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Kwai Fung Hui, Tsz Fung Chan, Wanling Yang, Jiangshan Jane Shen, Ki Pui Lam, Hin Kwok, Pak C Sham, Sai Wah Tsao, Dora L Kwong, Maria Li Lung, Alan Kwok Shing Chiang
Whether certain variants of Epstein-Barr virus (EBV) are linked to the pathogenesis of nasopharyngeal carcinoma (NPC), which shows a marked geographic restriction, remains an unresolved issue. We performed a case-control study comparing genomic sequences of EBV isolated from saliva samples of 142 population carriers with those from primary tumour biopsies derived from 62 patients with NPC of Hong Kong. Cluster analysis discovered five EBV subgroups 1A-C and 2A-B amongst the population carriers in contrast to the predominance of 1A and -B in the majority of NPC...
December 10, 2018: International Journal of Cancer. Journal International du Cancer
Santhosh Kotian, Ravikanth Haridas Jujare, Foo Guang Ian, Lee Guan Yao, Nurfarah Nadira Binti Dzainuddin, Woh Pui Man
No abstract text is available yet for this article.
October 2018: Journal of Indian Prosthodontic Society
Pak Cheung Ng, Kathy Yuen Yee Chan, Terence Ping Yuen, Tony Sit, Hugh Simon Lam, Kam Tong Leung, Raymond Pui On Wong, Lawrence Chi Ngong Chan, Yennie Lap Ian Pang, Hon Ming Cheung, Winnie Chiu Wing Chu, Karen Li
OBJECTIVE: To discover specific circulating microRNA (miRNA) biomarkers for the early differentiation of necrotizing enterocolitis (NEC) from neonatal sepsis and inflammatory conditions. STUDY DESIGN: The study comprised 3 distinct phases: differential microarray analysis to compare plasma miRNA expression profiles of NEC vs sepsis and non-NEC/nonsepsis cases, a case-control study to quantify dysregulated miRNAs as potential specific biomarkers of NEC, and a prospective cohort study to assess the diagnostic usefulness of the best miRNA biomarker(s)...
October 24, 2018: Journal of Pediatrics
Billy Chun-Lung So, Calvin Hong-Nin Yuen, Ken Long-Hin Tung, Sheena Lam, Sammy Lan Cheng, Zina Wing-Lam Hung, Rainy Wai-Kwan Leung, Grace Pui-Yuk Szeto
CONTEXT: Deep water running (DWR) is an aquatic aerobic exercise which involves running in water without the feet touching the bottom of the pool, and it may involve different activation of trunk muscles compared to running or walking on land. This form of exercise is gradually being adopted as a form of therapeutic exercise for people with low back pain. It is proposed that different types of running or walking in water may be a more comfortable form of training for the trunk and abdominal muscles compared to exercising on dry land...
December 11, 2018: Journal of Sport Rehabilitation
Edmond Pui Hang Choi, Janet Yuen Ha Wong, Daniel Yee Tak Fong
The methodological issues of using self-reported human immunodeficiency virus (HIV) testing history to determine HIV infection status are understudied. This study aimed to assess the disparities between HIV testing history and self-reported HIV status, with a specific objective of estimating the prevalence of self-reported HIV-negative status in sexually active students who had never had an HIV test (inaccurate self-disclosure). Participants were recruited from four Hong Kong universities; 255 students were included in the analysis, with 16...
December 10, 2018: Journal of Sex Research
Valérie de Haas, Nofisat Ismaila, Anjali Advani, Daniel A Arber, Raetasha S Dabney, Dipti Patel-Donelly, Elizabeth Kitlas, Rob Pieters, Ching-Hon Pui, Kendra Sweet, Ling Zhang
PURPOSE: The College of American Pathologists (CAP) and the American Society of Hematology (ASH) developed an evidence-based guideline on the initial diagnostic work-up of acute leukemia (AL). Because of the relevance of this topic to the ASCO membership, ASCO reviewed the guideline and applied a set of procedures and policies for endorsing clinical practice guidelines that have been developed by other professional organizations. METHODS: The CAP-ASH guideline on initial diagnostic work-up of AL was reviewed for developmental rigor by methodologists...
December 3, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Arnold Y L Wong, Dino Samartzis, Prudence W H Cheung, Jason Pui Yin Cheung
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common spine deformity in adolescent patients. Although structural deformity may affect spinal biomechanics of patients with AIS, little is known regarding various period prevalence proportions of back pain and chronic back pain and factors associated with back pain in such patients. QUESTIONS/PURPOSES: (1) What are the period prevalence rates of back pain among teenagers with AIS? (2) Is back pain in patients with AIS associated with curve severity? METHODS: A total of 987 patients with AIS who were treated without surgery were recruited from a single center's scoliosis clinic...
November 13, 2018: Clinical Orthopaedics and related Research
Uruj Zehra, Jason Pui Yin Cheung, Cora Bow, William Lu, Dino Samartzis
The aim of the current study was to investigate the multi-dimensional characteristics of lumbar endplate defects in humans in relation to disc degeneration and other MRI phenotypes as well as their role with pain and disability. 108 subjects were recruited and underwent 3T MRI of the lumbar spine. Structural endplate defects were identified and their dimensions were measured in terms of maximum width and depth, and were then standardized to the actual width of the endplate and depth of the vertebral body, respectively...
December 4, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Jason C Yam, Yuning Jiang, Shu Min Tang, Antony K P Law, Joyce J Chan, Emily Wong, Simon T Ko, Alvin L Young, Clement C Tham, Li Jia Chen, Chi Pui Pang
PURPOSE: Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0.025%, and 0.01% compared with placebo over a 1-year period. DESIGN: Randomized, placebo-controlled, double-masked trial. PARTICIPANTS: A total of 438 children aged 4 to 12 years with myopia of at least -1...
July 6, 2018: Ophthalmology
Chengyu Liu, Cong-Qiao Xu, Junguang Yu, Yipshu Pui, Huijun Chen, Shan Wang, Alan Donghua Zhu, Jun Li, Feng Qian
We aim to understand the potential impact of a modest chemical modification of a drug molecule on the downstream design of its amorphous solid dispersion (ASD) formulation. To this end, we used sorafenib (SOR) and its fluorinated form, regorafenib (REG), as model drugs, to assess the impact of a single hydrogen substitution by fluorine on the molecular interaction and miscibility between drug and PVP or PVP-VA, two commonly used polymers for ASDs. In this study, we observed that the Tg values of PVP or PVP-VA based SOR ASDs deviated positively from Gordon-Taylor prediction that assumes ideal mixing, yet the Tg of REG ASDs deviated negatively from or matched well with this ideal mixing model, suggesting much stronger drug-polymer interactions in SOR ASDs compared with the REG ones...
December 4, 2018: Molecular Pharmaceutics
Maoxiang Qian, Heng Xu, Virginia Perez-Andreu, Kathryn G Roberts, Hui Zhang, Wenjian Yang, Shouyue Zhang, Xujie Zhao, Colton Smith, Meenakshi Devidas, Julie M Gastier-Foster, Elizabeth Raetz, Eric Larsen, Esteban G Burchard, Naomi Winick, W Paul Bowman, Paul L Martin, Michael Borowitz, Brent Wood, Federico Antillon-Klussmann, Ching-Hon Pui, Charles G Mullighan, William E Evans, Stephen P Hunger, Mary V Relling, Mignon L Loh, Jun J Yang
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Characterized by high levels of Native American ancestry, Hispanics are disproportionally affected by this cancer with high incidence and inferior survival, but the genetic basis for this disparity remains poorly understood because of a paucity of genome-wide investigation of ALL in Hispanics. Performing a genome-wide association study in 940 Hispanic children with ALL and 681 ancestry-matched non-ALL controls, we identified a novel susceptibility locus in the ERG gene (rs2836365; P = 3...
December 3, 2018: Blood
N A Fineberg, Z Demetrovics, D J Stein, K Ioannidis, M N Potenza, E Grünblatt, M Brand, J Billieux, L Carmi, D L King, J E Grant, M Yücel, B Dell'Osso, H J Rumpf, N Hall, E Hollander, A Goudriaan, J Menchon, J Zohar, J Burkauskas, G Martinotti, M Van Ameringen, O Corazza, S Pallanti, S R Chamberlain
The Internet is now all-pervasive across much of the globe. While it has positive uses (e.g. prompt access to information, rapid news dissemination), many individuals develop Problematic Use of the Internet (PUI), an umbrella term incorporating a range of repetitive impairing behaviours. The Internet can act as a conduit for, and may contribute to, functionally impairing behaviours including excessive and compulsive video gaming, compulsive sexual behaviour, buying, gambling, streaming or social networks use...
November 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Chee Yik Chang, Wei Chieng Pui, Khamisah Abdul Kadir, Balbir Singh
BACKGROUND: Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease, including fatal outcomes. Spontaneous splenic rupture is a rare, but severe complication of malaria and has not been reported previously for knowlesi malaria. CASE PRESENTATION: A 46-year-old man presented with fever and acute surgical abdomen with concomitant P...
December 4, 2018: Malaria Journal
Jason Pui Yin Cheung, Keith Dip Kei Luk
PURPOSE: The purpose of this study was to review the current understanding of high-intensity zones (HIZ) in the lumbar spine with particular attention to its imaging phenotype and clinical relevance. METHODS: A review was conducted of studies related to HIZ. Particular attention was made to imaging phenotypes and classification, and its relationship with discogenic low back pain (LBP). RESULTS: The most current classification system of HIZ is based on location (anterior and posterior), morphology (round, fissure, vertical, rim, or giant types), and its appearance on both T1- and T2-weighted magnetic resonance imaging (MRI)...
November 30, 2018: International Orthopaedics
Alvin Ho-Kwan Cheung, Chit Chow, Mei-Yung Yu, Wendy Wai-Tak Law, Peggy Pui-Ying Law, Paul Cheung-Lung Choi, Wei Kang, Ka-Fai To
Malignant transformation of benign mature ovarian teratoma can result in a wide spectrum of cancer, including a variety of carcinoma, sarcoma, or melanoma. The role of mismatch repair defects in such malignant transformation is still elusive. In view of current immunotherapy, the role of mismatch repair deficiency can have significant implications on therapeutic strategy. Thus, we aimed to investigate the possible involvement of mismatch repair deficiency in somatic-type carcinoma arising from teratoma. We examined seven cases of malignant transformation of ovarian teratoma to carcinoma from the years 2000-2017...
November 27, 2018: Pathology
Josephine Pui-Hing Wong, Roula Kteily-Hawa, Lori A Chambers, Shriya Hari, Chikermane Vijaya, Ragulan Suruthi, Shazia Islam, Mandana Vahabi
Story-based learning is well recognized as an effective strategy for adult health education. However, there is a scarcity of research on story-based health education among women in South Asian diasporic communities. To address this gap, we undertook a pilot study in Toronto to explore how South Asian women respond to the use of fact-based and story-based materials for HIV/STI prevention. A total of 78 women were recruited from across the city. We engaged nearly half of the women (n=40) using fact sheets on HIV/STIs, and the remainder (n=38) using stories written by South Asian women on HIV/STIs...
November 27, 2018: Health Education Research
Pui W Cheung, Abby Terlouw, Sam Antoon Janssen, Dennis Brown, Richard Bouley
KEY POINTS: Aquaporin-2 (AQP2) is crucial for water homeostasis, and vasopressin (VP) induces AQP2 membrane trafficking by increasing intracellular cAMP, activating PKA, and causing phosphorylation of AQP2 at serine 256, 264 and 269 residues and dephosphorylation of serine 261 residue on the AQP2 c-terminus. It is thought that serine 256 is the master regulator of AQP2 trafficking, and its phosphorylation has to precede the change of phosphorylation state of other serine residues. We found that Src inhibition causes serine 256 independent AQP2 membrane trafficking and induces phosphorylation of serine 269 independent of serine 256...
November 28, 2018: Journal of Physiology
Salvatore Papa, Pui Man Choy, Concetta Bubici
Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved in cell growth. This metabolic reprogramming, known as aerobic glycolysis or the Warburg effect, allows tumor cells to sustain their fast proliferation and evade apoptosis. Interfering with oncogenic signaling pathways that regulate the Warburg effect in cancer cells has therefore become an attractive anticancer strategy. However, evidence for the occurrence of the Warburg effect in physiological processes has also been documented...
November 28, 2018: Oncogene
Jian-Feng Li, Yu-Ting Dai, Henrik Lilljebjörn, Shu-Hong Shen, Bo-Wen Cui, Ling Bai, Yuan-Fang Liu, Mao-Xiang Qian, Yasuo Kubota, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Linda Olsson, Ah Moy Tan, Hany Ariffin, Jing Chen, Junko Takita, Takahiko Yasuda, Hiroyuki Mano, Bertil Johansson, Jun J Yang, Allen Eng-Juh Yeoh, Fumihiko Hayakawa, Zhu Chen, Ching-Hon Pui, Thoas Fioretos, Sai-Juan Chen, Jin-Yan Huang
Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion of BCP ALL remains poorly characterized in relation to its underlying genomic abnormalities. We therefore initiated a large-scale international study to reanalyze and delineate the transcriptome landscape of 1,223 BCP ALL cases using RNA sequencing. Fourteen BCP ALL gene expression subgroups (G1 to G14) were identified. Apart from extending eight previously described subgroups (G1 to G8 associated with MEF2D fusions, TCF3-PBX1 fusions, ETV6-RUNX1 -positive/ ETV6-RUNX1 -like, DUX4 fusions, ZNF384 fusions, BCR-ABL1 /Ph-like, high hyperdiploidy, and KMT2A fusions), we defined six additional gene expression subgroups: G9 was associated with both PAX5 and CRLF2 fusions; G10 and G11 with mutations in PAX5 (p...
November 28, 2018: Proceedings of the National Academy of Sciences of the United States of America
Pui-Pik Law, Michelle L Holland
Protein encoding genes constitute a small fraction of mammalian genomes. In addition to the protein coding genes, there are other functional units within the genome that are transcribed, but not translated into protein, the so called non-coding RNAs. There are many types of non-coding RNAs that have been identified and shown to have important roles in regulating gene expression either at the transcriptional or post-transcriptional level. A number of recent studies have highlighted that dietary manipulation in mammals can influence the expression or function of a number of classes of non-coding RNAs that contribute to the protein translation machinery...
November 27, 2018: Nutrients
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