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Biniam Kebede, Pui Yee Lee, Sze Ying Leong, Vidya Kethireddy, Qianli Ma, Kemal Aganovic, Graham T Eyres, Nazimah Hamid, Indrawati Oey
High-Pressure Processing (HPP) and Pulsed Electric Fields (PEF) processing technologies are being used increasingly on a commercial basis, with high-quality labelled fruit juices being one of the most important promotion strategies. Quality-related enzymes, which might still be active after HPP and PEF pasteurization, can cause undesirable aroma changes during storage. This study investigated volatile changes during the shelf life of PEF (15.5 kV/cm and specific energy of 158 kJ/L), HPP (600 MPa for 3 min), and thermally (72 °C for 15 s) pasteurized Jazz apple juices-up to five weeks...
October 17, 2018: Foods (Basel, Switzerland)
Jason Pui Yin Cheung, Prudence Wing Hang Cheung, Chee Kidd Chiu, Chris Yin Wei Chan, Mun Keong Kwan
Study Design: Surgeon survey. Purpose: To study the various surgical practices of different surgeons in the Asia-Pacific region. Overview of Literature: Given the diversity among Asia-Pacific surgeons, there is no clear consensus on the preferred management strategies for cervical myelopathy. In particular, the role of prophylactic decompression for silent cervical spinal stenosis is under constant debate and should be addressed. Methods: Surgeons from the Asia-Pacific Spine Society participated in an online questionnaire comprising 50 questions...
October 18, 2018: Asian Spine Journal
Marabelle L Heng, Priathashini Krishnasamy, Pui W Kong
BACKGROUND: While posterior tibial tendon dysfunction (PTTD) commonly presents with flat feet and has been thought to be associated with first ray mobility, many flat-footed individuals are asymptomatic and do not experience any symptoms of PTTD. Thus, there is a need to control for foot type when studying factors related to PTTD. This study aimed to clarify if first ray mobility differed between flat-footed individuals with and without symptoms of PTTD. It was hypothesized that PTTD patients would display higher mobility of the first ray than asymptomatic flat-footed controls...
August 3, 2018: Foot
Vui Heng Chong, Sumitro Kosasih, Pui Ling Chong
No abstract text is available yet for this article.
October 16, 2018: QJM: Monthly Journal of the Association of Physicians
Liwen Huang, Pui-Kin So, Zhong-Ping Yao
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful technique for studying protein dynamics, which is an important factor governing protein functions. However, the process of hydrogen deuterium exchange (HDX) of proteins is highly complex and the underlying mechanism has not yet been fully understood. Meanwhile, molecular dynamics (MD) simulation is a computational technique that can be used to elucidate HDX behaviour on proteins and facilitate interpretation of HDX-MS data. This article aims to summarize the current understandings on the mechanism of HDX and its correlation with MD simulation, and to discuss the recent development in the techniques of HDX-MS and MD simulation and the perspectives of these two techniques in protein dynamics study...
October 15, 2018: Rapid Communications in Mass Spectrometry: RCM
Olivia A Bernal, Heather F McClintock, Jibby E Kurichi, Pui L Kwong, Dawei Xie, Joel E Streim, Liliana E Pezzin, Hillary R Bogner
OBJECTIVE: To examine the association between activity limitation stages and patient satisfaction and perceived quality of medical care among younger Medicare beneficiaries. DESIGN: Cross-sectional study. SETTING: Medicare Current Beneficiary Survey (MCBS) for calendar years 2001-2011. PARTICIPANTS: A population-based sample (n=9323) of Medicare beneficiaries less than 65 years of age living in the community. INTERVENTIONS: Not applicable...
October 11, 2018: Archives of Physical Medicine and Rehabilitation
Tze-Peng Lim, Reyna Wang, Gang Quan Poh, Tse-Hsien Koh, Thean-Yen Tan, Winnie Lee, Jocelyn Qi-Min Teo, Yiying Cai, Thuan-Tong Tan, Pui Lai Rachel Ee, Andrea L Kwa
Objectives: Treatment for nosocomial bloodstream infections (BSI) caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) is challenging. Rising antimicrobial resistance, especially in extended spectrum beta-lactamase production, inadvertently increases empiric carbapenem consumption. Three antipseudomonal carbapenems (imipenem, meropenem [MER], and doripenem [DOR]) are available commercially against MDR GNB in Singapore. The study aims to determine the most optimal empiric carbapenem dosing regimens (CDR) and evaluate their cost-effectiveness for GNB-BSI in the face of increasing MDR GNB...
2018: Infection and Drug Resistance
Ella W Yeung, Yan-Wing Sin, Sweetie R Lui, Toni W T Tsang, Ka-Wing Ng, Pui-Ka Ma, Simon S Yeung, Peter Y Woo, Tracy M Ma
Objective: The aim of this study was to translate, adapt and validate the Sport Concussion Assessment Tool 3rd edition (SCAT3), a test for assessing athletes for concussion, into the Chinese context. Methods: Translation and adaptation were performed in several stages, which included forward translation by two independent teams, translation merging, backward translation, reviews by both native Cantonese-speaking and Mandarin-speaking multidisciplinary expert panels (n=49) for semantic and conceptual equivalence and reviews by pitch-side physiotherapists (n=18) as end-users of the SCAT3 and rugby players (n=11) for face validity...
2018: BMJ Open Sport & Exercise Medicine
Sophie Lohmann, Benjamin X White, Zhen Zuo, Man-Pui Sally Chan, Alex Morales, Bo Li, Chengxiang Zhai, Dolores Albarracín
OBJECTIVES: Social media messages have been increasingly used in health campaigns about prevention, testing, and treatment of HIV. We identified factors leading to the retransmission of messages from expert social media accounts to create data-driven recommendations for online HIV messaging. DESIGN AND METHODS: We sampled 20,201 HIV-related tweets (posted between 2010 and 2017) from 37 HIV experts. Potential predictors of retransmission were identified based on prior literature and machine learning methods and were subsequently analyzed using multilevel negative binomial models...
October 4, 2018: AIDS
Daniel Kerage, Megan S F Soon, Brianna L Doff, Takumi Kobayashi, Michael D Nissen, Pui Yeng Lam, Graham R Leggatt, Stephen R Mattarollo
Immunomodulatory therapies can effectively control haematological malignancies. Previously we reported the effectiveness of combination immunotherapies that centre on 4-1BB-targeted co-stimulation of CD8 + T cells, particularly when simultaneously harnessing the immune adjuvant properties of Natural Killer T (NKT) cells. The objective of this study was to assess the effectiveness of agonistic anti-4-1BB antibody-based combination therapy against two aggressive forms of acute myeloid leukemia (AML). Anti-4-1BB treatment alone resulted in transient suppression of established AML-ETO9a tumor growth in 50% of mice, however the majority of these mice subsequently succumbed to disease...
2018: Oncoimmunology
Ana Cl Marques, Bernardo A Aguiar, Luciana Ma Frota, Bruno M Guimarães, Nilton Vivacqua-Gomes, Rodrigo R Vivan, Marco Ah Duarte, Bruno C de Vasconcelos
AIM: The purpose of this study was to evaluate the influence of widening the apical root canal preparation (RCP) on the efficiency of different ethylenediaminetetraacetic acid (EDTA) agitation protocols on smear layer removal: EDTA; EDTA + Easy Clean in rotary movement (ECROT); EDTA + Easy Clean in reciprocating movement (ECREC); and EDTA + Passive ultrasonic irrigation (PUI). MATERIALS AND METHODS: A total of 80 mandibular premolars had their crowns sectioned and then were divided into two groups according to widening: size 25 or 40, 0...
September 1, 2018: Journal of Contemporary Dental Practice
Joseph J Lee, Jan Y Verbakel, Clare Rosemary Goyder, Thanusha Ananthakumar, Pui San Tan, Phillip James Turner, Gail Hayward, Ann Van den Bruel
Background: Point-of-care tests (POCTs) for influenza are diagnostically superior to clinical diagnosis, but their impact on patient outcomes is unclear. Methods: A systematic review of influenza POCTs versus usual care in ambulatory care settings. Studies were identified by searching six databases and assessed using the Cochrane risk of bias tool. Estimates of risk ratios (RR), standardised mean differences, 95% confidence intervals and I2 were obtained by random effects meta-analyses...
October 4, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Eric Tsz-Chun Poon, Feng-Hua Sun, Anthony Pui-Wan Chung, Stephen Heung-Sang Wong
High-intensity interval training (HIIT) is considered a time-efficient exercise strategy for weight management. However, data regarding the acute appetite and energy intake responses to HIIT versus continuous training remain inconclusive. This study investigated the ad libitum energy intake and appetite responses to a single session of HIIT versus moderate-intensity continuous training (MICT) and vigorous-intensity continuous training (VICT). Using a randomized crossover design, 11 middle-aged physically inactive men (45...
October 2, 2018: Nutrients
Pui-Ying Iroh Tam, Patrick Musicha, Kondwani Kawaza, Jenifer Cornick, Brigitte Denis, Bridget Freyne, Dean Everett, Queen Dube, Neil French, Nicholas Feasey, Robert Heyderman
Background: The adequacy of the WHO Integrated Management of Childhood Illness (IMCI) antimicrobial guidelines for the treatment of suspected severe bacterial infections is dependent on a low prevalence of antimicrobial resistance (AMR). We describe trends in etiologies and susceptibility patterns of bloodstream infections (BSI) in hospitalized children in Malawi. Methods: We determined the change in population-based incidence of BSI in children admitted to Queen Elizabeth Central Hospital, Blantyre, Malawi (1998-2017)...
October 1, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Yin Ting Cheung, Aaron Eskind, Hiroto Inaba, Melissa M Hudson, Ching-Hon Pui, Kevin R Krull, Joshua Wolf
No abstract text is available yet for this article.
September 24, 2018: JAMA Pediatrics
Qichen Yang, Vishal Jhanji, Sze Qin Tan, Kwok Ping Chan, Di Cao, Wai Kit Chu, Mingzhi Zhang, Chi Pui Pang, Tsz Kin Ng
Pterygium is a triangular-shaped hyperplastic growth, characterized by conjunctivalization, inflammation, and connective tissue remodeling. Our previous meta-analysis found that cigarette smoking is associated with a reduced risk of pterygium. Yet, the biological effect of cigarette smoke components on pterygium has not been studied. Here we reported the proliferation and migration properties of human primary pterygium cells with continuous exposure to nicotine and cotinine. Human primary pterygium cells predominantly expressed the α5, β1, and γ subunits of the nicotinic acetylcholine receptor...
September 27, 2018: Journal of Cellular Biochemistry
Minakshi Rana, Yurong Fei-Bloom, Myoungsun Son, Andrea La Bella, Mahendar Ochani, Yaakov A Levine, Pui Yan Chiu, Ping Wang, Sangeeta S Chavan, Bruce T Volpe, Barbara Sherry, Betty Diamond
Patients surviving a septic episode exhibit persistent immune impairment and increased mortality due to enhanced vulnerability to infections. In the present study, using the cecal ligation and puncture (CLP) model of polymicrobial sepsis, we addressed the hypothesis that altered vagus nerve activity contributes to immune impairment in sepsis survivors. CLP-surviving mice exhibited less TNFα in serum following administration of LPS, a surrogate for an infectious challenge, than control-operated (control) mice...
2018: Frontiers in Immunology
Abida Haq Syed M Haq, Faridah Aryani Md Yusof, Pui Lim Chan, Mary Chiew Fong Chok, Gillian Shih Yen Phua, Chee Jia Teoh, Noorazlinda Yaacob, Yusmiza Azmi, Nurul Afifah Osman, Ahmad Farhan Paiman, Siti Fauziah Abu, Nurul Adha Othman, Salwati Abd Kadir, Kamarunnesa Mokhtar Ahmad
BACKGROUND: The pharmacy internship program is designed to provide comprehensive training for interns to perform various roles in pharmacy practice. In Malaysia, the current internship program has been in place since 2004 in public health facilities, but has never been extensively evaluated. AIM: To assess the level of job satisfaction and perception of Provisionally Registered Pharmacists (PRP) towards the internship training provided. METHODS: A cross-sectional nationwide survey was conducted amongst all PRPs undergoing training between December 2015 and February 2016 to assess their level of job satisfaction and perception towards the training requirements stipulated by the Pharmacy Board of Malaysia...
July 2018: Currents in Pharmacy Teaching & Learning
Aimin Wu, Wenlan Dong, Shiwei Liu, Jason Pui Yin Cheung, Kenny Yat Hong Kwan, Xinying Zeng, Kai Zhang, Zhenyu Sun, Xiangyang Wang, Kenneth Man Chee Cheung, Maigeng Zhou, Jie Zhao
The aim of this work was to quantify the prevalence and years lived with disability (YLDs) caused by low back pain (LBP) in China from 1990 to 2016. Data from the GBD 2016 (Global Burden of Diseases, Injuries, and Risk Factors Study 2016) were used. We analyzed the age-sex-province-specific prevalence and YLDs for LBP of 33 provinces/regions in China. Comparisons were made with the data retrieved from the 1990 GBD study. We estimated that 5.45 × 10 individuals had LBP in 1990, which rose to 6.73 × 10 in 2016...
October 3, 2018: Pain
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