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submandibular gland

Javan Nation, Bharat Panuganti, Alexander Manteghi, Seth Pransky
INTRODUCTION: Recurrent salivary gland swelling of the parotid and submandibular glands results in painful swelling in the pediatric population. There is no defined algorithm for workup and treatment of these disorders, resulting in wide heterogeneity and in some cases overuse of computed tomography (CT) imaging. Sialendoscopy (SE) is an interventional option for recurrent swelling of both glands; however, its effectiveness in the pediatric population is still being determined. OBJECTIVES: To assess preoperative imaging utilization and benefit in the workup of recurrent pediatric sialadenitis, intraoperative SE findings, and postoperative outcomes after intervention with SE...
January 11, 2019: Annals of Otology, Rhinology, and Laryngology
H X Lyu, Z R Wang, Y Q Gao, M Yu, B Q Li, Z B Zhang
Objective: To investigate the incidence and proportion of salivary gland tumors in order to provide new thinking for clinical diagnosis and treatment. Methods: Collected 3 724 cases salivary gland tumors diagnosed by Pathology Department of Hospital of Stomatology, Jilin University from January 1961 to December 2016. The pathological diagnosis referred to the fourth edition of head and neck-salivary gland tumor histopathological classification standard of WHO. The database was established with Microsoft Excel and analyzed with SPSS 18...
January 9, 2019: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Sung Jun Ma, Charlotte I Rivers, Lucas M Serra, Anurag K Singh
Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen, submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia...
January 10, 2019: World Journal of Clinical Oncology
Mohamed H Khattab, Alexander D Sherry, Carolyn G Ahlers, Austin N Kirschner
BACKGROUND: Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical literature. CASE SUMMARY: In this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma...
December 20, 2018: World Journal of Clinical Oncology
Yuichiro Kusuda, Yusuke Kondo, Yuta Miyagi, Takashi Munemasa, Yusuke Hori, Fumiko Aonuma, Shintaro Tsuka, Taro Mukaibo, Chihiro Masaki, Ryuji Hosokawa
Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gland function. This study aimed to evaluate the effects of dexamethasone on mouse submandibular gland function to gain insight into the mechanism of dexamethasone-induced salivary hypofunction. The muscarinic agonist carbachol (CCh) induced salivary secretion and was not affected by short-term dexamethasone treatment but was decreased following long-term dexamethasone administration...
January 3, 2019: International Journal of Oral Science
Tomohiro Yasumitsu, Osamu Shimizu, Hiroshi Shiratsuchi, Yusuke Miyake, Yoshiyuki Yonehara
The aim of this study was to determine the localization of aquaporin-5 (AQP5), transforming growth factor-β1 (TGF-β1 ) and laminin during regeneration of the rat submandibular gland. After duct ligation for 7 days, the regenerating glands were collected on days 0, 1, 3, 7, and 14 after ligation release to study the process of regeneration. Immunohistochemical staining revealed apical expression of AQP5 in many acinar cells, strong expression in intercalated ducts (ICDs) of the normal submandibular gland at Day 14, and strong expression in duct-like structures (DLSs) during regeneration from Day 0 to 7...
2018: Journal of Oral Science
Brittany N Dugger, Brittany R Hoffman, Alex Scroggins, Geidy E Serrano, Charles H Adler, Holly A Shill, Christine M Belden, Marwan N Sabbagh, John N Caviness, Erika Driver Dunckley, Thomas G Beach
Many studies have been directed at understanding mechanisms of tau aggregation and therapeutics, nearly all focusing on the brain. It is critical to understand the presence of tau in peripheral tissues since this may provide new insights into disease progression and selective vulnerability. The current study sought to determine the presence of select tau species in peripheral tissues in elderly individuals and across an array of tauopathies. Using formalin fixed paraffin embedded sections, we examined abdominal skin, submandibular gland, and sigmoid colon among 69 clinicopathologically defined cases: 19 lacking a clinical neuropathological diagnosis (normal controls), 26 progressive supranuclear palsy (PSP), 21 Alzheimer's disease (AD), and 3 with corticobasal degeneration (CBD)...
December 20, 2018: Neuroscience Letters
Carlos Saga-Gutierrez, Carlos Miguel Chiesa-Estomba, Ekhiñe Larruscain, José Ángel González-García, Jon Alexander Sistiaga, Xabier Altuna
INTRODUCTION: The treatment of salivary obstructive pathology by minimally invasive techniques has been an object of assessment by different studies for decades. Lithiasis at the level of the salivary duct will be the most frequent cause of obstruction, representing more than 50% of the pathology of the major salivary glands and almost 80% of these affecting the Wharton duct. MATERIAL AND METHODS: A prospective study comparing the results of combined transoral sialolitectomy (CTS) and open submaxillectomy techniques by cervicotomy in 2 groups of patients treated by lithiasis at the level of the hilum of the submaxillary gland...
December 19, 2018: Acta Otorrinolaringológica Española
Satomi Sugiyama, Toshinori Iwai, Nobuhide Ohashi, Senri Oguri, Makoto Hirota, Kenji Mitsudo
Intraoral removal of a submandibular gland stone is less invasive than submandibulectomy, with no life-threatening airway complications reported until now. We report a case involving airway obstruction caused by pharyngolaryngeal swelling after intraoral removal of a submandibular gland stone. A 31-year-old man with a left submandibular gland stone underwent intraoral removal of the stone under general anesthesia and was discharged 1 day after surgery. That night, he was transported back to our hospital by ambulance for dyspnea...
2018: Therapeutics and Clinical Risk Management
Kashi Raj Bhattarai, Hwa-Young Lee, Seung-Hyun Kim, Jong-Sug Park, Hyung-Ryong Kim, Han-Jung Chae
Dry mouth is a common complaint among the elderly population. The aim of this study was to investigate the effect of Ixeris dentata (IXD) extract on aging-induced dry mouth. We used young (two months) and aged (20 months) SD rats in our study. Using water as the vehicle, IXD extract (25, 50, and 100 mg/kg) was given via oral gavage to the young and aged rats for eight weeks. We found that the salivary flow rate relative to the submandibular gland weight was differently influenced by IXD extract treatment. IXD extract augmented the submandibular gland acinar cells, which are depleted during aging...
December 15, 2018: Nutrients
Peter M Vila, Margaret A Olsen, Jay F Piccirillo, M Allison Ogden
OBJECTIVE: To determine frequencies and trends in sialoendoscopy and sialoadenectomy for the treatment of obstructive, nonneoplastic submandibular gland disease in the United States. METHODS: Epidemiologic study of insurance claims from 2006 to 2013 in a large, private insurance claims database. Rates were calculated for patients undergoing one or both index procedures. RESULTS: A total of 5,111 adults with sialadenitis who underwent sialoendoscopy or submandibular gland excision were included...
December 16, 2018: Laryngoscope
Yoh Isogai, Zheng Wu, Michael I Love, Michael Ho-Young Ahn, Dhananjay Bambah-Mukku, Vivian Hua, Karolina Farrell, Catherine Dulac
Newborn mice emit signals that promote parenting from mothers and fathers but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Seven vomeronasal receptors were identified based on infant-mediated activity, and the involvement of two receptors, Vmn2r65 and Vmn2r88, in infant-directed aggression was demonstrated by genetic deletion...
December 13, 2018: Cell
Joshua E Fabie, Anvesh R Kompelli, Tate M Naylor, Shaun A Nguyen, Eric J Lentsch, M Boyd Gillespie
BACKGROUND: Sialoendoscopy is the standard treatment for sialolithiasis; however, some patients may be unlikely to benefit from an endoscopic approach. This study assesses predictors of failure in the endoscopic management of sialoliths. METHODS: Patients treated for sialolithiasis from 2012 to 2017 at two centers were stratified into 3 groups: successful interventional sialendoscopy, incisional sialolithotomy, and gland excision. Patient, disease, and surgical factors were compared...
December 14, 2018: Head & Neck
Jamyson Oliveira Santos, Brunna da Silva Firmino, Matheus Santos Carvalho, Jean de Pinho Mendes, Lucas Novaes Teixeira, Sérgio Lúcio Pereira de Castro Lopes, André Luiz Ferreira Costa, Antonione Santos Bezerra Pinto
Imaging examinations play an important role in the diagnosis of sialolithiasis, whose symptoms are initially confounded with other diseases. The objective of the present case report is to highlight imaging and processing techniques as well as image analysis for the preoperative assessment and planning of surgical interventions and adequate treatment of massive sialoliths. A 35-year-old male patient presented complaining of pain in the submandibular region and purulent secretions from a lingual caruncle with slightly increased volume in the region...
2018: Case Reports in Dentistry
Lei Zeng, Qin Zhang, Fan Ao, Chun-Ling Jiang, Yun Xiao, Hong-Hui Xie, Yi-Qiang Tang, Xiao-Chang Gong, Jin-Gao Li
OBJECTIVE: The objective of this study is to investigate the risk factors and distribution features for level IB metastasis in nasopharyngeal carcinoma (NPC) and provide clinical evidence for defining the indications and clinical target volume (CTV) of prophylactic level IB irradiation. METHODS: We retrospectively analyzed 798 patients with newly-diagnosed, non-metastatic and histologically confirmed NPC underwent intensity-modulated radiation therapy (IMRT). Two sides of neck in each patient have been analyzed separately...
December 5, 2018: Auris, Nasus, Larynx
Kristy A Warner, Alexandra E Oklejas, Alexander T Pearson, Zhaocheng Zhang, Weishing Wu, Vasu Divi, Christie Rodriguez-Ramirez, Rogerio M Castilho, Peter J Polverini, Jacques E Nör
OBJECTIVES: Limited availability of validated human adenoid cystic carcinoma (ACC) cell lines has hindered the mechanistic understanding of the pathobiology of this malignancy and the development of effective therapies. The purpose of this work was to generate and characterize a human ACC cell line. MATERIAL AND METHODS: Immediately after surgery, a tumor fragment from a minor salivary gland from the tongue of a female Caucasian was minced, dissociated, and a single cell suspension was plated in fibronectin-coated flasks...
December 2018: Oral Oncology
Y N Zhao, Y Q Zhang, X Ye, Y Meng, X Y Xie, D G Liu
Objective: To investigate the different surgical approaches and long-term outcomes of endoscopy-assisted transoral removal of deep hilar and intraparenchymal stones in the Wharton's duct. Methods: From January 2008 to March 2018, 481 consecutive patients with deep hilar and intraparenchymal calculi in the Wharton's duct underwent endoscopy-assisted transoral removal at Deparment of Oral and Maxillofacial Radiology, Peking University School and Hospital of Stomatology. There were 250 males and 231 females. Their ages ranged from 9-86 years...
December 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Jorge Pinheiro, Margarida Sá Fernandes, Ana Rodrigues Pereira, José Manuel Lopes
INTRODUCTION: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate. MATERIAL AND METHODS: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Disease-free survival and overall survival were evaluated using Kaplan-Meier survival curves and compared using the Mantel-Cox log-rank test...
November 30, 2018: Acta Médica Portuguesa
Pranav Lakshminarayanan, Wei Jiang, Scott P Robertson, Zhi Cheng, Peijin Han, Michael Bowers, Joseph A Moore, Ilya Shpitser, Sauleh A Siddiqui, Harry Quon, Russ Taylor, Todd McNutt
PURPOSE: In radiotherapy, it is necessary to characterize dose over the patient anatomy to target areas and organs at risk. Current tools provide methods to describe dose in terms of percentage of volume and magnitude of dose, but are limited by assumptions of anatomical homogeneity within a region of interest (ROI) and provide a non-spatially aware description of dose. A practice termed radio-morphology is proposed as a method to apply anatomical knowledge to parametrically derive new shapes and substructures from a normalized set of anatomy, ensuring consistently identifiable spatially-aware features of the dose across a patient set...
December 3, 2018: Medical Physics
Ethar Al-Husseinawi, Soheila Hamidpour, Evanthia Omoscharka
Mammary analogue secretory carcinoma (MASC) of the salivary glands morphologic and molecular similarities to secretory carcinoma of the breast(sc). (1) Here, we report a 46 year old female who presented with a right submandibular gland mass. Fine needle aspiration differential diagnosis included oncocytosis, oncocytoma, acinic cell carcinoma and MASC.We also review the current literature regarding clinical presentation, and diagnostic workup of this entity. This article is protected by copyright. All rights reserved...
December 1, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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