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JOURNAL ARTICLE
Irshat Ibrahim, Yilimire Nuermaimaiti, Gulijianaiti Maimaituxun, Xinling Luo, Mailudemu Maimaituxun, Azimat Akbar, Kahaer Tuerxun, Yuanquan Wu
INTRODUCTION: The prevalence of diabetes mellitus and its sequelae has been on the rise, and diabetic foot ulcer (DFU) is the leading cause of non-traumatic lower limb amputation globally. The rising occurrence and financial burden associated with DFU necessitate improved clinical assessment and treatment. Diabetes has been found to enhance the formation of neutrophil extracellular traps (NETs) by neutrophils, and excessive NETs have been implicated in tissue damage and impaired wound healing...
April 15, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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No abstract text is available yet for this article.
April 2024: International Wound Journal
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JOURNAL ARTICLE
Shaoling Yang, Liye Hu, Yue Zhao, Guangzhe Meng, Sijia Xu, Rui Han
Multidrug-resistant (MDR) bacterial infections have become increasingly common in recent years due to the increased prevalence of diabetic foot ulcers (DFUs). We carried out a meta-analysis aimed at investigating the prevalence of MDR bacteria isolated from DFUs and analysing the risk factors for MDR bacterial infection in patients with DFUs. The PubMed/Medline, Web of Science, Embase, Cochrane Library, Ovid, Scopus, and ProQuest databases were searched for studies published up to November 2023 on the clinical outcomes of MDR bacteria in DFUs...
April 2024: International Wound Journal
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JOURNAL ARTICLE
Huiren Zhuang, Hai-Ping Yu, Ying-Jie Gu, Ling-Jun Li, Jia-Li Yao
OBJECTIVE: The meta-analysis was performed to evaluate the effectiveness of telemedicine interventions on patients with diabetic foot ulcers(DFU). APPROACH: The authors conducted a comprehensive search across eight databases. The aim was to identify randomized controlled trials examining the effectiveness of telemedicine for patients with DFU. Methodological qualities of included studies were assessed using Cochrane Handbook for Systematic Reviews of Intervention...
April 15, 2024: Advances in Wound Care
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REVIEW
Sarah Craus, Abigail Mula, David V Coppini
The term 'diabetic foot disease' (DFD) often signifies the presence of foot ulceration and infection, but one must also be wary of the rarer occurrence of Charcot foot disease. The worldwide prevalence of DFD is 6.3% (95%CI: 5.4-7.3%). Foot complications present a major challenge to both patients and healthcare systems, with increased rates of hospitalisation and an almost trebled 5-year mortality. The Charcot foot often occurs in patients with long-standing diabetes, presenting as an inflamed or swollen foot or ankle, following unrecognised minor trauma...
May 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
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JOURNAL ARTICLE
Sebouh Bazikian, Alyssa J Pyun, Hanke Zheng, William Padula, Tanzim Khan, Kenneth Ziegler, Laura Shin, Gregory A Magee, Vincent L Rowe, David G Armstrong
BACKGROUND: This study examined the efficacy of an interdisciplinary limb preservation service (LPS) in improving surgical outcomes for diabetic foot ulcer (DFU) patients compared to traditional care. METHODS: Data from January 1, 2017 to September 30, 2020 were retrospectively reviewed. An interdisciplinary LPS clinic began on August 1, 2018, coexisting with a preexisting single specialty service. Primary outcomes were major/minor amputation rates and ratios and hospital length of stay...
June 2024: Journal of Foot and Ankle Research
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JOURNAL ARTICLE
Hongshuo Shi, Zhicheng Zhang, Xin Yuan, Guobin Liu, Weijing Fan, Wenbo Wang
BACKGROUND: Diabetic foot ulcers (DFUs) pose a serious long-term threat because of elevated mortality and disability risks. Research on its biomarkers is still, however, very limited. In this paper, we have effectively identified biomarkers linked with macrophage excretion in diabetic foot ulcers through the application of bioinformatics and machine learning methodologies. These findings were subsequently validated using external datasets and animal experiments. Such discoveries are anticipated to offer novel insights and approaches for the early diagnosis and treatment of DFU...
April 10, 2024: Aging
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JOURNAL ARTICLE
Wenli Shi, Qianya Zhou, Dan Yang, Jie Yang, Chao Liu, Hongying Pan
This study aimed to investigate the contemporary status and influencing factors of foot self-care behavior in diabetic foot amputation patients. A total of 250 patients with diabetic foot amputation were included. The general information questionnaire, Chinese Version of the Nottingham Assessment of Function Footcare (CNAFF), Knowledge of Diabetic Foot Questionnaire, and The Third Version of the Diabetes Attitude Scale were used to investigate the status and influencing factors of foot self-care behavior in patients with diabetic foot amputation...
April 13, 2024: International Journal of Lower Extremity Wounds
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REVIEW
Karolina Kondej, Małgorzata Zawrzykraj, Katarzyna Czerwiec, Milena Deptuła, Agata Tymińska, Michał Pikuła
Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin...
March 26, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Federica Li Pomi, Alfonso Motolese, Alessia Paganelli, Mario Vaccaro, Alberico Motolese, Francesco Borgia
Necrobiosis Lipoidica (NL) is a dermatological condition characterized by the development of granulomatous inflammation leading to the degeneration of collagen and subsequent formation of yellowish-brown telangiectatic plaques usually localized on the pretibial skin of middle-aged females. Due to its rarity and unclear etiopathogenesis, therapeutic options for NL are not well-standardized. Among them, photodynamic therapy (PDT) is an emerging tool, although its efficacy has primarily been evaluated in single case reports or small case series...
March 23, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Belgin Coşkun, Müge Ayhan, Serap Ulusoy
The prognostic nutritional index (PNI) is a new marker used to assess a patient's nutritional and immune status. It is calculated using serum albumin levels and total lymphocyte count. The aim of this study was to investigate the relationship between PNI and amputation in patients with diabetic foot ulcer (DFU). Patients with DFU were enrolled in this retrospective study. In our study, a total of 386 patient data, of 110 (28.5%) amputated and 276 (71.5%) non-amputated patients, were statistically analyzed. PNI values were significantly lower in the amputated patient group than in the non-amputee patient group ( p < 0...
March 29, 2024: Diagnostics
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REVIEW
Gerhard Rümenapf, Nour Abilmona, Stephan Morbach, Martin Sigl
Background : In vascular medicine, peripheral arterial disease (PAD) and diabetic foot syndrome (DFS) are often considered synonymous with respect to the need for revascularization. In PAD patients, clinical symptoms reflect the degree of atherosclerotic disease, since peripheral innervation, including pain sensation, is not usually compromised. In DFS patients, however, symptoms of relevant foot ischemia are often absent and progression of ischemia goes unnoticed owing to diabetic polyneuropathy, the loss of nociception being the main trigger for foot ulcers...
April 8, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Sebastián Flores-Escobar, Mateo López-Moral, Marta García-Madrid, Francisco J Álvaro-Afonso, Aroa Tardáguila-García, José Luis Lázaro-Martínez
Background: This study aims to assess the atherogenic index of plasma (AIP) diagnostic value in detecting diabetic foot osteomyelitis (DFO) among patients with diabetic foot ulcers (DFUs). Methods: A prospective cohort study was conducted on 80 patients with DFUs and suspected DFO between January 2022 and December 2023. The primary outcome measures included the diagnosis of DFO, determined by positive microbiological analysis results from bone samples and its correlation with the AIP. Receiver operating characteristic (ROC) curves were utilized to select the optimal diagnostic cut-off points for AIP and post hoc analysis was performed to evaluate the difference in the AIP for diagnosing DFO in patients with and without peripheral arterial disease (PAD)...
March 27, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Laura Hailstone, David Tovmassian, Chu Luan Nguyen, Pearl Wong, Philip Alexander Le Page, David Martin, Craig Taylor
PURPOSE: This study presents the short- (less than 6 months) and medium-term (6 months to 2 years) outcomes for weight loss and type 2 diabetes mellitus (T2DM) for all patients undergoing one anastomosis gastric bypass (OAGB) across multiple institutions between 2015 and 2021. MATERIALS AND METHODS: A retrospective analysis of prospectively collected databases was performed including 1022 participants who underwent OAGB at multiple institutions by multiple surgeons between 2015 and 2021...
April 12, 2024: Obesity Surgery
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JOURNAL ARTICLE
Nada Bechara, Tien-Ming Hng, Jenny E Gunton
Smoking may increase the risk of diabetic foot disease and ulceration. It does so by impairing glycaemic control and promoting the formation of advanced glycated end-products. Additionally, smoking is known to delay surgical wound healing and accelerate peripheral arterial disease. We aimed to determine whether toe pressures differed in smokers with a foot ulcer, when compared to non-smokers and ex-smokers, as well as ulcer outcomes at 12 months, among patients attending Blacktown Hospital High Risk Foot Service (HRFS)...
April 12, 2024: Scientific Reports
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JOURNAL ARTICLE
David G Armstrong, Dennis P Orgill, Robert D Galiano, Paul M Glat, Jarrod P Kaufman, Marissa J Carter, Lawrence A DiDomenico, Charles M Zelen
As the incidence of diabetic foot ulcers (DFU) increases, better treatments that improve healing should reduce complications of these ulcers including infections and amputations. We conducted a randomized controlled trial comparing outcomes between a novel purified reconstituted bilayer membrane (PRBM) to the standard of care (SOC) in the treatment of non-healing DFUs. This study included 105 patients who were randomized to either of two treatment groups (n = 54 PRBM; n = 51 SOC) in the intent to treat (ITT) group and 80 who completed the study per protocol (PP) (n = 47 PRBM; n = 33 SOC)...
April 2024: International Wound Journal
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JOURNAL ARTICLE
Rongyan Wei, Shangyu Chen, Xiuxian Huang, Zhenwei Zhai, Qiu Wang, Jingxia Sun, Jianming Mo, Jianhao Huang, Yancheng Xu, Wensheng Lu
The triglyceride glucose (TyG) index has been confirmed a predictive value for type 2 diabetes mellitus (T2DM). However, no research has yet confirmed whether there is a linear correlation between the TyG index and MACCEs in DFUs. The present study aimed to delve into the association between the TyG index and the risk of MACCEs in patients with DFUs. A total of 960 inpatients with DFUs were recruited. All participants were followed up every 6 months for 11 years with a median of 83 months...
April 2024: International Wound Journal
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JOURNAL ARTICLE
Jiaying Li, Daniel Yee Tak Fong, Kris Yuet Wan Lok, Janet Yuen Ha Wong, Mandy Man Ho, Edmond Pui Hang Choi, Vinciya Pandian, Patricia M Davidson, Wenjie Duan, Marie Tarrant, Jung Jae Lee, Chia-Chin Lin, Oluwadamilare Akingbade, Khalid M Alabdulwahhab, Mohammad Shakil Ahmad, Mohamed Alboraie, Meshari A Alzahrani, Anil S Bilimale, Sawitree Boonpatcharanon, Samuel Byiringiro, Muhammad Kamil Che Hasan, Luisa Clausi Schettini, Walter Corzo, Josephine M De Leon, Anjanette S De Leon, Hiba Deek, Fabio Efficace, Mayssah A El Nayal, Fathiya El-Raey, Eduardo Ensaldo-Carrasco, Pilar Escotorin, Oluwadamilola Agnes Fadodun, Israel Opeyemi Fawole, Yong-Shian Shawn Goh, Devi Irawan, Naimah Ebrahim Khan, Binu Koirala, Ashish Krishna, Cannas Kwok, Tung Thanh Le, Daniela Giambruno Leal, Miguel Ángel Lezana-Fernández, Emery Manirambona, Leandro Cruz Mantoani, Fernando Meneses-González, Iman Elmahdi Mohamed, Madeleine Mukeshimana, Chinh Thi Minh Nguyen, Huong Thi Thanh Nguyen, Khanh Thi Nguyen, Son Truong Nguyen, Mohd Said Nurumal, Aimable Nzabonimana, Nagla Abdelrahim Mohamed Ahmed Omer, Oluwabunmi Ogungbe, Angela Chiu Yin Poon, Areli Reséndiz-Rodriguez, Busayasachee Puang-Ngern, Ceryl G Sagun, Riyaz Ahmed Shaik, Nikhil Gauri Shankar, Kathrin Sommer, Edgardo Toro, Hanh Thi Hong Tran, Elvira L Urgel, Emmanuel Uwiringiyimana, Tita Vanichbuncha, Naglaa Youssef
BACKGROUND: Central and bridge nodes can drive significant overall improvements within their respective networks. We aimed to identify them in 16 prevalent chronic diseases during the coronavirus disease 2019 (COVID-19) pandemic to guide effective intervention strategies and appropriate resource allocation for most significant holistic lifestyle and health improvements. METHODS: We surveyed 16 512 adults from July 2020 to August 2021 in 30 territories. Participants self-reported their medical histories and the perceived impact of COVID-19 on 18 lifestyle factors and 13 health outcomes...
April 12, 2024: Journal of Global Health
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REVIEW
Sayantan Mukherjee, Aditi Chopra, Shaswata Karmakar, Subraya Giliyar Bhat
Periodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis, and cancers. The oral-systemic link between periodontal disease and systemic diseases is attributed to the spread of inflammation, microbial products and microbes to distant organ systems. Oral bacteria reach the gut via swallowed saliva, whereby they induce gut dysbiosis and gastrointestinal dysfunctions...
April 11, 2024: Critical Reviews in Microbiology
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JOURNAL ARTICLE
Dakota T Thompson, Ethan G Breyfogle, Catherine G Tran, Mohammed O Suraju, Aditi Mishra, Hussain A Lanewalla, Paolo Goffredo, Imran Hassan
BACKGROUND: Frailty has been associated with worse postoperative outcomes. The 5-factor modified frailty index (mFI-5) is an objective measure although its validity in measuring frailty in patients undergoing ileal pouch-anal anastomosis (IPAA) for chronic ulcerative colitis (CUC) has not been reported. METHODS: This study used the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) targeted proctectomy database. The mFI-5 was calculated by five preoperative diagnoses: insulin-dependent or noninsulin-dependent diabetes, congestive heart failure, hypertension, chronic obstructive pulmonary disease, and dependent or partially dependent functional status...
June 2024: Surgery open science
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