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https://www.readbyqxmd.com/read/29158322/optogenetic-activation-of-ephb2-receptor-in-dendrites-induced-actin-polymerization-by-activating-arg-kinase
#1
Clifford Locke, Kazuya Machida, Yi Wu, Ji Yu
Erythropoietin-producing hepatocellular (Eph) receptors regulate a wide array of developmental processes by responding to cell-cell contacts. EphB2 is well-expressed in brain and known to be important for dendritic spine development, as well as for the maintenance of the synapses, although the mechanisms of these functions have not been fully understood. Here we studied EphB2's functions in hippocampal neurons with an optogenetic approach, which allows us to specify spatial regions of signal activation and monitor in real-time the consequences of signal activation...
November 20, 2017: Biology Open
https://www.readbyqxmd.com/read/29143864/correction-to-cell-type-specific-localization-of-ephs-pairing-with-ephrin-b2-in-the-rat-postnatal-pituitary-gland
#2
Saishu Yoshida, Takako Kato, Naoko Kanno, Naoto Nishimura, Hiroto Nishihara, Kotaro Horiguchi, Yukio Kato
The published online version contains mistakes in Table 1, Table 2 and Fig. 2. See below for the corrected Tables and Figure.
November 16, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29137214/eph-receptors-as-oncotargets
#3
EDITORIAL
Sara Charmsaz, Andrew W Boyd
No abstract text is available yet for this article.
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133876/eph-b4-regulates-adaptive-venous-remodeling-to-improve-arteriovenous-fistula-patency
#4
Clinton D Protack, Trenton R Foster, Takuya Hashimoto, Kota Yamamoto, Monica Y Lee, Jan R Kraehling, Hualong Bai, Haidi Hu, Toshihiko Isaji, Jeans M Santana, Mo Wang, William C Sessa, Alan Dardik
Low rates of arteriovenous fistula (AVF) maturation prevent optimal fistula use for hemodialysis; however, the mechanism of venous remodeling in the fistula environment is not well understood. We hypothesized that the embryonic venous determinant Eph-B4 mediates AVF maturation. In human AVF and a mouse aortocaval fistula model, Eph-B4 protein expression increased in the fistula vein; expression of the arterial determinant Ephrin-B2 also increased. Stimulation of Eph-B-mediated signaling with Ephrin-B2/Fc showed improved fistula patency with less wall thickness...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131996/development-and-application-of-the-diffusive-gradients-in-thin-films-technique-for-simultaneous-measurement-of-methcathinone-and-ephedrine-in-surface-river-water
#5
Yan Zhang, Tingting Zhang, Changsheng Guo, Song Hou, Zhendong Hua, Jiapei Lv, Yuan Zhang, Jian Xu
In this study, a passive sampling technique, diffusive gradients in thin films (DGT) was developed to simultaneously measure two drugs, methcathinone (MC) and ephedrine (EPH) in surface water. Four types of binding gels and four types of filter membranes were tested for the optimal configuration. XAD18 agarose binding gel and agarose diffusive gel, together with polyethersulfone filter membrane were used for measuring MC and EPH in the DGT device. 5% NH3 in acetonitrile was used as the elution solvent, with the elution efficiency for MC and EPH higher than 71%...
November 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29129483/pharmacological-evaluation-of-new-bioavailable-small-molecules-targeting-eph-ephrin-interaction
#6
Carmine Giorgio, Matteo Incerti, Miriam Corrado, Marco Rusnati, Paola Chiodelli, Simonetta Russo, Donatella Callegari, Francesca Ferlenghi, Vigilio Ballabeni, Elisabetta Barocelli, Alessio Lodola, Massimiliano Tognolini
Eph/ephrin system is an emerging target for cancer therapy but the lack of potent, stable and orally bioavailable compounds is impairing the development of the field. Since 2009 our research group has been devoted to the discovery and development of small molecules targeting Eph/ephrin system and our research culminated with the synthesis of UniPR129, a potent but problematic Eph/ephrin antagonist. Herein, we describe the in vitro pharmacological properties of two derivatives (UniPR139 and UniPR502) stemmed from structure of UniPR129...
November 9, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29128632/genome-wide-mapping-of-estrogen-receptor-%C3%AE-binding-sites-by-chip-seq-to-identify-genes-related-to-sexual-maturity-in-hens
#7
Miao Guo, Yi Li, Yuxia Chen, Xiaoli Guo, Zhenjie Yuan, Yunliang Jiang
In ovarian follicle development, estrogen acts as a regulatory molecule to mediate proliferation and differentiation of follicular cells. ERα (estrogen receptor α) exerts regulatory function classically by binding directly to the estrogen response element, recruiting co-factors and activating or repressing transcription in response to E2. In this study, we used ChIP-seq to map ERα-binding sites in ovaries of Hy-line Brown commercial hens at 45d, 90d and 160d. In total, 24,886, 21,680 and 23,348 binding sites were identified in the ovaries of hens at 45d, 90d and 160d, which are linked to 86, 83 and 74 genes, respectively...
November 8, 2017: Gene
https://www.readbyqxmd.com/read/29127057/quantitative-analysis-of-clonidine-and-ephedrine-by-a-microfluidic-system-on-chip-electromembrane-extraction-followed-by-high-performance-liquid-chromatography
#8
Mahroo Baharfar, Yadollah Yamini, Shahram Seidi, Monireh Karami
In this work, a microfluidic device was developed for on-chip electromembrane extraction of trace amounts of ephedrine (EPH) and clonidine (CLO) in human urine and plasma samples followed by HPLC-UV analysis. Two polymethylmethacrylate plates were used as substrates and a microchannel was carved in each plate. The microchannel channel on the underneath plate provided the flow pass of the sample solution and the one on the upper plate dedicated to a compartment for the stagnant acceptor phase. A piece of polypropylene sheet was impregnated by an organic solvent and mounted between the two parts of the chip device...
November 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29120470/modulation-of-cellular-polarization-and-migration-by-ephrin-eph-signal-mediated-boundary-formation
#9
Sahar Javaherian, Elisa D'Arcangelo, Benjamin Slater, Camila Londono, Bin Xu, Alison P McGuigan
Compartment boundaries are essential for ensuring proper cell organization during embryo development and in adult tissues, yet the mechanisms underlying boundary establishment are not completely understood. A number of mechanisms, including (i) differential adhesion, (ii) differential tension, and (iii) cell signaling-mediated cell repulsion, are known to contribute and likely a context-dependent balance of each of these dictates boundary implementation. The ephrin/Eph signaling pathway is known to impact boundary formation in higher animals...
November 9, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29113248/gene-expression-profile-comparison-between-colorectal-cancer-and-adjacent-normal-tissues
#10
Qian Yang, Maohui Feng, Xiang Ma, Huachi Li, Wei Xie
The present study aimed to compare gene expression profiles between colorectal cancer and adjacent normal tissues, and to perform a preliminarily analysis of the key genes and underlying molecular mechanisms implicated in colorectal cancer development. Gene expression microarray chips were used to screen genes that were differently expressed between colorectal cancer and adjacent normal tissues. Approximately 1,183 genes were differentially expressed in cancer tissues compared with adjacent normal tissues (P≤0...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29091719/correction-sensory-neuron-derived-eph-regulates-glomerular-arbors-and-modulatory-function-of-a-central-serotonergic-neuron
#11
Ajeet Pratap Singh, Rudra Nayan Das, Gururaj Rao, Aman Aggarwal, Soeren Diegelmann, Jan Felix Evers, Hrishikesh Karandikar, Matthias Landgraf, Veronica Rodrigues, K VijayRaghavan
[This corrects the article DOI: 10.1371/journal.pgen.1003452.].
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29059157/ephrinb1-promotes-cancer-cell-migration-and-invasion-through-the-interaction-with-rhogdi1
#12
H J Cho, Y-S Hwang, J Yoon, M Lee, H G Lee, I O Daar
Eph receptors and their corresponding ephrin ligands have been associated with regulating cell-cell adhesion and motility, and thus have a critical role in various biological processes including tissue morphogenesis and homeostasis, as well as pathogenesis of several diseases. Aberrant regulation of Eph/ephrin signaling pathways is implicated in tumor progression of various human cancers. Here, we show that a Rho family GTPase regulator, Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1), can interact with ephrinB1, and this interaction is enhanced upon binding the extracellular domain of the cognate EphB2 receptor...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29039721/a-recurrent-splice-site-mutation-in-epha2-causing-congenital-posterior-nuclear-cataract
#13
Vanita Berry, Nikolas Pontikos, Monica Albarca-Aguilera, Vincent Plagnol, Andreas Massouras, DeQuincy Prescott, Anthony T Moore, Gavin Arno, Michael E Cheetham, Michel Michaelides
Intoduction: Inherited cataract, opacification of the lens, is the most common worldwide cause of blindness in children. We aimed to identify the genetic cause of autosomal dominant (AD) posterior nuclear cataract in a four generation British family. METHODS: Whole genome sequence (WGS) was performed on two affected and one unaffected individual of the family and further validated by direct sequencing. Haplotype analysis was performed via genotying. RESULTS: A splice-site mutation c...
October 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29034014/improving-the-outcome-of-vein-grafts-should-vascular-surgeons-turn-veins-into-arteries
#14
REVIEW
Toshihiko Isaji, Takuya Hashimoto, Kota Yamamoto, Jeans M Santana, Bogdan Yatsula, Haidi Hu, Hualong Bai, Guo Jianming, Tambudzai Kudze, Toshiya Nishibe, Alan Dardik
Autogenous vein grafts remain the gold standard conduit for arterial bypass, particularly for the treatment of critical limb ischemia. Vein graft adaptation to the arterial environment, i.e., adequate dilation and wall thickening, contributes to the superior performance of vein grafts. However, abnormal venous wall remodeling with excessive neointimal hyperplasia commonly causes vein graft failure. Since the PREVENT trials failed to improve vein graft outcomes, new strategies focus on the adaptive response of the venous endothelial cells to the post-surgical arterial environment...
March 24, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29031500/transcription-and-signaling-regulators-in-developing-neuronal-subtypes-of-mouse-and-human-enteric-nervous-system
#15
Fatima Memic, Viktoria Knoflach, Khomgrit Morarach, Rebecca Sadler, Catia Laranjeira, Jens Hjerling-Leffler, Erik Sundström, Vassilis Pachnis, Ulrika Marklund
BACKGROUND AND AIMS: The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity is created within the embryonic ENS-information required for development of cell-based therapies and models of enteric neuropathies. We aimed to identify proteins that regulate ENS differentiation and network formation. METHODS: We generated and compared RNA expression profiles of the entire ENS, ENS progenitor cells, and non-ENS gut cells of mice, collected at embryonic days 11...
October 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29028233/ethics-in-public-health-call-for-shared-moral-public-health-literacy
#16
Els L M Maeckelberghe, Peter Schröder-Bäck
Public Health (PH) in Europe has become much more vocal about its moral understandings since 1992. The rising awareness that PH issues were inseparable from issues of human rights and social justice almost self-evidently directed the agenda of EUPHA and the European Public Health (EPH)-conferences. Problems of cultural and behavioural change, and environmental issues on a global scale were also added. The Section Ethics in PH invited the EPH community to join in 'arm chair thinking': coming together at conferences not only to share the 'how' and 'what' of PH research, practices and policies but also the 'why'...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29023004/selection-of-drought-tolerant-maize-hybrids-using-path-coefficient-analysis-and-selection-index
#17
Abdalla Dao, Jacob Sanou, Edgar V S Traore, Vernon Gracen, Eric Y Danquah
BACKGROUND: In drought-prone environments, direct selection for yield is not adequate because of the variable environment and genotype x environment interaction. Therefore, the use of secondary traits in addition to yield has been suggested. The relative usefulness of secondary traits as indirect selection criteria for maize grain yield is determined by the magnitudes of their genetic variance, heritability and genetic correlation with the grain yield. MATERIALS AND METHODS: Forty eight testcross hybrids derived from lines with different genetic background and geographical origins plus 7 checks were evaluated in both well-watered and water-stressed conditions over two years for grain yield and secondary traits to determine the most appropriate secondary traits and select drought tolerant hybrids...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28993206/targeting-receptor-tyrosine-kinase-ephb4-in-cancer-therapy
#18
REVIEW
Yinnan Chen, Hongmei Zhang, Yanmin Zhang
Eph receptors and their Eph receptor-interacting (ephrin) ligands together form an important cell communication system with diverse roles. Experimental evidence demonstrated Eph receptor bidirectional signaling with both tumor-suppressing and tumor-promoting activities in cancer cells. The tyrosine kinase EphB4, a member of the Eph receptor family, has been associated with tumor angiogenesis, growth and metastasis, thus making it a valuable and attractive target for drug design for therapeutic applications...
October 6, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28985758/pharmacological-targeting-of-the-ephrin-receptor-kinase-signalling-by-glpg1790-in-vitro-and-in-vivo-reverts-oncophenotype-induces-myogenic-differentiation-and-radiosensitizes-embryonal-rhabdomyosarcoma-cells
#19
Francesca Megiorni, Giovanni Luca Gravina, Simona Camero, Simona Ceccarelli, Andrea Del Fattore, Vincenzo Desiderio, Federica Papaccio, Heather P McDowell, Rajeev Shukla, Antonio Pizzuti, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Ellen Van der Aar, Roberto Maggio, Francesca De Felice, Cinzia Marchese, Carlo Dominici, Vincenzo Tombolini, Claudio Festuccia, Francesco Marampon
BACKGROUND: EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell lines. METHODS: EPH-A2 and Ephrin-A1 mRNA expression was quantified by real-time PCR in 14 ERMS tumour samples and in normal skeletal muscle (NSM). GLPG1790 effects were tested in RD and TE671 cell lines, two in vitro models of ERMS, by performing flow cytometry analysis, Western blotting and immunofluorescence experiments...
October 6, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28985269/impact-of-the-national-essential-public-health-services-policy-on-hypertension-control-in-china
#20
Donglan Zhang, Xi Pan, Shukai Li, Di Liang, Zhiyuan Hou, Yan Li, Lu Shi
BACKGROUND: Hypertension remains a severe challenge to population health worldwide. This study assessed the impact of a nationwide program in China-Essential Public Health Services (EPHS) on improvement of hypertension treatment and control. METHODS: A cohort of hypertensive patients was identified from the 2011-2013 China Health and Retirement Longitudinal Study. Hypertension was defined based on: (i) an average systolic blood pressure of ≥140 mm Hg, and/or an average diastolic blood pressure of ≥90 mm Hg; and/or (ii) currently taking antihypertensive medications...
August 23, 2017: American Journal of Hypertension
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