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Metastasic bladder cancer

Su Zhang, Yong-Yan Chang, Yu-Wen Gong, Yan-Jun Gao, Qi Guo, Yu-Han Wang, You-Li Zhao, Zhi-Ping Wang
Chemotherapy is still a standard treatment of unresectable bladder cancer or distant metastases. The chemotherapy resistance always occurs after a period of treatment indicating poor prognosis. The current study aimed to explore the molecular mechanism of chemoresistance in bladder cancer cells. The gene expression profiles of GSE77883, including three untreated T24 cells samples and three gemcitabine-resistant T24 cells samples, was downloaded from Gene Expression Omnibus database. The screening of differentially expressed genes (DEGs), gene function analysis, and interaction prediction between microRNAs (miRNAs) and DEGs were performed by R software...
October 10, 2018: Journal of Cellular Biochemistry
W Loidl, F Luger
Urothelial carcinoma of the bladder is difficult to treat in advanced and metastatic stages. Several factors play a role: age, multimorbidity including impaired renal function and neuropathy make access to life-prolonging chemotherapy impossible in many cases. Improvements of response rates and overall survival in the second-line setting are not much different compared to best supportive care. However, the therapeutic landscape has changed dramatically during the last 2 years. Immunotherapies represented by checkpoint inhibitors have showed positive trial outcomes and have been approved by EMA (European Medicines Agency)...
October 9, 2018: Der Urologe. Ausg. A
Manuel Neves, Rita Azevedo, Luís Lima, Marta I Oliveira, Andreia Peixoto, Dylan Ferreira, Janine Soares, Elisabete Fernandes, Cristiana Gaiteiro, Carlos Palmeira, Sofia Cotton, Stefan Mereiter, Diana Campos, Luís Pedro Afonso, Ricardo Ribeiro, Avelino Fraga, Ana Tavares, Hélder Mansinho, Eurico Monteiro, Paula A Videira, Paulo P Freitas, Celso A Reis, Lúcio Lara Santos, Lorena Dieguez, José Alexandre Ferreira
Circulating tumour cells (CTCs) originating from a primary tumour, lymph nodes and distant metastases hold great potential for liquid biopsies by providing a molecular fingerprint for disease dissemination and its temporal evolution through the course of disease management. CTC enumeration, classically defined on the basis of surface expression of Epithelial Cell Adhesion Molecule (EpCAM) and absence of the pan-leukocyte marker CD45, has been shown to correlate with clinical outcome. However, existing approaches introduce bias into the subsets of captured CTCs, which may exclude biologically and clinically relevant subpopulations...
September 28, 2018: New Biotechnology
Yin Wang, Mark L Day, Diane M Simeone, Phillip L Palmbos
Bladder cancer is a significant health problem. It is estimated that more than 16,000 people will die this year in the United States from bladder cancer. While 75% of bladder cancers are non-invasive and unlikely to metastasize, about 25% progress to an invasive growth pattern. Up to half of the patients with invasive cancers will develop lethal metastatic relapse. Thus, understanding the mechanism of invasive progression in bladder cancer is crucial to predict patient outcomes and prevent lethal metastases...
September 13, 2018: Journal of Visualized Experiments: JoVE
Asim Afaq, Jamshed Bomanji
Introduction: There is an unmet clinical need for early, accurate imaging of recurrent prostate cancer to improve patient outcomes. Staging, by conventional bone scintigraphy and CT have become outdated. 68Ga-PSMA PET/CT imaging in this setting has developed rapidly, with widespread International adoption in line with evidence-based guidelines in this group of patients. Sources of data: A PubMed search of English language articles was performed using following keywords: PSMA, PET/CT, biochemical recurrence, prostate cancer...
September 29, 2018: British Medical Bulletin
M Spinelli, R Gillibrand
High grade bladder malignancies have tendency to local and distant invasion. The most commonly involved sites are lymph nodes, lungs, bone and liver. Muscle metastases are generally rare and have been described in few cases of Genito-Urinary cancer. In this work we describe a rare case of high grade transitional cell carcinoma from bladder metastatising to the left gluteal muscle together with the review of the pertinent literature.
March 2018: Pathologica
Yi-Ren Jin, Xie-Lan Yang, Qin-Qing Li, Zhi-Ling Yan, Hong-Ying Yang, Chengde Liao
BACKGROUND: Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (CR) has the potential to depict anatomic details accurately. CASE PRESENTATION: (Case 1) A 44-year-old married woman was diagnosed with recurrent ovarian cancer...
September 26, 2018: Journal of Ovarian Research
Michael Poch, MacLean Hall, Autumn Joerger, Krithika Kodumudi, Matthew Beatty, Pasquale P Innamarato, Brittany L Bunch, Mayer N Fishman, Jingsong Zhang, Wade J Sexton, Julio M Pow-Sang, Scott M Gilbert, Philippe E Spiess, Jasreman Dhillon, Linda Kelley, John Mullinax, Amod A Sarnaik, Shari Pilon-Thomas
Advanced bladder cancer patients have limited therapeutic options resulting in a median overall survival (OS) between 12 and 15 months. Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) has been used successfully in treating patients with metastatic melanoma, resulting in a median OS of 52 months. In this study, we investigated the feasibility of expanding TIL from the tumors of bladder cancer patients. Primary bladder tumors and lymph node (LN) metastases were collected. Tumor specimens were minced into fragments, placed in individual wells of a 24-well plate, and propagated in high dose IL-2 for four weeks...
2018: Oncoimmunology
Marco Moschini, Stefania Zamboni, Agostino Mattei, Alberto Martini, Emanuele Zaffuto, Alberto Briganti, Andrea Gallina, Francesco Montorsi
No abstract text is available yet for this article.
August 2018: Translational Andrology and Urology
Valérie Fonteyne, Elke Rammant, Piet Ost, Yolande Lievens, Bart De Troyer, Sylvie Rottey, Gert De Meerleer, Daan De Maeseneer, Dirk De Ridder, Karel Decaestecker
INTRODUCTION: There is a gap between optimal and actual use of radiotherapy (RT) in muscle-invasive bladder cancer (MIBC). We investigated the opinions of radiation-oncologists, urologists, and medical oncologists on use of RT in different cases. Barriers and facilitators for applying guidelines were examined. MATERIAL AND METHODS: A web-based survey was developed at Ghent University Hospital and conducted from November 18, 2016 to July 17, 2017. The place of primary, adjuvant, and palliative RT was evaluated...
August 11, 2018: Clinical Genitourinary Cancer
A Saad Abdalla, Anita Lazarevska, Mohammed Murwan Omer, Elizabeth Tan, Amira Asaad, Sharlini Sathananthan
The most common sites of invasive breast cancer metastasis are the lungs, liver, bones and brain. Less frequent sites include the gastrointestinal tract, pancreas, spleen, thyroid, adrenals, kidneys, heart and female genital tract. The uterus is reported as a rare site for metastasis, and even more so for an isolated metastasis. Other sites of extra-genital sources for uterine metastases include the colon, stomach, pancreas, gallbladder, lung, cutaneous melanoma, urinary bladder and thyroid. The rarity of breast cancer metastasis to the uterine cervix could be explained by the fact that the cervix has a small blood supply and an afferent lymph drainage system alone...
July 2018: Chirurgia
Ding Peng, Guangzhe Ge, Zhengzheng Xu, Qin Ma, Yue Shi, Yuanyuan Zhou, Yanqing Gong, Gengyan Xiong, Cuijian Zhang, Shiming He, Zhisong He, Xuesong Li, Weimin Ci, Liqun Zhou
AIM: We intended to construct DNA methylation-based models for the diagnosis and prognosis of three common urological cancers including prostate adenocarcinoma, renal clear cell carcinoma and bladder urothelial carcinoma. MATERIALS & METHODS:  Total 450K methylation array data from the cancer genome atlas and gene expression omnibus datasets were downloaded. Moderated t-statistics and least absolute shrinkage and selection operator method were used to build diagnosis and prognosis models...
September 2018: Epigenomics
Jingjing Hu, Raji D Khalifa, Andres A Roma, Oluwole Fadare
The problems associated with the pathologic distinction of primary ovarian mucinous tumors from their metastatic counterparts are well-recognized. Herein, we systematically evaluate a variety of gross parameters to determine the combination of features that most optimally separate primary from secondary mucinous ovarian tumors, and to address the tumor types that are most frequently associated with exceptions. 129 consecutive mucinous tumors involving the ovary formed the study set, including 61 primary mucinous tumors (16 carcinomas, 45 borderline tumors), and 68 metastatic carcinomas (21 colon; 28 appendix; 5 breast; 3 lung; 3 pancreas; 3 cervix; 1 bladder; 4 stomach)...
August 8, 2018: Annals of Diagnostic Pathology
Bernhard Kiss, Gautier Marcq, Joseph C Liao
Optical and cross-sectional imaging plays critical roles in bladder cancer diagnostics. White light cystoscopy remains the cornerstone for the management of non-muscle-invasive bladder cancer. In the last decade, significant technological improvements have been introduced for optical imaging to address the known shortcomings of white light cystoscopy. Enhanced cystoscopy modalities such as blue light cystoscopy and narrowband imaging survey a large area of the urothelium and provide contrast enhancement to detect additional lesions and decrease cancer recurrence...
2018: Cancer Treatment and Research
Frank S Fan, Chung-Fan Yang
Careful morphology and immunohistochemistry study can make an accurate differential diagnosis of primary adenocarcinoma of urinary bladder from metastatic lesions involving bladder, especially cancer arising in colon, but there is yet no consensus regarding the standard chemotherapy for advanced adenocarcinoma of urinary bladder among medical oncologists. Sustained response to modified FOLFOX6 (fluorouracil, oxaliplatin plus leucovorin) regimen and oral capecitabine for multiple metastases in a patient with primary nonurachal adenocarcinoma of urinary bladder is presented here as a strong support that the frontline chemotherapy for this infrequent malignant disease is just like what could be chosen for colorectal cancer...
August 2018: Oxford Medical Case Reports
Isabella Syring, Richard Weiten, Tim Müller, Doris Schmidt, Susanne Steiner, Glen Kristiansen, Stefan C Müller, Jörg Ellinger
The Mediator complex, a multi-subunit protein complex, plays an integral role in regulating transcription. Genetic alterations of the mediator subunit 15 (MED15) in separate tumor entities have been described previously. However, till now, not much is known about the role of MED15 in urothelial bladder cancer (BCa). Using cBioPortal, database analysis was executed for the mRNA expression and survival analysis of MED15 in BCa. Immunohistochemistry (IHC) analysis against MED15 was performed on tissue microarrays with 18 benign, 126 BCa, and 38 metastases samples...
September 2018: Oncology Letters
Adam Lauko, Bicky Thapa, Vyshak Alva Venur, Manmeet S Ahluwalia
PURPOSE OF THE REVIEW: Brain metastasis is a common complication of advanced malignancies, especially, lung cancer, breast cancer, renal cell carcinoma, and melanoma. Traditionally surgery, when indicated, and radiation therapy, either as whole-brain radiation therapy or stereotactic radiosurgery, constituted the major treatment options for brain metastases. Until recently, most of the systemic chemotherapy agents had limited activity for brain metastases. However, with the advent of small molecule tyrosine kinase inhibitors and immunotherapy agents, there has been renewed interest in using these agents in the management of brain metastases...
August 18, 2018: Current Neurology and Neuroscience Reports
Jack Crozier, Nathan Papa, Marlon Perera, Brian Ngo, Damien Bolton, Shomik Sengupta, Nathan Lawrentschuk
PURPOSE: The detection of lymph node metastases in bladder cancer has a significant impact on treatment decisions. Multiple imaging modalities are available to clinicians including magnetic resonance imaging, computed tomography and positron emission tomography. We aimed to investigate the utility of alternate imaging modalities on pre-cystectomy imaging in bladder cancer for the detection of lymph node metastases. METHODS: We performed systematic search of Web of Science (including MEDLINE), EMBASE and Cochrane libraries in accordance with the PRISMA statement...
August 17, 2018: World Journal of Urology
Hiroshi Juri, Mitsuhiro Koyama, Haruhito Azuma, Yoshifumi Narumi
PURPOSE: The purpose of the study was to retrospectively determine whether there are metastases to the chest in patients with primary non-muscle-invasive urothelial carcinoma in the bladder on the follow-up computed tomography (CT). METHODS: We analyzed 328 patients with follow-up chest CT for urothelial carcinoma of the bladder diagnosed between January 2004 and September 2013. We divided patients into four groups: Ta (n = 74), T1 (n = 78), carcinoma in situ (CIS, n = 25), and ≥ T2 (n = 151)...
October 2018: International Urology and Nephrology
Feras Abu Saadeh, Ciaran O Riain, Ciara Mc Cormack, Noreen Gleeson
Uterine leiomyomas are the most common benign gynaecological tumours. However, 0.13 to 6% of them have malignant potential (Robboy et al. Environ Health Perspect 108(Suppl 5):779-784, 2000). Uterine smooth muscle tumours with unusual growth patterns include a spectrum of lesions such as intravenous leiomyomatosis, benign metastasizing leiomyoma and disseminated peritoneal leiomyomatosis (Vaquero et al. J Minim Invasive Gynecol 16:263-268, 2009). Benign metastasizing leiomyoma (BML) is a very rare condition with around 100 cases reported to date...
August 3, 2018: Irish Journal of Medical Science
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