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D J Buurman, T Blokzijl, E A M Festen, B T Pham, K N Faber, E Brouwer, G Dijkstra
INTRODUCTION: TNF-α-neutralizing antibodies, such as infliximab (IFX) and adalimumab (ADA), are effective in the treatment of inflammatory bowel diseases (IBD), but they are expensive and become ineffective when patients develop anti-IFX or anti-ADA antibodies (ATI and ATA, respectively). Second-generation anti-TNF-α antibodies, such as Golimumab, Etanercept, Certolizumab-pegol and IFX biosimilars, may solve these issues. AIM: To determine the neutralizing capacity of first- and second generation anti-TNF-α antibodies and to determine whether ATI show cross-reactivity with the IFX biosimilar CT-P13 (Inflectra)...
2018: PloS One
Sung-Wook Park, Tae Jun Kim, June Young Lee, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Mi Yang, Seonwoo Kim, Myung-Hee Shin, Young-Ho Kim
BACKGROUND: Although a higher risk of other immune-mediated diseases has been reported in inflammatory bowel disease (IBD) patients, the risk factors of immune-mediated diseases development and the effect of concomitant immune-mediated diseases on outcomes remain poorly defined. AIM: To determine the risk factors of incident immune-mediated diseases and the impact of comorbid immune-mediated diseases on outcomes in IBD. METHODS: Using the National Health Insurance claims data for the entire Korean population, we identified 35 581 IBD patients without immune-mediated diseases and 595 IBD patients with immune-mediated diseases from 2012 to 2013, and follow-up until 2016...
December 2, 2018: Alimentary Pharmacology & Therapeutics
Bharati Kochar, Hans H Herfarth
Background: Patients with moderate-severe inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are commonly treated with long-term immunosuppressive therapies involving immunomodulators such as thiopurines, biologics (anti-TNF and anti-adhesion molecules), or novel small molecules such as Janus kinase inhibitors. Summary: Some infections seen with immunosuppressive therapy in IBD are preventable with vaccines. IBD-specific immunosuppressive therapy is generally initiated by gastroenterologists...
November 2018: Inflammatory Intestinal Diseases
Anne Grosen, Mona Bungum, Lisbet Ambrosius Christensen, Eugenia Cordelli, Ole Halfdan Larsen, Giorgio Leter, Mette Julsgaard, Thea Vestergaard, Paola Villani, Christian Lodberg Hvas, Jens Kelsen
Background & Aims: The impact of severe inflammation on semen quality, including sperm DNA integrity, in men with inflammatory bowel disease (IBD) is unknown, as are the potential effects of anti-tumour necrosis factor-alpha (TNF-alpha) therapy. We investigated the influence of severe active IBD and anti-TNF-alpha treatment on semen quality. Methods: We prospectively included 20 patients admitted with severe active IBD. Further, 19 patients who initiated and 17 who stopped anti-TNF-alpha therapy were included...
November 30, 2018: Journal of Crohn's & Colitis
Mohita Sharma, Ramanpreet Kaur, Kuldeep Kaushik, Naveen Kaushal
Ulcerative colitis (UC), a form of inflammatory bowel disease (IBD), is an immune-modulated disorder characterized by chronic and recurring inflammatory episodes. Oxidative stress and COX pathway of prostaglandin (PG) biosynthesis is indispensable to pathogenesis of UC. Any imbalance between PGs can compromise the mucosal homeostasis, leading to mucosal damage and chronic inflammation. However, blocking these PGs using classical Cox inhibitors such as Non-steroidal anti-inflammatory drugs (NSAIDs) can instead aggravate signs of IBD...
November 29, 2018: Toxicology Mechanisms and Methods
Elen Farinelli de Campos Silva, Júlio Pinheiro Baima, Jaqueline Ribeiro de Barros, Fernanda Lofiego Renosto, Carina de Fatima de Sibia, Rogério Saad-Hossne, Ligia Yukie Sassaki
Inflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn's disease patients who received anti-TNF therapy during pregnancy and present a literature review. We reported 4 cases composed of young women who became pregnant while receiving anti-TNF agents. The patients presented a satisfactory response to the clinical treatment and the pregnancies progressed without complications...
September 2018: Case Reports in Gastroenterology
Paolo Biancheri, Alastair J M Watson
No abstract text is available yet for this article.
November 22, 2018: Gastroenterology
Mengya Zhang, Yan Zhao, Na Wu, Yao Yao, Mingsheng Xu, Huaying Du, Yonggang Tu
Peptides DEDTQAMPFR (DR-10), MLGATSL (ML-7), SLSFASR (SR-7), and MSYSAGF (MF-7) derived from simulated gastrointestinal digestion of preserved egg white (SGD-PEW) exerted anti-inflammatory effects on Caco-2 cells. Here, we aimed to evaluate the anti-inflammatory effects of these peptides derived from SGD-PEW in a mouse model of dextran sodium sulfate (DSS)-induced colitis. The results showed that DR-10, ML-7, SR-7 and MF-7 significantly ameliorated the clinical symptoms of DSS-induced mice colitis, such as weight loss, disease activity index (DAI), colon shortening, spleen hypertrophy and histological scores...
November 21, 2018: Food & Function
Laura E Targownik, Eric I Benchimol, Charles N Bernstein, Harminder Singh, MSc Lisa Lix, Aruni Tennakoon, Stella Leung, Antonio Aviña, Stephanie Coward, Jennifer Jones, Gil Kaplan, Sanjay K Murthy, Geoffrey C Nguyen, Juan Nicolás Peña-Sánchez
BACKGROUND & AIMS: Although guidelines recommend inclusion of immune modulators in anti-tumor necrosis factor (TNF) initiation therapy for Crohn's disease (CD) or ulcerative colitis (UC), there are limited data on the incremental effectiveness of this treatment strategy from the real world. METHODS: We collected data from the Manitoba Inflammatory Bowel Disease (IBD) Epidemiology database on persons with CD (n=852) or UC (n=303), from 2001 through 2016, who began treatment with a TNF antagonist...
November 15, 2018: Clinical Gastroenterology and Hepatology
Kenechukwu O Chudy-Onwugaje, Kaci E Christian, Francis A Farraye, Raymond K Cross
Over the last 2 decades, novel therapies targeting several immune pathways have been developed for the treatment of patients with inflammatory bowel disease (IBD). Although anti-tumor necrosis factor (anti-TNF) agents remain the firstline treatment for moderate to severe Crohn's disease and ulcerative colitis, many patients will require alternative agents, due to nonresponse, loss of response, or intolerance of anti-TNFs. Furthermore, patients may request newer therapies due to improved safety profiles or improved administration (ie, less frequent injection, oral therapy)...
November 15, 2018: Inflammatory Bowel Diseases
Abhijeet Yadav, Pamela Vasquez, Natasha H Dolgin, Kenneth R Falchuk, Joseph D Feuerstein
BACKGROUND: The American Gastroenterological Association (AGA) published guidelines on therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD) in August 2017 recommending use of reactive TDM to guide treatment changes in patients with active IBD who are being treated with anti-tumor necrosis factor (anti-TNF) agents or thiopurines. We sought to determine if changes in national clinical practice guidelines result in changes in health care insurance policies within 6 months of publication...
November 14, 2018: Journal of Clinical Gastroenterology
María Chaparro, Manuel Barreiro-de Acosta, Ana Echarri, Rosendo Almendros, Jesús Barrio, Jordina Llao, Fernando Gomollón, Maribel Vera, José Luis Cabriada, Jordi Guardiola, Iván Guerra, Belén Beltrán, Oscar Roncero, David Busquets, Carlos Taxonera, Xavier Calvet, Rocío Ferreiro-Iglesias, Virginia Ollero Pena, David Bernardo, María G Donday, Ana Garre, Ana Godino, Ana Díaz, Javier P Gisbert
OBJECTIVES: (a) To evaluate the diagnostic accuracy of anti-TNF trough levels to predict mucosal healing in inflammatory bowel disease (IBD); (b) to determine the best cut-off point to predict mucosal healing in IBD patients treated with anti-TNF. METHODS: This is a multicenter, prospective study. IBD patients under anti-TNF treatment for at least 6 months that had to undergo an endoscopy were included. Mucosal healing was defined as: Simple endoscopic score for Crohn's Disease < 3 for Crohn's disease (CD), Rutgeerts score < i2 for CD in postoperative setting, or Mayo endoscopic score ≤ 1 for ulcerative colitis (UC)...
November 13, 2018: Digestive Diseases and Sciences
N A Soliman, W A Keshk, F H Rizk, M A Ibrahim
OBJECTIVE: Inflammatory bowel diseases (IBD) are chronic and recurrent disorders of the gastrointestinal tract with unknown etiology and have two major forms, ulcerative colitis (UC) and Crohn diseases. In view of the adverse effects and incomplete efficacy of currently administered drugs, it is essential to investigate new and harmless drugs with more desirable beneficial effects. Statins have many additional pleiotropic effects other than their lipid-lowering effect. This study aims to investigate the role of simvastatin (SIM) at different doses against induced UC in rats...
November 5, 2018: Chemico-biological Interactions
Abbi R Saniabadi, Tomotaka Tanaka, Takayuki Yamamoto, Wolfgang Kruis, Rodolfo Sacco
Ulcerative colitis (UC) and Crohn's disease (CD) are major phenotypes of the chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms. The chronic nature of IBD means that patients require life-long medications, and this may lead to drug dependency, loss of response together with adverse side effects as additional morbidity factors. The efficacy of antitumour necrosis factor (TNF)-α biologics has validated the role of inflammatory cytokines notably TNF-α in the exacerbation and perpetuation of IBD...
November 8, 2018: Journal of Clinical Apheresis
Alaa El-Hussuna, Niels Qvist, Marie Strøm Zangenberg, Anne Langkilde, Volkert Siersma, Sara Hjort, Ismail Gögenur
BACKGROUND: TNF-α plays a role in angiogenesis and collagen synthesis, both essential in the wound healing process. There are concerns that pre-operative anti-TNF-α treatment may influence the surgical stress response and increase the risk of surgical complications. The aim of this study was to describe the surgical stress response in patients with inflammatory bowel disease (IBD) and to investigate whether the pre-operative administration of anti-tumor necrosis factor alpha (anti-TNF-α) agents modify the surgical stress response...
November 3, 2018: BMC Surgery
Döndü Üsküdar Cansu, Hava Üsküdar Teke, Tuncer Temel, Adem Ertürk, Osman Kahraman, Cengiz Korkmaz
OBJECTIVE: The aim of this study was to determine whether there is any association with anti-tumor necrosis factor (TNF) agent administration and development of new-onset inflammatory bowel disease (IBD) in ankylosing spondylitis (AS) patients. METHODS: Records of the patients who met 1984 modified New York criteria for AS between 1998 and 2016 at Rheumatology Department were evaluated retrospectively and data about the patients, IBD properties and medication were obtained...
October 30, 2018: Journal of the National Medical Association
Vincenzo Villanacci, Moris Cadei, Francesco Lanzarotto, Chiara Ricci, Elisabetta Antonelli, Rosanna Cannatelli, Tiziana Gulotta, Lucia Fontana, Valentina Pasquali, Sandra Sigala, Tiziana Salviato, Riccardo Nascimbeni, Gabrio Bassotti
BACKGROUND: Although antitumor necrosis factor alfa (TNFα) agents are widely used to treat patients with inflammatory bowel diseases (IBD) - both Crohn's disease (CD) and ulcerative colitis (UC) - there is still some uncertainty in the cell type expressing TNFα in human ileo-colonic segments. AIMS: We investigated the immunohistochemical (IHC) expression of TNFα in the ileo-colonic segments of patients with both active CD and UC, to establish its anatomic and cellular localization in the inflamed sites...
October 27, 2018: Annals of Diagnostic Pathology
Vaclav Vetvicka, Ofer Gover, Hilla Hayby, Ofer Danay, Nirit Ezov, Yitzhak Hadar, Betty Schwartz
: Pleurotus eryngii is recognized for its prominent nutritional and medicinal value. In our study, we tested the effect of glucans on lipopolysaccharide (LPS)-induced production of TNF-α. We demonstrated that glucan extracts are more effective than mill mushroom preparations. Additionally, the effectiveness of stalk-derived glucans were slightly more pronounced than of caps. Cap and stalk glucans from mill or isolated glucan competed dose-dependently with anti-Dectin-and anti-CR-3 antibodies, indicating that they contain β-glucans recognized by these receptors...
October 28, 2018: International Journal of Molecular Sciences
Meng-Tzu Weng, Chien-Chih Tung, Yuan-Ting Chang, Yew-Loong Leong, Yu-Ting Wang, Jau-Min Wong, Shu-Chen Wei
BACKGROUND: No nationwide, long-term follow-up study has assessed medication-associated outcomes for Asian patients with inflammatory bowel disease (IBD). This study examined medication-associated outcomes for Taiwanese patients with IBD. METHODS: In this nationwide cohort study, 3806 patients who had received catastrophic illness registration for IBD from 2001 to 2015 were enrolled. RESULTS: A higher accumulated dosage of 5-aminosalicylic acid (5-ASA) was associated with decreased risks of hospitalization (hazard ratio (HR) = 0...
October 27, 2018: Journal of Clinical Medicine
Damita Cota, Sanjay Mishra, Sushant Shengule
ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia arjuna Roxb. (Combretaceae) is traditionally used in Ayurveda medicine and holds ethnomedicinal importance for treatment of gastrointestinal disorders. In view of its anti-inflammatory, antidiarrheal and antioxidant potential, it could be beneficial for the treatment of inflammatory bowel disease (IBD), which is associated with interaction between genetic, environmental factors and intestinal microbiome leading to dysregulated immune responses...
October 24, 2018: Journal of Ethnopharmacology
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