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https://www.readbyqxmd.com/read/30110606/orexinergic-neurons-are-involved-in-the-chemosensory-control-of-breathing-during-the-dark-phase-in-a-parkinson-s-disease-model
#1
Luiz M Oliveira, Barbara Falquetto, Thiago S Moreira, Ana C Takakura
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra compacta (SNpc) and the only risk factor is aging. We showed that in 6-hydroxydopamine (6-OHDA)-model of PD there is a reduction in the neuronal profile within the brainstem ventral respiratory column with a decrease in the hypercapnic ventilatory response. Here we tested the involvement of orexin cells from the lateral hypothalamus/perifornical area (LH/PeF) on breathing in a 6-OHDA PD model...
August 12, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/30109824/the-neurobiological-basis-of-sleep-and-sleep-disorders
#2
William J Joiner
The functions of sleep remain a mystery. Yet they must be important since sleep is highly conserved, and its chronic disruption is associated with various metabolic, psychiatric, and neurodegenerative disorders. This review will cover our evolving understanding of the mechanisms by which sleep is controlled and the complex relationship between sleep and disease states.
September 1, 2018: Physiology
https://www.readbyqxmd.com/read/30109368/post-traumatic-stress-disorder-anxiety-and-depression-symptoms-among-adolescent-earthquake-victims-comorbidity-and-associated-sleep-disturbing-factors
#3
Wanjie Tang, Yi Lu, Jiuping Xu
PURPOSE: Our study aimed to examine the prevalence of psychiatric symptoms and their comorbidity and correlation with sleep problems among adolescent survivors 3 years after the 2013 Ya'an earthquake. METHODS: A representative sample of 6132 adolescent students was analysed from 11 primary and high schools in the three counties most severely affected by the earthquake. Students were invited to complete the Pittsburgh Sleep Quality Index, Children's Revised Impact of Event Scale-13, Short Mood and Feelings Questionnaire, the Adolescent Self-Rating Life Events Checklist, and Screen for Child Anxiety-Related Emotional Disorders...
August 14, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/30109150/fast-convolutional-method-for-automatic-sleep-stage-classification
#4
Intan Nurma Yulita, Mohamad Ivan Fanany, Aniati Murni Arymurthy
Objectives: Polysomnography is essential to diagnose sleep disorders. It is used to identify a patient's sleep pattern during sleep. This pattern is obtained by a doctor or health practitioner by using a scoring process, which is time consuming. To overcome this problem, we developed a system that can automatically classify sleep stages. Methods: This paper proposes a new method for sleep stage classification, called the fast convolutional method. The proposed method was evaluated against two sleep datasets...
July 2018: Healthcare Informatics Research
https://www.readbyqxmd.com/read/30108546/contribution-of-neurochemical-inputs-to-the-decrease-of-motoneuron-excitability-during-non-rem-and-rem-sleep-a-systematic-review
#5
Victor B Fenik
The sleep-related depression of excitability of upper airway motoneurons is a major neurological cause of obstructive sleep apnea whereas a disruption in the inhibition of spinal motoneurons during rapid eye movement (REM) sleep causes the REM sleep behavioral disorder. The large amount of experimental data has been obtained that deal with neurochemical mechanisms that are responsible for sleep-related depression of various motoneuron groups. However, there is a disagreement regarding the outcome of these studies primarily due to the use of different animal models and approaches, as well as due to differences in quantification and interpretation of obtained results...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30108203/absent-sleep-eeg-spindle-activity-in-glua1-gria1-knockout-mice-relevance-to-neuropsychiatric-disorders
#6
Gauri Ang, Laura E McKillop, Ross Purple, Cristina Blanco-Duque, Stuart N Peirson, Russell G Foster, Paul J Harrison, Rolf Sprengel, Kay E Davies, Peter L Oliver, David M Bannerman, Vladyslav V Vyazovskiy
Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor...
August 14, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30107963/-exercise-capacity-in-children-with-mild-sleep-disordered-breathing
#7
J Ricard, H Vlachos, M-E Dumas, J-P Praud, F-P Counil
INTRODUCTION: While the association between sleep-disordered breathing (SDB) and low physical activity has been reported in children, little information is available on the impact of SDB on exercise capacity. The aim of this study was to assess exercise capacity in children with SDB in order to estimate the relevance of exercise training intervention. METHODS: Twelve young patients with suspected SDB matched with 11 presumably healthy subjects of same age range (aged 13±0...
August 11, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/30107682/-roles-of-rapid-eye-movement-sleep-behavior-disorder-in-understanding-the-etiology-and-developing-preventive-strategies-for-parkinson-s-disease
#8
Y P Liu, Y H Li, W B Ma
No abstract text is available yet for this article.
August 7, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/30107533/syt1-associated-neurodevelopmental-disorder-a-case-series
#9
Kate Baker, Sarah L Gordon, Holly Melland, Fabian Bumbak, Daniel J Scott, Tess J Jiang, David Owen, Bradley J Turner, Stewart G Boyd, Mari Rossi, Mohammed Al-Raqad, Orly Elpeleg, Dawn Peck, Grazia M S Mancini, Martina Wilke, Marcella Zollino, Giuseppe Marangi, Heike Weigand, Ingo Borggraefe, Tobias Haack, Zornitza Stark, Simon Sadedin, Tiong Yang Tan, Yunyun Jiang, Richard A Gibbs, Sara Ellingwood, Michelle Amaral, Whitley Kelley, Manju A Kurian, Michael A Cousin, F Lucy Raymond
Synaptotagmin 1 (SYT1) is a critical mediator of fast, synchronous, calcium-dependent neurotransmitter release and also modulates synaptic vesicle endocytosis. This paper describes 11 patients with de novo heterozygous missense mutations in SYT1. All mutations alter highly conserved residues, and cluster in two regions of the SYT1 C2B domain at positions Met303 (M303K), Asp304 (D304G), Asp366 (D366E), Ile368 (I368T) and Asn371 (N371K). Phenotypic features include infantile hypotonia, congenital ophthalmic abnormalities, childhood-onset hyperkinetic movement disorders, motor stereotypies, and developmental delay varying in severity from moderate to profound...
August 13, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30107101/obstructive-sleep-apnea-in-posttraumatic-stress-disorder-comorbid-with-mood-disorder-significantly-higher-incidence-than-in-either-diagnosis-alone
#10
Bettina S Fehr, William F Katz, Erin A Van Enkevort, Imran S Khawaja
Objective: To examine the correlations between obstructive sleep apnea (OSA) and psychiatric disorders such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), or bipolar disorder (BD) and whether comorbid psychiatric diagnosis increases the risk of OSA. Methods: This retrospective chart review study included all patients (N = 413) seen within a randomly selected 4-month period (August 2014 to November 2014) in a Veterans Administration outpatient psychiatry clinic...
August 9, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/30106239/sleep-disturbances-and-depression-severity-in-patients-with-parkinson-s-disease
#11
Daniel B Kay, Jared J Tanner, Dawn Bowers
OBJECTIVES: Parkinson's disease (PD) is a multisystem movement disorder associated with sleep disturbance and depression. Sleep disturbances and depression severity share a bidirectional association. This association may be greater in individuals who are more vulnerable to the deleterious consequences of sleep disturbance and depression severity. We investigated whether the association between sleep disturbances and depression severity is greater in patients with PD than in matched controls (MC)...
June 2018: Brain and Behavior
https://www.readbyqxmd.com/read/30105851/cognitive-performance-in-dswpd-patients-upon-awakening-from-habitual-sleep-compared-with-forced-conventional-sleep
#12
Brandy Solheim, Alexander Olsen, Håvard Kallestad, Knut Langsrud, Bjørn Bjorvatn, Michael Gradisar, Trond Sand
Difficult early morning awakening is one of the defining symptoms of delayed sleep-wake phase disorder. It is accompanied by low cognitive arousal and drowsiness resulting in difficulty concentrating and focusing attention upon awakening. We designed the current study to quantitate cognitive performance (i.e. omissions, commissions, reaction time [average and variability]) and cognitive domains (i.e. focused attention, sustained attention, impulsivity and vigilance) with Conners' Continuous Performance Test II during both habitual and conventional (00:00-07:00 hr) sleep-wake schedule in young adult patients with delayed sleep-wake phase disorder (n = 20, mean age = 24...
August 13, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/30104658/bipolar-mood-cycles-associated-with-lunar-entrainment-of-a-circadian-rhythm
#13
Thomas A Wehr
In bipolar disorder, episodes of depression and mania are associated with dramatic disturbances in sleep, which experiments show are likely to contribute to the pathogenesis of the episodes. A recent finding that 18 patients' manic-depressive cycles oscillated in synchrony with biweekly surges in amplitude of the moon's tides provided a clue to the cause of the sleep-disturbances. Analyses of one of the patients' sleep-wake cycles suggest that his mood cycles arose when a circadian rhythm that normally is entrained to dawn and controls the daily onset of wakefulness became entrained instead to 24...
August 13, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30104186/a-remote-intervention-to-prevent-or-delay-cognitive-impairment-in-older-adults-design-recruitment-and-baseline-characteristics-of-the-virtual-cognitive-health-vc-health-study
#14
Nicholas Bott, Shefali Kumar, Caitlyn Krebs, Jordan M Glenn, Erica N Madero, Jessie L Juusola
BACKGROUND: A growing body of evidence supports the use of lifestyle interventions for preventing or delaying the onset of Alzheimer disease and other forms of dementia in at-risk individuals. The development of internet-delivered programs would increase the scalability and reach of these interventions, but requires validation to ensure similar effectiveness to brick-and-mortar options. OBJECTIVE: We describe the study design, recruitment process, and baseline participant characteristics of the sample in the Virtual Cognitive Health (VC Health) study...
August 13, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30104184/correlations-between-objective-behavioral-features-collected-from-mobile-and-wearable-devices-and-depressive-mood-symptoms-in-patients-with-affective-disorders-systematic-review
#15
REVIEW
Darius A Rohani, Maria Faurholt-Jepsen, Lars Vedel Kessing, Jakob E Bardram
BACKGROUND: Several studies have recently reported on the correlation between objective behavioral features collected via mobile and wearable devices and depressive mood symptoms in patients with affective disorders (unipolar and bipolar disorders). However, individual studies have reported on different and sometimes contradicting results, and no quantitative systematic review of the correlation between objective behavioral features and depressive mood symptoms has been published. OBJECTIVE: The objectives of this systematic review were to (1) provide an overview of the correlations between objective behavioral features and depressive mood symptoms reported in the literature and (2) investigate the strength and statistical significance of these correlations across studies...
August 13, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/30103483/pharmacologic-treatment-options-for-insomnia-in-patients-with-schizophrenia
#16
REVIEW
Lauren Stummer, Marija Markovic, Megan E Maroney
Background: Symptoms of sleep disorders, such as disturbances in sleep initiation and continuity, are commonly reported in patients with schizophrenia, especially in the acute phase of illness. Studies have shown that up to 80% of patients diagnosed with schizophrenia report symptoms of insomnia. Sleep disturbances have been shown to increase the risk of cognitive dysfunction and relapse in patients with schizophrenia. Currently, there are no medications approved specifically for the treatment of insomnia in patients with schizophrenia...
August 11, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/30103064/restless-legs-syndrome-leg-motor-restlessness-and-their-variants-in-patients-with-parkinson-s-disease-and-related-disorders
#17
Takeo Matsubara, Keisuke Suzuki, Hiroaki Fujita, Yuji Watanabe, Hirotaka Sakuramoto, Masanori Matsubara, Koichi Hirata
OBJECTIVE: The objective of this study was to investigate the prevalence of restless leg syndrome (RLS), leg motor restlessness (LMR) and RLS/LMR variants and their relationship with clinical factors in patients with Parkinson's disease (PD) and related disorders. METHODS: Sixty-three PD patients, 17 multiple system atrophy (MSA) patients and 11 progressive supranuclear palsy (PSP) patients were included in this study. Through face-to-face interviews, the patients were diagnosed with RLS/LMR, or with RLS/LMR variants in which the symptoms occur predominantly in body parts other than the legs...
August 7, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30102847/cardiovascular-sequelae-of-the-sleep-apnoea-syndrome-sex-stress-and-therapeutic-strategies
#18
EDITORIAL
Ken D O'Halloran
In this issue of Acta Physiologica, Ribon-Demars et al.1 report that exogenous oestradiol administration mitigates vascular oxidative stress and elevated blood pressure in an ovariectomized rat model of sleep-disordered breathing. Sleep apnoea is a major public health issue. If untreated, it leads to premature death. Obstructive sleep apnoea, the most prevalent form of sleep-disordered breathing, is very common, but remains under-diagnosed. This article is protected by copyright. All rights reserved.
August 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/30101898/work-to-family-conflict-rather-than-family-to-work-conflict-is-more-strongly-associated-with-sleep-disorders-in-upper-egypt
#19
Ehab Salah Eshak
An important factor for which work and family compete is time. Due to lack of evidence, I investigated the associations between work-family conflict (assessed by the National Study of Midlife Development in the US) and sleep disorders (assessed by the Jenkins Sleep Questionnaire) in a cross-sectional study included 1,021 Egyptians aged 18-59 years. Both work-to-family (WFC) and family-to-work (FWC) were associated with reduced sleep quantity. Moreover, high WFC was associated with sleep disorders; the multivariable ORs (95% CIs) were 2...
August 11, 2018: Industrial Health
https://www.readbyqxmd.com/read/30101863/-cellular-mechanisms-involved-in-induction-of-selective-degeneration-of-orexin-neurons-in-the-hypothalamus
#20
Hiroshi Katsuki
Narcolepsy is a kind of sleep disorder featured by selective loss of orexin neurons in the lateral hypothalamus. Several lines of evidence, including association with specific HLA haplotypes, gene polymorphism in T cell receptor and detection of autoantibodies in a subpopulation of patients, suggest that autoimmune responses play an important role in the pathogenesis of this disorder. Potential relationship with influenza virus infection has also been a matter of interest. However, these events may not be able to explain all cases of narcolepsy...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
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