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I E Hof, J F van der Heijden, E G Kranias, D Sanoudou, R A de Boer, J P van Tintelen, P A van der Zwaag, P A Doevendans
Pathogenic mutations in the phospholamban (PLN) gene may give rise to inherited cardiomyopathies due to its role in calcium homeostasis. Several PLN mutations have been identified, with the R14del mutation being the most prevalent cardiomyopathy-related mutation in the Netherlands. It is present in patients diagnosed with arrhythmogenic cardiomyopathy as well as dilated cardiomyopathy. Awareness of the phenotype of this PLN mutation is of great importance, since many carriers remain to be identified. Patients with the R14del mutation are characterised by older age at onset, low-voltage electrocardiograms and a high frequency of ventricular arrhythmias...
December 13, 2018: Netherlands Heart Journal
Anthony Jehn, Anna Zajacova
OBJECTIVES: Disability is a major concern for the health of midlife and older Canadians. Understanding disability trends is critical for detecting socio-economic and health precursors that could be amenable to policy interventions. The purpose of this study is to assess trends in rates of disability among Canadian adults age 40-64 and 65+. We also examine the impact of changing socio-demographic and health factors over time on the trends. METHODS: Data from the 2001-2014 Canadian Community Health Survey (CCHS), a repeated cross-sectional nationally representative study, are used to estimate age- and gender-stratified logistic regression models of disability as a function of the year of interview to assess trends...
December 13, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
Azza Hamed, Sebastian Bohm, Falk Mersmann, Adamantios Arampatzis
BACKGROUND: The risk of falling and associated injuries increases with age. Therefore, the prevention of falls is a key priority in geriatrics and is particularly based on physical exercising, aiming to improve the age-related decline in motor performance, which is crucial in response to postural threats. Although the benefits and specifications of effective exercise programs have been well documented in pre-post design studies, that is during the treatment, the definitive retention and transfer of these fall-related exercise benefits to the daily life fall risk during follow-up periods remains largely unclear...
December 13, 2018: Sports Medicine—Open
Michele L Callisaya, Richard Beare, Chris Moran, Thanh Phan, Wei Wang, Velandai K Srikanth
AIMS/HYPOTHESIS: The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline. METHODS: Participants without dementia aged 55-90 years from the Cognition and Diabetes in Older Tasmanians (CDOT) study underwent brain MRI (ventricular and total brain volume) and neuropsychological measures (global function and seven cognitive domains) at three time points over 4...
December 13, 2018: Diabetologia
Benjamin W Iles, Julie B Samora, Satbir Singh, Lynne Ruess
BACKGROUND: Treatment pathways for isolated distal radius fractures in children are becoming more tailored to specific fracture types and include different management plans for stable buckle fractures versus potentially unstable distal radius fractures. OBJECTIVE: To propose a measurement rule to aid in differentiating stable buckle fractures from other distal radius fractures in children. MATERIALS AND METHODS: A medical record search identified 203 children with closed distal radius fractures during a 14-month period...
December 13, 2018: Pediatric Radiology
Hira S Mian, Tanya M Wildes, Mark A Fiala
Purpose: To develop a frailty index using the Rockwood Accumulation of Deficits approach for the Medicare Health Outcomes Survey (MHOS) and apply it in a subset of older patients with newly diagnosed multiple myeloma. Methods: Data from 2,692,361 patients without cancer, > 66 years of age, in SEER-MHOS linked databases between 1998 and 2009 were analyzed. A frailty index was constructed, resulting in a 25-item scale; cutoff values were created for individuals classified as frail...
2018: JCO Clinical Cancer Informatics
Alison C Burggren, Prabha Siddarth, Zanjbeel Mahmood, Edythe D London, Theresa M Harrison, David A Merrill, Gary W Small, Susan Y Bookheimer
Background and Aims: Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise to increasing usage rates across the country. Of particular concern are indications that frequent CB use may be selectively harmful to the developing adolescent brain compared with adult-onset usage. However, the long-term effects of heavy, adolescent CB use on brain structure and cognitive performance in late-life remain unknown. A critical brain region is the hippocampus (HC), where there is a striking intersection between high concentrations of cannabinoid 1 (CB1) receptors and age-related pathology...
2018: Cannabis and Cannabinoid Research
Keeley J Pratt, Joseph A Skelton, Ihuoma Eneli, David N Coliler, Suzanne Lazorick
Family-based interventions are the current standard for the treatment of pediatric obesity, yet the details of how providers are involving family members, and the barriers to family involvement, are largely unknown. The objective of this study is to describe how providers in pediatric weight management (PWM) involve family members, identify barriers to family involvement, and how they address challenging family dynamics. A cross-sectional survey was administered to PWM centers/clinics and their providers in the United States and Canada...
2018: Global Pediatric Health
Noriko Yamamoto-Mitani, Yumiko Saito, Manami Takaoka, Yukari Takai, Ayumi Igarashi
Despite the growing importance of long-term care for older adults, there has been limited attention to its quality assurance issues in Japan. To start planning the initiation of continuous quality improvement in long-term care hospitals, we explored how nurses and care workers themselves perceived current approaches to quality assurance and improvement on their ward. We interviewed 16 licensed nurses and nine care workers, transcribed and analyzed data using qualitative content analysis techniques, and derived six categories: keeping clients alive is barely possible, the absence of a long-term care practice model, the lack of quality indicators, long-term care hospitals as places for castaways, client quality of life as a source of satisfaction , and conflict between staff and client well-being ...
January 2018: Global Qualitative Nursing Research
Theresa E Gildner, Nawi Ng, Fan Wu, Yanfei Guo, J Josh Snodgrass, Paul Kowal
Evidence suggests that cognitive decline in older adults is influenced by cardiovascular health (CVH), with metabolic and vascular mechanisms hypothesized to underlie the etiology of cognitive impairment. Research in high-income nations suggests that improved CVH is linked with decreased cognitive impairment risk, but it is unclear if this pattern is evident in low-income countries. Nationally-representative data collected in China were drawn from the World Health Organization's Study on global AGing and adult health Wave 1 (2007-2010; n = 11,295)...
2018: Frontiers in Public Health
Aunaly Palmer, Lisa A Taitsman, May J Reed, Bala G Nair, Itay Bentov
Hip fractures result in significant morbidity and mortality in elders. Indicators of frailty are associated with poor outcomes. Commonly used frailty tools rely on motor skills that cannot be performed by this population. We determined the association between the Charlson Comorbidity Score (CCS), intraoperative hypotension (IOH), and a geriatric medicine consult index (GCI) with short-term mortality in hip fracture patients. A retrospective cohort study was conducted at a single institution over a 2-year period...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
Massimo Ralli, Massimo Fusconi, Irene Claudia Visconti, Salvatore Martellucci, Marco de Vincentiis, Antonio Greco
'Juvenile' nasopharyngeal angiofibroma, which accounts for <1% of all head and neck neoplasms, occurs predominantly in males between 10 and 18 years of age. The small number of patients older than 30 years confirms that presentation after this age is exceptional. Only rare cases of nasopharyngeal angiofibroma in female patients have been documented to date, and some authors believe that sex chromosome studies are indicated in such cases. The pathogenesis of nasopharyngeal angiofibroma remains unknown, but it has been hypothesized that it is a testosterone-dependent tumor...
December 2018: Molecular and Clinical Oncology
Yoshinori Yanai, Takeo Kosaka, Hiroshi Hongo, Kazuhiro Matsumoto, Toshiaki Shinojima, Eiji Kikuchi, Akira Miyajima, Ryuichi Mizuno, Shuji Mikami, Masahiro Jinzaki, Mototsugu Oya
There is an increasing proportion of individuals aged 70 years and older, as well as an increasing life expectancy worldwide. The present study may guide the management of older patients with elevated prostate specific antigen (PSA). The medical records of 241 older men aged >70 years who underwent multiparametric magnetic resonance imaging (mpMRI) before prostate biopsy (PBx) at our institution were reviewed retrospectively. Multiple variables were evaluated as predictors for the diagnosis of prostate cancer (PCa)...
December 2018: Molecular and Clinical Oncology
Chirn-Bin Chang, Hsiu-Yun Lai, Shinn-Jang Hwang, Shu-Yu Yang, Ru-Shu Wu, Hsing-Cheng Liu, Ding-Cheng Chan
Background: PIM-Taiwan criteria were first established in 2010 for potentially inappropriate medications (PIMs). Currently, updating of PIM criteria is mandatory because of newly established evidence and newly developed medications. This study aims to evaluate the prevalence of PIM based on country-specific PIM criteria and factors associated with PIM use by applying 2010 version and newly updating PIM-Taiwan criteria in a cohort with polypharmacy. Methods: The baseline data of Medication Safety Review Clinic Taiwan (MSRC-Taiwan) study were used to investigate the prevalence of PIMs...
December 2018: Therapeutic Advances in Drug Safety
Minoo Sharbafshaaer
Traumatic brain injury (TBI) is one of main causes of death and disability among many young and old populations in different countries. Objective: The aim of this study were to consider and predict the cognitive impairments according to different levels and causes of TBI, and education status. Methods: The study was performed using the Mini-Mental State Examination (MMSE) to estimate cognitive impairment in patients at a trauma center in Zahedan city. Individuals were considered eligible if 18 years of age or older...
October 2018: Dementia & Neuropsychologia
Evelise Saia Rodolpho Duarte, Liciane Vaz de Arruda Silveira, Vanessa de Albuquerque Cítero, Alessandro Ferrari Jacinto
Objective: Population aging is a global phenomenon associated with a rising prevalence of chronic degenerative diseases such as dementia. Dementia poses a challenge not only for patients but also their family caregivers who, in exercising this role, are at higher risk of mental illness. The present study investigated the prevalence of common mental disorders (CMD) in family caregivers of demented elderly seen at a geriatric outpatient clinic of a Brazilian teaching hospital. Methods: A cross-sectional study was conducted in which the following assessment instruments were applied: the Self Reporting Questionnaire, Zarit Burden Interview, Hospital Anxiety and Depression Scale and Mini-Mental State Examination (caregivers aged ≥65 years) plus a sociodemographic questionnaire...
October 2018: Dementia & Neuropsychologia
Rafael Coelho, Paulo Mattos, Rosemary Tannock
Attention-Deficit Hyperactivity Disorder (ADHD) encompasses other symptoms besides inattention, hyperactivity, and impulsivity, such as language problems. ADHD can have a non-remitting course and is also found in older individuals, although there are no studies on language problems in elderly individuals with the disorder. Objective: To investigate the presence of language impairment in older adults with ADHD. Methods: Language impairment was investigated in three older ADHD adults, and compared with two matched control subjects using a narrative discourse task...
October 2018: Dementia & Neuropsychologia
Andressa Hermes Pereira, Ana Bresolin Gonçalves, Maila Holz, Hosana Alves Gonçalves, Renata Kochhann, Yves Joanette, Nicolle Zimmermann, Rochele Paz Fonseca
Verbal fluency (VF) is a widely used tool in neuropsychological assessment. Objective: We aimed to investigate the influence of age and educational level on clustering and switching in three VF modalities: phonemic (PVF), semantic (SVF) and unconstrained (UVF). We evaluated type of cluster, mean cluster size, and quantity of clusters, intersections, and returns. A total of 260 healthy subjects were assessed. Methods: Participants were divided into three age groups: young adults (18 to 39 years), middle-aged adults (40 to 59 years) and older adults (60 to 80 years) and into two groups of educational level: 1-8 years (low), 9 years or more (high)...
October 2018: Dementia & Neuropsychologia
Yasuyuki Shimada, Hiroyoshi Sekii, Takeshi Enmoto, Yasushi Terada
Background: Older pacemaker systems, which are magnetic resonance imaging (MRI) incompatible, require replacement with compatible systems when patients are in need of MRI. Replacement involves extraction of the pacing lead, which is usually done with a laser sheath under general anesthesia. Case presentation: We report two cases of complete pacing system replacements allowing patient access to MRI. Both replacements were made under local anesthesia and without the use of special devices over 6 years after the initial surgery...
November 2018: Journal of Rural Medicine: JRM
Dasavanh Manivong, Mosiur Rahman, Keiko Nakamura, Kaoruko Seino
Objective: Evidence from developing countries on the association between women's endorsement of attitudes justifying partner abuse and their use of reproductive health services is suggestive but inconclusive. This study uses a nationally representative dataset from Lao PDR to provide strong evidence for the relationship between women's endorsement of attitudes justifying partner abuse and use of reproductive health services. Methods: This study used data from the 2011-2012 Lao Social Indicator survey (LSIS)...
November 2018: Journal of Rural Medicine: JRM
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