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Caroline Lang, Mandy Gottschall, Maik Sauer, Juliane Köberlein-Neu, Antje Bergmann, Karen Voigt
OBJECTIVES: The aim of the study was to identify interface problems between inpatient, GP and outpatient specialist care from the perspective of general practitioners in Dresden, especially in older multimorbid patients. METHODS: The data were collected in the context of the pilot study "Multimedication and its Consequences for the Primary Care of Patients in Saxony" and included guided interviews with 7 general practitioners. The interviews were transcribed and analyzed according to the inductive content analysis of Mayring...
August 16, 2018: Das Gesundheitswesen
Hisato Takagi, Shohei Mitta, Tomo Ando
OBJECTIVE:  The objective of this study was to determine whether valve-in-valve transcatheter aortic valve implantation (VIV-TAVI) is associated with better survival than redo surgical aortic valve replacement (SAVR) in patients with degenerated aortic valve bioprostheses, and we performed a meta-analysis of comparative studies. METHODS:  To identify all comparative studies of VIV-TAVI versus redo SAVR; MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched through October 2017...
August 16, 2018: Thoracic and Cardiovascular Surgeon
Ben Godde, Patrick Bruns, Volker Wendel, Mireille Trautmann
Tactile perception results from the interplay of peripheral and central mechanisms for detection and sensation of objects and the discrimination and evaluation of their size, shapes, and surface characteristics. For different tasks, we investigated this interaction between more bottom-up stimulus-driven and rather top-down attention-related and cognitive processes in tactile perception. Moreover, we were interested in effects of age and tactile experiences on this interaction. 299 right-handed women participated in our study and were divided into five age groups: 18-25 years (N = 77), 30-45 years (N = 76), 50-65 years (N = 62), 66-75 years (N = 63) and older than 75 years (N = 21)...
August 13, 2018: Acta Psychologica
Francesca Ferraro, Feng Gao, Keith Stockerl-Goldstein, Peter Westervelt, John F DiPersio, Armin Ghobadi
Secondary acute lymphoblastic leukemia (s-ALL) is rare and poorly defined and data regarding outcomes post-transplant are lacking. Here, we report a detailed analysis of s-ALL at our Institution. Among 211 eligible patients with ALL from 2006 to 2017, 30 (14%) were defined as s-ALL and the remaining as primary ALL (p-ALL). s-ALL patients were older and had higher incidence of adverse risk factors. Overall response (OR) after induction was not different between s-ALL and p-ALL (79% versus 90% respectively, p = 0...
July 31, 2018: Leukemia Research
Nise Ribeiro Marques, Deborah Hebling Spinoso, Bruna Carvalho Cardoso, Vinicius Christianini Moreno, Marina Hiromi Kuroda, Marcelo Tavella Navega
BACKGROUND: Gait kinematic parameters have been reported as an important clinical tool to assess the risk of falls in older adults. However, the ability of these parameters to predict falls in the older population is still unclear. OBJECTIVE: To identify the ability that gait kinematic parameters present to predict fall in older adults. METHODS: Data from 102 older adults, who live in a community setting, were considered for this study. For data collection, older subjects had to walk on a 14 meter-walkway in their preferred gait speed...
August 11, 2018: Clinical Biomechanics
K E Brown, J L Neva, S J Feldman, W R Staines, L A Boyd
Sensorimotor integration is the process through which somatosensory information is incorporated to inform motor output. Given its important behavioural implications, understanding the influence of healthy aging on the underlying neurophysiology of sensorimotor integration and whether it is modifiable through intervention is important. The aims of the current work were to: 1) profile aging-related differences in sensorimotor integration, and 2) to determine if sensorimotor integration in older adults can be modulated in response to sensory training...
August 13, 2018: Experimental Gerontology
Bénédicte Mj Merle, Johanna M Colijn, Audrey Cougnard-Grégoire, Alexandra P M de Koning-Backus, Marie-Noëlle Delyfer, Jessica C Kiefte-de Jong, Magda Meester-Smoor, Catherine Féart, Timo Verzijden, Cécilia Samieri, Oscar H Franco, Jean-François Korobelnik, Caroline C W Klaver, Cécile Delcourt
OBJECTIVE: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced AMD (the symptomatic form of AMD) in two European population-based prospective cohorts. DESIGN: Prospective cohorts: the Rotterdam Study I (RS-I) and the Alienor Study. PARTICIPANTS: 4 446 participants aged ≥55 years from RS-I (The Netherlands) and 550 French adults aged 73 years or older from Alienor Study with complete ophthalmologic and dietary data were included in the present study...
August 13, 2018: Ophthalmology
Anna Marseglia, Laura Fratiglioni, Grégoria Kalpouzos, Rui Wang, Lars Bäckman, Weili Xu
INTRODUCTION: The impact of prediabetes and diabetes on cognitive decline and the potential underlying mechanisms remain unclear. We investigated whether prediabetes and diabetes accelerate cognitive decline and brain aging, and the initial pathological changes linked to microvascular processes. METHODS: Nine-year longitudinal data from the Swedish National Study on Aging and Care-Kungsholmen (n = 2746, age ≥60 years) and the magnetic resonance imaging subsample (n = 455) were used...
August 13, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Amir A Sadighi Akha
The world is witnessing a rapid demographic shift towards an older population, a trend with major medical, social, economic and political implications. Aging is a multifaceted process, involving numerous molecular and cellular mechanisms in the context of different organ systems. A crucial component of aging is a set of functional and structural alterations in the immune system that can manifest as a decreased ability to fight infection, diminished response to vaccination, increased incidence of cancer, higher prevalence of autoimmunity and constitutive low-grade inflammation, among others...
August 13, 2018: Journal of Immunological Methods
Sasha C Druskin, Mufaddal Mamawala, Jeffrey J Tosoian, Jonathan I Epstein, Christian P Pavlovich, H Ballentine Carter, Bruce J Trock
PURPOSE: Age at prostate cancer (PCa) diagnosis has been positively associated with PCa-specific mortality, and for men on active surveillance (AS), a higher risk of biopsy grade reclassification (BGR) to Gleason score ≥3+4 (grade group [GG]≥2); however, the association between age and BGR to an aggressive phenotype (Gleason score ≥4+3 [GG≥3]) has not been explored. MATERIALS & METHODS: From 1995-2016, 1625 men aged 41-81y with NCCN very-low (68%) or low (32%) risk PCa were followed on AS...
August 13, 2018: Journal of Urology
Anupama Kotha, Beatrice A Chen, Lauren Lewis, Shannon Dunn, Katherine P Himes, Elizabeth Krans
BACKGROUND: Many women with opioid use disorder (OUD) do not use highly effective postpartum contraception such as long-acting reversible contraception (LARC). We evaluated factors associated with prenatal intent and postpartum receipt of LARC among women receiving medication-assisted treatment (MAT) for OUD. STUDY DESIGN: This was a retrospective cohort study of 791 pregnant women with OUD on MAT who delivered at an academic institution without immediate postpartum LARC services between 2009 and 2012...
August 13, 2018: Contraception
Katharina Limbach, Jürgen M Kaufmann, Holger Wiese, Otto W Witte, Stefan R Schweinberger
A common cognitive problem reported by older people is compromised face recognition, which is often paralleled by age-related changes in face-sensitive and memory-related components in event-related brain potentials (ERPs). We developed a new training using photorealistic caricatures based on evidence that caricatures are beneficial for people with compromised face processing. Twenty-four older participants (62-75yrs, 13 female) completed 12 training sessions (3 per week, 60min each) and 24 older participants (61-76yrs, 12 female) acted as controls...
August 13, 2018: Neuropsychologia
Annie C Spokes, Elizabeth S Spelke
Adults report more willingness to help siblings over close friends when the stakes are extremely high, such as when deciding whether to donate a kidney or risk injury to rescue someone in peril. When dividing plentiful, low-value resources, in contrast, children expect people to share equally with friends and siblings. Even when distributing limited resources-one instead of many-and distributing to their own social partners rather than fictional characters, children share more with kin and friends than with strangers but do not favor kin over friends until 5...
2018: PloS One
Ziyue Huang, Qingyue Liu, Hongdao Meng, Danping Liu, Debra Dobbs, Kathryn Hyer, Kyaien O Conner
OBJECTIVE: To describe Chinese older adults' willingness to enter long-term care facilities and to examine individual factors associated with the willingness of using this growing model of long-term care in China. METHODS: A cross-sectional study involving a random sample of 670 adults aged 60+ in the Hezuo community in Chengdu, China in 2016. Respondents were interviewed by trained staff on socio-demographics, health status, quality of life, social support, and willingness to enter long-term care facilities...
2018: PloS One
Rosa Maria Laterza, Ksenia Halpern, Daniela Ulrich, Alexandra Graf, Karl Tamussino, Wolfgang Umek
AIMS: Our aim was to evaluate, in a second data analysis of the prospective randomized controlled trial conducted by Austrian Urogynaecology Working Group, the effect of age, BMI and parity at the time of surgery on short- and long-term outcomes of women primarily treated for SUI (stress urinary incontinence) with midurethral slings. METHODS: In the original study 554 patients received randomly a retropubic (TVT) or a transobturator midurethral (TVT-O) sling procedure...
2018: PloS One
Catherine A Okoro, NaTasha D Hollis, Alissa C Cyrus, Shannon Griffin-Blake
Persons with disabilities face greater barriers to health care than do those without disabilities (1). To identify characteristics of noninstitutionalized adults with six specific disability types (hearing, vision, cognition, mobility, self-care, and independent living),* and to assess disability-specific disparities in health care access, CDC analyzed 2016 Behavioral Risk Factor Surveillance System (BRFSS) data. The prevalences of disability overall and by disability type, and access to health care by disability type, were estimated...
August 17, 2018: MMWR. Morbidity and Mortality Weekly Report
Benjamin L Brett, Scott L Zuckerman, Douglas P Terry, Gary S Solomon, Grant L Iverson
OBJECTIVE: Static balance, postural stability, and reaction time are commonly impaired after a sport-related concussion. The Sway Balance System assesses postural sway (ie, stability) and simple reaction time using the triaxial accelerometer built into iOS mobile devices. The purpose of this study was to provide normative data for children and adolescents and to examine for age and sex differences on the Sway Balance System. DESIGN: Cross-sectional study. SETTING: Middle and high schools across the United States...
August 15, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Carolina Puchi, Tatiana Paravic-Klijn, Alide Salazar
The comfort theory was applied in the development of a nursing process for the clinical case of an older adult with pneumonia treated under hospital at home. It was observed that the theory is easy to apply in the domiciliary context and that it allows the implementation of a holistic care plan.
September 2018: Holistic Nursing Practice
Alex H S Harris, Alfred C Kuo, Kevin J Bozic, Edmund Lau, Thomas Bowe, Shalini Gupta, Nicholas J Giori
BACKGROUND: The American Joint Replacement Registry (AJRR) Total Joint Risk Calculator uses demographic and clinical parameters to provide risk estimates for 90-day mortality and 2-year periprosthetic joint infection (PJI). The tool is intended to help surgeons counsel their Medicare-eligible patients about their risk of death and PJI after total joint arthroplasty (TJA). However, for a predictive risk model to be useful, it must be accurate when applied to new patients; this has yet to be established for this calculator...
September 2018: Clinical Orthopaedics and related Research
Vasiliki Panou, Meghana Gadiraju, Arthur Wolin, Caroline M Weipert, Emily Skarda, Aliya N Husain, Jyoti D Patel, Buerkley Rose, Shannon R Zhang, Madison Weatherly, Viswateja Nelakuditi, Amy Knight Johnson, Maria Helgeson, David Fischer, Arpita Desai, Nanna Sulai, Lauren Ritterhouse, Oluf D Røe, Kiran K Turaga, Dezheng Huo, Jeremy Segal, Sabah Kadri, Zejuan Li, Hedy L Kindler, Jane E Churpek
Purpose The aim of the current study was to determine the prevalence and clinical predictors of germline cancer susceptibility mutations in patients with malignant mesothelioma (MM). Methods We performed targeted capture and next-generation sequencing of 85 cancer susceptibility genes on germline DNA from 198 patients with pleural, peritoneal, and tunica vaginalis MM. Results Twenty-four germline mutations were identified in 13 genes in 23 (12%) of 198 patients. BAP1 mutations were the most common (n = 6; 25%)...
August 16, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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