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https://www.readbyqxmd.com/read/30103050/neonatal-intubation-competency-assessment-tool-development-and-validation
#1
Lindsay Johnston, Taylor Sawyer, Akira Nishisaki, Travis Whtifill, Anne Ades, Heather French, Kristen Glass, Rita Dadiz, Christie Bruno, Orly Levit, Sandeep Gangadharan, Daniel Scherzer, Ahmed Moussa, Marc Auerbach
BACKGROUND: Neonatal tracheal intubation (NTI) is an important clinical skill. Suboptimal performance is associated with patient harm. Simulation training can improve NTI performance. Improving performance requires an objective assessment of competency. Competency assessment tools need strong evidence of validity. We hypothesized that a NTI competency assessment tool with multi-source validity evidence could be developed, and could be used for formative and summative assessment during simulation-based training...
August 10, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/30102822/rh-catalyzed-4-2-1-cycloaddition-of-in-situ-generated-ene-yne-ene-allenes-and-co
#2
Zhixiang Yu
We report here the first Rh-catalyzed [4+2+1] cycloaddition of in situ generated ene/yne-ene-allenes and CO to synthesize challenging seven-membered carbocycles fused with five-membered rings. This reaction is designed based on the 1,3-acyloxy migration of ene/yne-ene-propargyl esters to ene/yne-ene-allenes, followed by oxidative cyclization, CO insertion and reductive elimination to form the final [4+2+1] cycloadducts. The possible competing [4+1], [4+2] and [2+2+1] cycloadditions were disfavored, making the present reaction as an efficient way to access functionalized 5/7 rings...
August 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30102642/mental-fatigue-in-central-field-and-peripheral-field-steady-state-visually-evoked-potential-and-its-effects-on-event-related-potential-responses
#3
Min-Ho Lee, John Williamson, Young-Eun Lee, Seong-Whan Lee
The steady-state visually evoked potential (SSVEP) is a natural response of the brain to visual stimulation at specific frequencies and is used widely for electroencephalography-based brain-computer interface (BCI) systems. Although the SSVEP is useful for its high level of decoding accuracy, visual fatigue from the repetitive visual flickering is an unavoidable problem. In addition, hybrid BCI systems that combine the SSVEP with the event-related potential (ERP) have been proposed recently. These hybrid BCI systems would improve the decoding accuracy; however, the competing effect by simultaneous presentation of the visual stimulus could possibly supervene the signal in the hybrid system...
August 10, 2018: Neuroreport
https://www.readbyqxmd.com/read/30102328/medication-adherence-is-associated-with-an-increased-risk-of-cancer-in-kidney-transplant-recipients-a-cohort-study
#4
Kunal Yadav, David M Vock, Arthur J Matas, William N Robiner, Thomas E Nevins
Background: Nonadherence to posttransplant immunosuppressive medication is associated with increased rates of rejection and graft loss, yet it is unknown to what degree ideal adherence is associated with the sequelae of overimmunosuppression. Specifically, we questioned whether excellent adherence increased the posttransplant cancer risk. Methods: Between August 1998 and August 2006, 195 consenting kidney transplant recipients had electronic monitoring of theirimmunosuppressive medication adherence...
August 8, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30102111/extremely-poor-patient-reported-outcomes-are-associated-with-lack-of-clinical-response-and-decreased-retention-rate-of-tumour-necrosis-factor-inhibitor-treatment-in-patients-with-axial-spondyloarthritis
#5
S Krabbe, B Glintborg, M Østergaard, M L Hetland
OBJECTIVE: To investigate whether axial spondyloarthritis (axSpA) patients with extremely poor patient-reported outcomes (PROs) at start of first tumour necrosis factor inhibitor (TNFi) treatment have poorer treatment response and shorter treatment retention than other patients. METHOD: This observational cohort study was based on the nationwide DANBIO registry. Patients with axSpA who started first TNFi during 2011-2016 were stratified according to baseline Bath Ankylosing Spondylitis Disease Activity Index (BASDAI ≥ 0...
August 13, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/30102068/giving-and-receiving-effective-feedback-a-review-article-and-how-to-guide
#6
Rachel Jug, Xiaoyin Sara Jiang, Sarah M Bean
CONTEXT: - Feedback is the delivery of information based on direct observation that is meant to improve performance. Learning is at the heart of feedback, and as such, feedback is a required competency in pathology resident education. In the laboratory setting, the ability of laboratory professionals in all practice settings and experience levels to give and receive feedback is crucial to workflow and ultimately patient care. OBJECTIVE: - To summarize the importance of feedback, strategies for optimizing feedback exchange, and overcoming barriers to giving and receiving feedback...
August 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/30102021/dental-public-health-in-action-barriers-to-oral-healthcare-provision-for-older-people-in-residential-and-nursing-care-homes-a-mixed-method-evaluation-and-strategy-development-in-county-durham-north-east-england
#7
B Ahmad, D Landes, S Moffatt
This paper presents a case study on the use of mixed methods in research into practice to inform policy. The study was undertaken as part of a review of oral healthcare for older people in residential and nursing care homes in County Durham, North East England. The findings highlighted challenges in the provision of good quality oral healthcare to older people in residential and nursing care homes and informed the county's oral health strategy (Durham County Council DCC, 2016). Key recommendations include the need to develop and implement a minimum set of best practice oral health standards within care home contracts and train care home staff in oral healthcare...
August 9, 2018: Community Dental Health
https://www.readbyqxmd.com/read/30102017/recent-advances-in-earth-abundant-photocathodes-for-photoelectrochemical-water-splitting
#8
Wooseok Yang, Jooho Moon
Conversion of solar energy into hydrogen through photoelectrochemical (PEC) water splitting is an attractive way to store renewable energy. Despite the intriguing concept of solar hydrogen production, efficient PEC devices based on earth-abundant semiconductors should be realized in order to economically compete with conventional steam reforming process. In this mini-review, we highlight recent milestones in photocathode development for PEC water splitting, particularly in earth-abundant semiconductors, in terms of new techniques for enhancing performance as well as theoretical aspects...
August 13, 2018: ChemSusChem
https://www.readbyqxmd.com/read/30101599/which-parents-dropout-from-an-evidence-based-parenting-programme-triple-p-at-camhs-comparison-of-programme-completing-and-dropout-parents
#9
Aylin Ozbek, Ozlem Gencer, Aybüke Tugçe Mustan
Evidence-based parenting programmes are beneficial for children's behavioural and emotional problems as well as parenting practices. Along with effectiveness, attendance affects the programme outcome and identification of risks associated with dropout may aid in development of special policy to increase engagement. In this study, we aimed to compare sociodemographics, parental attitudes, child behavioural and emotional problems of programme-completing and dropout parents from Level-4 Triple-P parenting programme applied at Child and Adolescent Mental Health Services (CAMHS)...
August 13, 2018: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/30101507/individual-participant-data-meta-analysis-of-continuous-outcomes-a-comparison-of-approaches-for-specifying-and-estimating-one-stage-models
#10
Amardeep Legha, Richard D Riley, Joie Ensor, Kym I E Snell, Tim P Morris, Danielle L Burke
One-stage individual participant data meta-analysis models should account for within-trial clustering, but it is currently debated how to do this. For continuous outcomes modeled using a linear regression framework, two competing approaches are a stratified intercept or a random intercept. The stratified approach involves estimating a separate intercept term for each trial, whereas the random intercept approach assumes that trial intercepts are drawn from a normal distribution. Here, through an extensive simulation study for continuous outcomes, we evaluate the impact of using the stratified and random intercept approaches on statistical properties of the summary treatment effect estimate...
August 13, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/30100730/farm-based-day-care-in-norway-a-complementary-service-for-people-with-dementia
#11
Tanja Louise Ibsen, Siren Eriksen, Grete Grindal Patil
Background: Day care services provide meaningful activities and coping experiences in a safe environment for people with dementia, as well as improve quality of life. Such services vary in types and settings. Farm-based day care (FDC) services are described as services that have been adapted from the farm setting, using farm resources to promote health. There is limited knowledge on the service offered in both FDC and regular day care services for people with dementia. The present study aims to investigate FDC in Norway and describe the services and the participants' care environment...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/30098740/simulation-to-manage-the-septic-patient-in-the-intensive-care-unit
#12
REVIEW
Alison H Davis, Sherri P Hayes
Sepsis and septic shock are complex, clinical conditions associated with high morbidity and mortality rates. There are evidence-based guidelines outlining priority care areas for sepsis, including early screening outside the intensive care unit. Nurses are directly involved with patient care and must be able to provide safe, competent care after graduation. High-fidelity human patient simulation is an educational tool that provides access to a safe learning environment where the care of a septic patient can be experienced...
September 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/30098426/lncrna-gacat3-acts-as-a-competing-endogenous-rna-of-hmga1-and-alleviates-cucurbitacin-b-induced-apoptosis-of-gastric-cancer-cells
#13
Yibin Lin, Jiahui Li, Shazhou Ye, Jiayi Chen, Yanru Zhang, Liu Wang, Yang Xi, Shizhong Bu, Xiaohui Qiu
Long non-coding RNAs (lncRNAs) have been demonstrated to perform important roles in cancer development. Previously, we have shown that lncRNA gastric cancer-associated transcript 3 (GACAT3) is overexpressed in gastric cancer and acts as a downstream target of interleukin 6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling. However, the role of GACAT3 in regulating gastric cancer cell growth remains unclear. In this study, we demonstrate that GACAT3 acts as a competing endogenous RNA of high mobility group A1 (HMGA1), a typical oncogene that is overexpressed in most types of cancer, based on a search for common miRNA-binding sites and on experiments involving in vitro cell transfection with synthesized miRNA mimics...
August 8, 2018: Gene
https://www.readbyqxmd.com/read/30097183/locomotion-postures-substrate-use-and-foot-grasping-in-the-marsupial-feathertail-glider-acrobates-pygmaeus-diprotodontia-acrobatidae-insights-into-early-euprimate-evolution
#14
Dionisios Youlatos, Dimitra Moussa, Nikolaos-Evangelos Karantanis, Leszek Rychlik
Debates on early euprimate evolution are related to the understanding of the ecological context that promoted their unique adaptations. Currently, these discussions mainly revolve around the habitual use of the small-branch niche or the frequent utilization of wider, and probably, strongly inclined substrates by euprimate ancestors. The current fossil evidence implies a diversity of arboreal quadrupedal behaviors for these early euprimates, associated with the use of various types of substrates. However, inferring the positional behavior of early euprimates based exclusively on fossils fails to unravel the positional flexibility in terms of modes and substrate use, which is important for understanding key adaptations related to limb postures...
August 7, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/30096587/assessment-of-risk-factors-for-cerebrovascular-disease-among-the-elderly-in-beijing-a-23-year-community-based-prospective-study-in-china
#15
Haibin Li, Jin Guo, Anxin Wang, Deqiang Zhang, Yanxia Luo, Wei Wang, Xia Li, Zhe Tang, Xiuhua Guo
INTRODUCTION: There are few studies on how lifestyle factors and mental conditions modulate the cerebrovascular diseases (CBVD) mortality risk are rare in the Asian elderly. AIM: To comprehensively assess the impact of lifestyle factors and mental conditions on the mortality risk of CBVD among the Chinese older adults. MATERIAL AND METHODS: This community-based prospective cohort study was based on the Beijing Longitudinal Study of Aging. We included 2101 participants aged ≥55 years who were interviewed in August 1992 and followed until December 2015...
July 29, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/30096435/methionine-sulfoxide-reductase-a-msra-mediates-the-ubiquitination-of-14-3-3-protein-isotypes-in-brain
#16
Yue Deng, Beichen Jiang, Carolyn L Rankin, Kazuhito Toyo-Oka, Mark L Richter, Julie A Maupin-Furlow, Jackob Moskovitz
The methionine sulfoxide reductase (Msr) system is known for its function in reducing protein-methionine sulfoxide to methionine. Recently, we showed that one member of the Msr system, MsrA, is involved in the ubiquitination-like process in Archaea. Here, the mammalian MsrA is demonstrated to mediate the ubiquitination of the 14-3-3 zeta protein and to promote the binding of 14-3-3 proteins to alpha synuclein in brain. MsrA was also found to enhance the ubiquitination and phosphorylation of Ser129 of alpha synuclein in brain...
August 7, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30096184/high-school-science-fair-student-opinions-regarding-whether-participation-should-be-required-or-optional-and-why
#17
Frederick Grinnell, Simon Dalley, Karen Shepherd, Joan Reisch
The goal of our research is to identify strengths and weaknesses of high school level science fair and improvements that might enhance learning outcomes based on empirical assessment of student experiences. We use the web-based data collection program REDCap to implement anonymous and voluntary surveys about science fair experiences with two independent groups-high school students who recently competed in the Dallas Regional Science and Engineering Fair and post high school students (undergraduates, 1st year medical students, and 1st year biomedical graduate students) on STEM education tracks doing research at UT Southwestern Medical Center...
2018: PloS One
https://www.readbyqxmd.com/read/30096178/ethnic-bias-amongst-medical-students-in-aotearoa-new-zealand-findings-from-the-bias-and-decision-making-in-medicine-bdmm-study
#18
Donna Cormack, Ricci Harris, James Stanley, Cameron Lacey, Rhys Jones, Elana Curtis
Although health provider racial/ethnic bias has the potential to influence health outcomes and inequities, research within health education and training contexts remains limited. This paper reports findings from an anonymous web-based study examining racial/ethnic bias amongst final year medical students in Aotearoa/New Zealand. Data from 302 students (34% of all eligible final year medical students) were collected in two waves in 2014 and 2015 as part of the Bias and Decision Making in Medicine (BDMM) study...
2018: PloS One
https://www.readbyqxmd.com/read/30096144/factors-explaining-variation-in-self-esteem-among-persons-with-type-1-diabetes-and-elevated-hba1c
#19
Jannike Mohn, Jannicke Igland, Vibeke Zoffmann, Mark Peyrot, Marit Graue
OBJECTIVES: To investigate associations between perceived autonomy support from health-care professionals, autonomy-driven motivation, diabetes self-perceived competence and self-esteem in adults (age 18-55 yrs) with suboptimally regulated type 1 diabetes mellitus (T1DM) with at least one HbA1c≥8.0% (≥64 mmol/mol) during the past year, and whether these factors could predict decrease in self-esteem over time. METHODS: A cross-sectional population-based survey was performed, and 9 months follow-up data were collected...
2018: PloS One
https://www.readbyqxmd.com/read/30096115/innovative-phd-dnp-faculty-collaboration-to-advance-baccalaureate-student-population-health-competencies
#20
Ann Marie P Mauro, Debora L Tracey, Maria Torchia LoGrippo, Diane Brienza-Arcilla, Mona Williams-Gregory, Suzanne Shugg, Angelica Bravo, Claire Byrne
Entry-level nurses require health promotion, chronic disease self-management, care coordination, data utilization, and evidence translation competencies to address complex population health needs. An innovative PhD-DNP faculty collaboration implemented a descriptive survey design to evaluate simulation-based strategies using an unfolding chronically ill adult case to address population health. Results showed the PhD-DNP faculty team was effective in developing clinically meaningful learning experiences to assist baccalaureate students to develop population health competencies...
September 2018: Nursing Education Perspectives
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