Jean-Charles Roy, Renaud Hédouin, Thomas Desmidt, Sébastien Dam, Iris Mirea-Grivel, Weyl Louise, Elise Bannier, Laurent Barantin, Dominique Drapier, Jean-Marie Batail, Renaud David, Julie Coloigner, Gabriel H Robert
BACKGROUND: Better understanding apathy in late-life depression (LLD) would help predicting poor prognosis of the disease such as dementia. Actimetry provides an objective and ecological measure of apathy from patients' daily motor activity. We aimed to determine if patterns of motor activity were associated with apathy and brain connectivity in networks underlying goal-directed behaviors. METHODS: Resting-state functional MRI and diffusion MRI were collected from 38 non-demented LLD subjects...
April 12, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging