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Resting state network

Jiajia Zhu, Wenming Zhao, Cun Zhang, Haibao Wang, Wenwen Cheng, Zipeng Li, Yinfeng Qian, Xiaohu Li, Yongqiang Yu
Motor function damage is one of the most common symptoms in patients with alcohol dependence (AD). However, relatively little is known about the neuropathology of the motor impairments in AD. The aim of this study was to identify changes in the topological organization of the motor execution network in AD. Here, a total of 39 male individuals, including 19 AD patients and 20 age-matched healthy controls, underwent resting-state functional magnetic resonance imaging (fMRI). The motor execution network was constructed and analyzed using graph theoretical approaches...
August 10, 2018: Psychiatry research. Neuroimaging
Chao Zhang, Stefi A Baum, Viraj R Adduru, Bharat B Biswal, Andrew M Michael
While static functional connectivity (sFC) of resting state fMRI (rfMRI) measures the average functional connectivity (FC) over the entire rfMRI scan, dynamic FC (dFC) captures the temporal variations of FC at shorter time windows. Although numerous studies have implemented dFC analyses, only a few studies have investigated the reliability of dFC and this limits the biological interpretation of dFC. Here, we used a large cohort (N = 820) of subjects and four rfMRI scans from the Human Connectome Project to systematically explore the relationship between sFC, dFC and their test-retest reliabilities through intra-class correlation (ICC)...
August 15, 2018: NeuroImage
Jungsoo Lee, Ahee Lee, Heegoo Kim, Won Hyuk Chang, Yun-Hee Kim
Most previous stroke studies have been performed in heterogeneous patient populations. Moreover, the brain network might demonstrate different recovery dynamics according to lesion location. In this study, we investigated variation in motor network alterations according to lesion location. Forty patients with subcortical ischemic stroke were enrolled. Patients were divided into two groups: 21 patients with supratentorial stroke (STS) and 19 patients with infratentorial stroke (ITS). All patients underwent resting-state functional magnetic resonance imaging and behavioral assessment at 2 weeks and 3 months poststroke...
August 18, 2018: Human Brain Mapping
Oren Contreras-Rodríguez, Marta Cano, Raquel Vilar-López, Jacqueline Schmidt Rio-Valle, Juan Verdejo-Román, Juan F Navas, Cristina Martín-Pérez, Fernando Fernández-Aranda, José Manuel Menchón, Carles Soriano-Mas, Antonio Verdejo-García
BACKGROUND/OBJECTIVES: Accumulation of visceral adiposity can disrupt the brain's sensitivity to interoceptive feedback, which is coded in the insula. This study aimed to test the link between visceral fat and the functional connectivity of two insulae regions relevant for eating behavior: the middle-dorsal insula (mIns), which codes homeostatic changes, and the rostral insula (rIns), which codes stable representations of food properties. We also assessed the impact of visceral adiposity-associated insulae networks on food craving...
August 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
George M Ibrahim, Alexander G Weil, Shaina Sedighim, Nathan B Schoen, Mirriam Mikhail, Priya Sharma, Magno R Guillen, Benjamin R Morgan, Simeon Wong, Iahn Cajigas, Walter J Jermakowicz, Carolina Sandoval-Garcia, Evan C Lewis, Aria Fallah, Nolan Altman, Santiago Medina, Esperanza Pacheco-Jacome, Prasanna Jayakar, Ann Hyslop, Ian Miller, John Ragheb, Sanjiv Bhatia, Byron Bernal
PURPOSE: Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) is an emerging minimally-invasive alternative to resective surgery for medically-intractable epilepsy. The precise lesioning effect produced by MRgLITT supplies opportunities to glean insights into epileptogenic regions and their interactions with functional brain networks. In this exploratory analysis, we sought to characterize associations between MRgLITT ablation zones and large-scale brain networks that portended seizure outcome using resting-state fMRI...
August 9, 2018: Seizure: the Journal of the British Epilepsy Association
Caroline Schlüter, Christoph Fraenz, Marlies Pinnow, Patrick Friedrich, Onur Güntürkün, Erhan Genç
Individuals differ in their ability to initiate self- and emotional-control mechanisms. These differences have been explicitly described in Kuhl's action-control theory. Although interindividual differences in action control make a major contribution to our everyday life, their neural foundation remains unknown. Here, we measured action control in a sample of 264 healthy adults and related interindividual differences in action control to variations in brain structure and resting-state connectivity. Our results demonstrate a significant negative correlation between decision-related action orientation (AOD) and amygdala volume...
August 17, 2018: Psychological Science
Efstratios K Kosmidis, Yiannis F Contoyiannis, Costas Papatheodoropoulos, Fotios K Diakonos
Evidence that neural circuits are operating near criticality has been provided at various levels of brain organization with a presumed role in maximizing information processing and multiscale activity association. Criticality has been linked to excitation at both the single cell and network levels, as action potential generation marks an obvious phase transition from a resting to an excitable state. Using in vitro intracellular recordings, we examine irregular, small amplitude membrane potential fluctuations from CA1 pyramidal neurons of Wistar male rats...
August 17, 2018: European Journal of Neuroscience
Chao Zhang, Hongyu Yang, Chang Liu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network connectivity alterations of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction before and after anterior temporal lobectomy (ATL) using resting-state functional magnetic resonance imaging (rs-fMRI) study and to further observe the correlation between the brain network connectivity with cognitive performance. Fourteen patients with unilateral left MTLE before and after ATL were compared with thirty healthy controls (HCs) on functional connectivity (FC) between resting-state networks (RSNs)...
August 13, 2018: Epilepsy & Behavior: E&B
Dongmei Zhi, Vince D Calhoun, Luxian Lv, Xiaohong Ma, Qing Ke, Zening Fu, Yuhui Du, Yongfeng Yang, Xiao Yang, Miao Pan, Shile Qi, Rongtao Jiang, Qingbao Yu, Jing Sui
Major depressive disorder (MDD) is a complex mood disorder characterized by persistent and overwhelming depression. Previous studies have identified abnormalities in large scale functional brain networks in MDD, yet most of them were based on static functional connectivity. In contrast, here we explored disrupted topological organization of dynamic functional network connectivity (dFNC) in MDD based on graph theory. One hundred and eighty-two MDD patients and 218 healthy controls were included in this study, all Chinese Han people...
2018: Frontiers in Psychiatry
Stanislas Lagarde, Nicolas Roehri, Isabelle Lambert, Agnès Trebuchon, Aileen McGonigal, Romain Carron, Didier Scavarda, Mathieu Milh, Francesca Pizzo, Bruno Colombet, Bernard Giusiano, Samuel Medina Villalon, Maxime Guye, Christian-G Bénar, Fabrice Bartolomei
Drug-refractory focal epilepsies are network diseases associated with functional connectivity alterations both during ictal and interictal periods. A large majority of studies on the interictal/resting state have focused on functional MRI-based functional connectivity. Few studies have used electrophysiology, despite its high temporal capacities. In particular, stereotactic-EEG is highly suitable to study functional connectivity because it permits direct intracranial electrophysiological recordings with relative large-scale sampling...
August 9, 2018: Brain: a Journal of Neurology
Ming Song, Ying Yang, Jianghong He, Zhengyi Yang, Shan Yu, Qiuyou Xie, Xiaoyu Xia, Yuanyuan Dang, Qiang Zhang, Xinhuai Wu, Yue Cui, Bing Hou, Ronghao Yu, Ruxiang Xu, Tianzi Jiang
Disorders of consciousness are a heterogeneous mixture of different diseases or injuries. Although some indicators and models have been proposed for prognostication, any single method when used alone carries a high risk of false prediction. This study aimed to develop a multidomain prognostic model that combines resting state functional MRI with three clinical characteristics to predict one year outcomes at the single-subject level. The model discriminated between patients who would later recover consciousness and those who would not with an accuracy of around 88% on three datasets from two medical centers...
August 14, 2018: ELife
Nan Lian, Hailong Lv, Wenbing Guo, Yidong Shen, Renlong Wu, Yong Liu, Furong Zhu, Maorong Hu, Jianjun Ou, Jingping Zhao
It is very difficult to predict the future development possibility of schizophrenia through the clinical symptoms of the high-risk cases. Therefore, how to determine the possibility of developing into schizophrenia individuals before the onset of the diseases are particularly important. The study investigated cerebral gray matter volume differences and resting-state functional connections among patients with psychosis risk syndrome (PRS), patients with first-episode schizophrenic (FES), and healthy controls (HC), aiming to provide scientific clinical evidence for schizophrenia early identification and intervention...
August 14, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Zhen Yang, Shi Gu, Nicolas Honnorat, Kristin A Linn, Russell T Shinohara, Irem Aselcioglu, Steven Bruce, Desmond J Oathes, Christos Davatzikos, Theodore D Satterthwaite, Danielle S Bassett, Yvette I Sheline
Despite widespread use of cognitive behavioral therapy (CBT) in clinical practice, its mechanisms with respect to brain networks remain sparsely described. In this study, we applied tools from graph theory and network science to better understand the transdiagnostic neural mechanisms of this treatment for depression. A sample of 64 subjects was included in a study of network dynamics: 33 patients (15 MDD, 18 PTSD) received longitudinal fMRI resting state scans before and after 12 weeks of CBT. Depression severity was rated on the Montgomery-Asberg Depression Rating Scale (MADRS)...
August 13, 2018: Molecular Psychiatry
Julien Dubois, Paola Galdi, Lynn K Paul, Ralph Adolphs
Individual people differ in their ability to reason, solve problems, think abstractly, plan and learn. A reliable measure of this general ability, also known as intelligence, can be derived from scores across a diverse set of cognitive tasks. There is great interest in understanding the neural underpinnings of individual differences in intelligence, because it is the single best predictor of long-term life success. The most replicated neural correlate of human intelligence to date is total brain volume; however, this coarse morphometric correlate says little about function...
September 26, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Vishal Samboju, Carissa L Philippi, Phillip Chan, Yann Cobigo, James L K Fletcher, Merlin Robb, Joanna Hellmuth, Khunthalee Benjapornpong, Netsiri Dumrongpisutikul, Mantana Pothisri, Robert Paul, Jintanat Ananworanich, Serena Spudich, Victor Valcour
Background: HIV RNA is identified in cerebrospinal fluid (CSF) within eight days of estimated viral exposure. Neurological findings and impaired neuropsychological testing performance are documented in a subset of individuals with acute HIV infection (AHI). The purpose of this study was to determine whether microstructural white matter and resting-state functional connectivity (rsFC) are disrupted in AHI. Methods: We examined 49 AHI (100% male; mean age = 30 ± SD 9...
2018: NeuroImage: Clinical
Ping Ren, Benjamin Chapman, Zhengwu Zhang, Giovanni Schifitto, Feng Lin
Locus of control (LOC) is an important personality trait. LOC over cognitive competency reflects an individual's perceived control of desired cognitive outcomes, which is critical for maintaining successful cognitive aging. It is important to understand the neural substrates of LOC over cognitive competency in older adults, especially for individuals at high risk of dementia. Here, we characterized a cohesive functional and structural connectivity profile underlying LOC among 55 older adults with amnestic mild cognitive impairment (aMCI), combining resting-state functional magnetic resonance imaging and diffusion tensor imaging...
2018: NeuroImage: Clinical
Xiaoxia Lei, Yunjie Liao, Mingtian Zhong, Wanrong Peng, Qian Liu, Shuqiao Yao, Xiongzhao Zhu, Changlian Tan, Jinyao Yi
In this study, combining degree centrality (DC) and fractional amplitude of low frequency fluctuation (fALFF) analyses of resting state (rs)-functional magnetic resonance imaging (fMRI) data, we aimed to explore functional connectivity density, local brain spontaneous activity, and their coupling strengths in borderline personality disorder (BPD). Forty-three BPD patients and 39 demographically-matched controls underwent rs-fMRI after completing a series of psychological tests. Two-sample t -tests were performed to compare DC and fALFF between these two groups...
2018: Frontiers in Psychiatry
Aleksandra M Herman, Hugo D Critchley, Theodora Duka
Binge drinking is associated with increased impulsivity and altered emotional processing. The current study investigated, in a group of university students who differed in their level of binge drinking, whether the ability to inhibit a pre-potent response and to delay gratification is disrupted in the presence of emotional context. We further tested whether functional connectivity within intrinsic resting-state networks was associated with alcohol use. Higher incidence of binge drinking was associated with enhanced activation of the lateral occipital cortex, angular gyrus, the left frontal pole during successful response inhibition irrespective of emotional context...
August 12, 2018: European Journal of Neuroscience
Kathleen T Watson, Tonita E Wroolie, Gabby Tong, Lara C Foland-Ross, Sophia Frangou, Manpreet Singh, Roger McIntyre, Siena Roat-Shumway, Alison Myoraku, Allan L Reiss, Natalie L Rasgon
Insulin resistance (IR) is a metabolic state preceding development of type 2 diabetes (DM2), cardiovascular disease, and neurodegenerative disorders, including Alzheimer's Disease (AD). Liraglutide, a glucagon-like peptide-1 (GLP) agonist, is an insulin-sensitizing agent with neuroprotective properties, as shown in animal studies. The purpose of this double-blinded, placebo-controlled study was to examine the neural effects of administration of liraglutide in cognitively normal late middle-aged individuals with subjective cognitive complaints (half of subjects had family history of AD)...
August 9, 2018: Behavioural Brain Research
Leonardo Iaccarino, Arianna Sala, Silvia Paola Caminiti, Roberto Santangelo, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
Visual hallucinations (VH) are a core clinical feature of dementia with Lewy bodies (DLB), but their specific neural substrate remains elusive. We used 18 F-FDG-PET to study the neural dysfunctional signature of VH in a group of 38 DLB patients (mean age±SD 72.9 ± 7.5) with available anamnestic records, cognitive and neurological examination and NeuroPsychiatric Inventory assessing VH. We tested the voxel-wise correlation between 18 F-FDG-PET hypometabolism and VH NPI scores at the whole-group level, then adopting inter-regional correlation analysis to explore the resting-state networks (RSNs) metabolic connectivity in DLB patients with and without visual hallucinations, as compared to N = 38 age-matched healthy controls (HCs) (mean age±SD 71...
July 4, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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