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https://www.readbyqxmd.com/read/30089162/quality-of-medicines-deficiencies-found-by-brazilian-health-regulatory-agency-anvisa-on-good-manufacturing-practices-international-inspections
#1
Andrea Renata Cornelio Geyer, Varley Dias Sousa, Dâmaris Silveira
The circulation of poor quality medicines, especially in the developing countries, is a public health concern. Compliance with good manufacturing practices (GMP) is essential to ensure the quality, efficacy, and safety of medicines. This study evaluated the outcomes of the Brazilian Health Regulatory Agency's (ANVISA) international inspections of two years (2015 and 2016) and compared these to those of other regulatory authorities. The information from 255 inspection reports was analyzed, and the type and extent of deficiencies were collected...
2018: PloS One
https://www.readbyqxmd.com/read/30083620/a-clostridium-difficile-outbreak-in-an-italian-hospital-the-efficacy-of-the-multi-disciplinary-and-multifaceted-approach
#2
A M Spagnolo, M Sartini, A Battistella, B Casini, G Lo Pinto, E Schinca, M L Cristina
Introduction: We described an outbreak of C. difficile that occurred in the Internal Medicine department of an Italian hospital and assessed the efficacy of the measures adopted to manage the outbreak. Methods: The outbreak involved 15 patients and was identified by means of continuous integrated microbiological surveillance, starting with laboratory data (alert organism surveillance). Diarrheal fecal samples from patients with suspected infection by C. difficile underwent rapid membrane immuno-enzymatic testing, which detects both the presence of the glutamate dehydrogenase antigen and the presence of the A and B toxins...
June 2018: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/30083057/marketplace-coverage-and-limited-access-to-care-among-employed-beneficiaries-evidence-from-ohio
#3
Evan V Goldstein, Jie Cai, Anqi Liu
This article examines the initial effect of Affordable Care Act (ACA) Health Insurance Marketplace (Exchange) insurance on access to care among employed beneficiaries in a highly populated US state. Does Exchange insurance lead to better/worse health care access for employed beneficiaries, compared with similar individuals covered through standard employer-sponsored insurance (ESI) coverage? This retrospective study uses data from the 2015 Ohio Medicaid Assessment Survey, a dual-frame and computer-assisted telephone survey administered by the Ohio Colleges of Medicine Graduate Resource Center, the Ohio Department of Medicaid, the Ohio Department of Health, and Ohio State University, in conjunction with RTI International...
2018: Health Services Insights
https://www.readbyqxmd.com/read/30078733/practice-patterns-among-korean-urologists-for-glans-penis-augmentation-using-hyaluronic-acid-filler-in-the-management-of-premature-ejaculation
#4
Hyeong Guk Jeong, Sun Tae Ahn, Jong Wook Kim, Kyung Keun Seo, Dong Soo Lee, Hong Sun Uh, Je Jong Kim, Du Geon Moon
INTRODUCTION: Glans penis augmentation (GPA) using hyaluronic acid (HA) gel has been developed for treating premature ejaculation (PE) with penile hypersensitivity. The injected HA filler creates a barrier that reduces the tactile stimuli to the hypersensitive dorsal nerve. Although the HA filler is biodegradable and is believed to not cause permanent loss of sexual function, the current International Society for Sexual Medicine guideline for PE does not recommend this procedure owing to concerns regarding sexual dysfunction...
August 2, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/30073976/response-to-radiological-protection-and-the-exposure-of-animals-as-patients-in-veterinary-medicine-by-r-j-pentreath
#5
Christopher Clement
In a Note to the Journal of Radiological Protection on 'Radiological Protection and the Exposure of Animals as Patients in Veterinary Medicine' (J. Radiol. Prot. 36 (2016) N42-N45) Professor J. Pentreath raised a number of issues relating to the rapidly increasing use of ionising radiation in diagnostic, interventional, and therapeutic procedures in veterinary medicine around the world, suggesting that perhaps there was a need to consider, explicitly, the radiological protection of animals as patients. The International Commission on Radiological Protection (ICRP) is the primary international body for formulating recommendations on protection against ionising radiation...
August 3, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/30073434/the-pitfalls-of-proceduralism-an-exploration-of-the-goods-internal-to-the-practice-of-clinical-ethics-consultation
#6
Annie B Friedrich
In an age of professionalization and specialization, the practice of clinical ethics is facing an identity crisis. Are clinical ethicists moral experts, ethics experts, or merely quasi-lawyers giving legal advice? Are they extensions of the hospital, always working to advance the hospital's interests? Or is there another option? Since 1998, when the American Society for Bioethics and Humanities (ASBH) first issued its Core Competencies for Healthcare Ethics Consultation, there has been debate about the role of standardization and proceduralism in clinical ethics consultation...
August 2, 2018: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/30066985/overexpression-immunodetection-and-site-directed-mutagenesis-of-anabaena-sp-pcc-7120-flavodoxin-a-comprehensive-laboratory-practice-on-molecular-biology
#7
Andrés González, María F Fillat
Recombinant protein expression and site-directed mutagenesis of target genes have demonstrated an increasing importance in the fields of molecular biology, biochemistry, biotechnology, and medicine. By using the flavodoxin of the model cyanobacterium Anabaena sp. PCC 7120 as a laboratory tool, we designed a comprehensive laboratory practice encompassing several well-established molecular biology techniques and procedures in order to fulfill two main objectives: (1) overexpression and immunodetection of Anabaena flavodoxin in recombinant Escherichia coli cell extracts, and (2) site-directed mutagenesis of the Anabaena flavodoxin gene isiB...
August 1, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/30044868/constructing-a-dna-barcode-reference-library-for-southern-herbs-in-china-a-resource-for-authentication-of-southern-chinese-medicine
#8
Lu Gong, Xiao Hui Qiu, Juan Huang, Wen Xu, Jun Qi Bai, Jing Zhang, He Su, Chu Mei Xu, Zhi Hai Huang
Southern Chinese Medicine (SCM) is an important sect of Traditional Chinese Medicine (TCM) with its own special cultural style. Species identification is essential for TCM quality control because authentic herbs are possibly substituted with adulterants that would threaten the health of the public or even cause death. Here, we provided the first local reference DNA barcode library based on the second internal transcribed spacer (ITS2) for the molecular identification of SCM. A total of 1512 specimens of southern herbs representing 359 species were collected under the instructions and identification of taxonomic experts...
2018: PloS One
https://www.readbyqxmd.com/read/30044257/the-impact-of-formal-training-and-certification-on-the-relationship-between-volume-and-outcomes-in-percutaneous-coronary-interventions
#9
Habib A Dakik, Wassef Karowni, Katia El-Sibai, Semaan Kobrossi, Karrar Abdul-Ameer, Hani Tamim
BACKGROUND: Little data are available on the impact of formal training and certification on the relationship between volumes and outcome in percutaneous coronary interventions (PCIs).The objective of this report is to study the relationship between PCI volume and outcome for a formally trained interventional cardiologist who is certified by the American Board on Internal Medicine - Interventional Cardiology subspecialty board. METHODS: The operator witnessed 3 different PCI volumes/yr over a 15-year practice period (2000-2014): <50 PCI/yr (years 2000-2006; n = 179), 50-100 PCI/yr (years 2007-2010; n = 256), and >100 PCI/yr (years 2011-2014; n = 427)...
September 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/30041262/management-of-spontaneous-pneumothorax-and-postinterventional-pneumothorax-german-s3-guideline
#10
Jost Schnell, Meinrad Beer, Stephan Eggeling, Wolfgang Gesierich, Jens Gottlieb, Felix Herth, Hans-Stefan Hofmann, Berthold Jany, Michael Kreuter, Julia Ley-Zaporozhan, Robert Scheubel, Thorsten Walles, Sebastian Wiesemann, Heinrich Worth, Erich Stoelben
In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery (DGT), in co-operation with the German Society for Pulmonology (DGP), the German Radiological Society (DRG) and the German Society of Internal Medicine (DGIM) has developed an S3 guideline on spontaneous pneumothorax and postinterventional pneumothorax moderated by the German Association of Scientific Medical Societies (AWMF). METHOD: Based on the source guideline of the British Thoracic Society (BTS2010) for spontaneous pneumothorax, a literature search on spontaneous pneumothorax was carried out from 2008 onwards, for post-interventional pneumothorax from 1960 onwards...
July 24, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/30041191/management-of-spontaneous-pneumothorax-and-post-interventional-pneumothorax-german-s3-guideline
#11
Jost Schnell, Meinrad Beer, Stephan Eggeling, Wolfgang Gesierich, Jens Gottlieb, Felix J F Herth, Hans-Stefan Hofmann, Berthold Jany, Michael Kreuter, Julia Ley-Zaporozhan, Robert Scheubel, Thorsten Walles, Sebastian Wiesemann, Heinrich Worth, Erich Stoelben
In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery, in co-operation with the German Society for Pulmonology, the German Radiological Society, and the German Society of Internal Medicine has developed an S3 guideline on spontaneous pneumothorax and post-interventional pneumothorax moderated by the German Association of Scientific Medical Societies. METHOD: Based on the source guideline of the British Thoracic Society (2010) for spontaneous pneumothorax, a literature search on spontaneous pneumothorax was carried out from 2008 onwards, for post-interventional pneumothorax from 1960 onwards...
July 24, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30022890/evaluating-analytical-quality-in-clinical-biochemistry-laboratory-using-six-sigma
#12
Xuehui Mao, Jing Shao, Bingchang Zhang, Yong Wang
Introduction: In recent years, Six Sigma metrics has became the hotspot in all trades and professions, which contributes a general procedure to explain the performance on sigma scale. Nowadays, many large companies, such as General Healthcare, Siemens, etc ., have applied Six Sigma to clinical medicine and achieved satisfactory results. In this paper, we aim to evaluate the process performance of our laboratory by using Sigma metrics, thereby choosing the correct analytical quality control approach for each parameter...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/30020270/carotid-ultrasound-examinations-indications-correlated-with-abnormal-findings
#13
James B Naidich, Amanda Weiss, Gregory M Grimaldi, Nina Kohn, Jason J Naidich, John S Pellerito
Our purpose was to evaluate the clinical indications for carotid duplex ultrasonography and determine for each indication how often carotid artery disease was identified.We retrospectively reviewed the consecutive reports for 3191 carotid ultrasound examinations. We tracked 14 indications to determine how often examinations were requested for each indication and correlated each indication with the finding of carotid artery disease.We found 26.5% of all examinations were abnormal; 17.5% of patients showed internal carotid artery disease; 10...
July 17, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/30004633/australian-students-perspective-on-interventional-radiology-education-a-prospective-cross-institutional-study
#14
Michelle Foo, Julian Maingard, Kevin Phan, Reuben Lim, Ronil V Chandra, Michael J Lee, Hamed Asadi, Hong Kuan Kok, Mark Brooks
INTRODUCTION: As interventional radiology (IR) adopts an increasingly pivotal role within therapeutic medicine, it is essential that medical students gain exposure to IR so as future doctors, they can fulfil the growing demand for interventional radiologists (IRs) and make appropriate referrals to IRs. Nonetheless, several international studies have reported no or little representation of IR in medical schools. Our study aims to assess the current awareness, exposure, knowledge and attitudes about IR among Australian medical students, so as to provide preliminary data on whether IR teaching in Australian medical schools needs improvement...
July 13, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/30001345/reducing-healthcare-associated-infections-incidence-by-a-probiotic-based-sanitation-system-a-multicentre-prospective-intervention-study
#15
Elisabetta Caselli, Silvio Brusaferro, Maddalena Coccagna, Luca Arnoldo, Filippo Berloco, Paola Antonioli, Rosanna Tarricone, Gabriele Pelissero, Silvano Nola, Vincenza La Fauci, Alessandro Conte, Lorenzo Tognon, Giovanni Villone, Nelso Trua, Sante Mazzacane
Healthcare Associated Infections (HAI) are a global concern, further threatened by the increasing drug resistance of HAI-associated pathogens. On the other hand, persistent contamination of hospital surfaces contributes to HAI transmission, and it is not efficiently controlled by conventional cleaning, which does not prevent recontamination, has a high environmental impact and can favour selection of drug-resistant microbial strains. In the search for effective approaches, an eco-sustainable probiotic-based cleaning system (Probiotic Cleaning Hygiene System, PCHS) was recently shown to stably abate surface pathogens, without selecting antibiotic-resistant species...
2018: PloS One
https://www.readbyqxmd.com/read/29991317/perceptions-of-slow-codes-by-nurses-working-on-internal-medicine-wards
#16
Freda DeKeyser Ganz, Rotem Sharfi, Nehama Kaufman, Sharon Einav
BACKGROUND: Cardio-pulmonary resuscitation is the default procedure during cardio-pulmonary arrest. If a patient does not want cardio-pulmonary resuscitation, then a do not attempt resuscitation order must be documented. Often, this order is not given; even if thought to be appropriate. This situation can lead to a slow code, defined as an ineffective resuscitation, where all resuscitation procedures are not performed or done slowly. RESEARCH OBJECTIVES: To describe the perceptions of nurses working on internal medicine wards of slow codes, including the factors associated with its implementation...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29978028/motivations-and-experiences-of-canadians-seeking-treatment-for-lyme-disease-outside-of-the-conventional-canadian-health-care-system
#17
Corinne R Boudreau, Vett K Lloyd, Odette N Gould
Objective: We aimed to describe the experiences of Canadians who seek diagnosis and treatment for Lyme disease outside of the conventional Canadian health-care system. Methods: Forty-five individuals who had sought treatment for Lyme disease outside of the conventional Canadian health-care system were recruited from Lyme support and advocacy groups across Canada to answer open-ended questions about their experiences. Results: Respondents sought treatment outside of the conventional medical system due to extensive diagnostic procedures and treatments that did not resolve symptoms...
June 2018: Journal of Patient Experience
https://www.readbyqxmd.com/read/29968026/select-choices-in-benign-breast-disease-an-initiative-of-the-american-society-of-breast-surgeons-for-the-american-board-of-internal-medicine-choosing-wisely-%C3%A2-campaign
#18
Roshni Rao, Kandace Ludwig, Lisa Bailey, Tiffany S Berry, Robert Buras, Amy Degnim, Oluwadamilola M Fayanju, Joshua Froman, Negar Golesorkhi, Caprice Greenburg, Ayemoe Thu Ma, Starr Koslow Mautner, Helen Krontiras, Michelle Sowden, Barbara Wexelman, Jeffrey Landercasper
BACKGROUND: Up to 50% of all women encounter benign breast problems. In contrast to breast cancer, high-level evidence is not available to guide treatment. Management is therefore largely based on individual physician experience/training. The American board of internal medicine (ABIM) initiated its Choosing Wisely® campaign to promote conversations between patients and physicians about challenging the use of tests or procedures which may not be necessary. The American society of breast surgeons (ASBrS) Patient safety and quality committee (PSQC) chose to participate in this campaign in regard to the management of benign breast disease...
July 2, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29953744/has-rheumatology-become-a-more-attractive-career-choice-comparison-of-trends-in-the-rheumatology-fellowship-match-from-2008-to-2013-with-2014-to-2017
#19
Huynh W Tran, Lauren M Mathias, Richard S Panush
OBJECTIVE: Rheumatology has been a less attractive career choice than other internal medicine (IM) subspecialties. Recent fellowship "Match" data suggested this may have changed. We therefore evaluated the current attractiveness of rheumatology and compared it with other medical subspecialties. METHODS: Data from the "Match" from 2008 - 2017, the 2015 American College of Rheumatology workforce study, and Medscape physician salaries from 2010 - 2017 were used to determine annual numbers of fellowship applicants, availability of positions, and post-fellowship salary trends...
June 28, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29951208/regulatory-requirements-for-the-registration-of-generic-medicines-and-format-of-drug-dossiers-procedures-in-sri-lanka-in-comparison-with-selected-regulatory-authorities
#20
D Thambavita, P Galappatthy, R L Jayakody
Background: The regulatory requirements for approval of generic medicines and the format of compiling drug dossiers vary among regulatory authorities. The variation is particularly wide between High-income countries (HIC) and lower and middle-income countries (LMIC) with different regulatory frameworks. In this study, document requirements for approval of generic products, approval timelines, and consideration of bioequivalence and/or biowaiver data by Regulatory Authorities (RAs) of 10 selected jurisdictions was studied...
2018: Journal of Pharmaceutical Policy and Practice
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