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https://www.readbyqxmd.com/read/30505586/stereotactic-body-radiation-therapy-in-primary-hepatocellular-carcinoma-current-status-and-future-directions
#1
REVIEW
Timothy A Lin, Jessica S Lin, Timothy Wagner, Ngoc Pham
Stereotactic body radiation therapy (SBRT) is a form of radiation therapy that has been used in the treatment of primary hepatocellular carcinoma (HCC) over the past decade. To evaluate the clinical efficacy of SBRT in primary HCC, a literature search was conducted to identify original research articles published from January 2000 through January 2018 in PubMed on SBRT in HCC. All relevant studies published from 2004 to 2018 were included. Prospective studies demonstrated 2-year local control (LC) rates ranging from 64-95% and overall survival (OS) rates ranging from 34% (2-year) to 65% (3-year)...
October 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30449117/supraumbilical-skin-necrosis-after-repeat-transarterial-chemoembolization
#2
Jasone Larrea Oleaga, Mikel Prieto Calvo, Mikel Gastaca Mateo
Transcatheter arterial chemoembolization TACE is an effective treatment for stage BCLC-B hepatocellular carcinoma (1). The development of skin lesions in the supraumbilical region is an unusual complication following this procedure. We report the case of an 80-year-old male with alcoholic liver cirrhosis, portal hypertension PHT (Child-Pugh A) and multifocal hepatocellular carcinoma. The patient had already undergone four radiofrequency ablations, one alcoholization procedure and four TACEs via femoral access...
November 19, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/30402840/the-effects-of-interventional-therapy-on-serum-htatip2-tip30-b7-h4-and-short-term-curative-effect-in-primary-hepatocellular-carcinoma
#3
Z-J Zheng, J Fu, F Zhi, W-J Liu, Y-J Guo, D-D Zhu, J-G Mo
OBJECTIVE: To explore the effects of interventional therapy on human immunodeficiency virus (HIV)-1 Tat interactive protein 2/Tat interactive protein 30 (HTATIP2/TIP30), B7-H4 and short-term curative effect in primary hepatocellular carcinoma. PATIENTS AND METHODS: 62 patients with primary hepatocellular carcinoma admitted in our hospital from June 2015 to June 2016 were enrolled in this study and divided into observation group (n = 31) and control group (n = 31) according to the random number table...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30360019/clinical-outcomes-of-patients-with-a-single-hepatocellular-carcinoma-less-than-5-cm-treated-with-transarterial-chemoembolization
#4
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE. Methods: This study analyzed 175 consecutive patients who underwent TACE as an initial treatment for single HCC ≤ 5 cm. Predictive factors for complete response (CR), recurrence after CR, and overall survival (OS) were evaluated...
October 26, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30345600/disparities-in-the-treatment-of-hepatocellular-carcinoma-based-on-geographical-region-are-decreasing
#5
Lindsay A Sobotka, Alice Hinton, Lanla F Conteh
BACKGROUND AND AIMS: Geographic differences have existed in the management of hepatocellular carcinoma (HCC), and efforts to reduce regional disparities have been initiated. The aim of this study is to use the Nationwide Inpatient Sample (NIS) to determine if regional disparities in the treatment of HCC continue to exist. METHOD: A retrospective database analysis using the Nationwide Inpatient Sample was performed that included patients with a primary diagnosis of HCC...
October 21, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30341113/comparative-efficacy-of-treatment-strategies-for-hepatocellular-carcinoma-systematic-review-and-network-meta-analysis
#6
Guo Tian, Shigui Yang, Jinqiu Yuan, Diane Threapleton, Qiyu Zhao, Fen Chen, Hongcui Cao, Tian'an Jiang, Lanjuan Li
OBJECTIVE: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. We conducted network meta-regression within a Bayesian framework to compare and rank different treatment strategies for HCC through direct and indirect evidence from international studies. METHODS AND ANALYSES: We pooled the OR for 1-year, 3-year and 5-year overall survival, based on lesions of size ˂ 3 cm, 3-5 cm and ≤5 cm, using five therapeutic options including resection (RES), radiofrequency ablation (RFA), microwave ablation (MWA), transcatheter arterial chemoembolisation (TACE) plus RFA (TR) and percutaneous ethanol injection (PEI)...
October 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/30334945/microwave-ablation-combined-with-transcatheter-arterial-chemoembolization-is-effective-for-treating-unresectable-hepatoblastoma-in-infants-and-children
#7
Yizhou Jiang, Shaoyi Zhou, Gang Shen, Hua Jiang, Jing Zhang
The present study is to evaluate the feasibility and efficacy of microwave ablation (MWA) combined with transcatheter arterial chemoembolization (TACE) in the treatment for unresectable hepatoblastoma in infants and children. A total of 17 patients with PRETEXT stage III and IV hepatoblastoma that was unresectable by conventional resection were included in the present study. The patients were treated with TACE, MWA, and chemotherapy. All cases were diagnosed by computed tomography (CT) and liver tumor biopsy before TACE procedure...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30306400/transarterial-chemoembolization-with-raltitrexed-based-or-floxuridine-based-chemotherapy-for-unresectable-colorectal-cancer-liver-metastasis
#8
N Wei, B Zhang, Y Wang, X H He, L C Xu, G D Li, Y H Wang, G Z Wang, H Z Huang, W T Li
PURPOSE: To evaluate and compare the efficiency and safety of raltitrexed- or floxuridine (FUDR)-based transarterial chemoembolization (TACE) in patients with unresectable colorectal cancer liver metastasis (CRCLM). METHODS: We conducted a retrospective analysis of 81 patients with unresectable CRCLM who failed systemic chemotherapy and were treated with TACE in our department from Oct 2014 to Oct 2017. Of these, 61 patients received TACE using raltitrexed, oxaliplatin, and pirarubicin (raltitrexed group), and 20 received TACE using FUDR, oxaliplatin, and pirarubicin (FUDR group)...
October 10, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30246025/serum-stem-cell-growth-factor-beta-for-the-prediction-of-therapy-response-in-hepatocellular-carcinoma
#9
Caecilia H C Sukowati, Riccardo Patti, Devis Pascut, Rusdina B Ladju, Paola Tarchi, Nunzia Zanotta, Manola Comar, Claudio Tiribelli, Lory S Crocè
Introduction: Chronic inflammatory response is one of major contributors in the development of hepatocellular carcinoma (HCC). Inflammatory molecules, such as cytokines and growth factors in the circulation, can be useful in the diagnosis and prognosis of the patients. The stem cell growth factor beta (SCGF β ), a newly found protein, is a secreted sulfated glycoprotein and it functions as a growth factor for primitive hematopoietic progenitor cells. The level of SCGF β had been reported to be elevated in several cancer types...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30226882/correction-percutaneous-thermal-ablation-combined-with-tace-versus-tace-monotherapy-in-the-treatment-for-liver-cancer-with-hepatic-vein-tumor-thrombus-a-retrospective-study
#10
Yang Wang, Liang Ma, Zhuhui Yuan, Jiasheng Zheng, Wei Li
[This corrects the article DOI: 10.1371/journal.pone.0201525.].
2018: PloS One
https://www.readbyqxmd.com/read/30183583/evaluation-of-tumor-response-using-alpha-fetoprotein-and-des-gamma-carboxy-prothrombin-in-hepatocellular-carcinoma-patients-who-underwent-transarterial-chemoembolization
#11
Razvan Cerban, Carmen Ester, Speranta Iacob, Liliana Paslaru, Radu Dumitru, Mugur Grasu, Georgiana Constantin, Irinel Popescu, Liliana Gheorghe
Introduction: The aim of the study is to evaluate the role of alpha-fetoprotein (AFP) and des-y-carboxy prothrombin (DCP) in the assessment of treatment response at one month in patients with hepatocellular carcinoma (HCC) treated with trans-arterial chemoembolization (TACE). Methods: From March 2016 to April 2017 a number of 59 patients diagnosed with HCC were prospectively enrolled. A TACE procedure as initial treatment modality was performed in 41 patients. AFP and DCP serum levels were measured and clinical features were determined for all the patients that were included...
July 2018: Chirurgia
https://www.readbyqxmd.com/read/30182267/-intrahepatic-cholangiocarcinoma-current-perspectives-and-treatment-algorithm
#12
REVIEW
G Lurje, J Bednarsch, C Roderburg, C Trautwein, U P Neumann
Cholangiocarcinoma (CCC) is the second most common primary malignancy of the liver and is typically diagnosed at advanced disease stages. Among curative treatment options for CCC, radical surgical resection with extrahepatic bile duct resection, hepatectomy, and en-bloc lymphadenectomy are considered the mainstay of curative therapy. The assessment of the functional liver reserve by dynamic liver function tests and the estimation of the remaining future liver volume (future liver remnant, FLR) are of paramount importance...
November 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/30151270/stereotactic-body-radiation-therapy-following-transarterial-chemoembolization-for-unresectable-hepatocellular-carcinoma
#13
Michael Buckstein, Edward Kim, Aaron Fischman, Seth Blacksburg, Marcelo Facciuto, Myron Schwartz, Kenneth Rosenzweig
Background: Transarterial chemoembolization (TACE) is the standard for unresectable Barcelona Clinic Liver Cancer (BCLC) B hepatocellular carcinoma (HCC) patients but is not an ablative therapy. This study explores stereotactic body radiation therapy (SBRT) as an adjuvant or salvage to drug eluting bead (DEB)-TACE. Methods: A retrospective review identified patients receiving SBRT within 2 years following DEB-TACE to a target lesion. Primary outcome was objective response (OR) using modified response evaluation criteria in solid tumors (mRECIST)...
August 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30148147/negative-impact-of-hepatitis-b-surface-seroclearance-on-prognosis-of-hepatitis-b-related-primary-liver-cancer
#14
Cheng Lou, Tong Bai, Le-Wei Bi, Ying-Tang Gao, Zhi Du
AIM: To assess the impact of hepatitis B surface (HBsAg) seroclearance on survival outcomes in hepatitis B-related primary liver cancer. METHODS: Information from patients with hepatitis B-related liver cancer admitted in our hospital from 2008-2017 was retrieved. Cases diagnosed with HBsAg (-) and HBcAb (+) liver cancer were included in the HBsAg seroclearance (SC) group. HBsAg (+) liver cancer patients strictly matched for liver cancer stage (AJCC staging system, 8th edition), Child-Pugh score, and first diagnosis/treatment method (surgery, ablation and TACE) were assigned to the HBsAg non-seroclearance (NSC) group...
August 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30132184/transcatheter-arterial-chemoembolization-combined-with-simultaneous-dynact-guided-radiofrequency-ablation-in-the-treatment-of-solitary-large-hepatocellular-carcinoma
#15
Hongjun Yuan, Fengyong Liu, Xin Li, Yang Guan, Maoqiang Wang
PURPOSE: To introduce the technique and investigate the clinical efficacy of transcatheter arterial chemoembolization (TACE) in combination with simultaneous DynaCT-guided radiofrequency ablation (RFA) in the treatment of solitary large hepatocellular carcinomas (HCCs) (maximal diameter > 5 cm). MATERIALS AND METHODS: Forty-six patients who received TACE combined with simultaneous DynaCT-guided RFA for solitary large HCCs between January 2012 and August 2016 were reviewed, and the success rate, safety, local tumor progression (LTP), and overall survival (OS) were retrospectively investigated...
August 21, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/30064514/clinical-efficacy-of-chemoembolization-with-simultaneous-radiofrequency-ablation-for-treatment-of-adrenal-metastases-from-hepatocellular-carcinoma
#16
Hongjun Yuan, Fengyong Liu, Xin Li, Yang Guan, Maoqiang Wang
BACKGROUND: This study investigated the safety and efficacy of transcatheter arterial chemoembolization (TACE) with simultaneous radiofrequency ablation (RFA) as treatment for adrenal metastases (AM) from hepatocellular carcinoma(HCC). METHODS: The records of 63 patients with AM who were treated at our Hospital between February 2013 and August 2016 were retrospectively reviewed. Patients were divided into a TACE+RFA group (n = 38) and a control group that received TACE alone (n = 25) according to different treatment methods...
July 31, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/30063737/percutaneous-thermal-ablation-combined-with-tace-versus-tace-monotherapy-in-the-treatment-for-liver-cancer-with-hepatic-vein-tumor-thrombus-a-retrospective-study
#17
Yang Wang, Liang Ma, Zhuhui Yuan, Jiasheng Zheng, Wei Li
PURPOSE: To investigate the efficacy of percutaneous thermal ablation combined with transarterial chemoembolization (TACE) versus TACE monotherapy in treating primary liver cancer with hepatic vein tumor thrombus (HVTT), and to identify potential factors of overall survival after combination therapy. MATERIALS AND METHODS: Patients with primary liver cancer and HVTT from 2011 to 2016 at our institute were retrospectively identified. They were divided into two groups (group A and group B)...
2018: PloS One
https://www.readbyqxmd.com/read/30003446/detection-of-needle-tract-implantation-and-peritoneal-seeding-after-radiofrequency-ablation-using-intraoperative-near-infrared-fluorescence-system-for-recurrent-hepatocellular-carcinoma-a-case-report
#18
Masashi Nakamura, Shinya Hayami, Masaki Ueno, Manabu Kawai, Atsushi Miyamoto, Norihiko Suzaki, Seiko Hirono, Ken-Ichi Okada, Motoki Miyazawa, Yuji Kitahata, Hiroki Yamaue
BACKGROUND: Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is already fully established worldwide. Needle tract implantation and peritoneal seeding occasionally occur by RFA, and the prognosis of these cases is thought to be poor. In this study, intraoperative real-time near-infrared fluorescence (NIRF) system by indocyanine green (ICG) incidentally detected both needle tract implantation and peritoneal seeding. As the utility of this system for identification of implanted and disseminated lesions after RFA for HCC has not been widely reported, we report a case of successful detection by real-time ICG-NIRF imaging and subsequent resection...
July 13, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29963463/hepatocellular-carcinoma-in-malaysia-and-its-changing-trend
#19
REVIEW
Ruksana Raihan, Amirah Azzeri, Fatiha H Shabaruddin, Rosmawati Mohamed
Hepatocellular carcinoma (HCC) is one of the leading causes of death globally. In Malaysia liver cancer is the eighth most common cause of cancer for both gender and fifth most common cause of cancer for males. Liver cancer is a cause of premature death in Malaysia: The trend from 1990 to 2010 was observed upward. Since 1990, the annual years of life lost (YLLs) from liver cancer have increased by 31.5%. Older persons are at higher risk and there is male predominance observed. Curative surgical resection, liver transplantation, and supportive symptomatic care, including percutaneous ethanol injection and radiofrequency ablation (RFA), and noncurative transarterial chemoembolization (TACE) are among available treatment facilities...
January 2018: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29962868/radiofrequency-ablation-combined-with-transcatheter-arterial-chemoembolization-therapy-versus-surgical-resection-for-hepatocellular-carcinoma-within-the-milan-criteria-a-meta-analysis
#20
Wei-Dong Wang, Li-Hua Zhang, Jia-Yan Ni, Xiong-Ying Jiang, Dong Chen, Yao-Ting Chen, Hong-Liang Sun, Jiang-Hong Luo, Lin-Feng Xu
Objective: To meta-analytically compare combined transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) and surgical resection (SR) for the treatment of hepatocellular carcinoma (HCC) within the Milan criteria. Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for studies comparing these two therapies that were published between January 2006 and August 2017. Overall survival rate (OS), recurrence-free survival rate (RFS), major complications and the average length of hospital stay were compared between these two therapies...
July 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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