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https://www.readbyqxmd.com/read/30516584/missing-a-beat-assessment-of-circadian-rhythm-abnormalities-in-bipolar-disorder-in-the-genomic-era
#1
Michael J McCarthy
Circadian rhythm abnormalities have been recognized as a central feature of bipolar disorder (BD) but a coherent biological explanation for them remains lacking. Using genetic mutation of 'clock genes', robust animal models of mania and depression have been developed that elucidate key aspects of circadian rhythms and the circadian clock-mood connection. However, translation of this knowledge into humans remains incomplete. In recent years, very large genome-wide association studies (GWAS) have been conducted and the genetic underpinnings of BD are beginning to emerge...
December 3, 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/30515935/sleep-patterns-and-insomnia-in-young-adults-a-national-survey-of-norwegian-university-students
#2
Børge Sivertsen, Øystein Vedaa, Allison G Harvey, Nick Glozier, Ståle Pallesen, Leif E Aarø, Kari J Lønning, Mari Hysing
The aim of this study was to describe sleep patterns and rate of insomnia according to diagnostic criteria in college and university students, as well as to examine potential changes in sleep problems from 2010 to 2018. Data stemmed from a national student health survey from 2018 for higher education in Norway (the SHoT study), which invited all 162,512 fulltime students in Norway. A total of 50,054 students (69.1% women) aged 18-35 years were included, yielding a response rate of 30.8%. Sleep parameters, reported separately for weekdays and weekends, included calculations of bedtime, rise time, sleep duration, sleep-onset latency, wake after sleep onset, sleep need and sleep deficit...
December 4, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/30515439/phenoconversion-from-idiopathic-rapid-eye-movement-sleep-behavior-disorder-to-lewy-body-disease
#3
Tomoyuki Miyamoto, Masayuki Miyamoto
Background: The conversion rate and estimated risk of neurodegenerative diseases vary with idiopathic rapid eye movement sleep behavior disorder (IRBD). Methods: This retrospective cohort study examined 273 patients (213 men, 60 women) with polysomnographic-confirmed IRBD (192 and 81 patients in the Sleep Center [SC] cohort and Neurological Center [NC] cohort, respectively) who were followed longitudinally. The date of diagnosis was determined as the onset of an overt neurological syndrome...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30513461/heart-rate-variability-changes-in-major-depressive-disorder-during-sleep-fractal-index-correlates-with-bdi-score-during-rem-sleep
#4
Hyun Bin Kwon, Heenam Yoon, Sang Ho Choi, Jae-Won Choi, Yu Jin Lee, Kwang Suk Park
We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI). Time- and frequency-domain, and fractal HRV parameters were derived from 5-min electrocardiogram segments during light sleep, deep sleep, rapid eye movement (REM) sleep, and the pre- and post-sleep wake periods...
November 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30513436/factors-contributing-to-excessive-daytime-sleepiness-in-korean-adults-with-epilepsy-a-sleep-questionnaire-based-study
#5
Sang-Ahm Lee, Young-Joo No, Kwang-Deog Jo, Jee-Hyun Kwon, Jeong Yeon Kim, Dong-Jin Shin
OBJECTIVES: We determined factors contributing to excessive daytime sleepiness (EDS) in Korean adults with epilepsy (AWE). METHODS: A total of 147 AWE who had been treated for >1 year were included. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Subjective sleep disturbances were assessed with the Sleep Apnea of Sleep Disorder Questionnaire (SA-SDQ) and questionnaires about insomnia and restless legs syndrome (RLS). The Hospital Anxiety and Depression Scale (HADS) was also used...
December 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30513274/a-review-of-sleep-research-in-patients-with-spinal-cord-injury
#6
Victoria Dreier Thøfner Hultén, Fin Biering-Sørensen, Niklas Rye Jørgensen, Poul Jørgen Jennum
STUDY DESIGN: Systematic review. OBJECTIVES: Sleep disturbances are a common complaint among individuals with spinal cord injury (SCI) and were not usually present before the SCI. Their sleep disturbances, including disrupted sleep, spasms, and problems with initiating and sustaining sleep through the night, affect SCI individuals' overall quality of life due to excessive tiredness and low energy levels during the day. Despite the high prevalence of sleep complaints in this population, current knowledge about sleep in the SCI population has not been systematically assessed...
December 4, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/30511341/sleep-and-alertness-in-shift-work-disorder-findings-of-a-field-study
#7
Päivi Vanttola, Mikko Härmä, Katriina Viitasalo, Christer Hublin, Jussi Virkkala, Mikael Sallinen, Kati Karhula, Sampsa Puttonen
PURPOSE: Although shift work disorder (SWD) affects a major part of the shift working population, little is known about its manifestation in real life. This observational field study aimed to provide a detailed picture of sleep and alertness among shift workers with a questionnaire-based SWD, by comparing them to shift workers without SWD during work shifts and free time. METHODS: SWD was determined by a questionnaire. Questionnaires and 3-week field monitoring, including sleep diaries, actigraphy, the Karolinska Sleepiness Scale (KSS), EEG-based sleep recordings, and Psychomotor Vigilance Tasks (PVT), were used to study 22 SWD cases and 9 non-SWD workers...
December 3, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/30511273/autism-spectrum-disorder-sleep-morbidities-and-sensory-impairment-emerging-paradigm-in-research-and-management
#8
REVIEW
Biswaroop Chakrabarty, Sheffali Gulati
No abstract text is available yet for this article.
December 4, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/30511252/impact-of-genetic-variations-in-adora2a-gene-on-depression-and-symptoms-a-cross-sectional-population-based-study
#9
Sílvia Oliveira, Ana Paula Ardais, Clarissa Ribeiro Bastos, Marta Gazal, Karen Jansen, Luciano de Mattos Souza, Ricardo Azevedo da Silva, Manuella Pinto Kaster, Diogo Rizzato Lara, Gabriele Ghisleni
Genetic variants involved in adenosine metabolism and its receptors were associated with increased risk for psychiatric disorders, including anxiety, depression, and schizophrenia. Here, we examined an association between a single nucleotide polymorphism in A2A receptor gene (ADORA2A, rs2298383 SNP) with current depressive episode and symptom profile. A total of 1253 individuals from a cross-sectional population-based study were analyzed by the Mini International Neuropsychiatric Interview 5.0. Our data showed that the TT genotype of ADORA2A rs2298383 SNP was associated with reduced risk for depression when compared to the CC/CT genotypes (p = 0...
December 3, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/30510244/hypercapnia-impaired-cognitive-and-memory-functions-in-obese-patients-with-obstructive-sleep-apnoea
#10
Shu-Chin Kung, Yu-Chih Shen, En-Ting Chang, Ya-Ling Hong, Ling-Yi Wang
Obstructive sleep apnoea (OSA) is a sleep disorder involving repeated nocturnal desaturation and sleep fragmentation. OSA can result in decreased daytime alertness and neurocognitive dysfunction. Hypercapnia status is also related to neurocognitive dysfunction in patients with pulmonary diseases. We evaluated the effects of hypercapnia on cognitive performance and memory function in a prospective case-controlled study. We enrolled thirty-nine obese patients with OSA and collected their arterial blood samples...
December 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30508930/treatment-of-persistent-postoperative-hiccups-with-stellate-ganglion-block-three-case-reports
#11
A Ran Lee, Young Woo Cho, Jae Min Lee, Yong Joon Shin, Il Sang Han, Hyung Kwan Lee
RATIONALE: Although persistent postoperative hiccups can cause various problems (such as sleep disorders, depression, fatigue) for the patient, there has been little research on this topic. The purpose of this study is to determine the effectiveness of treating persistent postoperative hiccups with a stellate ganglion block (SGB), an injection of local anesthetic in the sympathetic nerve tissue of the neck. PATIENT CONCERNS AND DIAGNOSES: Three patients each developed persistent hiccups within 3 days of abdominal surgery, lasting for 3 to 6 days...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30508781/disease-specific-attention-impairment-in-disorders-of-chronic-excessive-daytime-sleepiness
#12
Markus Ramm, Matthias Boentert, Nelly Lojewsky, Arsalan Jafarpour, Peter Young, Anna Heidbreder
OBJECTIVE: Patients with chronic excessive daytime sleepiness (EDS) complain of substantial attention deficits. However, their underlying neuronal dysfunction is largely unknown. Previous studies showed similar attention performances in central disorders of hypersomnolence suggesting that EDS-related cognitive impairment is independent of its cause. The aim of the current study was to further explore attentional profiles in disorders of chronic EDS. METHODS: Ten patients with narcolepsy type 1 (NT1; age 26...
October 15, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/30508671/chronobiological-dis-rhythmicity-is-related-to-emotion-dysregulation-and-suicidality-in-depressive-bipolar-ii-disorder-with-mixed-features
#13
Laura Palagini, Giada Cipollone, Umberto Moretto, Isabella Masci, Beniamino Tripodi, Danila Caruso, Giulio Perugi
In Bipolar Disorder, chronobiological rhythm alterations play a key role by negatively influencing its entire trajectory. Our aim was to assess their potential association with emotion dysregulation and suicidality in subjects with Bipolar Disorder. Eighty-five patients with Bipolar Disorder - II depressive episode with mixed features were recruited and 35 as healthy controls. Subjects were evaluated with SCID-DSM-5, the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), the DERS: Difficulties in Emotion Regulation Scale, the Beck Depression Inventory-II (BDI-II), the Young Mania Rating Scale (YMRS) and the Scale for Suicide Ideation (SSI)...
November 24, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30508227/abstracts
#14
A D Irvine, A P Jones, P Beattie, S Baron, F Browne, F Ashoor, L O'Neill, A Rosala-Hallas, T Sach, C Spowart, L Taams, C Walker, M Wan, N Webb, P Williamson, C Flohr
Atopic eczema is a skin disease affecting around 20% of UK children, 16% of whom have moderate to severe disease. Severe atopic eczema can cause sleep disturbance, poor school attendance and social withdrawal, as well as attention-deficit hyperactivity disorder, anxiety and clinical depression. Skin can become infected and this can be a reason for hospital admission. Although most cases of atopic eczema can be treated with emollients, topical anti-inflammatory treatments and/or ultraviolet (UV) therapy, around 2% of children require oral (taken by mouth) immuno-suppressive treatment...
December 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30507667/measurement-and-nonpharmacologic-management-of-sleep-disturbance-in-the-intensive-care-units-a-literature-review
#15
Mohammad Bani Younis, Feryal Hayajneh, Abdu-Monim Batiha
The general goal of this review is to summarize, clarify, and evaluate what is known about patients' sleep in the intensive care units (ICUs) in terms of sleep measurement and management. In addition, this review focuses on the gap in knowledge in this field. A review of online databases for relevant articles in the period between 2000 and 2017 was conducted. The results of this study indicate that there are several methods to measure patients' quality of sleep. Polysomnography and actigraphy are the most common standard objective and valid methods used to measure sleep disorders in the ICU...
January 2019: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/30506922/neurocognitive-function-in-moderate-severe-pediatric-atopic-dermatitis-a-case-control-study
#16
Lacey L Kruse, Ahuva Cices, Anna B Fishbein, Amy S Paller
BACKGROUND/OBJECTIVES: Epidemiological studies have shown an increased prevalence of attention deficit hyperactivity disorder (ADHD) in children with atopic dermatitis (AD), but many of the features of ADHD may occur as a result of the poor sleep and itch distraction associated with AD. METHODS: A case-control study was performed in children aged 6-17 years with moderate/severe AD compared with age-/sex-matched healthy controls. Participants were screened for ADHD using Vanderbilt assessments...
December 2, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/30506358/comparison-of-online-and-face-to-face-parent-education-for-children-with-autism-and-sleep-problems
#17
Cristine A Roberts, Kevin C Smith, Ashley K Sherman
Many children with autism spectrum disorder (ASD) have sleep disorders. Face-to-face (F2F) sessions have empowered parents to help their child sleep. Our goal was whether online technologies could provide similar improvements in children's sleep while also improving parents' quality of life. Identical programs were taught in two sessions to F2F and online parents. Measurements were compared from baseline to 4 and 8 weeks post teaching sessions. Twenty-three participants completed the program. Parent quality of life improved for both groups...
November 30, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/30505482/left-ventricular-diastolic-dysfunction-in-patients-with-obesity-hypoventilation-syndrome
#18
Hadil A Al Otair, Fayez Elshaer, Alaa Elgishy, Samar Z Nashwan, Aljohara S Almeneessier, Awad H Olaish, Ahmed S BaHammam
Background: Obesity hypoventilation syndrome (OHS) can be complicated by several cardiovascular conditions. We assessed the prevalence and factors associated with left ventricular diastolic dysfunction (LVDD) in patients with OHS. Methods: In this prospective observational study, all consecutive OHS patients referred to the sleep disorders clinic between January 2002 to December 2016 were included (n=113). Demographic data, echocardiography, sleep parameters, arterial blood gases (ABGs), and lung functions were recorded...
October 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30505290/a-pilot-randomized-controlled-trial-on-the-effect-of-cpap-treatment-on-glycemic-control-in-gestational-diabetes-study-design-and-methods
#19
Sushmita Pamidi, Sara J Meltzer, Natasha Garfield, Lorraine Lavigne, Allen Olha, Ahamed Khalyfa, Andrea Benedetti, Geneviève Tremblay, Robert Gagnon, Evelyne Rey, Kaberi Dasgupta, R John Kimoff
Background: Gestational diabetes (GDM) is associated with adverse short- and long-term maternal and fetal outcomes. Observational data support a link between sleep-disordered breathing (SDB) during pregnancy and GDM. However, it is unknown whether treatment of SDB with continuous positive airway pressure (CPAP) improves glucose control in this patient population. In addition, CPAP adherence and feasibility as a treatment option in pregnancy is unknown. This pilot randomized, controlled trial aims to primarily determine the feasibility of CPAP treatment in pregnant women with SDB and GDM...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30505012/sleep-disorders-in-patients-with-psoriatic-arthritis-and-psoriasis
#20
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Objectives: To assess and measure occurrence of sleep disorders in patients with psoriatic arthritis (PsA) and psoriasis (Ps). Material and methods: The study included 62 patients with psoriatic arthritis and 52 patients with psoriasis. The measurement of sleep quality was conducted using the Pittsburgh Sleep Quality Index (PSQI), the evaluation of fatigue by the fatigue subscale of the FACIT-F questionnaire and the patient's quality of life by the Health Assessment Questionnaire (HAQ)...
2018: Reumatologia
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