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Antioxidants health

Sajjad Abbasi, Behnam Keshavarzi, Farid Moore, Andrew Turner, Frank J Kelly, Ana Oliete Dominguez, Neemat Jaafarzadeh
While the distribution and effects of microplastics (MPs) have been extensively studied in aquatic systems, there exits little information on their occurrence in the terrestrial environment and their potential impacts on human health. In the present study, street dust and suspended dust were collected from the city and county of Asaluyeh, Iran. Samples were characterized by various microscopic techniques (fluorescence, polarized light, SEM) in order to quantify and classify MPs and microrubbers (MRs) in the urban and industrial environments that are potentially ingestible or inhalable by humans...
October 10, 2018: Environmental Pollution
Wang Wang, Jibing Wu, Qingyan Zhang, Xue Li, Xixi Zhu, Qiuying Wang, Shasha Cao, Linfang Du
Lung cancer is the main health threat in the world. Recently, oleuropein has been reported to have potent antioxidant and anticancer activities. However, the antitumor effects of oleuropein on H1299 cells are not well understood. Therefore, the purpose of this paper is tantamount to explore the effects of oleuropein on H1299 cells and its underlying mechanism that may be involved. Oleuropein treatment in H1299 cells resulted in cell cycle distribution at G2 /M arrest and apoptosis in a dose-dependent manner...
October 15, 2018: Journal of Cellular Biochemistry
Munesh Kumar, Rajesh Thakur
Background: Arsenic is a well-documented human carcinogen widely distributed in the environment. Chronic exposure of humans to inorganic arsenicals causes many adverse health effects. The present work was conducted to evaluate the protective effect of Syzygium cumini seed extract (SCE) on arsenic-induced genotoxicity and hepatotoxicity in Wistar albino rats. Methods: Rats were randomly divided into five groups of six animals each. Group 1 served as normal control, Group 2 received SCE, 200 mg/kg daily, and Group 3 received arsenic, 100 ppm in drinking water...
October 2018: Reports of Biochemistry & Molecular Biology
Olugbenga David Oloruntola, Johnson Oluwasola Agbede, Simeon Olugbenga Ayodele, Eyanlola Soladoye Ayedun, Olajumoke Temidayo Daramola, Deborah Adebukola Oloruntola
Background: Following the ban on the importation of import-dependent fed ingredients in most developing countries, the need to look inward for local content is now compelling. Thus, leaf meals that have phytogenic additive potentials are envisaged will be a viable feed ingredient in rabbit diets. Methods: The effect of dietary inclusion of gliricidia leaf meal (GLM) with or without multi-enzyme (E) supplementation in rabbits was investigated using ninety-six 35-day old rabbits of crossbreed (Newzealand and Chinchilla)...
2018: Journal of Animal Science and Technology
Bruce N Ames
It is proposed that proteins/enzymes be classified into two classes according to their essentiality for immediate survival/reproduction and their function in long-term health: that is, survival proteins versus longevity proteins. As proposed by the triage theory, a modest deficiency of one of the nutrients/cofactors triggers a built-in rationing mechanism that favors the proteins needed for immediate survival and reproduction (survival proteins) while sacrificing those needed to protect against future damage (longevity proteins)...
October 15, 2018: Proceedings of the National Academy of Sciences of the United States of America
Laurine Garros, Samantha Drouet, Cyrielle Corbin, Cédric Decourtil, Thibaud Fidel, Julie Lebas de Lacour, Emilie A Leclerc, Sullivan Renouard, Duangjai Tungmunnithum, Joël Doussot, Bilal Haider Abassi, Benoit Maunit, Éric Lainé, Ophélie Fliniaux, François Mesnard, Christophe Hano
Flaxseeds are a functional food representing, by far, the richest natural grain source of lignans, and accumulate substantial amounts of other health beneficial phenolic compounds (i.e., flavonols, hydroxycinnamic acids). This specific accumulation pattern is related to their numerous beneficial effects on human health. However, to date, little data is available concerning the relative impact of genetic and geographic parameters on the phytochemical yield and composition. Here, the major influence of the cultivar over geographic parameters on the flaxseed phytochemical accumulation yield and composition is evidenced...
October 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Josef Fontana, Michal Zima, Vaclav Vetvicka
Numerous conditions, including cancer, diabetes, aging, and atherosclerosis, are thought to be associated with oxidative stress. Oxidative stress is defined as a persistent imbalance between oxidation and antioxidation, resulting in the damage of cellular macromolecules and is often considered to be involved in wide variety of human diseases. However, the current literature is very heterogeneous making it rather difficult to draw general conclusions. Often, different biomarkers have been used in different health problems...
October 15, 2018: Immunological Investigations
Yanqing Wu, Yiyang Li, Ting Jiang, Yuan Yuan, Rui Li, Zeping Xu, Xingfeng Zhong, Gaili Jia, Yanlong Liu, Ling Xie, Ke Xu, Hongyu Zhang, Xiaokun Li, Jian Xiao
Diabetic nephropathy (DN) is one of general and common complication of diabetes, which severely affects the physical and mental health of diabetic patients. Fibroblast growth factor 1 (FGF1), an effective control agent of blood glucose, plays an effective treatment role on diabetes-induced renal injury. But the specific molecule mechanism underlying it is still unclear. Since induction of cellular stress is the main and common mechanism of diabetes-induced complication, we hypothesized that reduction of cellular stress is also the molecular mechanism of FGF1 treatment for DN...
October 15, 2018: Journal of Cellular and Molecular Medicine
Mamta Gupta, Jian Zha, Xing Zhang, Gyoo Yeol Jung, Robert J Linhardt, Mattheos A G Koffas
Anthocyanins are plant secondary metabolites that, despite their chemical instability, have found many applications as natural food colorants. They are also known for their beneficial health effects because of their antioxidant and anticancer properties. More stable versions of these molecules, particularly at neutral pH conditions, are required to study the anthocyanin pharmacokinetic properties and obtain effective therapeutic results. In the present report, a cost-effective technique was developed to prepare the deuterated anthocyanin using recombinant Escherichia coli as a production host and deuterated glycerol and D2 O in the culture media...
September 30, 2018: ACS Omega
Chang Hee Jeong, Haram Ryu, Ting Zhang, Chi Ho Lee, Han Geuk Seo, Sung Gu Han
Yogurt is a fermented dairy food produced by growth of lactic acid bacteria (LAB). Green tea is associated with beneficial health effects. Thus, the aim of this study was to evaluate the effects of green tea powder (GTP) on the fermentation and bioactive properties of yogurt. Yogurt was supplemented with 0-3% GTP (w/v), and effects on fermentation were determined. In addition, antioxidant and anti-inflammatory effects of GTP supplemented yogurts were determined in HT-29 colon cells. GTP (1-3%) supplementation significantly increased the acidification rate and growth of LAB during yogurt fermentation...
October 2018: Food Science and Biotechnology
Kathiroli Sujithra, Srinivasan Subramani, Indumathi Dhananjayan, Veerasamy Vinothkumar
Diabetes is a major non-communicable life threatening chronic and pervasive condition that is consuming the world health in a petrifying rate. The circulatory system is one of the major sources of hyperglycemia induced ROS generation. Historically, garlic has been revered as part of a healthful diet. Organosulfur compounds have been attributed to the medicinal properties and health benefits of garlic. The present study focuses on the ameliorative role of Allyl methyl sulfide (AMS) in combating diabetic complications in diabetic rats...
October 15, 2018: Toxicology Mechanisms and Methods
Yaser Khajebishak, Laleh Payahoo, Mohammadreza Alivand, Beitollah Alipour
Diabetes is one of the most prevalent diseases in the worldwide. Type 2 diabetes mellitus (T2DM), the most common form of the disease, has become a serious threat to public health and is a growing burden on global economies. Due to the unexpected adverse effects of antidiabetic medicines, the use of nutraceuticals as a complementary therapy has drawn extensive attention by investigators. In this issue, a novel nutraceutical, Punicic acid (PA)-the main ingredient of pomegranate seed oil (PSO) that has potential therapeutic effects in T2DM-has been investigated...
October 14, 2018: Journal of Cellular Physiology
Prokop Jiří, Anzenbacher Pavel, Mrkvicová Eva, Pavlata Leoš, Zapletalová Iveta, Šťastník Ondřej, Martinek Petr, Kosina Pavel, Anzenbacherová Eva
Wheat is one of the most important agricultural crops worldwide. Recently, anthocyanin-rich wheat genotypes were introduced to the market as a food with added value. In the experiment described here, two different genotypes with blue grain were studied (UC66049 and Skorpion. The aim of the investigation was to determine whether a 72-day-long intake of anthocyanin-rich wheat can influence the drug-metabolizing microsomal cytochromes P450 (using standard drug substrates of rat/human liver microsomal cytochromes P450) and antioxidant status, which indicated the ability of the rats' liver to metabolize drugs or xenobiotics...
October 11, 2018: Food and Chemical Toxicology
Ignacio Niizawa, Brenda Y Espinaco, Susana E Zorrilla, Guillermo A Sihufe
Nowadays, consumers are more conscious about healthier products consumption benefits. Astaxanthin obtained from the microalgae Haematococcus pluvialis represents a natural ingredient for the nutraceutical and functional food industries. It is claimed that astaxanthin has much stronger antioxidant activity than vitamin E and β-carotene, providing different health benefits. However, the unstable structure of the molecule limits its application in functional foods development. Therefore, the present study evaluates the effect of five independent formulation and process variables for natural astaxanthin oleoresin encapsulation using an external ionic gelation technique...
October 11, 2018: International Journal of Biological Macromolecules
Shaorong Luan, Solange Muhayimana, Jiuyong Xu, Xianfei Zhang, Ciying Xiao, Qingchun Huang
Emamectin benzoate (EMB) toxicity contributes a potential risk to environment and human health. To investigate the effect of α-tocopherol (VitE) and dithiothreitol (DTT) in ameliorating EMB-induced cytotoxicity in human K562 cells, in vitro cultured human K562 cells were incubated with different concentrations of EMB in supplement with VitE and DTT when the cells were in the logarithmic phase. Next, the cell growth inhibition was evaluated using the MTT assay and cellular morphology observation. Reactive oxygen species (ROS) production was monitored using DCFH-DA probe and NF-κB signaling was determined using Western blotting...
October 10, 2018: Ecotoxicology and Environmental Safety
Chengliang Luo, Qiang Yang, Yuancai Liu, Shuanhu Zhou, Jiying Jiang, Russel J Reiter, Pallab Bhattacharya, Yongchun Cui, Hongwei Yang, He Ma, Jiemin Yao, Sean E Lawler, Xinmu Zhang, Jianfang Fu, Renato Rozental, Hany Aly, Mark D Johnson, E Antonio Chiocca, Xin Wang
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly produced by the pineal gland in animals. Numerous physiological functions of melatonin have been demonstrated including anti-inflammation, suppressing neoplastic growth, circadian and endocrine rhythm regulation, and its potent antioxidant activity as well as its role in regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. In this review, we summarize the recent advances related to the multiple protective roles of melatonin receptor agonists, melatonin and N-acetylserotonin (NAS) in brain injury, liver damage, and bone health...
October 10, 2018: Free Radical Biology & Medicine
Johanna O Zeitz, Susanne Kaltenböck, Erika Most, Klaus Eder
This study investigated the hypothesis that dietary supplementation of L-methionine (L-Met) in weaned piglets in relation to DL-methionine (DL-Met) results in a higher antioxidant status and lower need for antioxidant enzyme activation in intestinal epithelium and body tissues, and improves gut morphology and gut barrier function as well as performance. A total of 99 early-weaned 21-day old piglets were allotted to six groups and fed a semi-synthetic wheat-barley-based basal diet supplemented with 0.067%, 0...
October 12, 2018: Journal of Animal Physiology and Animal Nutrition
Xindi Yin, Dongxu Ming, Lili Bai, Fei Wu, Hu Liu, Yifan Chen, Linlin Sun, Yidong Wan, Philip Alfred Thacker, Guoyao Wu, Fenglai Wang
This study was conducted to explore the effect of graded levels of pyrroloquinoline quinone disodium (PQQ·Na2) on the performance and intestinal development of weaned pigs. A total of 216 pigs weaned at 28 d were assigned in a randomized complete block design to 6 diets containing 0, 1.5, 3.0, 4.5, 6.0, or 7.5 mg/kg PQQ·Na2 for 28 d. Performance, diarrhea incidence, intestinal morphology, redox status, cytokines, and the expression of tight junction proteins were determined. Pigs had increased ADG (linear, P < 0...
October 12, 2018: Journal of Animal Science
JeanYu Hwang, Den-En Shieh, Yung-Shin Shyu, Cheng-Kuang Hsu, Chuan-Wang Lin
Mulberry lees are the sediment in the bottom of the barrel, which can be obtained from the processing of mulberry wine, and they are considered as low-value byproducts. In this study, mulberry lees were extracted with ethanol, and then fermented with Monascus pilosus to obtain fermented products (M × M). Male ICR mice were diabetes induced by STZ, and then oral administration of fermented products. The results showed that fermented products could reduce 31.9% to 47.9% plasma glucose, 25.8% to 48.2% total cholesterol, and 16...
October 12, 2018: Journal of Food Science
Gulay Ozkan, Paola Franco, Iolanda De Marco, Jianbo Xiao, Esra Capanoglu
Bioactivities and numerous health benefits against a number of oxidative stress related diseases have been attributed to the role of dietary antioxidants. The development of physical (spray drying, lyophilization, supercritical fluid precipitation and solvent evaporation), physico-chemical (coacervation, liposomes and ionic gelation) and chemical encapsulation techniques (interfacial polymerization and molecular inclusion complexation) enable to obtain healthier and acceptable bioactive compounds. This review focuses on the impacts of microencapsulation techniques on the encapsulation characteristics of food antioxidants...
January 30, 2019: Food Chemistry
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