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https://www.readbyqxmd.com/read/30309286/progressive-reduction-of-serum-complement-levels-a-risk-factor-for-relapse-in-patients-with-hypocomplementemia-in-systemic-lupus-erythematosus
#1
Y Miyawaki, K Sada, Y Asano, K Hayashi, Y Yamamura, S Hiramatsu, K Ohashi, M Morishita, H Watanabe, Y Matsumoto, T Kawabata, J Wada
OBJECTIVE: Serologically active clinically quiescent (SACQ)-SLE is a subtype of systemic lupus erythematosus (SLE); most SACQ-SLE patients relapse. Although complement and/or anti-dsDNA level fluctuations during SACQ status are reportedly not useful for predicting relapse, they might be useful in specific clinical settings. We aimed to assess the correlation between future relapse and progressive reductions in serum complement levels following remission in patients with hypocomplementemia ...
November 2018: Lupus
https://www.readbyqxmd.com/read/26692544/impaired-phagocytosis-of-apoptotic-cell-material-in-serologically-active-clinically-quiescent-patients-with-systemic-lupus-erythematosis
#2
Wen-Nan Huang, Tim K Tso, Hsiao-Chih Wu, Hsiu-Fen Yang, Gregory J Tsay
AIM: Serologically active clinically quiescent (SACQ) patients with systemic lupus erythematosus (SLE) account for 8-12% of all patients with SLE, but there is disagreement about whether such patients are indeed clinically stable. Patients with clinically active SLE have decreased macrophage function, although the status of SACQ patients with SLE is unclear. METHOD: This study compared 18 patients who met the diagnostic criteria for SACQ SLE with 18 healthy volunteers with regard to the capability of macrophages to clear apoptotic bodies by use of a modified serum-free phagocytosis test...
December 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/26568589/lack-of-interferon-and-proinflammatory-cyto-chemokines-in-serologically-active-clinically-quiescent-systemic-lupus-erythematosus
#3
COMPARATIVE STUDY
Amanda J Steiman, Dafna D Gladman, Dominique Ibañez, Babak Noamani, Carolina Landolt-Marticorena, Murray B Urowitz, Joan E Wither
OBJECTIVE: Serologically active clinically quiescent (SACQ) patients with systemic lupus erythematosus (SLE) remain clinically quiescent for prolonged periods despite anti-dsDNA antibodies and/or low complements, indicating the presence of immune complexes. The immune mechanisms leading to this quiescence are unknown. However, in addition to activating complement, immune complex uptake by various cells leads to the production of interferon (IFN)-α and other proinflammatory factors that are also involved in tissue damage...
December 2015: Journal of Rheumatology
https://www.readbyqxmd.com/read/26554745/analysis-of-complete-remission-in-systemic-lupus-erythematosus-patients-over-a-32-year-period
#4
Carmen V Medina-Quiñones, Lucía Ramos-Merino, Pablo Ruiz-Sada, David Isenberg
OBJECTIVE: Systemic lupus erythematosus (SLE) is characterized by an unpredictable and fluctuating course. Although various methods have been developed to measure disease activity, there is still a lack of consensus about the optimal criteria for SLE remission. The principal aim of our study was to identify the number of lupus patients achieving a complete remission (implying that for 3 years there were no clinical or serologic features and no treatment with steroids and immunosuppressive drugs) in a single cohort of patients followed for a period of up to 32 years...
July 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26223434/prolonged-remission-in-caucasian-patients-with-sle-prevalence-and-outcomes
#5
Margherita Zen, Luca Iaccarino, Mariele Gatto, Silvano Bettio, Linda Nalotto, Anna Ghirardello, Leonardo Punzi, Andrea Doria
AIM: To assess the prevalence of prolonged remission in Caucasian patients affected with systemic lupus erythematosus (SLE) and its relationship with damage accrual. METHODS: Caucasian patients diagnosed with SLE between 1990 and 2009 and quarterly seen from 2009 to 2013 were included in the study. We defined remission as prolonged when lasting ≥5 consecutive years. Three levels of remission were defined using the SLE Disease Activity Index-2000 (SLEDAI-2K): complete remission: no disease activity in corticosteroid-free and immunosuppressant-free patients; clinical remission off corticosteroids: serologically active clinical quiescent (SACQ) disease in corticosteroid-free patients and clinical remission on corticosteroids: SACQ disease in patients taking prednisone 1-5 mg/day...
December 2015: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25729033/anti-dsdna-and-antichromatin-antibody-isotypes-in-serologically-active-clinically-quiescent-systemic-lupus-erythematosus
#6
Amanda J Steiman, Murray B Urowitz, Dominique Ibañez, Timothy T Li, Dafna D Gladman, Joan Wither
OBJECTIVE: Serologically active clinically quiescent (SACQ) patients with systemic lupus erythematosus (SLE) are clinically quiescent despite serologic activity. Since studies suggest that antichromatin antibodies are more sensitive than anti-dsDNA antibodies in detecting active SLE, and that immunoglobulin (Ig) G, in particular complement-fixing subclasses, may be more pathogenic than IgM, we investigated the levels of anti-dsDNA and antichromatin isotypes in SACQ patients as compared to non-SACQ patients with SLE...
May 2015: Journal of Rheumatology
https://www.readbyqxmd.com/read/23029327/flare-persistently-active-disease-and-serologically-active-clinically-quiescent-disease-in-systemic-lupus-erythematosus-a-2-year-follow-up-study
#7
Fabrizio Conti, Fulvia Ceccarelli, Carlo Perricone, Francesca Miranda, Simona Truglia, Laura Massaro, Viviana Antonella Pacucci, Virginia Conti, Izabella Bartosiewicz, Francesca Romana Spinelli, Cristiano Alessandri, Guido Valesini
OBJECTIVE: Several indices have been proposed to assess disease activity in patients with Systemic Lupus Erythematosus (SLE). Recent studies have showed a prevalence of flare between 28-35.3%, persistently active disease (PAD) between 46%-52% and serologically active clinically quiescent (SACQ) disease ranging from 6 to 15%. Our goal was to evaluate the flare, PAD and SACQ rate incidence in a cohort of SLE patients over a 2-year follow-up. METHODS: We evaluated 394 SLE patients...
2012: PloS One
https://www.readbyqxmd.com/read/22162433/outcomes-in-patients-with-systemic-lupus-erythematosus-with-and-without-a-prolonged-serologically-active-clinically-quiescent-period
#8
Amanda J Steiman, Dafna D Gladman, Dominique Ibañez, Murray B Urowitz
OBJECTIVE: Serologically active clinically quiescent (SACQ) systemic lupus erythematosus (SLE) patients' discordance presents a clinical dilemma. Does active serology alone warrant treatment? We explore outcomes in patients with and without a prolonged SACQ period, comparing the rate of damage accrual by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) and incidences of renal damage and coronary artery disease (CAD) over a decade. METHODS: SACQ was defined as a ≥2-year sustained period without clinical activity, with persistent serologic activity (increased anti-double-stranded DNA and/or hypocomplementemia)...
April 2012: Arthritis Care & Research
https://www.readbyqxmd.com/read/20595281/prolonged-serologically-active-clinically-quiescent-systemic-lupus-erythematosus-frequency-and-outcome
#9
Amanda J Steiman, Dafna D Gladman, Dominique Ibañez, Murray B Urowitz
OBJECTIVE: Some patients with systemic lupus erythematosus (SLE) are clinically quiescent despite persistent serologic activity. We determined the frequency of serologically active clinically quiescent (SACQ) SLE and its outcomes in prospectively followed patients with SLE. METHODS: Patients with SLE followed between July 1970 and April 2008 with visits < or = 18 months apart were identified. SACQ was defined as a > or = 2-year sustained period without clinical activity with persistent serologic activity (increased anti-dsDNA and/or hypocomplementemia), during which antimalarials but neither steroids nor immunosuppressives were permissible...
September 2010: Journal of Rheumatology
https://www.readbyqxmd.com/read/17139667/association-of-antinucleosome-antibodies-with-disease-flare-in-serologically-active-clinically-quiescent-patients-with-systemic-lupus-erythematosus
#10
K P Ng, J J Manson, A Rahman, D A Isenberg
OBJECTIVE: To identify the prevalence of serologically active clinically quiescent (SACQ) patients in a cohort of 290 patients with systemic lupus erythematosus (SLE). We investigated if the presence of anti-double-stranded DNA (anti-dsDNA) or antinucleosome (anti-NCS) antibodies during the SACQ period was associated with future flares. METHODS: SACQ patients defined as clinically inactive for 6 months (global British Isles Lupus Activity Group index [BILAG] scores <6) and serologically active (anti-dsDNA antibodies >50 units/ml on at least 2 occasions by enzyme-linked immunosorbent assay [ELISA]) were identified...
December 15, 2006: Arthritis and Rheumatism
https://www.readbyqxmd.com/read/16078321/prolonged-remission-in-systemic-lupus-erythematosus
#11
Murray B Urowitz, Marie Feletar, Ian N Bruce, Dominique Ibañez, Dafna D Gladman
OBJECTIVE: To determine the frequency of prolonged remission in systemic lupus erythematosus (SLE) using strict criteria for remission and to define disease characteristics and prognosis of patients achieving this state. To also determine the frequency of remission utilizing less restrictive definitions, such as allowing shorter period of disease quiescence, persistence of serological activity, or treatment in the absence of clinical disease. METHODS: Patients registered in the Lupus Clinic database between 1970 and 1997 with visits no more than 18 months apart were identified...
August 2005: Journal of Rheumatology
https://www.readbyqxmd.com/read/12966598/clinically-active-serologically-quiescent-systemic-lupus-erythematosus
#12
COMPARATIVE STUDY
Dafna D Gladman, Naushad Hirani, Dominique Ibañez, Murray B Urowitz
OBJECTIVE: To identify the frequency and characteristics of clinical activity with serological quiescence (CASQ) in a large cohort of patients with systemic lupus erythematosus (SLE) followed prospectively at a single center. METHODS: Patients followed at the Lupus Clinic between 1991 and 1995 who on at least 3 consecutive visits had clinical activity in the absence of a low complement and elevated DNA binding were identified. Demographics, disease characteristics, and therapy for the CASQ periods, as well as prior and subsequent disease course until April 2002 were analyzed...
September 2003: Journal of Rheumatology
https://www.readbyqxmd.com/read/7699623/serologically-active-clinically-quiescent-systemic-lupus-erythematosus-predictors-of-clinical-flares
#13
COMPARATIVE STUDY
B A Walz LeBlanc, D D Gladman, M B Urowitz
OBJECTIVE: To identify the frequency of serologic activity in the face of clinical quiescence in a large cohort of patients with systemic lupus erythematosus (SLE) followed prospectively in a single center. METHODS: In a prospective cohort study, patients serologically active but clinically quiescent (SACQ) in 3 consecutive clinic visits were analyzed for the development of a clinical flare over the subsequent year and were evaluated for predictive factors for flare before and during their SACQ period...
December 1994: Journal of Rheumatology
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