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https://www.readbyqxmd.com/read/30121715/management-of-brain-metastases-in-the-new-era-of-checkpoint-inhibition
#1
REVIEW
Adam Lauko, Bicky Thapa, Vyshak Alva Venur, Manmeet S Ahluwalia
PURPOSE OF THE REVIEW: Brain metastasis is a common complication of advanced malignancies, especially, lung cancer, breast cancer, renal cell carcinoma, and melanoma. Traditionally surgery, when indicated, and radiation therapy, either as whole-brain radiation therapy or stereotactic radiosurgery, constituted the major treatment options for brain metastases. Until recently, most of the systemic chemotherapy agents had limited activity for brain metastases. However, with the advent of small molecule tyrosine kinase inhibitors and immunotherapy agents, there has been renewed interest in using these agents in the management of brain metastases...
August 18, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/30093473/synchronous-colon-cancer-with-pulmonary-metastasis-and-follicular-variant-of-papillary-thyroid-cancer-metastasising-to-kidney
#2
Arun Kadamkulam Syriac, Murtaza Mirza, Ashley Rose Malekunnel, Alberto Locante, Palak Desai
Thyroid malignancies are one of the fastest growing cancers in the world, with the majority being papillary thyroid cancer. Follicular variant of papillary thyroid cancer accounts for about 10%-20% of papillary thyroid carcinomas. The usual sites for metastases of these tumours are lungs and bones with renal metastases being extremely rare. We describe a case of a 64-year-old woman who presented with abdominal pain. On subsequent imaging, she was found to have a colonic mass with metastatic lesions in the lungs and tumour involving left kidney...
August 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30093182/solid-malignant-metastases-in-the-jaw-bones
#3
A Andabak Rogulj, C Tomasovic Loncaric, D Muller, I Blivajs, M Andabak, V Vucicevic Boras, M Sekerija
Metastatic tumours to the jaw bones are rare, and usually develop during the final stages of cancer. Some, such as those of lung, breast, and kidney, are more likely to metastasise to the jaw. We have therefore analysed the clinical and epidemiological characteristics of patients with metastatic tumours. We retrieved the notes of 4 478 patients with metastatic tumours to the jawbones who were treated in the Clinical Hospital Centre Dubrava in Zagreb, Croatia, during the 15 years 2002-17 and made a retrospective analysis of patients' age, sex, site of primary tumour, site and clinical presentation of the metastases, time interval since diagnosis of the primary tumour and oral metastases, and time interval from diagnosis of oral metastases to death...
August 6, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/30038687/metastatic-pulmonary-calcification-as-a-rare-complication-of-end-stage-renal-disease-with-coexistence-of-pulmonary-metastases-from-renal-cell-carcinoma-case-report-and-literature-review
#4
Marta Michali-Stolarska, Anna Zacharzewska-Gondek, Joanna Bladowska, Maciej Guziński, Marek J Sąsiadek
Purpose: We present a case of metastatic pulmonary calcification (MCP) in an asymptomatic patient with chronic kidney disease after renal transplantation and nephrectomy due to renal cancer. Chest computed tomography (CT) revealed bilateral, diffuse, centrilobular ground-glass opacities and heterogeneous, high-density areas distributed throughout the lungs, predominantly in the upper and middle lobes. Unusually, in our patient the metastatic calcification coexisted with pulmonary metastases from renal cell carcinoma associated with end-stage renal disease...
2018: Polish Journal of Radiology
https://www.readbyqxmd.com/read/30026428/-a-case-of-rectal-cancer-and-multiple-liver-metastases-treated-using-mfolfox-and-bevacizumab-under-maintenance-dialysis
#5
Yuka Aimono, Toshiro Kamoshida, Atsushi Okawara, Tatsunori Ogawa, Shunichi Suzuki, Risa Sakamoto, Yoshiko Saito, Yoshifumi Aoyama
A 50s man receiving dialysis for chronic kidney disease due to IgA nephropathy underwent laparoscopic reversal via Hartmann 's procedure for rectal cancer and multiple liver metastases, followed by chemotherapy for the liver metastases. Following a single course of mFOLFOX therapy, bevacizumab was administered for 8 courses, resulting in tumor shrinkage and a decrease in tumor marker levels. The initial doses were 60mg/m2 oxaliplatin and 280(bolus injection)and 1,680mg/m2 (continuous infusion)of 5-FU. Subsequently, these doses were adjusted to be administered every 3 weeks...
June 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/30009389/nrh-quinone-oxidoreductase-2-nqo2-and-glutaminase-gls-both-play-a-role-in-large-extracellular-vesicles-lev-formation-in-preclinical-lncap-c4-2b-prostate-cancer-model-of-progressive-metastasis
#6
Thambi Dorai, Ankeeta Shah, Faith Summers, Rajamma Mathew, Jing Huang, Tze-Chen Hsieh, Joseph M Wu
In the course of studies aimed at the role of oxidative stress in the development of metastatic potential in the LNCaP-C4-2B prostate cancer progression model system, we found a relative decrease in the level of expression of the cytoplasmic nicotinamide riboside: quinone oxidoreductase (NQO2) and an increase in the oxidative stress in C4-2B cells compared to that in LNCaP or its derivatives C4 and C4-2. It was also found that C4-2B cells specifically shed large extracellular vesicles (LEVs) suggesting that these LEVs and their cargo could participate in the establishment of the osseous metastases...
July 15, 2018: Prostate
https://www.readbyqxmd.com/read/30007959/curious-residents-of-the-thyroid-gland-two-case-reports-of-colorectal-carcinoma-metastasis-by-fine-needle-aspiration-diagnosis
#7
Céline Melis, Florence Ballaux, Claire Bourgain
BACKGROUND: The most frequent metastases to the thyroid originate in the kidney, lung or breast. Colorectal adenocarcinoma represents less than 4% of metastases to the thyroid gland. Solitary metastases of colorectal cancer with no other manifestation of disseminated cancer disease are exceedingly rare. Within the Bethesda Classification for Reporting -Thyroid Cytopathology, metastases are included in Diagnostic Categories "Suspicious for Malignancy" and "Malignant." CASES: We present 2 cases of colorectal adenocarcinoma metastatic to the thyroid gland, diagnosed by fine-needle aspiration (FNA)...
July 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29970539/pathological-high-risk-renal-cell-carcinoma-trends-in-clinical-characteristics-over-25-years
#8
Ettore DI Trapani, Paolo Dell'oglio, Alessandro Larcher, Alessandro Nini, Fabio Muttin, Francesco Cianflone, Federico Dehò, Rayan Matloob, Dario DI Trapani, Massimo Freschi, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Roberto Bertini, Umberto Capitanio
BACKGROUND/AIM: The incidence of renal cell carcinoma (RCC) has been increasing mainly due to the increase in the incidental detection of small renal masses. The aim of this study was to verify whether the trend towards early diagnosis changed the clinical characteristics of pathologically-defined high-risk RCC patients over the last decades. PATIENTS AND METHODS: A total of 741 patients with pathologically-confirmed high-risk RCC (pT1-4, and/or pN1 and/or Fuhrman grade 3-4 and/or all M1 patients) treated with radical (RN) or partial nephrectomy (PN) at a single tertiary referral center between 1987 and 2011 were included in the study...
July 2018: Anticancer Research
https://www.readbyqxmd.com/read/29970253/leptin-and-its-receptor-can-they-help-to-differentiate-chromophobe-renal-cell-carcinoma-from-renal-oncocytoma
#9
K L Ng, S J Del Vecchio, H Samaratunga, C Morais, R Rajandram, D A Vesey, S T Wood, G C Gobe
One of the challenges in differentiating chromophobe renal cell carcinoma (chRCC) from benign renal oncocytoma (RO) is overlapping morphology between the two subtypes. The aim of this study was to investigate the usefulness of expression of leptin (Ob) and its receptor (ObR) in discriminating chRCC from RO. Sections from paraffin-embedded, formalin-fixed tumour nephrectomy specimens of 45 patients, made up of 30 chRCC (15 eosinophilic variant and 15 non-eosinophilic variant) and 15 RO, were used in this study...
August 2018: Pathology
https://www.readbyqxmd.com/read/29955398/a-complex-cardiac-mass-originating-from-interatrial-septum-in-a-patient-with-history-of-kidney-cancer-a-case-report-and-literature-review
#10
Negar Faramarzi, Sumit Sohal, Roshanak Habibi, Muhammad Sikander Akbar
Cardiac tumors are a rare phenomenon, and most cases are secondary to metastatic cancers rather than primary tumors. Renal cell carcinoma (RCC) is notorious for metastasis to cardiac tissue. Tumor thrombus migration to the renal vein and inferior vena cava happens in up to 10% of patients with RCC. Transitional cell carcinomas are another form of renal cancer, which may metastasize to the heart and are associated with widespread metastasis. Here, we report a patient with a past medical history of metastatic transitional cell cancer of renal pelvis under treatment with checkpoint inhibitor therapy presenting with shortness of breath...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29946927/a-case-of-laparoscopic-high-anterior-resection-of-rectosigmoid-colon-cancer-associated-with-a-horseshoe-kidney-using-preoperative-3d-ct-angiography
#11
Naoki Kubo, Norihiko Furusawa, Shinichiro Imai, Masaru Terada
BACKGROUND: Horseshoe kidney is a congenital malformation in which the bilateral kidneys are fused. It is frequently complicated by other congenital malformations and is often accompanied by anomalies of the ureteropelvic and vascular systems, which must be evaluated to avoid iatrogenic injury. We report a case of laparoscopic high anterior resection of rectosigmoid colon cancer associated with a horseshoe kidney using preoperative 3D-CT angiography. CASE PRESENTATION: A 52-year-old Japanese man with lower abdominal pain underwent lower endoscopy, revealing a type 2 lesion in the rectosigmoid colon...
June 27, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29935727/nuclear-factor-kappa-b-subunits-and-their-prognostic-cancer-specific-survival-value-in-renal-cell-carcinoma-patients
#12
Keng Lim Ng, Ning Yi Yap, Retnagowri Rajandram, David Small, Jayalakshmi Pailoor, Teng Aik Ong, Azad Hassan Razack, Simon Thomas Wood, Christudas Morais, Glenda Carolyn Gobe
Better characterisation and understanding of renal cell carcinoma (RCC) development and progression lead to better diagnosis and clinical outcomes. In this study, expression of nuclear factor-kappa B (NF-κB) subunits: p65 (RelA), p105/p50, p100/p52, and cRel in RCC tissue were compared with corresponding normal kidney, along with tumour characteristics and survival outcome. Ninety-six cases of RCC with paired normal kidney were analysed. Clinicopathological data, demographics and survival data were available...
August 2018: Pathology
https://www.readbyqxmd.com/read/29934067/oral-and-maxillofacial-metastasis-of-male-breast-cancer-report-of-a-rare-case-and-literature-review
#13
Nathalia de Almeida Freire, Bruno Augusto Benevenuto de Andrade, Nathalie Henriques Silva Canedo, Michelle Agostini, Mário José Romañach
Oral and maxillofacial metastatic tumors are uncommon, with the breast, prostate, lung, and kidney representing the most common primary sites. Less than 1% of all breast cancers occur in male patients, and to date, only 8 cases of metastatic breast adenocarcinoma to the oral and maxillofacial region in a male patient have been reported in the literature. An 88-year-old male with previous history of a successfully treated primary breast adenocarcinoma 12 years earlier was referred for evaluation of an oral swelling lasting 6 months...
May 30, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29930748/serum-levels-of-soluble-urokinase-plasminogen-activator-receptor-supar-predict-outcome-after-resection-of-colorectal-liver-metastases
#14
Sven H Loosen, Frank Tacke, Marcel Binnebosel, Catherine Leyh, Mihael Vucur, Florian Heitkamp, Wenzel Schoening, Tom F Ulmer, Patrick H Alizai, Christian Trautwein, Alexander Koch, Thomas Longerich, Christoph Roderburg, Ulf P Neumann, Tom Luedde
Background: In colorectal cancer (CRC), the liver is the most common site of metastasis. Surgical resection represents the standard therapy for patients with colorectal liver metastases (CRLM). However, 5-year survival rates after resection do not exceed 50%, and despite existing preoperative stratification algorithms it is still debated which patients benefit most from surgical treatment. The soluble urokinase plasminogen activator receptor (suPAR) has recently evolved as a promising biomarker for distinct clinical conditions...
June 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29920108/effects-of-linker-modification-on-tumor-to-kidney-contrast-of-68-ga-labeled-psma-targeted-imaging-probes
#15
Hsiou-Ting Kuo, Jinhe Pan, Zhengxing Zhang, Joseph Lau, Helen Merkens, Chengcheng Zhang, Nadine Colpo, Kuo-Shyan Lin, François Bénard
68 Ga-PSMA-11 is currently the most popular prostate-specific membrane antigen (PSMA) radioligand used in the clinic to detect prostate cancer and metastases. However, the high uptake of 68 Ga-PSMA-11 in kidneys can create halo-artifacts resulting in lower detection sensitivity for lesions adjacent to the kidneys. In this study, we developed two 68 Ga-labeled PSMA-targeted tracers, 68 Ga-HTK01166 and 68 Ga-HTK01167, based on 68 Ga-PSMA-617 with the goal of improving tumor-to-kidney ratio compared to 68 Ga-PSMA-11...
August 6, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29912582/biomarkers-of-aggressiveness-in-genitourinary-tumors-with-emphasis-on-kidney-bladder-and-prostate-cancer
#16
Alessia Cimadamore, Silvia Gasparrini, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Nicola Battelli, Francesco Massari, Francesca Giunchi, Michelangelo Fiorentino, Marina Scarpelli, Rodolfo Montironi
Over the last decade, the improvement in molecular techniques and the acquisition of genomic information has transformed and increased the quality of patient care and our knowledge of diseases. Areas covered: Protein expression levels in immunohistochemistry and molecular biomarkers are reported for their ability to predict recurrence, progression, development of metastases, or patient survival. In particular, for renal cell carcinoma, we take into consideration the biomarkers applicable to immunohistochemistry and with molecular and genetic analyses...
July 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29904105/an-interdisciplinary-consensus-on-the-management-of-bone-metastases-from-renal-cell-carcinoma
#17
REVIEW
Viktor Grünwald, Berit Eberhardt, Axel Bex, Anne Flörcken, Thomas Gauler, Thorsten Derlin, Martin Panzica, Hans Roland Dürr, Knut Achim Grötz, Rachel H Giles, Christian von Falck, Anno Graser, Alexander Muacevic, Michael Staehler
Bone is a major site of haematogenous tumour cell spread in renal cell carcinoma (RCC), and most patients with RCC will develop painful and functionally disabling bone metastases at advanced disease stages. The prognosis of these patients is generally poor and the treatment is, therefore, aimed at palliation. However, RCC-associated bone metastases can be curable in select patients. Current data support a multimodal management strategy that includes wide resection of lesions, radiotherapy, systemic therapy, and other local treatment options, which can improve quality of life and survival...
June 14, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29896402/oral-metastasis-of-renal-cell-carcinoma-mimicking-recurrence-of-excised-malignant-myoepithelioma-a-case-report
#18
Yoshihiro Morita, Takaki Iwagami, Chisato Kawakita, Yukiko Kusuyama, Atsuko Niki-Yonekawa, Nobuo Morita
Following breast and lung cancers, renal cell carcinoma (RCC) is the third most frequent cancer to metastasize to the head and neck region, though such cases are rarely reported. Distinguishing between malignant tumors of salivary gland origin and metastatic RCC is very important. The case of a 75-year-old man with an oral cavity lesion in the left buccal submucosa measuring 40×30 mm that had grown substantially over several weeks is presented. His medical history included left kidney cancer 26 years earlier and a malignant myoepithelioma of the left buccal region 7 years earlier...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29895293/robotic-treatment-of-oligometastatic-kidney-tumor-with-synchronous-pancreatic-metastasis-case-report-and-review-of-the-literature
#19
Andrea Boni, Giovanni Cochetti, Stefano Ascani, Michele Del Zingaro, Francesca Quadrini, Alessio Paladini, Diego Cocca, Ettore Mearini
BACKGROUND: The management of metastatic Renal Cell Carcinoma (RCC) has changed dramatically in the last 20 years, and the role of surgery in the immunotherapy's era is under debate. Metastatic lesions interesting pancreas are infrequent, but those harbouring from RCC have an high incidence. If metachronous resections are not rare, synchronous resection of primary RCC and its pancreatic metastasis is uncommonly reported, and accounts for a bad prognosis. CASE PRESENTATION: We report the case of a 68 years old woman, who presented hematuria at hospital incoming, with radiological appearance of a 13 cm left renal mass, with a 2...
June 13, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29892149/a-preliminary-study-on-the-estimation-of-the-number-of-cancer-patients-eligible-for-hadron-therapy-in-iran-and-fars-province
#20
Mohammad Amin Hosseini, Mohammad Mohamadianpanah, Mohammad Zare-Bandeamiri, Mohammad Amin Mosleh-Shirazi
Hadron therapy (HT) with protons and carbon ions is an advanced radiotherapy technique. As the first report addressing this topic, the present study aimed to estimate the number of patients eligible for HT in Fars province and the whole of Iran. The data were collected through direct inspection of medical records of the patients treated at the Radiotherapy Department, Namazi Hospital, Shiraz, Iran in 2014. The patients who were treated with external-beam radiotherapy and declared to be a resident of Fars province were extracted from the medical records...
May 2018: Iranian Journal of Medical Sciences
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