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Resting state network

Helena Bejr-Kasem, Javier Pagonabarraga, Saül Martínez-Horta, Frederic Sampedro, Juan Marín-Lahoz, Andrea Horta-Barba, Ignacio Aracil-Bolaños, Jesús Pérez-Pérez, M Ángeles Botí, Antonia Campolongo, Cristina Izquierdo, Berta Pascual-Sedano, Beatriz Gómez-Ansón, Jaime Kulisevsky
BACKGROUND: Minor hallucinations and well-structured hallucinations are considered in the severity continuum of the psychotic spectrum associated with Parkinson's disease. Although their chronological relationship is largely unknown, the spatial patterns of brain atrophy in these 2 forms of hallucinations partially overlap, suggesting they share similar pathophysiological processes. Functional connectivity studies show that disruption of functional networks involved in perception and attention could be relevant in the emergence of well-structured hallucinations...
December 10, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Xiang Chu-Qing, Wen-Feng Liu, Xu Qian-Hui, Ting Su, Shu Yong-Qiang, You-Lan Min, Qing Yuan, Pei-Wen Zhu, Liu Kang-Cheng, Nang Jiang, Lei Ye, Yi Shao
OBJECTIVE: Neuroimaging studies have reported that patients with pain-related conditions have altered neuronal activity and structural functions. The purpose of this study was to investigate whether classical trigeminal neuralgia (CTN) patients exhibit changes in corresponding neuronal activity via analysis of neuronal activity regional homogeneity (ReHo). METHODS: A total of 28 patients presenting with sore eyes (12 men and 16 women) were matched with 28 healthy controls (12 men and 16 women)...
December 11, 2018: Pain Practice: the Official Journal of World Institute of Pain
L Labache, M Joliot, J Saracco, G Jobard, I Hesling, L Zago, E Mellet, L Petit, F Crivello, B Mazoyer, Nathalie Tzourio-Mazoyer
We herein propose an atlas of 32 sentence-related areas based on a 3-step method combining the analysis of activation and asymmetry during multiple language tasks with hierarchical clustering of resting-state connectivity and graph analyses. 144 healthy right-handers performed fMRI runs based on language production, reading and listening, both with sentences and lists of over-learned words. Sentence minus word-list BOLD contrast and left-minus-right BOLD asymmetry for each task were computed in pairs of homotopic regions of interest (hROIs) from the AICHA atlas...
December 7, 2018: Brain Structure & Function
Sepideh Sadaghiani, Pascasie L Dombert, Marianne Løvstad, Ingrid Funderud, Torstein R Meling, Tor Endestad, Robert T Knight, Anne-Kristin Solbakk, Mark D'Esposito
Long-range phase synchrony in the α-oscillation band (near 10 Hz) has been proposed to facilitate information integration across anatomically segregated regions. Which areas may top-down regulate such cross-regional integration is largely unknown. We previously found that the moment-to-moment strength of high-α band (10-12 Hz) phase synchrony co-varies with activity in a fronto-parietal (FP) network. This network is critical for adaptive cognitive control functions such as cognitive flexibility required during set-shifting...
December 7, 2018: Cerebral Cortex
Yuehua Xu, Miao Cao, Xuhong Liao, Mingrui Xia, Xindi Wang, Tina Jeon, Minhui Ouyang, Lina Chalak, Nancy Rollins, Hao Huang, Yong He
Individual variability in human brain networks underlies individual differences in cognition and behaviors. However, researchers have not conclusively determined when individual variability patterns of the brain networks emerge and how they develop in the early phase. Here, we employed resting-state functional MRI data and whole-brain functional connectivity analyses in 40 neonates aged around 31-42 postmenstrual weeks to characterize the spatial distribution and development modes of individual variability in the functional network architecture...
December 7, 2018: Cerebral Cortex
Annika Dimitrov, Katharina Demin, Phöbe Fehlner, Henrik Walter, Susanne Erk, Ilya M Veer
Adaptive recovery from a stressor fosters resilience. So far, however, few studies have examined brain functional connectivity in the aftermath of stress, with inconsistent results reported. Focusing on the immediate recovery from psychosocial stress, the current study compared amygdala resting-state functional connectivity (RSFC) before and immediately after psychosocial stress between cortisol responders and non-responders. Differences between groups were expected for amygdala RSFC with regions involved in down-regulation of the physiological stress response, emotion regulation, and memory consolidation...
2018: Frontiers in Psychiatry
Federico Nemmi, Margot A Schel, Torkel Klingberg
The adult brain contains cortical areas thought to be specialized for the analysis of numbers (the putative number form area, NFA) and letters (the visual word form area, VWFA). Although functional development of the VWFA has been investigated, it is largely unknown when and how the NFA becomes specialized and connected to the rest of the brain. One hypothesis is that NFA and VWFA derive their special functions through differential connectivity, but the development of this differential connectivity has not been shown...
2018: Frontiers in Human Neuroscience
Si Zhang, Junhao Hu, Weijie Fan, Bo Liu, Li Wen, Guangxian Wang, Mingfu Gong, Chunyan Yang, Dong Zhang
Background : Early postmenopausal women frequently suffer from cognitive impairments and emotional disorders, such as lack of attention, poor memory, deficits in executive function and depression. However, the underlying mechanisms of these impairments remain unclear. Method : Forty-three early postmenopausal women and forty-four age-matched premenopausal controls underwent serum sex hormone analysis, neuropsychological testing and resting-state functional magnetic resonance imaging (rs-fMRI). Degree centrality (DC) analysis was performed to confirm the peak points of the functionally abnormal brain areas as the centers of the seeds...
2018: Frontiers in Cellular Neuroscience
Mengmeng Zhi, Zhenghua Hou, Yuqun Zhang, Yingying Yue, Ling Li, Yonggui Yuan
Background and Purpose: Recent studies suggest that abnormal structure and function in the brain network were related to cognitive and emotional impairment in hyperthyroid patients (HPs). The association between altered voxel-mirrored homotopic connectivity (VMHC) and neuropsychological impairment in HPs remains unclear. This study is aimed at investigating the association between the disrupted functional coordination and psychological dysfunction in hyperthyroidism. Method: Thirty-three hyperthyroid patients and thirty-three matched healthy controls (HCs) were recruited, and they received resting-state functional magnetic resonance imaging (fMRI) scans and neuropsychological evaluation...
2018: Neural Plasticity
Gwenda Engels, Annemarie Vlaar, Brónagh McCoy, Erik Scherder, Linda Douw
Research has shown that dynamic functional connectivity (dFC) in Parkinson's disease (PD) is associated with better attention performance and with motor symptom severity. In the current study, we aimed to investigate dFC of both the default mode network (DMN) and the frontoparietal network (FPN) as neural correlates of cognitive functioning in patients with PD. Additionally, we investigated pain and motor problems as symptoms of PD in relation to dFC. Twenty-four PD patients and 27 healthy controls participated in this study...
2018: Frontiers in Aging Neuroscience
Yunfan Wu, Mengchen Liu, Shaoqing Zeng, Xiaofen Ma, Jianhao Yan, Chulan Lin, Guang Xu, Guomin Li, Yi Yin, Shishun Fu, Kelei Hua, Chao Li, Tianyue Wang, Cheng Li, Guihua Jiang
Purpose: Primary insomnia (PI) is the second most common mental disorder. However, the topologic alterations in structural brain connectome in patients with PI remain largely unknown. Methods: A total of 44 PI patients and 46 age-, gender-, and education level matched healthy control (HC) participants were recruited in this study. Diffusion tensor imaging (DTI) and resting state MRI were used to construct structural connectome for each participant, and the network parameters were employed by non-parametric permutations to evaluate the significant differences between the two groups...
2018: Frontiers in Neuroscience
Bin Zhao, Hu Liu, Huanhuan Li, Xiuli Shang
Purpose: Depressive symptoms are frequent nonmotor symptoms that occur in multiple system atrophy (MSA) patients. However, possible changes that can present in the amygdala (AMY) functional connectivity (FC) of the brain in MSA patients with depressive symptoms (DMSA patients) remain largely unknown. Materials and methods: Resting-state functional magnetic resonance imaging scans were obtained from 29 DMSA patients, 28 MSA patients without depression symptoms (NDMSA patients), and 34 healthy controls (HCs)...
2018: Neuropsychiatric Disease and Treatment
Jordan C Rozum, Réka Albert
We present a technique applicable in any dynamical framework to identify control-robust subsets of an interacting system. These robust subsystems, which we call stable modules, are characterized by constraints on the variables that make up the subsystem. They are robust in the sense that if the defining constraints are satisfied at a given time, they remain satisfied for all later times, regardless of what happens in the rest of the system, and can only be broken if the constrained variables are externally manipulated...
December 10, 2018: PLoS Computational Biology
David J Schaeffer, Kyle M Gilbert, Joseph S Gati, Ravi S Menon, Stefan Everling
The common marmoset ( Callithrix jacchus ) is a small New World primate species that has been recently targeted as a potentially powerful preclinical model of human prefrontal cortex dysfunction. Although the structural boundaries of frontal cortex were described in marmosets at the start of the 20th century (Brodmann, 1909) and refined more recently (e.g., Paxinos et al., 2012), the broad functional boundaries of marmoset frontal cortex have yet to be established. In this study, we sought to functionally derive boundaries of marmoset lateral frontal cortex (LFC) using ultra-high field (9...
December 10, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Rasmus M Birn, Alexander K Converse, Abigail Z Rajala, Andrew L Alexander, Walter F Block, Alan B McMillan, Bradley T Christian, Caitlynn N Filla, Dhanabalan Murali, Samuel A Hurley, Rick L Jenison, Luis C Populin
Dopamine (DA) levels in the striatum are increased by many therapeutic drugs, such as methylphenidate (MPH), which also alters behavioral and cognitive functions thought to be controlled by the prefrontal cortex (PFC) dose-dependently. We linked DA changes and functional connectivity (FC) using simultaneous [18 F]fallypride PET and resting state functional magnetic resonance imaging (fMRI) in awake male rhesus monkeys after oral administration of various doses of MPH. We found a negative correlation between [18 F]fallypride nondisplaceable binding potential (BPND ) and MPH dose in the head of the caudate (hCd), demonstrating increased extracellular DA resulting from MPH administration...
December 10, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Rui Zhao, Xinxin Zhang, Yuanqiang Zhu, Ningbo Fei, Jinbo Sun, Peng Liu, Xuejuan Yang, Wei Qin
Previous studies have revealed that sleep deprivation (SD) alters hippocampal functional connectivity (FC). However, the effects of SD on the FC of hippocampal subregions are still unknown. In this study, we used a masked independent component analysis (mICA) to partition the hippocampus into several small regions and investigated the changes in the FC of each small region within the whole brain after 24 hours of SD in 40 normal young subjects. First, we determined the optimal number of hippocampal subregions in a data-driven manner using a reproducibility analysis and chose 17 as the optimal number of hippocampal subregions...
December 6, 2018: Neuroscience
Heonsoo Lee, Daniel Golkowski, Denis Jordan, Sebastian Berger, Rüdiger Ilg, Joseph Lee, George A Mashour, UnCheol Lee
Recent modeling and empirical studies support the hypothesis that large-scale brain networks function near a critical state. Similar functional connectivity patterns derived from resting state empirical data and brain network models at criticality provide further support. However, despite the strong implication of a relationship, there has been no principled explanation of how criticality shapes the characteristic functional connectivity in large-scale brain networks. Here, we hypothesized that the network science concept of partial phase locking is the underlying mechanism of optimal functional connectivity in the resting state...
December 6, 2018: NeuroImage
Sou Nobukawa, Mitsuru Kikuchi, Tetsuya Takahashi
The dynamics of the human brain network has attracted broad attention, in recognition of the concept that functional connectivity is not static, but changes its pattern over time, even in the resting state. We hypothesized that analysis of continuously captured time-varying instantaneous phase synchronization between signals from different brain regions might add another dimension to already identified network dynamics. To validate this hypothesis as an aid to elucidating the physiological mechanisms of aging, we examined time-series of instantaneous phase synchronization events in resting-state EEG activity across the brain, in healthy younger and healthy older subjects...
December 7, 2018: NeuroImage
Christopher E Zwilling, Tanveer Talukdar, Marta K Zamroziewicz, Aron K Barbey
A central aim of research in the psychological and brain sciences is to establish therapeutic interventions to promote healthy brain aging. Accumulating evidence indicates that diet and the many bioactive substances present in food are reasonable interventions to examine for dementia prevention. However, interdisciplinary research that applies methods from nutritional epidemiology and network neuroscience to investigate the role of nutrition in shaping functional brain network efficiency remains to be conducted...
December 7, 2018: NeuroImage
Kathryn Y Manning, Alberto Llera, Gregory A Dekaban, Robert Bartha, Christy Barreira, Arthur Brown, Lisa Fischer, Tatiana Jevremovic, Kevin Blackney, Timothy J Doherty, Douglas D Fraser, Jeff Holmes, Christian F Beckmann, Ravi S Menon
Acute brain changes are expected after concussion, yet there is growing evidence of persistent abnormalities well beyond clinical recovery and clearance to return to play. Multiparametric MRI is a powerful approach to non-invasively study structure-function relationships in the brain, however it remains challenging to interpret the complex and heterogeneous cascade of brain changes that manifest after concussion. Emerging conjunctive, data-driven analysis approaches like linked independent component analysis can integrate structural and functional imaging data to produce linked components that describe the shared inter-subject variance across images...
December 3, 2018: NeuroImage: Clinical
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