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Dong-Hee Choi, Jin-Hee Ahn, In-Ae Choi, Ji-Hye Kim, Bo-Ram Kim, Jongmin Lee
Recent evidence indicates that the ephrin receptors and ephrin ligands (Eph/ephrin) expression modulates axonal reorganization and synaptic plasticity in stroke recovery. To investigate the effect of task-specific training (TST) on Eph/ephrin expression in the corticospinal tract (CST) after stroke, we compared Eph/ephrin expression in the peri-infarct cortex, pyramid, and spinal cord of the photothrombotic stroke rats treated with or without TST. The TST treatment showed significantly better recovery in the behavioral tests...
October 19, 2016: BMB Reports
Elisa Wiedemann, Stefanie Jellinghaus, Georg Ende, Antje Augstein, Ronny Sczech, Ben Wielockx, Sönke Weinert, Ruth H Strasser, David M Poitz
Endothelial migration and proliferation are fundamental processes in angiogenesis and wound healing of injured or inflamed vessels. The present study aimed to investigate the regulation of the Eph/ephrin-system during endothelial proliferation and the impact of the ligand ephrin-A1 on proliferation and migration of human umbilical venous (HUVEC) and arterial endothelial cells (HUAEC). Endothelial cells that underwent contact inhibition showed a massive induction of ephrin-A1. In contrast, an injury to a confluent endothelial layer, associated with induction of migration and proliferation, showed reduced ephrin-A1 levels...
October 11, 2016: Cellular Signalling
Karen Stanic, Natalia Saldivia, Benjamín Förstera, Marcela Torrejón, Hernán Montecinos, Teresa Caprile
Extracellular matrix (ECM) molecules are pivotal for central nervous system (CNS) development, facilitating cell migration, axonal growth, myelination, dendritic spine formation, and synaptic plasticity, among other processes. During axon guidance, the ECM not only acts as a permissive or non-permissive substrate for navigating axons, but also modulates the effects of classical guidance cues, such as netrin or Eph/ephrin family members. Despite being highly important, little is known about the expression of ECM molecules during CNS development...
2016: Frontiers in Neuroanatomy
Dustin D Wheeler, Matthew M Willmering, Erika L Sesti, Xingyuan Pan, Dipta Saha, Christopher J Stanton, Sophia E Hayes
We have modified the model for optically-pumped NMR (OPNMR) to incorporate a revised expression for the expectation value of the z-projection of the electron spin, 〈Sz〉 and apply this model to both bulk GaAs and a new material, InP. This expression includes the photon energy dependence of the electron polarization when optically pumping direct-gap semiconductors in excess of the bandgap energy, Eg. Rather than using a fixed value arising from coefficients (the matrix elements) for the optical transitions at the k=0 bandedge, we define a new parameter, Sopt(Eph)...
September 29, 2016: Journal of Magnetic Resonance
Rudolf Winklbauer, Serge E Parent
Adhesion differences are the main driver of cell sorting and related processes such as boundary formation or tissue positioning. In the early amphibian embryo, graded variations in cadherin density and localized expression of adhesion-modulating factors are associated with regional differences in adhesive properties including overall adhesion strength. The role of these differences in embryonic boundary formation has not been studied extensively, but available evidence suggests that adhesion strength differentials are not essential...
September 30, 2016: Mechanisms of Development
Xiaolei Wang, Jian Sun, Chaocui Li, Bingyu Mao
Eph receptor tyrosine kinases (RTKs) and their ephrin ligands play multiple roles in the developing nervous system, including cell segregation, axon guidance and synaptic plasticity. Here we report the expression and function of EphA7 in Xenopus hindbrain development. EphA7 is specifically expressed in the hindbrain throughout neurulation in Xenopus embryos. Knockdown of EphA7 by specific morpholino oligonucleotide (MO) disrupted cranial neural tube closure and disturbed apical constriction of hindbrain neuroepithelial cells, indicating weakened cell surface tension...
October 28, 2016: Biochemical and Biophysical Research Communications
Hongxu Zhang, Jianguang Zhong, Zhenyu Bian, Xiang Fang, You Peng, Yongping Hu
BACKGROUND: Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and eph-receptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. However, the results were not consistent. The objective of this study was to examine the role of these two gene polymorphisms in ARC susceptibility. METHODS: Eligible case-control studies published between January 2000 and 2015 were searched and retrieved in the electronic databases...
September 29, 2016: BMC Ophthalmology
Krystallia Mantziki, Carry M Renders, Achilleas Vassilopoulos, Gabriella Radulian, Jean-Michel Borys, Hugues du Plessis, Maria João Gregório, Pedro Graça, Stefaan de Henauw, Svetoslav Handjiev, Tommy L S Visscher, Jacob C Seidell
BACKGROUND: Increasing social inequalities in health across Europe are widening the gap between low and high socio-economic groups, notably in the prevalence of obesity. Public health interventions may result in differential effects across population groups. Therefore, the EPHE (EPODE for the Promotion of Health Equity) project analysed the added value of community-based programmes, based on the EPODE (Ensemble Prévenons l'Obésité Des Enfants-Together Let's Prevent Obesity) model, to reduce socio-economic inequalities in energy balance-related behaviours of children and their family-environmental related determinants in seven European communities...
September 29, 2016: International Journal for Equity in Health
S U Din, H Ashamalla, K S T Gilbert, L M Graves, P R Graves
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Shudong Gu, Jia Feng, Qin Jin, Wei Wang, Shu Zhang
Colorectal carcinoma (CRC) is the third most common cancer and a major cause of morbidity and mortality throughout the world. The prognosis of patients has improved markedly over the last 15 years because of the introduction of new therapy including molecular target drugs. To comprehensively understand the molecular process of carcinogenesis of colorectal carcinoma is essential for the diagnosis, prognosis and treatment. EphA5 is a member of the Eph family and plays a critical role in carcinogenesis of lung cancer, prostate cancer, and breast cancer...
September 21, 2016: Histology and Histopathology
M Hernández-Restrepo, J Z Groenewald, P W Crous
Based on morphology and DNA sequence data the taxonomic relationships of Microdochium, Monographella and Idriella were reassessed. Microdochium is morphologically and phylogenetically circumscribed, and the sexual genus Monographella treated as synonym on the basis that Microdochium has more species, is more commonly encountered, and more frequently used in literature. An epitype is designated for Microdochium phragmites, and several well-known species are redefined based on their morphology and DNA sequence data (LSU, ITS, BTUB and RPB2)...
June 2016: Persoonia
Svea Hinrichsen, Ann-Christin Schnoor, Katharina Grund, Benedikt Flöser, Alexander Schlimm, Christian Näther, Jan Krahmer, Felix Tuczek
The syntheses of molybdenum dinitrogen complexes supported by the tridentate PEP ligands (E = N, P) prPP(Ph)P = (Ph2PCH2CH2CH2)2P(Ph), prPPHP = (Ph2PCH2CH2CH2)2PH, PN(Ph)P = (Ph2PCH2CH2)2N(Ph) and prPN(Ph)P = (Ph2PCH2CH2CH2)2N(Ph) are reported. Together with the coligand dmpm = (CH3)2PCH2P(CH3)2 dinitrogen complexes of the type [Mo(N2)(PEP)(dmpm)] are formed. The new systems are characterized by IR and NMR spectroscopy and compared with the literature-known complex [Mo(N2)(dpepp)(dmpm)] (1) (dpepp = PhP(CH2CH2PPh2)2)...
October 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Changyu Zhou, Jiayu Li, Jiarui Li, Yingchun Wan, Tao Li, Piyong Ma, Yingjian Wang, Haiyan Sang
The aim of the present study was to identify the differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and the normal colonic (N-C) control samples, predict the target genes (TGs) and analyze the potential functions of the DEMs and TGs. The miRNA expression dataset GSE30454, which included data of 13 LS and 20 N-C tissue samples, was downloaded from the Gene Expression Omnibus. The classical t-test in Linear Models for Microarray Data package was used for DEM identification. TG prediction was performed using 5 databases...
September 2016: Oncology Letters
Thomas N Gaitanos, Jorg Koerner, Ruediger Klein
Ephrin receptors interact with membrane-bound ephrin ligands to regulate contact-mediated attraction or repulsion between opposing cells, thereby influencing tissue morphogenesis. Cell repulsion requires bidirectional trans-endocytosis of clustered Eph-ephrin complexes at cell interfaces, but the mechanisms underlying this process are poorly understood. Here, we identified an actin-regulating pathway allowing ephrinB(+) cells to trans-endocytose EphB receptors from opposing cells. Live imaging revealed Rac-dependent F-actin enrichment at sites of EphB2 internalization, but not during vesicle trafficking...
September 12, 2016: Journal of Cell Biology
Xiaolin Wang, Haifei Xu, Guangxin Cao, Zhijun Wu, Jiandong Wang
BACKGROUND: Erythropoietin-producing hepatocellular carcinoma (Eph) receptors constitute the largest family of receptor tyrosine kinases. Ephs and their ligands ephrins play an important role in development and carcinogenesis. The expression of EphA3, an Eph family member, has been investigated in a variety of human cancers, with mixed results. High levels of EphA3 protein expression have been reported in colorectal, prostate, and gastric cancers, whereas loss of protein expression has been reported in lung and hematopoietic cancers...
August 8, 2016: Clinical Genitourinary Cancer
Xinlong Zang, Huaiwei Ding, Xiufeng Zhao, Xiaowei Li, Zhouqi Du, Haiyang Hu, Mingxi Qiao, Dawei Chen, Yuihui Deng, Xiuli Zhao
Therapeutic delivery of small interfering RNA (siRNA) is a major challenge that limits its potential clinical application. Here, a pH-sensitive cholesterol-Schiff base-polyethylene glycol (Chol-SIB-PEG)-modified cationic liposome-siRNA complex, conjugated with the recombinant humanized anti-EphA10 antibody (Eph), was developed as an efficient nonviral siRNA delivery system. Chol-SIB-PEG was successfully synthesized and confirmed with FTIR and (1)H-NMR. An Eph-PEG-SIB-Chol-modified liposome-siRNA complex (EPSLR) was prepared and characterized by size, zeta potential, gel retardation, and encapsulation efficiency...
2016: International Journal of Nanomedicine
Candace Johnson, Briana Segovia, Raj P Kandpal
Erythropoietin-producing hepatocellular carcinoma cell (EPH) receptors comprise the most abundant receptor tyrosine kinase family characterized to date in mammals including humans. These proteins are involved in axon guidance, tissue organization, vascular development and the intricate process of various diseases including cancer. These diverse functions of EPH receptors are attributed, in part, to their abilities for heterodimerization. While the interacting partners of kinase-deficient EPHB6 receptor have been characterized, the interaction of the kinase-dead EPHA10 with any other receptor has not been identified...
September 2016: Cancer Genomics & Proteomics
Aleksandra Jurek, Maria Genander, Parag Kundu, Timothy Catchpole, Xiao He, Klas Strååt, Hanna Sabelström, Nan-Jie Xu, Sven Pettersson, Mark Henkemeyer, Jonas Frisén
Cancer often arises by the constitutive activation of mitogenic pathways by mutations in stem cells. Eph receptors are unusual in that although they regulate the proliferation of stem/progenitor cells in many adult organs, they typically fail to transform cells. Multiple ephrins and Eph receptors are often co-expressed and are thought to be redundant, but we here describe an unexpected dichotomy with two homologous ligands, ephrin-B1 and ephrin-B2, regulating specifically migration or proliferation in the intestinal stem cell niche...
October 15, 2016: Experimental Cell Research
Xiaoping Liu, Ying Hu, Xiaoxia Liu, Yanfang Zheng, Minglian Luo, Weifang Liu, Yin Zhao, Li Zou
PROBLEM: Preeclampsia is characterized by endothelial activation and excessive inflammation, of which interferon (IFN)-γ is a potent inducer. Eph receptor B4 (EPHB4) also involved in endothelial activation in inflammation. Their role and relationship in preeclampsia remain unclear. METHOD OF STUDY: Intercellular adhesion molecular (ICAM)-1 was employed as the hallmark of endothelial activation. The serum levels of IFN-γ and the expression of EPHB4 and ICAM-1 were assessed by ELISA, qRT-PCR and WB, respectively...
October 2016: American Journal of Reproductive Immunology: AJRI
Thomas Jungas, Renaud T Perchey, Mohamad Fawal, Caroline Callot, Carine Froment, Odile Burlet-Schiltz, Arnaud Besson, Alice Davy
Cytokinesis is the last step of cell division, culminating in the physical separation of daughter cells at the end of mitosis. Cytokinesis is a tightly regulated process that until recently was mostly viewed as a cell-autonomous event. Here, we investigated the role of Ephrin/Eph signaling, a well-known local cell-to-cell communication pathway, in cell division. We show that activation of Eph signaling in vitro leads to multinucleation and polyploidy, and we demonstrate that this is caused by alteration of the ultimate step of cytokinesis, abscission...
August 29, 2016: Journal of Cell Biology
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