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https://www.readbyqxmd.com/read/28819830/identification-and-characterization-of-tyrosine-kinases-in-anole-lizard-indicate-the-conserved-tyrosine-kinase-repertoire-in-vertebrates
#1
Ake Liu, Funan He, Xun Gu
The tyrosine kinases (TKs) play principal roles in regulation of multicellular aspects of the organism and are implicated in many cancer types and congenital disorders. The anole lizard has recently been introduced as a model organism for laboratory-based studies of organismal function and field studies of ecology and evolution. However, the TK family of anole lizard has not been systematically identified and characterized yet. In this study, we identified 82 TK-encoding genes in the anole lizard genome and classified them into 28 subfamilies through phylogenetic analysis, with no member from ROS and STYK1 subfamilies identified...
August 17, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28808385/anti-inflammatory-effect-of-etlingera-pavieana-pierre-ex-gagnep-r-m-sm-rhizomal-extract-and-its-phenolic-compounds-in-lipopolysaccharide-stimulated-macrophages
#2
Ekaruth Srisook, Mullika Palachot, Sakulrat Mankhong, Klaokwan Srisook
BACKGROUND: In our continuing search for anti-inflammatory agents from Thai herbs, Etlingera pavieana (Pierre ex Gagnep.) R.M.Sm. showed potent inhibition on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophages. However, the mechanism behind its inhibitory effect has not been yet explored, and little is known regarding its bioactive compounds responsible for the anti-inflammatory effect. OBJECTIVE: In the present study, anti-inflammatory effect of hexane, ethyl acetate, and water fractions of rhizomal ethanol extracts of E...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28804916/lane-s-disease-erythema-palmare-hereditarium-a-report-of-five-cases-and-a-review-of-the-literature
#3
Carlotta Gurioli, Annalisa Patrizi, Martina Lambertini, Iria Neri
BACKGROUND: Erythema palmare hereditarium (EPH), also known as Lane's disease, is a rare, benign condition presenting as persistent erythema involving the palms. EPH can appear at birth or later in life and usually in at least two members of the same family, although a sporadic case has been reported. METHODS: We report five cases of EPH and offer a review of the current literature. The first and second cases are twin boys presenting with erythema mainly on the thenar and hypothenar eminences and on the phalanges that appeared 8 months after birth...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28801142/synergistic-experimental-and-numerical-characterization-of-a-dry-heat-fluid-warming-device
#4
Winston Tan, Eph M Sparrow, John M Gorman, Jungwon Ahn
Fluids that are infused into the human body must be at a temperature that is compatible with the internal thermal state of the body. Since infusants are typically stored at temperatures that are too low for compatibility, a heating means is required to achieve the appropriate infusion temperature. This paper sets forth a synergistic investigation involving coupled experimentation and numerical simulation of the characteristics of one of the main categories of body-fluid heating means. The methodology developed here serves equally well as a design optimization tool...
August 8, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28800788/mir-204-regulates-cell-proliferation-and-invasion-by-targeting-ephb2-in-human-cervical-cancer
#5
Shanhong Duan, Ali Wu, Zhengyu Chen, Yarong Yang, Liying Liu, Qi Shu
MicroRNAs (miRNAs) are small non-coding RNAs that involved in human carcinogenesis and progression. miR-204 has been reported to be a tumor suppressor in several cancer types. However, the function and underlying molecular mechanism of miR-204 in cervical cancer (CC) are still unclear. In the present study, the expression level of miR-204 was measured using qRT-PCR method in 30 paired CC clinical samples and 6 CC cell lines. We found that the expression of miR-204 was significantly down-regulated in CC tissues and cell lines compared to normal cervical tissues and cell line...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28792499/revisiting-chemoaffinity-theory-chemotactic-implementation-of-topographic-axonal-projection
#6
Honda Naoki
Neural circuits are wired by chemotactic migration of growth cones guided by extracellular guidance cue gradients. How growth cone chemotaxis builds the macroscopic structure of the neural circuit is a fundamental question in neuroscience. I addressed this issue in the case of the ordered axonal projections called topographic maps in the retinotectal system. In the retina and tectum, the erythropoietin-producing hepatocellular (Eph) receptors and their ligands, the ephrins, are expressed in gradients. According to Sperry's chemoaffinity theory, gradients in both the source and target areas enable projecting axons to recognize their proper terminals, but how axons chemotactically decode their destinations is largely unknown...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28780190/targeting-eph-ephrin-system-in-cancer-therapy
#7
REVIEW
Alessio Lodola, Carmine Giorgio, Matteo Incerti, Ilaria Zanotti, Massimiliano Tognolini
It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of tumors, with a primary involvement in tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. Targeting the Eph/ephrin system with biologicals, including antibodies and recombinant proteins, reduces tumor growth in animal models of hematological malignancies, breast, prostate, colon, head and neck cancers and glioblastoma...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28777434/bifunctional-role-of-ephrin-a1-eph-system-in-stimulating-cell-proliferation-and-protecting-cells-from-cell-death-through-the-attenuation-of-er-stress-and-inflammatory-responses-in-bovine-mammary-epithelial-cells
#8
Minkyung Kang, Wooyoung Jeong, Hyocheol Bae, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Structural and functional development of the mammary gland is constant in the mammary gland life cycle. Eph receptors and their ligands, ephrins, control events through cell-to-cell interactions during embryonic development and adult tissue homeostasis; however, little information on participation of ephrin A1, a representative ligand of the Eph receptor, in the development and function of normal mammary glands is known. In this study, we demonstrated functional effects of the ephrin A1-Eph system and mechanisms of its action on bovine mammary epithelial (MAC-T) cells...
August 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28768156/the-syk-kinases-orchestrate-cerebellar-granule-cell-tangential-migration
#9
Aurélien Benon, Choua Ya, Laurent Martin, Chantal Watrin, Naura Chounlamountri, Iness Jaaoini, Jérôme Honnorat, Véronique Pellier-Monnin, Nelly Noraz
The tyrosine kinases of the Syk family are essential components of the well-characterized immunoreceptor ITAM-based signaling pathway. However, ITAM-based signaling typically does not function in isolation. Instead, it is enmeshed in the molecular network controlling cellular adhesion and chemotaxis. Consistent with the increasing number of data involving ITAM-bearing molecules in neuronal functions, we previously depicted a role for Syk kinases in the establishment of neuronal connectivity. In the developing cerebellum, we found that Syk is essentially expressed in the granule cells (GC) and more importantly, phosphorylated on tyrosine residues representative of an active form of the kinase in tangentially migrating GC...
July 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28761157/sorting-at-embryonic-boundaries-requires-high-heterotypic-interfacial-tension
#10
Laura Canty, Eleyine Zarour, Leily Kashkooli, Paul François, François Fagotto
The establishment of sharp boundaries is essential for segregation of embryonic tissues during development, but the underlying mechanism of cell sorting has remained unclear. Opposing hypotheses have been proposed, either based on global tissue adhesive or contractile properties or on local signalling through cell contact cues. Here we use ectoderm-mesoderm separation in Xenopus to directly evaluate the role of these various parameters. We find that ephrin-Eph-based repulsion is very effective at inducing and maintaining separation, whereas differences in adhesion or contractility have surprisingly little impact...
July 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28751189/targeted-therapies-in-hematological-malignancies-using-therapeutic-monoclonal-antibodies-against-eph-family-receptors
#11
REVIEW
Sara Charmsaz, Andrew M Scott, Andrew W Boyd
The use of monoclonal antibodies and molecules derived from them has achieved considerable attention and success in recent years establishing this mode of therapy as important therapeutic strategy in many cancers and in particular in hematological tumors. Monoclonal antibodies recognize cell surface antigens expressed on target cells and mediate their function through various mechanisms, such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity or by modulating the immune system. The efficacy of monoclonal antibody therapy can be improved when conjugates to a highly potent payloads including cytotoxic drugs and radiolabelled isotopes...
July 24, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28747680/glycoengineering-of-epha4-fc-leads-to-a-unique-long-acting-and-broad-spectrum-eph-receptor-therapeutic-antagonist
#12
Cassandra L Pegg, Leanne T Cooper, Jing Zhao, Michael Gerometta, Fiona M Smith, Michael Yeh, Perry F Bartlett, Jeffrey J Gorman, Andrew W Boyd
Eph receptors have emerged as targets for therapy in both neoplastic and non-neoplastic disease, however, particularly in non-neoplastic diseases, redundancy of function limits the effectiveness of targeting individual Eph proteins. We have shown previously that a soluble fusion protein, where the EphA4 ectodomain was fused to IgG Fc (EphA4 Fc), was an effective therapy in acute injuries and demonstrated that EphA4 Fc was a broad spectrum Eph/ephrin antagonist. However, a very short in vivo half-life effectively limited its therapeutic development...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747399/cell-segregation-and-border-sharpening-by-eph-receptor-ephrin-mediated-heterotypic-repulsion
#13
Harriet B Taylor, Anaïs Khuong, Zhonglin Wu, Qiling Xu, Rosalind Morley, Lauren Gregory, Alexei Poliakov, William R Taylor, David G Wilkinson
Eph receptor and ephrin signalling has a major role in cell segregation and border formation, and may act through regulation of cell adhesion, repulsion or tension. To elucidate roles of cell repulsion and adhesion, we combined experiments in cell culture assays with quantitations of cell behaviour which are used in computer simulations. Cells expressing EphB2, or kinase-inactive EphB2 (kiEphB2), segregate and form a sharp border with ephrinB1-expressing cells, and this is disrupted by knockdown of N-cadherin...
July 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28739735/knockdown-of-epha1-using-crispr-cas9-suppresses-aggressive-properties-of-ovarian-cancer-cells
#14
Yuxin Cui, B O Wu, Valentina Flamini, Bronwen A J Evans, Deshan Zhou, Wen G Jiang
BACKGROUND/AIM: Overexpression of erythropoietin-producing hepatocellular A1 (EPHA1), a member of the EPH super family, is frequently observed in various cancer types. The dysregulated interaction of EPHA1 with its ligand Ephrin A1 has been linked to the progression of ovarian cancer (OC). However, the contribution of EPHA1 in the regulation of the aggressive properties of OC cells remains unknown. MATERIALS AND METHODS: In this study we investigated the differential expression of EPHA1 in human OC cells...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738630/simultaneous-determination-of-paracetamol-and-ciprofloxacin-in-biological-fluid-samples-using-a-glassy-carbon-electrode-modified-with-graphene-oxide-and-nickel-oxide-nanoparticles
#15
Anderson Martin Santos, Ademar Wong, Adriana Araújo Almeida, Orlando Fatibello-Filho
A simple and highly selective electrochemical method using a glassy carbon electrode (GCE) modified with graphene oxide (GO) and nickel oxide nanoparticles (NiONPs) was developed for the simultaneous determination of paracetamol (PAR) and ciprofloxacin (CIP). The electrochemical characterisation of the modified GCE was performed by cyclic voltammetry and electrochemical impedance spectroscopy. The morphological characterisation of the GO and NiONPs was performed by scanning electron microscopy and transmission electron microscopy...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28701025/epidemiology-of-hepatic-encephalopathy-in-german-hospitals-the-ephe-study
#16
Christian Labenz, Marcus-Alexander Wörns, Jörn M Schattenberg, Yvonne Huber, Peter Robert Galle, Joachim Labenz
Background Hepatic encephalopathy (HE) is a serious complication of liver cirrhosis. The proportion of patients with liver cirrhosis attending German hospitals suffering from HE is unknown. Methods In the first part of the study, data of 14 community hospitals and 5 university hospitals covering the years 2010 and 2011 were analyzed retrospectively for the DRG codes of liver cirrhosis and hepatic encephalopathy. In the second prospective part of the multicenter observational study, all patients with liver cirrhosis attending the departments of gastroenterology of 16 participating community hospitals within a study period of 3 months were included and screened for HE clinically according to the West Haven criteria (grades 1 - 4)...
July 12, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28698029/critical-role-of-epha4-in-early-brain-injury-after-subarachnoid-hemorrhage-in-rat
#17
Ruiming Fan, Budbazar Enkhjargal, Richard Camara, Feng Yan, Lei Gong, ShengtaoYao, Jiping Tang, Yangmei Chen, John H Zhang
Early brain injury (EBI) is reported as a primary cause of mortality in subarachnoid hemorrhage (SAH) patients. Eph receptor A4 (EphA4) has been associated with blood-brain barrier integrity and pro-apoptosis. We aimed to investigate a role of EphA4 in EBI after SAH. One hundred and seventy-nine male adult Sprague-Dawley rats were randomly divided into sham versus endovascular perforation model of SAH groups. SAH grade, neurological score, Evans blue dye extravasation, brain water content, mortality, Fluoro-Jade staining, immunofluorescence staining, and western blot experiments were performed after SAH...
July 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28694447/impacts-of-early-life-stress-on-the-methylome-and-transcriptome-of-atlantic-salmon
#18
Hooman K Moghadam, Hanne Johnsen, Nicholas Robinson, Øivind Andersen, Even H Jørgensen, Helge K Johnsen, Vegar J Bæhr, Helge Tveiten
Exposure to environmental stressors during early-life stages can change the rate and timing of various developmental processes. Epigenetic marks affecting transcriptional regulation can be altered by such environmental stimuli. To assess how stress might affect the methylome and transcriptome in salmon, fish were treated using cold-shock and air-exposure from the eye-stage until start-feeding. The fish were either stressed prior to hatching (E), post-hatching (PH), pre- and post-hatching (EPH) or not stressed (CO)...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692132/plasma-protein-electrophoresis-as-a-prognostic-indicator-in-aspergillus-species-infected-gentoo-penguins-pygoscelis-papua-papua
#19
Adam D Naylor, Simon J Girling, Donna Brown, Claire G Crompton, Romain Pizzi
BACKGROUND: Avian aspergillosis presents a significant threat to captive penguin populations. Currently, a lack of objective prognostic factors limits disease staging, objective reassessment throughout treatment, comparative evaluation of treatment regimes, and appropriate timing of euthanasia. OBJECTIVE: The study objective was to investigate absolute and relative plasma protein fractions by agarose gel electrophoresis (EPH) as predictors of survival in Gentoo penguins (Pygoscelis papua papua) under treatment for aspergillosis...
July 10, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28686668/molecular-interactions-of-epha4-growth-hormone-receptor-janus-kinase-2-and-signal-transducer-and-activator-of-transcription-5b
#20
Takahiro Sawada, Daiki Arai, Xuefeng Jing, Masayasu Miyajima, Stuart J Frank, Kazushige Sakaguchi
We previously reported that EphA4, a member of the Eph family of receptor tyrosine kinases, is an important modulator of growth hormone (GH) signaling, leading to augmented synthesis of insulin-like growth factor 1 (IGF1) for postnatal body growth. In the present study, we report the molecular interactions of EphA4, GH receptor (GHR), Janus kinase 2 (JAK2), and signal transducer and activator of transcription 5B (STAT5B). EphA4 binds to GHR at both its extracellular and intracellular domains and phosphorylates GHR when stimulated with a ligand...
2017: PloS One
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