Adeel
Objective Burnout is exceptionally pervasive among medical professionals, especially surgeons, and is considered the main indicator of surgeons' fulfillment with career choice. Our objectives are to discover the extent of orthopedic specialist burnout in Pakistan and to explore the clinical impact of burnout. The efficacy of surgeons may be enhanced by implementing burnout prevention and treatment plans. Data collection This observational study was conducted from April 2018 to May 2018 in various tertiary care hospitals in Pakistan and includes post-graduate trainees and consultants...
August 4, 2018: Curēus
Muhammad Nazir, Asim Al-Ansari, Mohammed Alabdulaziz, Yousif AlNasrallah, Murtada Alzain
BACKGROUND: Continuing education (CE) activities help dentists update their knowledge and skills to ensure high standards of patient care. AIM: This study aimed to evaluate the reasons for and barriers to attending CE activities including the priorities for different dental specialities. METHODS: The study involves a cross-sectional research design. After statistical consultation, a questionnaire was distributed among 323 dental practitioners in the Eastern province of Saudi Arabia...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
Tomislav Pavlović, Marina Milošević, Sanja Trtica, Hrvoje Budinčević
BACKGROUND: Vertigo is a common symptom and reason for admission to the emergency department (ED). AIM: This research aimed to determine the incidence of clinically significant findings on computed tomography (CT) in patients with vertigo without focal neurological abnormalities in the ED. MATERIAL AND METHODS: The results of the native CT scans in the ED were retrospectively analysed. Exclusion criteria included: focal neurological abnormalities, underlying malignancy, brain metastasis, previous brain operation, headache, fever, nausea, vomiting, head trauma, coagulopathy...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
Yuanjun Dong, Sabrina Berens, Wolfgang Eich, Rainer Schaefert, Jonas Tesarz
OBJECTIVE: The aim of this study was to describe the body mass index (BMI) distribution in patients with irritable bowel syndrome (IBS) based on the Rome III criteria and to evaluate the association of BMI with symptom severity and quality of life (QOL). METHODS: A cross-sectional study was carried out in patients visiting our outpatient functional gastrointestinal disorders specialty clinic. IBS diagnosis was made based on Rome III criteria. IBS symptom severity was investigated using the IBS severity score system...
October 17, 2018: BMJ Open
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