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Keywords Hurthle cell carcinoma and pap...

Hurthle cell carcinoma and papillary carcinoma

https://read.qxmd.com/read/38285158/the-role-of-5-hydroxymethylcytosine-as-a-potential-epigenetic-biomarker-in-a-large-series-of-thyroid-neoplasms
#1
JOURNAL ARTICLE
Sule Canberk, João Gonçalves, Elisabete Rios, Antónia A Povoa, Ebru Tastekin, Manuel Sobrinho-Simões, Aysun Uguz, Ozlem Aydin, Umit Ince, Paula Soares, Valdemar Máximo
Cytosine modifications at the 5-carbon position play a critical role in gene expression regulation and have been implicated in cancer development. 5-Hydroxymethylcytosine (5hmC), arising from 5-methylcytosine (5-mC) oxidation, has shown promise as a potential malignancy marker due to its depletion in various human cancers. However, its significance in thyroid tumors remains underexplored, primarily due to limited data. In our study, we evaluated 5hmC expression levels by immunohistochemistry in a cohort of 318 thyroid tumors...
January 29, 2024: Endocrine Pathology
https://read.qxmd.com/read/38002585/braf-k601e-mutation-in-oncocytic-carcinoma-of-the-thyroid-a-case-report-and-literature-review
#2
Antonio Matrone, Fabrizia Citro, Carla Gambale, Alessandro Prete, Elisa Minaldi, Raffaele Ciampi, Teresa Ramone, Gabriele Materazzi, Liborio Torregrossa, Rossella Elisei
BACKGROUND: Thyroid carcinoma (TC) is the most common endocrine cancer, with papillary thyroid carcinoma (PTC) being the most common subtype. BRAF and RAS oncogene were characterized as the most frequently altered genes in PTC, with a strong association between genotype and histotype. The most common mutation in BRAF gene is V600E and is prevalent in classic and aggressive variants of PTC, while BRAF K601E mutation is the most common among the other rare BRAF mutations. BRAF K601E mutated thyroid carcinomas are usually characterized by low aggressiveness, except for anecdotal cases of poorly differentiated TC...
November 7, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37926582/diagnostic-performance-of-molecular-testing-in-indeterminate-bethesda-iii-and-iv-thyroid-nodules-with-h%C3%A3-rthle-cell-cytology
#3
JOURNAL ARTICLE
Rajam Raghunathan, Xochitl R Longstaff, Elena G Hughes, Shanpeng J Li, Vivek R Sant, Chi-Hong Tseng, Jianyu Rao, James X Wu, Michael W Yeh, Masha J Livhits
BACKGROUND: Indeterminate thyroid nodules with Hürthle cell cytology remain a diagnostic challenge. The low benign call rate and positive predictive value of first-generation molecular tests precluded their use to rule out malignancy. We examined the diagnostic performance of current tests. METHOD: This subset analysis of our prospective randomized trial compared the benign call rate and positive predictive value of Afirma Gene Sequencing Classifier and Thyroseq v3 in Bethesda III and IV nodules with Hürthle cell cytology...
January 2024: Surgery
https://read.qxmd.com/read/37885286/fine-needle-aspiration-biopsy-findings-of-the-thyroid-gland-in-renal-transplant-patients
#4
JOURNAL ARTICLE
Eda Yılmaz Akçay, Merih Tepeoğlu, Alev Ok Atilgan, Sergen Yağcı, Binnaz Handan Özdemir, Mehmet Haberal
OBJECTIVES: For patients with end-stage renal disease, thyroid diseases are common due to altered hormone excretion and transport, and for renal transplant recipients this is due to immunosuppressive drugs. We investigated the prevalence of thyroid disorders, including thyroid cancer, by fine-needle aspiration biopsy in kidney transplant candidates and recipients and estimated the outcomes. MATERIALS AND METHODS: For 305 thyroid fine-needle aspiration biopsies performed from January 2000 to December 2020 in patients with end-stage renal disease, we recorded patient demographics, thyroid ultrasonography, and biopsy findings...
September 2023: Experimental and Clinical Transplantation
https://read.qxmd.com/read/37853680/thyroglobulin-as-a-rapid-and-cost-effective-biomarker-for-diagnosis-of-thyroid-carcinoma-brain-metastasis-a-case-report-of-a-patient-with-metastatic-hurthle-cell-thyroid-carcinoma
#5
JOURNAL ARTICLE
Konstantinos Ntotsikas, Sofia Lazarioti, Vasiliki Daraki, Elias Drakos, Panagiotis-Nikolaos Tsakalomatis, Eleni-Konstantina Syntzanaki, Nikolaos Moustakis, Anastasios I Marinis, Aris Salapatas-Gkinis, Paraskevi Xekouki, Antonis Vakis, Christos Tsitsipanis
BACKGROUND Brain metastasis of papillary thyroid cancer (PTC) is rare. Treatment of these patients is challenging due to the lack of specific guidelines. Early diagnosis is accompanied by immediate treatment and less morbidity. Total resection of brain lesions may be unattainable when they include infiltration of eloquent areas. This report is of an 81-year-old man who had undergone total thyroidectomy for goiter in the past and presented with metastatic papillary thyroid carcinoma (PTC) to the neck after a gap of 16 years...
October 19, 2023: American Journal of Case Reports
https://read.qxmd.com/read/37058803/coexistence-of-oncocytic-h%C3%A3-rthle-cell-carcinoma-with-foci-of-anaplastic-carcinoma-and-a-metastasizing-papillary-carcinoma-in-one-thyroid-gland-rare-case-report
#6
Sara A Assiri, Dhuha A Alhumaidi, Amjad A Althagafi, Sarah A Alkashgry, Hamdan S Alaamri, Arif Khurshid
INTRODUCTION AND IMPORTANCE: Anaplastic thyroid cancer is considered one of the most fatal aggressive malignancies with a survival duration estimated in months. When compared to anaplastic thyroid cancer, a well-differentiated thyroid tumor has a better prognosis and a longer survival duration even if it metastasized. Left untreated, the transformation of well-differentiated thyroid carcinoma to aggressive anaplastic malignancy has been considered one of the most devastating complications...
May 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/36884299/large-4%C3%A2-cm-intrathyroidal-encapsulated-well-differentiated-follicular-cell-derived-carcinoma-without-vascular-invasion-may-have-negligible-risk-of-recurrence-even-when-treated-with-lobectomy-alone
#7
JOURNAL ARTICLE
Ronald Ghossein, Ian Ganly, R Michael Tuttle, Bin Xu
Background: Thyroid carcinoma >4 cm in size is staged as T3a. The current American Thyroid Association guidelines recommend subtotal/total thyroidectomy and consideration for postoperative radioactive iodine (RAI) treatment for these tumors. In this retrospective cohort study, we aimed to explore the clinical course of large encapsulated thyroid carcinoma without other risk factors. Methods: Eighty-eight patients with large (>4 cm) encapsulated well-differentiated thyroid carcinoma resected between 1995 and 2021 were included in this retrospective cohort study...
May 2023: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/36459776/psammomatous-calcifications-in-thyroid-oncocytic-h%C3%A3-rthle-cell-follicular-tumors
#8
JOURNAL ARTICLE
Natali Ronen, David Suster
Concentric calcifications, also known as psammoma bodies, are a relatively frequent finding in certain types of tumors, particularly papillary thyroid carcinoma (PTC). In the thyroid, they have been assigned a significant role in the diagnosis of PTC and in distinguishing between these tumors and other types of thyroid neoplasms. Concentric calcifications have also less commonly been noted in other processes in the thyroid, such as in tumors characterized by cells containing abundant oxyphilic cytoplasm (i...
February 2023: Annals of Diagnostic Pathology
https://read.qxmd.com/read/36452789/circumferential-laryngotracheal-resection-in-thyroid-cancer-experience-and-outcome-in-a-single-center
#9
JOURNAL ARTICLE
Vikram Sharanappa, Raouef Ahmed Bichoo, Anjali Mishra, Prasanta Kumar Pradhan, Saroj Kanta Mishra
There is limited experience of laryngotracheal resection in patients with differentiated thyroid carcinoma (DTC). The aim of this study was to report our experience of circumferential laryngotracheal resection in DTC and its long-term outcome. In this retrospective study, 10 patients of locally invasive DTC who underwent circumferential laryngotracheal resection between January 2000 and December 2015 were included. Clinicopathologic profile and follow up was noted. Mean age of the cohort was 50.1 ± 7...
October 2022: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/36414338/synchronous-mucoepidermoid-carcinoma-and-papillary-microcarcinomas-of-the-thyroid-gland
#10
JOURNAL ARTICLE
Keshav Kumar Gupta, George Garas, Jonathan Wilkes, Mriganka De
Thyroid mucoepidermoid carcinoma (MEC) is a rare thyroid malignancy first documented in 1977. The majority of thyroid MECs are indolent, low-grade tumours with excellent prognosis. A woman in her 60s presented with an ongoing sensation of a lump in the left neck. There were no swallowing, voice or airway concerns. Ultrasound of the neck showed an enlarged thyroid with U5 and U3 features on the right and left lobes, respectively. Right fine needle aspiration cytology (FNAC) demonstrated certain features of Hurthle cell or anaplastic carcinoma (Thy5)...
November 22, 2022: BMJ Case Reports
https://read.qxmd.com/read/36248037/factors-determining-risk-categories-in-differentiated-thyroid-carcinoma-study-of-an-indian-cohort
#11
JOURNAL ARTICLE
Shiga Rappai Chirayath, Usha V Menon, Vasantha Nair, Harish Kumar, V P Praveen, Nisha Bhavani, Nithya Abraham
Introduction: Differentiated thyroid carcinoma/cancer (DTC) burden in developing countries could be different from that of the developed nations. Aims and Objectives: To describe the clinicopathological characteristics in a cohort of DTC patients in a south Indian state of Kerala and to compare with the data from other centres. Materials and Methods: A retrospective analysis of the data collected on DTC patients, from January 2010 to August 2018, attending thyroid cancer clinic at a tertiary care centre...
May 2022: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/36193717/update-from-the-2022-world-health-organization-classification-of-thyroid-tumors-a-standardized-diagnostic-approach
#12
REVIEW
Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms "follicular nodular disease" and "differentiated high-grade thyroid carcinoma" are introduced to account for multifocal hyperplastic/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively...
October 2022: Endocrinology and Metabolism
https://read.qxmd.com/read/36084253/thyroid-oncocytic-h%C3%A3-rthle-cell-nodules-with-longitudinal-nuclear-grooves-clinicopathologic-immunohistochemical-and-molecular-genetic-study-of-15-cases
#13
JOURNAL ARTICLE
David Suster, Alexander Craig Mackinnon, Saul Suster
CONTEXT.—: Thyroid nodules with longitudinal nuclear grooves have been widely regarded as synonymous with papillary thyroid carcinoma (PTC). OBJECTIVE.—: To study a series of cases of thyroid nodules that exhibited oncocytic (Hürthle cell) features and contained longitudinal nuclear grooves yet failed to display aggressive behavior or the full features of papillary thyroid carcinoma. DESIGN.—: The clinicopathologic, immunohistochemical, and molecular genetic features of 15 patients with these features were studied...
June 1, 2023: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/35948029/thyroid-carcinoma-version-2-2022-nccn-clinical-practice-guidelines-in-oncology
#14
JOURNAL ARTICLE
Robert I Haddad, Lindsay Bischoff, Douglas Ball, Victor Bernet, Erik Blomain, Naifa Lamki Busaidy, Michael Campbell, Paxton Dickson, Quan-Yang Duh, Hormoz Ehya, Whitney S Goldner, Theresa Guo, Megan Haymart, Shelby Holt, Jason P Hunt, Andrei Iagaru, Fouad Kandeel, Dominick M Lamonica, Susan Mandel, Stephanie Markovina, Bryan McIver, Christopher D Raeburn, Rod Rezaee, John A Ridge, Mara Y Roth, Randall P Scheri, Jatin P Shah, Jennifer A Sipos, Rebecca Sippel, Cord Sturgeon, Thomas N Wang, Lori J Wirth, Richard J Wong, Michael Yeh, Carly J Cassara, Susan Darlow
Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment of choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine ablation (iodine-131) in select patients and thyroxine therapy in most patients. Surgery is also the main treatment for medullary thyroid carcinoma, and kinase inhibitors may be appropriate for select patients with recurrent or persistent disease that is not resectable. Anaplastic thyroid carcinoma is almost uniformly lethal, and iodine-131 imaging and radioactive iodine cannot be used...
August 2022: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/35900492/correlation-of-fine-needle-aspiration-cytology-and-cell-block-study-of-category-iii-iv-and-v-tbsrtc-2017-thyroid-lesions-with-special-reference-to-cytokeratin-19-immunohistochemical-staining
#15
JOURNAL ARTICLE
Gourab Mukherjee, Sumana Biswas, Biswajit Haldar, Tanmoy Dutta
Context: Ascertaining the role of cytokeratin-19 (CK19) and its staining pattern helps to differentiate papillary carcinoma from other thyroid lesions. Aims: To correlate fine needle aspiration cytology (FNAC) and cell block study of equivocal cases (Category III, IV, and V) with the role of CK19 staining in it. Settings and Design: A hospital-based cross-sectional observational study was designed and conducted at North Bengal Medical College and Hospital, Shusrutnagar, Darjeeling...
July 2022: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/35775861/probability-of-malignancy-as-determined-by-thyroseq-v3-genomic-classifier-varies-according-to-the-subtype-of-atypia
#16
JOURNAL ARTICLE
David C Gajzer, Youley Tjendra, Darcy A Kerr, Khaled Algashaamy, Yiqin Zuo, Silvia Gra Menendez, Merce Jorda, Monica Garcia-Buitrago, Carmen Gomez-Fernandez, Jaylou M Velez Torres
BACKGROUND: ThyroSeq assesses the probability of malignancy (POM) in thyroid fine-needle aspiration cytology specimens diagnosed as atypia of undetermined significance (AUS). The authors investigated whether defined AUS subcategories are associated with specific molecular alterations, the molecular-derived risk of malignancy (MDROM), and the risk of malignancy (ROM). METHODS: Fine-needle aspiration cytology reports of AUS and corresponding results from the ThyroSeq version 3 genomic classifier results were retrieved and subcategorized as follicular cells with either cytologic atypia (FC-C), architectural atypia (FC-A), both cytologic and architectural atypia (FC-CA), or a predominance of Hurthle cells (PHC)...
July 1, 2022: Cancer Cytopathology
https://read.qxmd.com/read/35657579/the-role-of-surgery-in-small-differentiated-thyroid-cancer
#17
JOURNAL ARTICLE
Firas Baidoun, Omar Abdel-Rahman
INTRODUCTION: The incidence of small, differentiated thyroid cancer (DTC) cases has been increasing in the United States and the world mainly due to incidental detection because of widespread use of diagnostic modalities. While the option of active surveillance instead of surgical resection is getting more popular, there is still an open discussion about the best approach in these cases. MATERIALS AND METHODS: The National Cancer Database was queried for patients diagnosed with non-metastatic small T1/N0 DTC between 2004 and 2016, who have known surgical status and Charlson comorbidity index of two or less...
September 2022: Endocrine
https://read.qxmd.com/read/35647132/middle-thyroid-vein-tumor-thrombus-in-metastatic-papillary-thyroid-microcarcinoma-a-case-report-and-review-of-literature
#18
Yan Gui, Jun-Yi Wang, Xu-Dong Wei
BACKGROUND: Although papillary thyroid microcarcinoma (PTMC) is not considered a threatening tumor, in some cases, it can be aggressive. Metastatic thrombosis of papillary thyroid carcinoma, follicular thyroid carcinoma, Hürthle cell carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma have been reported in the literature, but there have been no reports about PTMC. CASE SUMMARY: A 45-year-old woman presented with a thyroid mass and thrombosis in a middle thyroid vein during a physical examination...
April 6, 2022: World Journal of Clinical Cases
https://read.qxmd.com/read/35355197/trop2-a-potential-marker-in-diagnosis-of-thyroid-neoplasms
#19
JOURNAL ARTICLE
Zübeyir Turan, Suna Erkılıç
BACKGROUND AND OBJECTIVES: The human trophoblast cell surface antigen (TROP-2), a transmembrane glycoprotein, has recently been investigated as a valuable marker of thyroid epithelial neoplasms. In this study, we aimed to demonstrate the diagnostic utility of TROP2 in thyroid neoplasms. METHODS: A total of 308 cases, including 170 cases of different PTC variants, 50 cases of benign and non-neoplastic lesions, and 86 cases of other neoplasms (NIFT-P, poorly differentiated thyroid carcinoma, anaplastic thyroid carcinoma, follicular thyroid carcinoma, Hürthle cell carcinoma, and medullary thyroid carcinoma), were included in this study...
March 30, 2022: Irish Journal of Medical Science
https://read.qxmd.com/read/35343605/clinicopathological-indicators-for-tert-promoter-mutation-in-papillary-thyroid-carcinoma
#20
JOURNAL ARTICLE
Hee Young Na, Hyeong Won Yu, Woochul Kim, Jae Hoon Moon, Chang Ho Ahn, Sang Il Choi, Yeo Koon Kim, June Young Choi, So Yeon Park
OBJECTIVE: Mutations in the telomerase reverse transcriptase (TERT) promoter have been reported as a convincing prognostic factor in papillary thyroid carcinomas (PTCs). We aimed to investigate the frequency of TERT promoter mutations in patients with thyroid cancer and identify the clinicopathological factors associated with them in PTCs. DESIGN: A total of 1086 consecutive cases of thyroid cancer composed of mostly PTCs were included in this study. TERT promoter and BRAF mutations were detected by pyrosequencing and their associations with clinicopathological features of tumour were analyzed...
July 2022: Clinical Endocrinology
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