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submandibular gland

Ling-Hang Qu, Ji-Yuan Tu, Guo-Sheng Cao, Jia-Wen Zhao, Xu-Ling Pan, Yan-Ju Liu
In order to establish a more perfect evaluation system for dryness effect of Atractylodis Rhizoma, determine the main dry parts of Atractylodis Rhizoma,and further define the mechanism of stir-baked Atractylodis Rhizoma in reducing the dryness. The healthy rats were given with different doses of water extract and volatile oil of raw Atractylodis Rhizoma and stir-baked Atractylodis Rhizoma for 21 days. Based on the theory of the dry-dry and dryness-induced Yin deficiency, the amount of drinking water, tissue morphology of submandibular glands, urine volume and the expression of aquaporin 2 (AQP2) in the kidneys, as well as blood rheology, ratio of cAMP/cGMP in serum and the content of Na⁺-K⁺-ATP enzyme were selected as the evaluation indexes...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Thomas G Beach, Geidy E Serrano, Thomas Kremer, Marta Canamero, Sebastian Dziadek, Hadassah Sade, Pascal Derkinderen, Anne-Gaëlle Corbillé, Franck Letournel, David G Munoz, Charles L White, Julie Schneider, John F Crary, Lucia I Sue, Charles H Adler, Michael J Glass, Anthony J Intorcia, Jessica E Walker, Tatiana Foroud, Christopher S Coffey, Dixie Ecklund, Holly Riss, Jennifer Goßmann, Fatima König, Catherine M Kopil, Vanessa Arnedo, Lindsey Riley, Carly Linder, Kuldip D Dave, Danna Jennings, John Seibyl, Brit Mollenhauer, Lana Chahine
Immunohistochemical (IHC) α-synuclein (Asyn) pathology in peripheral biopsies may be a biomarker of Parkinson disease (PD). The multi-center Systemic Synuclein Sampling Study (S4) is evaluating IHC Asyn pathology within skin, colon and submandibular gland biopsies from 60 PD and 20 control subjects. Asyn pathology is being evaluated by a blinded panel of specially trained neuropathologists. Preliminary work assessed 2 candidate immunoperoxidase methods using a set of PD and control autopsy-derived sections from formalin-fixed, paraffin-embedded blocks of the 3 tissues...
August 13, 2018: Journal of Neuropathology and Experimental Neurology
Satheesha B Nayak, Naveen Kumar
Lingual nerve (LN) is one among the 3 branches of posterior division of mandibular nerve. It might get entrapped in the infratemporal fossa by lateral pterygoid muscle, pterygospinous ligament, or lateral pterygoid plate. Its entrapment in the submandibular region has not been reported yet. A unique entrapment of LN in the fused submandibular and sublingual salivary glands in a cadaver was reported. The deep parts of the submandibular and sublingual salivary glands were completely fused with each other. The LN passed through the center of the fused part...
August 13, 2018: Journal of Craniofacial Surgery
Alina M Yelins'ka, Olena O Shvaykovs'ka, Vitalii O Kostenko
OBJECTIVE: Introduction: The connective tissue remodeling is essential for periodontal and salivary glands (SG) pathology. Recently there has been demonstrated the number of pharmacological effects of green tea (Camellia sinensis) such as antioxidant, anti-inflammatory, anti-aging, antibacterial, antiviral and DNA-protective effects, associated with the presence of epigallocatechin-3-gallate (EGCG) as an inducer of the Keap1 / Nrf2 / antioxidant response element signaling pathway. However, the EGCG effects on the components of soft connective tissues of periodontium and SG are still unclear...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Saravanabavaan Suntharalingam, Elena Stenzel, Axel Wetter, Nika Guberina, Lale Umutlu, Thomas Schlosser, Kai Nassenstein
Background Dual-energy CT (DECT) provides additional image datasets which enable improved tumor delineation or reduction of beam hardening artifacts in patients with head and neck squamous cell carcinoma (SCC). Purpose To assess radiation dose and image quality of third-generation DECT of the head and neck in comparison to single-energy CT (SECT). Material and Methods Thirty patients with SCC who underwent both SECT (reference tube voltage 120 kVp) and DECT (80/150 Sn kVp) of the head and neck region for staging were retrospectively selected...
August 8, 2018: Acta Radiologica
Pieter D de Veij Mestdagh, Tomas Janssen, Emmy Lamers, Casper Carbaat, Olga Hamming-Vrieze, Wouter V Vogel, Jan-Jakob Sonke, Abrahim Al-Mamgani
BACKGROUND AND PURPOSE: The great majority of patients with lateralized head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy routinely undergo bilateral elective nodal irradiation (ENI), even though the incidence of contralateral regional failure after unilateral ENI is low. Excluding the contralateral neck from elective irradiation could reduce radiation-related toxicity and improve quality-of-life. The current study investigated the dosimetric benefits of a novel approach using lymph drainage mapping by SPECT/CT to select patients for unilateral ENI...
August 4, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Naoto Fukunaga, Ved Bissoondath, Vivek Rao
No abstract text is available yet for this article.
August 6, 2018: Transplantation
Michael D Turner
No abstract text is available yet for this article.
September 2018: Atlas of the Oral and Maxillofacial Surgery Clinics of North America
Dongun Lee, Sang A Lee, Dong M Shin, Jeong H Hong
Secretory glands including salivary glands by many hormonal inputs produce and secrete biological fluids determined by variety of ion transporters. Spinophilin is a multifunctional scaffolding protein, which involved in receptor signaling and regulation of anion exchangers AE2 activity. We found that spinophilin expressed in salivary glands. The role of salivary spinophilin on the modulation of chloride/bicarbonate exchange remains unknown. The spinophilin enhanced AE2 activity and associated with a STE20/SPS1-related kinase and showed an additive effect on the modulation of the activity of AE2...
2018: Frontiers in Physiology
M V T Araujo, M A Spadella, A B Chies, G V Arruda, T de M Santos, M M Cavariani, R F Domeniconi
Head and neck cancers are common in several regions of the world and the treatment usually includes radiotherapy. This treatment can generate adverse effects to the salivary flow, with a relationship between the dose and the damage caused. Salivary gland cells are highly permeable to water and therefore, they express aquaporins (AQPs). This study analyzed changes in the expression and location of these proteins and identified morphological changes induced by low radiation in rat submandibular gland. Female rats were divided into control and irradiated groups...
August 2018: Tissue & Cell
L Zhang, J-Z Su, Z-G Cai, L Lv, L-H Zou, X-J Liu, J Wu, Z-H Zhu, C Mao, Y Wang, X Peng, B Song, X-X Li, G-Y Yu
We assessed long-term outcomes of autologous microvascular submandibular gland (SMG) transplantation for severe dry eye disease and investigated factors influencing long-term results. From August 1999 to January 2015, 185 patients (200 eyes) with severe dry eye received SMG transplantation. Subjective assessments and ophthalmologic evaluations were performed before and after transplantation. Follow-up results showed successful transplantation in 180 of 200 eyes (success rate: 90%), resulting in marked symptomatic relief of xerophthalmia...
July 26, 2018: International Journal of Oral and Maxillofacial Surgery
Faisal Alali, Nabil Kochaji
Objective: To investigate the proliferative activity of myoepithelial cells (MEC) in normal salivary glands (NSG) and adenoid cystic carcinomas (ACC)) Study design. Twenty -three salivary gland specimens (13 ACC, 10 NSG) were studied using double immunohistochemical labeling for α smooth muscle actin (a-SMA) and proliferative cell nuclear antigen (PCNA)). Results: There was a significant difference in PCNA reactivity in normal samples between myoepithelial cells of the parotid glands and of the submandibular glands, rates being higher in the latter...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
X F Shan, L Lv, Z-G Cai, G-Y Yu
The aim of this study was to explore whether botulinum toxin A (BTXA) injection treats epiphora secondary to submandibular gland (SMG) transplantation for severe keratoconjunctivitis sicca. Fifteen patients with epiphora after SMG transplantation were separated to three groups, and received 15U, 20U and 25U BTXA injection in the transplanted SMG, respectively. Secretion of transplanted SMG was assessed subjectively by visual analogue scale (VAS) regarding epiphora, and objectively by Schirmer test. There were no significant differences in the 15-U BTXA group regarding the values of the VAS on epihora before and 1 month after BTXA injection...
July 20, 2018: International Journal of Oral and Maxillofacial Surgery
Cai-Yue Gao, Yuan Yao, Liang Li, Shu-Han Yang, Hui Chu, Koichi Tsuneyama, Xiao-Mei Li, M Eric Gershwin, Zhe-Xiong Lian
OBJECTIVE: Although a role for CD4+ T cells in the pathology of Sjögren's syndrome (SS) has been documented, the pathogenic significance of CD8+ T cells is unclear. The aim of this study is to investigate the role of CD8+ T cells in the development of SS. METHODS: Flow cytometry and immunofluorescence were utilized to detect T cell infiltration within the labial glands of patients with primary SS. In parallel p40-/- CD25-/- mice were used as a murine model of SS...
July 23, 2018: Arthritis & Rheumatology
Feride Kural Rahatli, Hale Turnaoglu, Ozlem Turhan Iyidir, Nazli Gulsoy Kirnap, Kemal Murat Haberal, Erdinç Aydın, Nihal Uslu
OBJECTIVES: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Radioactive iodine (RAI) therapy is used for remnant ablation following thyroidectomy. Side effects such as dysphagia, xerostomia, and sialoadenitis may occur. We aimed to determine the differences in the parotid and submandibulary glands between healthy patients and patients with PTC who had undergone RAI therapy and have dry mouth symptoms using both shear wave elastography and ultrasonography. METHODS: We enrolled 30 patients with PTC who had undergone RAI therapy following surgery and 30 healthy controls...
July 19, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Ikuho Kojima, Maya Sakamoto, Masahiro Iikubo, Yusuke Shimada, Takashi Nishioka, Takashi Sasano
OBJECTIVE: We analysed the correlation between magnetic resonance images of the parotid and submandibular glands and the salivary flow rate in patients with Sjögren's syndrome. METHODS: We retrospectively reviewed magnetic resonance images (heterogeneous signal-intensity distribution and gland volume on T1- and fat-suppressed T2-weighted images, and multiple high-signal-intensity spots on magnetic resonance sialograms in the parotid and submandibular glands) obtained from 66 patients who were diagnosed with Sjögren's syndrome...
July 14, 2018: Oral Diseases
Si-En Zhang, Shi-Hong Wen, Yu-Xiong Su, Guang-Sen Zheng, Di-Kan Wang, Yu-Jie Liang, Gui-Qing Liao
Submandibular gland autotransplantation is an effective approach for treating severe keratoconjunctivitis sicca. However, ischemia/reperfusion (I/R) injury, which inevitably occurs during transplantation, is involved in the hypofunction and structural damage that occur early after transplantation. Therefore, it is critical to identify effective strategies to ameliorate I/R injury in submandibular glands. In this study, we investigated the ability of immediate post-conditioning combined with ischemic preconditioning to attenuate I/R injury...
August 2018: European Journal of Oral Sciences
Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Yui Umeyama, Tsukasa Ataka, Haruka Wada, Yumiko Oyamada, Naoki Hyakushima, Ken-Ichiro Seino
Background: Cysts of the salivary glands are common lesions that occur in the context of various etiologies. Although the diagnostic importance of cysts in salivary gland diseases has been well studied, molecular mechanisms that control the related pathological process remain largely unknown. IL-34 is a novel cytokine that was discovered recently as a tissue-specific ligand of colony stimulating factor-1 receptor. Since its discovery, accumulating evidence has revealed emerging roles of IL-34 in various pathological conditions and has been suggested to correlate remarkably with inflammation...
2018: Inflammation and Regeneration
Mateusz Szewczyk, Paweł Golusiński, Jakub Pazdrowski, Piotr Pieńkowski, Sławomir Marszałek, Jacek Sygut, Wojciech Golusiński
Aim: The purpose of the study was to publish our experience of salivary gland cancer treatment with large number of patients treated at a single institution. Background: Salivary gland cancers are rare tumors of the head and neck representing about 5% of cancers in that region and about 0.5% of all malignancies. Due to the rarity of the disease, most of the studies regarding treatment outcome consist of low number of patients, thus making it difficult to draw conclusions...
July 2018: Reports of Practical Oncology and Radiotherapy
Saskia E Kok, Corrie E Erasmus, Arthur R T Scheffer, Karen van Hulst, Maroeska M Rovers, Frank J A van den Hoogen
OBJECTIVE: To evaluate the effectiveness of submandibular duct relocation in drooling children with neurological disorders. DESIGN: Prospective cohort study. SETTING: Academic Outpatient Saliva Control Clinic. PARTICIPANTS: Ninety-one children suffering from moderate to severe drooling. MAIN OUTCOME MEASURES: Direct observational drooling quotient (DQ; 0-100) and caretaker Visual Analogue Scale (VAS; 0-100)...
July 10, 2018: Clinical Otolaryngology
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