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https://www.readbyqxmd.com/read/28931592/ubiquitin-ligase-spsb4-diminishes-cell-repulsive-responses-mediated-by-ephb2
#1
Fumihiko Okumura, Akiko Joo-Okumura, Keisuke Obara, Alexander Petersen, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura
Eph receptor tyrosine kinases and their ephrin ligands are overexpressed in various human cancers, including colorectal malignancies, suggesting important roles in many aspects of cancer development and progression as well as in cellular repulsive responses. The ectodomain of EphB2 receptor is cleaved by metalloproteinases (MMPs) MMP-2/MMP-9 and released into the extracellular space after stimulation by its ligand. The remaining membrane-associated fragment is further cleaved by the presenilin-dependent γ-secretase and releases an intracellular peptide that has tyrosine kinase activity...
September 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28924206/ephrin-a2-regulates-excitatory-neuron-differentiation-and-interneuron-migration-in-the-developing-neocortex
#2
Jihane Homman-Ludiye, William C Kwan, Mitchell J de Souza, Jennifer Rodger, James A Bourne
The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we consistently observed focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons. Loss of ephrin-A2 in the pre-optic area of the diencephalon reduced the migration of neocortex-bound interneurons from this region...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910333/reduced-proliferation-of-endothelial-colony-forming-cells-in-unprovoked-venous-thromboembolic-disease-as-a-consequence-of-endothelial-dysfunction
#3
Rubicel Hernandez-Lopez, Antonieta Chavez-Gonzalez, Patricia Torres-Barrera, Dafne Moreno-Lorenzana, Norma Lopez-DiazGuerrero, David Santiago-German, Irma Isordia-Salas, David Smadja, Mervin C Yoder, Abraham Majluf-Cruz, J Antonio Alvarado-Moreno
BACKGROUND: Venous thromboembolic disease (VTD) is a public health problem. We recently reported that endothelial colony-forming cells (ECFCs) derived from endothelial cells (EC) (ECFC-ECs) from patients with VTD have a dysfunctional state. For this study, we proposed that a dysfunctional status of these cells generates a reduction of its proliferative ability, which is also associated with senescence and reactive oxygen species (ROS). METHODS AND RESULTS: Human mononuclear cells (MNCs) were obtained from peripheral blood from 40 healthy human volunteers (controls) and 50 patients with VTD matched by age (20-50 years) and sex to obtain ECFCs...
2017: PloS One
https://www.readbyqxmd.com/read/28895507/functional-impact-of-exercise-pulmonary-hypertension-in-patients-with-borderline-resting-pulmonary-arterial-pressure
#4
Rudolf K F Oliveira, Mariana Faria-Urbina, Bradley A Maron, Mario Santos, Aaron B Waxman, David M Systrom
Borderline resting mean pulmonary arterial pressure (mPAP) is associated with adverse outcomes and affects the exercise pulmonary vascular response. However, the pathophysiological mechanisms underlying exertional intolerance in borderline mPAP remain incompletely characterized. In the current study, we sought to evaluate the prevalence and functional impact of exercise pulmonary hypertension (ePH) across a spectrum of resting mPAP's in consecutive patients with contemporary resting right heart catheterization (RHC) and invasive cardiopulmonary exercise testing...
July 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28877393/polyester-vascular-patches-acquire-arterial-or-venous-identity-depending-on-their-environment
#5
Hualong Bai, Haidi Hu, Jianming Guo, Maryam Ige, Tun Wang, Toshihiko Isaji, Tambudzai Kudze, Haiyang Liu, Bogdan Yatsula, Hashimoto Takuya, Ying Xing, Alan Dardik
Polyester is commonly used in vascular surgery for patch angioplasty and grafts. We hypothesized that polyester patches heal by infiltration of arterial or venous progenitor cells depending on the site of implantation. Polyester patches were implanted to the Wistar rat aorta or inferior vena cava and explanted on days 7 or 30. Neointima that formed on polyester patches was thicker in the venous environment compared to the amount that formed on patches in the arterial environment. Venous patches had more cell proliferation and greater numbers of VCAM-positive and CD68-positive cells, whereas arterial patches had greater numbers of vimentin-positive and alpha-actin-positive cells...
September 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28873977/one-step-derivatization-extraction-method-for-rapid-analysis-of-eleven-amphetamines-and-cathinones-in-oral-fluid-by-gc-ms
#6
Khaled Mohamed
A simple analytical method was developed for in-matrix derivatization of 11 amphetamine-like molecules. Ethyl chloroformate as the derivatization reagent and ethyl acetate as the extraction solvent were added directly to oral fluid samples at alkaline pH. Samples were analyzed by gas chromatography-mass spectrometry. Ions monitored for quantification were m/z 44, 91 and 116 for amphetamine (AMP); m/z 58, 91 and 130 for methamphetamine (MA); m/z 44, 105 and 116 for 4-methylamphetamine; m/z 44, 116 and 251 for 3,4-methylenedioxyamphetamine; m/z 58, 130 and 265 for 3,4-methylenedioxymethamphetamine (MDMA); m/z 72, 116 and 144 for 3,4-methylenedioxyethylamphetamine; m/z 44, 105 and 116 for cathinone; m/z 58, 105 and 130 for methcathinone; m/z 58, 119 and 130 for mephedrone; m/z 58, 107 and 130 for ephedrine (EPH); m/z 207, 250 and 322 for fenethylline; m/z 48, 92 and 120 for AMP-D5; m/z 62, 92 and 134 for MA-D5; m/z 48, 120 and 256 for MDA-D5; and m/z 62, 134 and 270 for MDMA-D5...
September 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28857971/state-and-local-health-department-activities-related-to-abortion-a-web-site-content-analysis
#7
Nancy F Berglas, Nicole E Johns, Caroline Rosenzweig, Lauren A Hunter, Sarah C M Roberts
CONTEXT: Recent legislation in states across the United States has required governmental health agencies to take on new and different roles in relation to abortion. While there has been media attention to health department roles in regulating abortion providers, there has been no systematic investigation of the range of activities in which state and local health departments are engaged. OBJECTIVE: To systematically investigate health department activities related to abortion...
August 29, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28851287/epha-receptors-and-ephrin-a-ligands-are-upregulated-by-monocytic-differentiation-maturation-and-promote-cell-adhesion-and-protrusion-formation-in-hl60-monocytes
#8
Midori Mukai, Norihiko Suruga, Noritaka Saeki, Kazushige Ogawa
BACKGROUND: Eph signaling is known to induce contrasting cell behaviors such as promoting and inhibiting cell adhesion/spreading by altering F-actin organization and influencing integrin activities. We have previously demonstrated that EphA2 stimulation by ephrin-A1 promotes cell adhesion through interaction with integrins and integrin ligands in two monocyte/macrophage cell lines. Although mature mononuclear leukocytes express several members of the EphA/ephrin-A subclass, their expression has not been examined in monocytes undergoing during differentiation and maturation...
August 29, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28832125/tetrametallic-thorium-compounds-with-th4e4-e-s-se-cubane-cores
#9
Matthew A Stuber, Anna Y Kornienko, Thomas J Emge, John G Brennan
Tetrametallic thorium compounds with a Th4E4 core (E = S, Se) having a distorted cubane structure can be prepared by ligand-based reductions of elemental E with thorium chalcogenolates, prepared by in situ oxidation of Th metal with a 3:1 mixture of PhEEPh and F5C6EEC6F5. Four compounds, (py)8Th4S4(μ2-SPh)4(SC6F5)4, (py)8Th4S4(μ2-SPh)4(SeC6F5)4, (py)8Th4Se4(μ2-SePh)4(SeC6F5)4, and (py)8Th4Se4(μ2-SePh)4(SC6F5)4, were isolated and characterized by NMR spectroscopy and X-ray diffraction. These compounds clearly demonstrate the chemical impact of ring fluorination, with the less-nucleophilic EC6F5 ligands occupying the terminal binding sites and the EPh ligands bridging two metal centers...
August 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28819830/identification-and-characterization-of-tyrosine-kinases-in-anole-lizard-indicate-the-conserved-tyrosine-kinase-repertoire-in-vertebrates
#10
Ake Liu, Funan He, Xun Gu
The tyrosine kinases (TKs) play principal roles in regulation of multicellular aspects of the organism and are implicated in many cancer types and congenital disorders. The anole lizard has recently been introduced as a model organism for laboratory-based studies of organismal function and field studies of ecology and evolution. However, the TK family of anole lizard has not been systematically identified and characterized yet. In this study, we identified 82 TK-encoding genes in the anole lizard genome and classified them into 28 subfamilies through phylogenetic analysis, with no member from ROS and STYK1 subfamilies identified...
August 17, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28808385/anti-inflammatory-effect-of-etlingera-pavieana-pierre-ex-gagnep-r-m-sm-rhizomal-extract-and-its-phenolic-compounds-in-lipopolysaccharide-stimulated-macrophages
#11
Ekaruth Srisook, Mullika Palachot, Sakulrat Mankhong, Klaokwan Srisook
BACKGROUND: In our continuing search for anti-inflammatory agents from Thai herbs, Etlingera pavieana (Pierre ex Gagnep.) R.M.Sm. showed potent inhibition on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophages. However, the mechanism behind its inhibitory effect has not been yet explored, and little is known regarding its bioactive compounds responsible for the anti-inflammatory effect. OBJECTIVE: In the present study, anti-inflammatory effect of hexane, ethyl acetate, and water fractions of rhizomal ethanol extracts of E...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28804916/lane-s-disease-erythema-palmare-hereditarium-a-report-of-five-cases-and-a-review-of-the-literature
#12
Carlotta Gurioli, Annalisa Patrizi, Martina Lambertini, Iria Neri
BACKGROUND: Erythema palmare hereditarium (EPH), also known as Lane's disease, is a rare, benign condition presenting as persistent erythema involving the palms. EPH can appear at birth or later in life and usually in at least two members of the same family, although a sporadic case has been reported. METHODS: We report five cases of EPH and offer a review of the current literature. The first and second cases are twin boys presenting with erythema mainly on the thenar and hypothenar eminences and on the phalanges that appeared 8 months after birth...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28801142/synergistic-experimental-and-numerical-characterization-of-a-dry-heat-fluid-warming-device
#13
Winston Tan, Eph M Sparrow, John M Gorman, Jungwon Ahn
Fluids that are infused into the human body must be at a temperature that is compatible with the internal thermal state of the body. Since infusants are typically stored at temperatures that are too low for compatibility, a heating means is required to achieve the appropriate infusion temperature. This paper sets forth a synergistic investigation involving coupled experimentation and numerical simulation of the characteristics of one of the main categories of body-fluid heating means. The methodology developed here serves equally well as a design optimization tool...
August 8, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28800788/mir-204-regulates-cell-proliferation-and-invasion-by-targeting-ephb2-in-human-cervical-cancer
#14
Shanhong Duan, Ali Wu, Zhengyu Chen, Yarong Yang, Liying Liu, Qi Shu
MicroRNAs (miRNAs) are small non-coding RNAs that involved in human carcinogenesis and progression. miR-204 has been reported to be a tumor suppressor in several cancer types. However, the function and underlying molecular mechanism of miR-204 in cervical cancer (CC) are still unclear. In the present study, the expression level of miR-204 was measured using qRT-PCR method in 30 paired CC clinical samples and 6 CC cell lines. We found that the expression of miR-204 was significantly down-regulated in CC tissues and cell lines compared to normal cervical tissues and cell line...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28792499/revisiting-chemoaffinity-theory-chemotactic-implementation-of-topographic-axonal-projection
#15
Honda Naoki
Neural circuits are wired by chemotactic migration of growth cones guided by extracellular guidance cue gradients. How growth cone chemotaxis builds the macroscopic structure of the neural circuit is a fundamental question in neuroscience. I addressed this issue in the case of the ordered axonal projections called topographic maps in the retinotectal system. In the retina and tectum, the erythropoietin-producing hepatocellular (Eph) receptors and their ligands, the ephrins, are expressed in gradients. According to Sperry's chemoaffinity theory, gradients in both the source and target areas enable projecting axons to recognize their proper terminals, but how axons chemotactically decode their destinations is largely unknown...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28780190/targeting-eph-ephrin-system-in-cancer-therapy
#16
REVIEW
Alessio Lodola, Carmine Giorgio, Matteo Incerti, Ilaria Zanotti, Massimiliano Tognolini
It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of tumors, with a primary involvement in tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. Targeting the Eph/ephrin system with biologicals, including antibodies and recombinant proteins, reduces tumor growth in animal models of hematological malignancies, breast, prostate, colon, head and neck cancers and glioblastoma...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28777434/bifunctional-role-of-ephrin-a1-eph-system-in-stimulating-cell-proliferation-and-protecting-cells-from-cell-death-through-the-attenuation-of-er-stress-and-inflammatory-responses-in-bovine-mammary-epithelial-cells
#17
Minkyung Kang, Wooyoung Jeong, Hyocheol Bae, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Structural and functional development of the mammary gland is constant in the mammary gland life cycle. Eph receptors and their ligands, ephrins, control events through cell-to-cell interactions during embryonic development and adult tissue homeostasis; however, little information on participation of ephrin A1, a representative ligand of the Eph receptor, in the development and function of normal mammary glands is known. In this study, we demonstrated functional effects of the ephrin A1-Eph system and mechanisms of its action on bovine mammary epithelial (MAC-T) cells...
August 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28768156/the-syk-kinases-orchestrate-cerebellar-granule-cell-tangential-migration
#18
Aurélien Benon, Choua Ya, Laurent Martin, Chantal Watrin, Naura Chounlamountri, Iness Jaaoini, Jérôme Honnorat, Véronique Pellier-Monnin, Nelly Noraz
The tyrosine kinases of the Syk family are essential components of the well-characterized immunoreceptor ITAM-based signaling pathway. However, ITAM-based signaling typically does not function in isolation. Instead, it is enmeshed in the molecular network controlling cellular adhesion and chemotaxis. Consistent with the increasing number of data involving ITAM-bearing molecules in neuronal functions, we previously depicted a role for Syk kinases in the establishment of neuronal connectivity. In the developing cerebellum, we found that Syk is essentially expressed in the granule cells (GC) and more importantly, phosphorylated on tyrosine residues representative of an active form of the kinase in tangentially migrating GC...
July 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28761157/sorting-at-embryonic-boundaries-requires-high-heterotypic-interfacial-tension
#19
Laura Canty, Eleyine Zarour, Leily Kashkooli, Paul François, François Fagotto
The establishment of sharp boundaries is essential for segregation of embryonic tissues during development, but the underlying mechanism of cell sorting has remained unclear. Opposing hypotheses have been proposed, either based on global tissue adhesive or contractile properties or on local signalling through cell contact cues. Here we use ectoderm-mesoderm separation in Xenopus to directly evaluate the role of these various parameters. We find that ephrin-Eph-based repulsion is very effective at inducing and maintaining separation, whereas differences in adhesion or contractility have surprisingly little impact...
July 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28751189/targeted-therapies-in-hematological-malignancies-using-therapeutic-monoclonal-antibodies-against-eph-family-receptors
#20
REVIEW
Sara Charmsaz, Andrew M Scott, Andrew W Boyd
The use of monoclonal antibodies (mAbs) and molecules derived from them has achieved considerable attention and success in recent years, establishing this mode of therapy as an important therapeutic strategy in many cancers, in particular hematological tumors. mAbs recognize cell surface antigens expressed on target cells and mediate their function through various mechanisms such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, or immune system modulation. The efficacy of mAb therapy can be improved when they are conjugated to a highly potent payloads, including cytotoxic drugs and radiolabeled isotopes...
July 24, 2017: Experimental Hematology
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