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Metastasic kidney cancer

Adam Maciejewski, Rafał Czepczyński, Marek Ruchała
Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. Post-therapy whole body scan allows detecting thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. On post-therapy whole body scan, abnormal uptake in the left upper abdomen was found, although stimulated thyroglobulin level was not suggestive for distant metastases of differentiated thyroid carcinoma...
October 11, 2018: Endokrynologia Polska
G Di Pietro, H N Luu, P E Spiess, W Sexton, S Dickinson, A Parker, J Y Park
OBJECTIVE: Renal Cell Carcinoma (RCC) is the most common malignancy in adult kidneys. The American Cancer Society estimated 62,700 new cases and 14,240 deaths in 2018. Although early detection has improved in recent years, the treatment remains a challenge and reliable biomarkers for poor outcomes become necessary for the prevention of metastases and improve the quality of patients' life during and after treatment. Then, the current status of the search for new RCC biomarkers was discussed, as well as the latest discoveries in the RCC risk and metastatic treatment were discussed in this review...
September 2018: European Review for Medical and Pharmacological Sciences
Aline Guillot, Charlotte Joly, Philippe Barthélémy, Emeline Meriaux, Sylvie Negrier, Damien Pouessel, Christine Chevreau, Hakim Mahammedi, Nadine Houede, Guilhem Roubaud, Gwenaelle Gravis, Sophie Tartas, Laurence Albiges, Cécile Vassal, Mathieu Oriol, Fabien Tinquaut, Sophie Espenel, Wafa Bouleftour, Stéphane Culine, Karim Fizazi
BACKGROUND: About one-third of patients with renal cell carcinoma (RCC) have detectable metastases at diagnosis. Among them, bone is the second most frequent metastatic site. Treatment of metastatic RCC mostly relies on anti-angiogenic (AA) therapies and, more recently, immunotherapy. Skeletal-related events (SREs) can be prevented with bone-targeted therapies such as denosumab (Dmab), which has demonstrated superiority when compared with zoledronic acid in solid tumors. However, there is limited available data on Dmab toxicity in combination with AA therapies in patients with kidney cancer...
September 6, 2018: Clinical Genitourinary Cancer
Inga Peters, Natalia Dubrowinskaja, Jörg Hennenlotter, Wiebke Inga Antonopoulos, Christoph A J Von Klot, Hossein Tezval, Arnulf Stenzl, Markus A Kuczyk, Jürgen Serth
Recent studies have shown that NELL1 expression is silenced epigenetically in human renal cell cancer (RCC) tissues and in RCC cell lines. However, it remains unknown whether NELL1 promoter methylation observed in clinical specimens might be associated with the clinicopathology or survival of patients with RCC. We analyzed NELL1 DNA methylation in tissues from patients with RCC and in adjacent normal renal tissues. In addition, we evaluated NELL1 methylation in cell lines derived from different urogenital tumors (prostate cancer, urothelial cancer and RCC)...
September 24, 2018: Oncology Reports
G Barbas Bernardos, F Herranz Amo, J Caño Velasco, M J Cancho Gil, J Mayor de Castro, J Aragón Chamizo, L Polanco Pujol, C Hernández Fernández
INTRODUCTION AND OBJECTIVE: One of the inherent features of kidney tumours is the capacity to spread inside the venous system as tumour thrombi. The aim of this study was to assess in patients with stage pT3apN0cM0 kidney cancer whether venous tumour involvement influenced tumour recurrence. MATERIALS AND METHODS: A retrospective analysis of patients with stage pT3apN0cM0 kidney cancer treated with radical nephrectomy between 1990-2015. Univariate and multivariate Cox regression analysis to identify predictive variables and independent predictive variables relating to recurrence...
September 26, 2018: Actas Urologicas Españolas
Boris Gershman, R Houston Thompson, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
BACKGROUND: Nephron-sparing surgery is the preferred surgical management of cT1 renal masses, but observational and randomized data conflict regarding a survival benefit. OBJECTIVE: To examine the associations of radical nephrectomy (RN) versus partial nephrectomy (PN) with oncologic and nononcologic outcomes. DESIGN, SETTING, AND PARTICIPANTS: A total of 2459 adults were treated with RN or PN between 1990 and 2011 for a unilateral, sporadic, cT1, M0 solid renal mass...
September 24, 2018: European Urology
Mike Sathekge, Frank Bruchertseifer, Otto Knoesen, Florette Reyneke, Ismaheel Lawal, Thabo Lengana, Cindy Davis, Johncy Mahapane, Ceceila Corbett, Mariza Vorster, Alfred Morgenstern
BACKGROUND: A remarkable therapeutic efficacy has been demonstrated with 225 Ac-prostate-specific membrane antigen (PSMA)-617 in heavily pre-treated metastatic castration-resistant prostate cancer (mCRPC) patients. We report our experience with 225 Ac-PSMA-617 therapy in chemotherapy-naïve patients with advanced metastatic prostate carcinoma. METHODS: Seventeen patients with advanced prostate cancer were selected for treatment with 225 Ac-PSMA-617 in 2-month intervals, with initial activity of 8 MBq, then de-escalation to 7 MBq, 6 MBq or 4 MBq in cases of good response...
September 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
A Saad Abdalla, Anita Lazarevska, Mohammed Murwan Omer, Elizabeth Tan, Amira Asaad, Sharlini Sathananthan
The most common sites of invasive breast cancer metastasis are the lungs, liver, bones and brain. Less frequent sites include the gastrointestinal tract, pancreas, spleen, thyroid, adrenals, kidneys, heart and female genital tract. The uterus is reported as a rare site for metastasis, and even more so for an isolated metastasis. Other sites of extra-genital sources for uterine metastases include the colon, stomach, pancreas, gallbladder, lung, cutaneous melanoma, urinary bladder and thyroid. The rarity of breast cancer metastasis to the uterine cervix could be explained by the fact that the cervix has a small blood supply and an afferent lymph drainage system alone...
July 2018: Chirurgia
Ciro Franzese, Davide Franceschini, Lucia Di Brina, Giuseppe Roberto D'Agostino, Pierina Navarria, Tiziana Comito, Pietro Mancosu, Stefano Tomatis, Marta Scorsetti
PURPOSE: Kidney cancer has been increasing by 1.7% annually. Renal cell carcinoma (RCC) is the most common kidney cancer, and can metastasize. Our aim is to analyze patients treated with Stereotactic Body Radiation Therapy (SBRT) on metastases from RCC. METHODS: from 2004 to 2016, fifty-eight patients and 73 lesions were treated. Patients were candidate if maximum 3 metastases were diagnosed and primary tumour was resected. Toxicity was classified according to Common Terminology Criteria for Adverse Events (CTCAE) version 3...
September 1, 2018: Journal of Urology
Carol L Shields, R Joel Welch, Kunal Malik, Luis A Acaba-Berrocal, Evan B Selzer, Jennifer H Newman, Eileen L Mayro, Alexandru B Constantinescu, Meredith A Spencer, Mark P McGarrey, Austen N Knapp, Alexander E Graf, Alex J Altman, Sean P Considine, Jerry A Shields
PURPOSE: The purpose of this study is to evaluate patients with uveal metastasis based on primary tumor site. METHODS: Retrospective analysis from Wills Eye Hospital, Philadelphia, PA, USA, for uveal metastasis clinical features and outcomes based on the primary tumor site. RESULTS: There were 2214 uveal metastases diagnosed in 1111 consecutive patients. The demographics included mean age of 60 years (median 61 years), Caucasian race (88%), and female gender (64%)...
April 2018: Middle East African Journal of Ophthalmology
Adam Lauko, Bicky Thapa, Vyshak Alva Venur, Manmeet S Ahluwalia
PURPOSE OF THE REVIEW: Brain metastasis is a common complication of advanced malignancies, especially, lung cancer, breast cancer, renal cell carcinoma, and melanoma. Traditionally surgery, when indicated, and radiation therapy, either as whole-brain radiation therapy or stereotactic radiosurgery, constituted the major treatment options for brain metastases. Until recently, most of the systemic chemotherapy agents had limited activity for brain metastases. However, with the advent of small molecule tyrosine kinase inhibitors and immunotherapy agents, there has been renewed interest in using these agents in the management of brain metastases...
August 18, 2018: Current Neurology and Neuroscience Reports
Arun Kadamkulam Syriac, Murtaza Mirza, Ashley Rose Malekunnel, Alberto Locante, Palak Desai
Thyroid malignancies are one of the fastest growing cancers in the world, with the majority being papillary thyroid cancer. Follicular variant of papillary thyroid cancer accounts for about 10%-20% of papillary thyroid carcinomas. The usual sites for metastases of these tumours are lungs and bones with renal metastases being extremely rare. We describe a case of a 64-year-old woman who presented with abdominal pain. On subsequent imaging, she was found to have a colonic mass with metastatic lesions in the lungs and tumour involving left kidney...
August 9, 2018: BMJ Case Reports
A Andabak Rogulj, C Tomasovic Loncaric, D Muller, I Blivajs, M Andabak, V Vucicevic Boras, M Sekerija
Metastatic tumours to the jaw bones are rare, and usually develop during the final stages of cancer. Some, such as those of lung, breast, and kidney, are more likely to metastasise to the jaw. We have therefore analysed the clinical and epidemiological characteristics of patients with metastatic tumours. We retrieved the notes of 4 478 patients with metastatic tumours to the jawbones who were treated in the Clinical Hospital Centre Dubrava in Zagreb, Croatia, during the 15 years 2002-17 and made a retrospective analysis of patients' age, sex, site of primary tumour, site and clinical presentation of the metastases, time interval since diagnosis of the primary tumour and oral metastases, and time interval from diagnosis of oral metastases to death...
October 2018: British Journal of Oral & Maxillofacial Surgery
Marta Michali-Stolarska, Anna Zacharzewska-Gondek, Joanna Bladowska, Maciej Guziński, Marek J Sąsiadek
Purpose: We present a case of metastatic pulmonary calcification (MCP) in an asymptomatic patient with chronic kidney disease after renal transplantation and nephrectomy due to renal cancer. Chest computed tomography (CT) revealed bilateral, diffuse, centrilobular ground-glass opacities and heterogeneous, high-density areas distributed throughout the lungs, predominantly in the upper and middle lobes. Unusually, in our patient the metastatic calcification coexisted with pulmonary metastases from renal cell carcinoma associated with end-stage renal disease...
2018: Polish Journal of Radiology
Yuka Aimono, Toshiro Kamoshida, Atsushi Okawara, Tatsunori Ogawa, Shunichi Suzuki, Risa Sakamoto, Yoshiko Saito, Yoshifumi Aoyama
A 50s man receiving dialysis for chronic kidney disease due to IgA nephropathy underwent laparoscopic reversal via Hartmann 's procedure for rectal cancer and multiple liver metastases, followed by chemotherapy for the liver metastases. Following a single course of mFOLFOX therapy, bevacizumab was administered for 8 courses, resulting in tumor shrinkage and a decrease in tumor marker levels. The initial doses were 60mg/m2 oxaliplatin and 280(bolus injection)and 1,680mg/m2 (continuous infusion)of 5-FU. Subsequently, these doses were adjusted to be administered every 3 weeks...
June 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Thambi Dorai, Ankeeta Shah, Faith Summers, Rajamma Mathew, Jing Huang, Tze-Chen Hsieh, Joseph M Wu
In the course of studies aimed at the role of oxidative stress in the development of metastatic potential in the LNCaP-C4-2B prostate cancer progression model system, we found a relative decrease in the level of expression of the cytoplasmic nicotinamide riboside: quinone oxidoreductase (NQO2) and an increase in the oxidative stress in C4-2B cells compared to that in LNCaP or its derivatives C4 and C4-2. It was also found that C4-2B cells specifically shed large extracellular vesicles (LEVs) suggesting that these LEVs and their cargo could participate in the establishment of the osseous metastases...
July 15, 2018: Prostate
Céline Melis, Florence Ballaux, Claire Bourgain
BACKGROUND: The most frequent metastases to the thyroid originate in the kidney, lung or breast. Colorectal adenocarcinoma represents less than 4% of metastases to the thyroid gland. Solitary metastases of colorectal cancer with no other manifestation of disseminated cancer disease are exceedingly rare. Within the Bethesda Classification for Reporting -Thyroid Cytopathology, metastases are included in Diagnostic Categories "Suspicious for Malignancy" and "Malignant." CASES: We present 2 cases of colorectal adenocarcinoma metastatic to the thyroid gland, diagnosed by fine-needle aspiration (FNA)...
July 13, 2018: Acta Cytologica
Ettore DI Trapani, Paolo Dell'oglio, Alessandro Larcher, Alessandro Nini, Fabio Muttin, Francesco Cianflone, Federico Dehò, Rayan Matloob, Dario DI Trapani, Massimo Freschi, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Roberto Bertini, Umberto Capitanio
BACKGROUND/AIM: The incidence of renal cell carcinoma (RCC) has been increasing mainly due to the increase in the incidental detection of small renal masses. The aim of this study was to verify whether the trend towards early diagnosis changed the clinical characteristics of pathologically-defined high-risk RCC patients over the last decades. PATIENTS AND METHODS: A total of 741 patients with pathologically-confirmed high-risk RCC (pT1-4, and/or pN1 and/or Fuhrman grade 3-4 and/or all M1 patients) treated with radical (RN) or partial nephrectomy (PN) at a single tertiary referral center between 1987 and 2011 were included in the study...
July 2018: Anticancer Research
K L Ng, S J Del Vecchio, H Samaratunga, C Morais, R Rajandram, D A Vesey, S T Wood, G C Gobe
One of the challenges in differentiating chromophobe renal cell carcinoma (chRCC) from benign renal oncocytoma (RO) is overlapping morphology between the two subtypes. The aim of this study was to investigate the usefulness of expression of leptin (Ob) and its receptor (ObR) in discriminating chRCC from RO. Sections from paraffin-embedded, formalin-fixed tumour nephrectomy specimens of 45 patients, made up of 30 chRCC (15 eosinophilic variant and 15 non-eosinophilic variant) and 15 RO, were used in this study...
August 2018: Pathology
Negar Faramarzi, Sumit Sohal, Roshanak Habibi, Muhammad Sikander Akbar
Cardiac tumors are a rare phenomenon, and most cases are secondary to metastatic cancers rather than primary tumors. Renal cell carcinoma (RCC) is notorious for metastasis to cardiac tissue. Tumor thrombus migration to the renal vein and inferior vena cava happens in up to 10% of patients with RCC. Transitional cell carcinomas are another form of renal cancer, which may metastasize to the heart and are associated with widespread metastasis. Here, we report a patient with a past medical history of metastatic transitional cell cancer of renal pelvis under treatment with checkpoint inhibitor therapy presenting with shortness of breath...
2018: Case Reports in Cardiology
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