keyword
MENU ▼
Read by QxMD icon Read
search

Eph

keyword
https://www.readbyqxmd.com/read/27899328/the-s48-45-six-cysteine-proteins-mediators-of-interaction-throughout-the-plasmodium-life-cycle
#1
REVIEW
Silvia A Arredondo, Stefan H I Kappe
During their life cycle Plasmodium parasites rely upon an arsenal of proteins that establish key interactions with the host or vector, and between the parasite sexual stages, with the purpose of ensuring infection, reproduction and proliferation. Among these is a group of secreted or membrane-anchored proteins known as the six-cysteine (6-cys) family. This is a small but important family with only 14 members thus far identified, each stage-specifically expressed during the parasite life cycle. 6-cys proteins often localise at the parasite surface or interface with the host and are conserved in different Plasmodium species...
November 27, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27887830/drugs-of-abuse-and-their-metabolites-in-the-urban-rivers-of-beijing-china-occurrence-distribution-and-potential-environmental-risk
#2
Yan Zhang, Tingting Zhang, Changsheng Guo, Jiapei Lv, Zhendong Hua, Song Hou, Yuan Zhang, Wei Meng, Jian Xu
The occurrence and distribution of five drugs of abuse and their metabolites, namely, methamphetamine (METH), amphetamine (AMP), ketamine (KET), ephedrine (EPH), and hydroxylimine (HY), were investigated in the surface water in urban rivers in Beijing, China. A total of 117 surface water samples were collected from the seven rivers in the Beijing urban areas during four different seasons. Laboratory analyses revealed that EPH and METH were the most predominant drugs, with detection frequency ranging from 94% to 100% and from 65% to 100%, respectively...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27887627/epha5-protein-a-potential-marker-for-distinguishing-histological-grade-and-prognosis-in-ovarian-serous-carcinoma
#3
Xiao Chen, Xuan Wang, Xue Wei, Jiandong Wang
BACKGROUND: Ovarian serous carcinoma (OSC) is the most common ovarian epithelial malignancy. Disregulation of Eph/ephrin signaling has been implicated in oncogenesis and tumor progression. EphA5 receptor is one of large families of Eph tyrosine kinase receptor and is documented in the development of nervous system. Till now, there is no published data about the role of EphA5 in ovarian epithelial neoplasmas. METHODS: This study aims to investigate the expression of EphA5 protein in ovarian serous carcinoma, and its relationship to clinical pathological characteristics...
November 25, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27869783/comparative-analysis-of-rnai-based-methods-to-down-regulate-expression-of-two-genes-expressed-at-different-levels-in-myzus-persicae
#4
Michaël Mulot, Sylvaine Boissinot, Baptiste Monsion, Maryam Rastegar, Gabriel Clavijo, David Halter, Nicole Bochet, Monique Erdinger, Véronique Brault
With the increasing availability of aphid genomic data, it is necessary to develop robust functional validation methods to evaluate the role of specific aphid genes. This work represents the first study in which five different techniques, all based on RNA interference and on oral acquisition of double-stranded RNA (dsRNA), were developed to silence two genes, ALY and Eph, potentially involved in polerovirus transmission by aphids. Efficient silencing of only Eph transcripts, which are less abundant than those of ALY, could be achieved by feeding aphids on transgenic Arabidopsis thaliana expressing an RNA hairpin targeting Eph, on Nicotiana benthamiana infected with a Tobacco rattle virus (TRV)-Eph recombinant virus, or on in vitro-synthesized Eph-targeting dsRNA...
November 19, 2016: Viruses
https://www.readbyqxmd.com/read/27868456/emergency-peripartum-hysterectomy-single-center-ten-year-experience
#5
Hüseyin Çağlayan Özcan, Mete Gurol Uğur, Özcan Balat, Neslihan Bayramoğlu Tepe, Seyhun Sucu
PURPOSE: The purpose of our study is to determine the incidence, risk factors, indications, outcomes, and complications of emergency peripartum hysterectomy (EPH) performed in a university hospital. METHODS: This retrospective study includes 54 cases of EPH performed at the department of obstetrics and gynecology of Gaziantep University Hospital between the years 2005-2015. We included all hysterectomy cases during the first 24 h after delivery beyond 20 weeks of gestation...
December 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27861585/cdc-42-orients-cell-migration-during-epithelial-intercalation-in-the-caenorhabditis-elegans-epidermis
#6
Elise Walck-Shannon, Bethany Lucas, Ian Chin-Sang, David Reiner, Kraig Kumfer, Hunter Cochran, William Bothfeld, Jeff Hardin
Cell intercalation is a highly directed cell rearrangement that is essential for animal morphogenesis. As such, intercalation requires orchestration of cell polarity across the plane of the tissue. CDC-42 is a Rho family GTPase with key functions in cell polarity, yet its role during epithelial intercalation has not been established because its roles early in embryogenesis have historically made it difficult to study. To circumvent these early requirements, in this paper we use tissue-specific and conditional loss-of-function approaches to identify a role for CDC-42 during intercalation of the Caenorhabditis elegans dorsal embryonic epidermis...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27825440/ephrinb1-ephb3b-coordinate-bidirectional-epithelial-mesenchymal-interactions-controlling-liver-morphogenesis-and-laterality
#7
Jordi Cayuso, Aliaksandr Dzementsei, Johanna C Fischer, Gopal Karemore, Sara Caviglia, Josefin Bartholdson, Gavin J Wright, Elke A Ober
Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric positioning of the zebrafish liver. EphrinB1 in hepatoblasts regulates directional migration and mediates interactions with the LPM, where EphB3b controls polarity and movement of the LPM...
November 7, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27825437/an-ephrin-eph-tug-and-push-in-left-right-organ-placement
#8
Leah Nantie, Xin Sun
During development, the placement of internal organs asymmetrically along the left-right axis is critical for their proper adult function. Reporting in Developmental Cell, Cayuso et al. (2016) demonstrate an active role of the endoderm in this process, challenging the prior view that the endoderm is passively pushed by the mesoderm.
November 7, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27811149/eph-receptor-tyrosine-kinases-in-tumor-immunity
#9
REVIEW
Eileen Shiuan, Jin Chen
The family of Eph receptor tyrosine kinases and their ephrin ligands regulate a diverse array of physiologic processes, such as axonal guidance, bone remodeling, and immune cell development and trafficking. Eph/ephrin interactions have also been implicated in various pathologic processes, including inflammation, cancer, and tumor angiogenesis. Because Eph receptors play prominent roles in both the immune system and cancer, they likely impact the tumor immune microenvironment, an area in which Eph receptors remain understudied...
November 3, 2016: Cancer Research
https://www.readbyqxmd.com/read/27810913/unidirectional-eph-ephrin-signaling-creates-a-cortical-actomyosin-differential-to-drive-cell-segregation
#10
Audrey K O'Neill, Abigail A Kindberg, Terren K Niethamer, Andrew R Larson, Hsin-Yi Henry Ho, Michael E Greenberg, Jeffrey O Bush
Cell segregation is the process by which cells self-organize to establish developmental boundaries, an essential step in tissue formation. Cell segregation is a common outcome of Eph/ephrin signaling, but the mechanisms remain unclear. In craniofrontonasal syndrome, X-linked mosaicism for ephrin-B1 expression has been hypothesized to lead to aberrant Eph/ephrin-mediated cell segregation. Here, we use mouse genetics to exploit mosaicism to study cell segregation in the mammalian embryo and integrate live-cell imaging to examine the underlying cellular and molecular mechanisms...
October 24, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27804871/the-sam-domain-of-epha2-receptor-and-its-relevance-to-cancer-a-novel-challenge-for-drug-discovery
#11
Flavia Mercurio, Marilisa Leone
BACKGROUND: Eph receptors play important functions in developmental processes and diseases and among them EphA2 is well known for its controversial role in cancer. Drug discovery strategies are mainly centered on EphA2 extracellular ligand-binding domain however, the receptor also contains a largely unexplored cytosolic Sam (Sterile alpha motif) domain at the C-terminus. EphA2-Sam binds the Sam domain from the lipid phosphatase Ship2 and the first Sam domain of Odin. Sam-Sam interactions may be important to regulate ligand-induced receptor endocytosis and degradation i...
November 1, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27788485/the-intrinsically-kinase-inactive-ephb6-receptor-predisposes-cancer-cells-to-dr5-induced-apoptosis-by-promoting-mitochondrial-fragmentation
#12
Amr M El Zawily, Behzad M Toosi, Tanya Freywald, Vijaya V Indukuri, Franco J Vizeacoumar, Scot C Leary, Andrew Freywald
Death Receptor 5 (DR5) is a promising target for cancer therapy due to its ability to selectively induce apoptosis in cancer cells. However, the therapeutic usefulness of DR5 agonists is currently limited by the frequent resistance of malignant tumours to its activation. The identification of molecular mechanisms that determine outcomes of DR5 action is therefore crucial for improving the efficiency of DR5-activating reagents in cancer treatment. Here, we provide evidence that an intrinsically kinase-inactive member of the Eph group of receptor tyrosine kinases, EPHB6, induces marked fragmentation of the mitochondrial network in breast cancer cells of triple-negative origin, lacking expression of the estrogen, progesterone and HER2 receptors...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27786587/eph-ective-control-of-cytokinesis
#13
Thomas Jungas, Arnaud Besson, Alice Davy
No abstract text is available yet for this article.
October 27, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27783670/dual-microrna-screens-reveal-that-the-immune-responsive-mir-181-promotes-henipavirus-entry-and-cell-cell-fusion
#14
Chwan Hong Foo, Christina L Rootes, Karla Cowley, Glenn A Marsh, Cathryn M Gould, Celine Deffrasnes, Christopher J Cowled, Reuben Klein, Sarah J Riddell, Deborah Middleton, Kaylene J Simpson, Lin-Fa Wang, Andrew G D Bean, Cameron R Stewart
Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are bat-borne viruses that cause fatal disease in humans and a range of other mammalian species. Gaining a deeper understanding of host pathways exploited by henipaviruses for infection may identify targets for new anti-viral therapies. Here we have performed genome-wide high-throughput agonist and antagonist screens at biosafety level 4 to identify host-encoded microRNAs (miRNAs) impacting henipavirus infection in human cells. Members of the miR-181 and miR-17~93 families strongly promoted Hendra virus infection...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27776928/the-sam-domain-inhibits-epha2-interactions-in-the-plasma-membrane
#15
Deo R Singh, Fozia Ahmed, Michael D Paul, Manasee Gedam, Elena B Pasquale, Kalina Hristova
All members of the Eph receptor family of tyrosine kinases contain a SAM domain near the C terminus, which has been proposed to play a role in receptor homotypic interactions and/or interactions with binding partners. The SAM domain of EphA2 is known to be important for receptor function, but its contribution to EphA2 lateral interactions in the plasma membrane has not been determined. Here we use a FRET-based approach to directly measure the effect of the SAM domain on the stability of EphA2 dimers on the cell surface in the absence of ligand binding...
October 21, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27775163/functional-roles-of-eph-a-ephrin-a1-system-in-endometrial-luminal-epithelial-cells-during-early-pregnancy
#16
Whasun Lim, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
Eph and ephrin regulate diverse biological events such as proliferation, adhesion, migration, and angiogenesis through cell-to-cell interactions. However, little is known of their functional role and mechanisms of action in uterine endometrial cells. In the present study, we demonstrated the effects of the Eph and ephrin on interactions between blastocysts and endometrial luminal epithelial (pLE) cells in the pig that is regarded as an excellent biomedical animal model for research on the peri-implantation period of pregnancy...
October 24, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27756445/effect-of-task-specific-training-on-eph-ephrin-expression-after-stroke
#17
Dong-Hee Choi, Jin-Hee Ahn, In-Ae Choi, Ji-Hye Kim, Bo-Ram Kim, Jongmin Lee
Recent evidence indicates that the ephrin receptors and ephrin ligands (Eph/ephrin) expression modulates axonal reorganization and synaptic plasticity in stroke recovery. To investigate the effect of task-specific training (TST) on Eph/ephrin expression in the corticospinal tract (CST) after stroke, we compared Eph/ephrin expression in the peri-infarct cortex, pyramid, and spinal cord of the photothrombotic stroke rats treated with or without TST. The TST treatment showed significantly better recovery in the behavioral tests...
October 19, 2016: BMB Reports
https://www.readbyqxmd.com/read/27742560/regulation-of-endothelial-migration-and-proliferation-by-ephrin-a1
#18
Elisa Wiedemann, Stefanie Jellinghaus, Georg Ende, Antje Augstein, Ronny Sczech, Ben Wielockx, Sönke Weinert, Ruth H Strasser, David M Poitz
Endothelial migration and proliferation are fundamental processes in angiogenesis and wound healing of injured or inflamed vessels. The present study aimed to investigate the regulation of the Eph/ephrin-system during endothelial proliferation and the impact of the ligand ephrin-A1 on proliferation and migration of human umbilical venous (HUVEC) and arterial endothelial cells (HUAEC). Endothelial cells that underwent contact inhibition showed a massive induction of ephrin-A1. In contrast, an injury to a confluent endothelial layer, associated with induction of migration and proliferation, showed reduced ephrin-A1 levels...
October 11, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27733818/expression-patterns-of-extracellular-matrix-proteins-during-posterior-commissure-development
#19
Karen Stanic, Natalia Saldivia, Benjamín Förstera, Marcela Torrejón, Hernán Montecinos, Teresa Caprile
Extracellular matrix (ECM) molecules are pivotal for central nervous system (CNS) development, facilitating cell migration, axonal growth, myelination, dendritic spine formation, and synaptic plasticity, among other processes. During axon guidance, the ECM not only acts as a permissive or non-permissive substrate for navigating axons, but also modulates the effects of classical guidance cues, such as netrin or Eph/ephrin family members. Despite being highly important, little is known about the expression of ECM molecules during CNS development...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27721104/modelling-of-opnmr-phenomena-using-photon-energy-dependent-%C3%A2-sz%C3%A2-%C2%AA-in-gaas-and-inp
#20
Dustin D Wheeler, Matthew M Willmering, Erika L Sesti, Xingyuan Pan, Dipta Saha, Christopher J Stanton, Sophia E Hayes
We have modified the model for optically-pumped NMR (OPNMR) to incorporate a revised expression for the expectation value of the z-projection of the electron spin, 〈Sz〉 and apply this model to both bulk GaAs and a new material, InP. This expression includes the photon energy dependence of the electron polarization when optically pumping direct-gap semiconductors in excess of the bandgap energy, Eg. Rather than using a fixed value arising from coefficients (the matrix elements) for the optical transitions at the k=0 bandedge, we define a new parameter, Sopt(Eph)...
September 29, 2016: Journal of Magnetic Resonance
keyword
keyword
16920
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"