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https://www.readbyqxmd.com/read/30406923/a-prospective-study-of-weekly-intensity-modulated-radiation-therapy-plan-adaptation-for-head-and-neck-cancer-improved-target-coverage-and-organ-at-risk-sparing
#1
F Aly, A A Miller, M G Jameson, P E Metcalfe
This prospective study of weekly CT scanning and plan adaption during H&N IMRT reports on the frequency of plan adaptations based on dosimetric differences between original and re-optimised IMRT plans. The volumetric and geometric change occurring in target volumes and salivary glands is also described. Ten H&N cancer patients underwent weekly planning CT imaging and re-optimisation of the IMRT plan if PTV or OAR coverage was unacceptable. Comparisons of PTV and parotid gland dosimetry between the original and adaptive plans were made...
November 8, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/30401471/determinants-of-level-ib-involvement-in-oral-squamous-cell-carcinoma-and-implications-for-submandibular-gland-sparing-neck-dissection
#2
N Subramaniam, D Balasubramanian, R Reddy, P Rathod, S Murthy, S Vidhyadharan, K Thankappan, S Iyer
Traditional neck dissection for oral squamous cell carcinoma (OSCC) involves removal of the submandibular salivary gland. Several studies have cited the low incidence of direct gland invasion by tumours and have recommended gland-sparing neck dissection. In this study, a detailed audit of level Ib involvement in OSCC was performed in order to assess the feasibility of submandibular gland-sparing in neck dissection; the rate of direct involvement by the primary tumours, the involvement of periglandular level Ib nodes, and their determinants were investigated...
December 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30389171/different-immunohistochemical-localization-for-tmem16a-and-cftr-in-acinar-and-ductal-cells-of-rat-major-salivary-glands-and-exocrine-pancreas
#3
Takuya Yokoyama, Masato Takemoto, Masato Hirakawa, Tomoyuki Saino
We investigated the mRNA expression and immunohistochemical localization of Cl- channels, transmembrane member 16A (TMEM16A or anoctamin 1), and cystic fibrosis transmembrane conductance regulator (CFTR) in rat major salivary glands and exocrine pancreas. RT-PCR detected mRNA expression of TMEM16A and CFTR in the extracts of the parotid gland (PG), submandibular gland (SMG), sublingual gland (SLG), and pancreas. Immunoreactivity for TMEM16A was localized in the apical membrane of serous acinar and intercalated ductal cells in the PG and SMG as well as mucous acinar cells in the SLG; however, it was not detected in striated ductal cells of these tissues...
October 30, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/30387129/parasympathectomy-increases-resting-secretion-of-the-submandibular-gland-in-minipigs-in-the-long-term
#4
Xue-Ming Zhang, Yan Huang, Xin Cong, Ling-Han Qu, Kuo Zhang, Li-Ling Wu, Yan Zhang, Guang-Yan Yu
Parasympathectomy leads to retrogressive alteration and dysfunction of the submandibular gland (SMG) within 1 month, but its long-term effect is unclear. Excessive secretion is observed in half of the patients 4-6 months after SMG transplantation, which completely denervates the gland. Here, we investigated the long-term effect of parasympathectomy on the secretion of SMGs in minipigs. The results showed that the resting salivary secretion of SMGs decreased by 82.9% of that in control at 2 months after denervation, but increased by 156% at 6 months...
November 1, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30383641/detection-of-a-metallic-foreign-body-in-the-wharton-duct-a-case-report
#5
Peng Li, HuiCong Zhu, DaHong Huang
RATIONALE: Foreign bodies are rarely found in the submandibular gland and the Wharton duct, due to their physiological and anatomical features. PATIENT CONCERNS: A 23-year-old man was referred to Foshan Stomatology Hospital in July 2016, with pain and intermittent swelling in the right submandibular area. DIAGNOSES: Physical examination revealed enlarged, indurated, and painful swelling in the right submandibular area, with a normal oral cavity...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30371109/pediatric-sialorrhea-submandibular-duct-rerouting-and-intraparotid-botulinum-toxin-a-injection-with-literature-review
#6
Omer Faruk Calim, Hasan N H Hassouna, Yavuz Selim Yildirim, Remzi Dogan, Orhan Ozturan
OBJECTIVES: The aim of this study was to assess the effectiveness of bilateral submandibular duct relocation and bilateral sublingual gland excision in combination with botulinum toxin A injection into the parotid glands in children with sialorrhea. Previously in the literature, either surgery or botulinum toxin injection but not their combination has been reported. METHODS: Preoperative and at least 6-month postoperative assessments using the Drooling Severity Scale and Drooling Frequency Scale (Thomas-Stonell and Greenberg classification) and the Teacher Drooling Scale and by interviewing parents and caregivers face to face or via telephone were performed...
October 29, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/30367746/simultaneous-monitoring-of-ca-2-responses-and-salivary-secretion-in-live-animals-reveals-a-threshold-intracellular-ca-2-concentration-for-salivation
#7
Akihiro Nezu, Takao Morita, Takeharu Nagai, Akihiko Tanimura
NEW FINDINGS: What is the central question of this study? The effects of Ca2+ responses on salivary fluid secretion have been studied indirectly by monitoring ion channel activities and other indices. Therefore, Ca2+ responses during salivary secretion remain poorly understood. What is the main finding and its importance? Herein, we developed a simultaneous monitoring system for Ca2+ responses and salivary secretion in live animals using a YC-Nano50-expressing submandibular gland (SMG) and a fiber-optic pressure sensor...
October 27, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/30367515/the-synergistic-effect-of-nod2-and-tlr4-on-the-activation-of-autophagy-in-human-submandibular-gland-inflammation
#8
Jiajie Li, Bo Li, Yong Cheng, Qingong Meng, Lili Wei, Wei Li, Jiali Zhang, Shengfu Huang
BACKGROUND: Sialadenitis is a nonneoplastic disease that causes salivary dysfunction. Autophagy may be involved in helping protect salivary function when the salivary gland is impaired; this process is primarily activated by sensors of innate immunity, such as Toll-like receptors and nucleotide-binding oligomerization domain (NOD)-like receptors. The role of these pattern recognition receptors (PRRs) in the regulation of salivary gland tissue defense and homeostasis has been underappreciated...
October 26, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/30366169/report-of-metastatic-ileal-neuroendocrine-tumor-to-the-submandibular-gland
#9
David Forner, Peter Cho, Martin Bullock, Daniel Rayson, S Mark Taylor, Robert D Hart, Jonathan R Trites, Matthew H Rigby
BACKGROUND: Neuroendocrine tumors (NETs) of small intestinal origin are generally slow-growing tumors with a relatively high propensity for metastases to surrounding organs and lymphatic tissue. We present the first case of an ileal NET metastasizing to the submandibular gland in a woman with metastatic carcinoid syndrome. CASE PRESENTATION: A 55-year-old female presented with a four-month history of a palpable, left-sided neck mass. The patient had a history of metastatic neuroendocrine tumor of ileal origin, initially treated with primary resection 4...
October 19, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30348462/analysis-of-eortc-1219-dahanca-29-trial-plans-demonstrates-the-potential-of-knowledge-based-planning-to-provide-patient-specific-treatment-plan-quality-assurance
#10
Jim P Tol, Max Dahele, Vincent Gregoire, Jens Overgaard, Ben J Slotman, Wilko F A R Verbakel
INTRODUCTION: Radiotherapy treatment plan quality can influence clinical trial outcomes and general QA may not identify suboptimal organ-at-risk (OAR) sparing. We retrospectively performed patient-specific quality assurance (QA) of 100 head-and-neck cancer (HNC) plans from the EORTC-1219-DAHANCA-29 study. MATERIALS AND METHODS: A 177-patient RapidPlan (Varian Medical Systems) model comprising institutional HNC plans was used to QA trial plans (Ptrial ). RapidPlan plans (Prapidplan ) were created using RapidPlan and Eclipse scripting to achieve a high degree of automation...
October 19, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30347705/outer-membrane-protein-of-gut-commensal-microorganism-induces-autoantibody-production-and-extra-intestinal-gland-inflammation-in-mice
#11
Naoko Yanagisawa, Hidehiro Ueshiba, Yoshihiro Abe, Hidehito Kato, Tomoaki Higuchi, Junji Yagi
Gut commensal microorganisms have been linked with chronic inflammation at the extra-intestinal niche of the body. The object of the study was to investigate on the chronic effects of a gut commensal Escherichia coli on extra-intestinal glands. The presence of autoimmune response was diagnosed by autoantibody levels and histological methods. Repeated injection of E. coli induced mononuclear cell inflammation in the Harderian and submandibular salivary glands of female C57BL/6 mice. Inflammation was reproduced by adoptive transfer of splenocytes to immune-deficient Rag2 knockout mice and CD4⁺ T cells to mature T cell-deficient TCRβ-TCRδ knockout mice...
October 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30344785/quantitative-single-photon-emission-computed-tomography-computed-tomography-for-evaluation-of-salivary-gland-dysfunction-in-sj%C3%A3-gren-s-syndrome-patients
#12
Jihyun Kim, Hyunjong Lee, Hwanhee Lee, Ji-In Bang, Yeon-Koo Kang, Sungwoo Bae, Yoo Sung Song, Won Woo Lee
Purpose: The purpose of the study was to investigate the usefulness of quantitative salivary single-photon emission computed tomography/computed tomography (SPECT/CT) using Tc-99m pertechnetate in Sjögren's syndrome (SS). Methods: We retrospectively reviewed quantitative salivary SPECT/CT data from 95 xerostomic patients who were classified as either SS ( n  = 47, male:female = 0:47, age = 54.60 ± 13.16 y [mean ± SD]) or non-SS ( n  = 48, male:female = 5:43, age = 54...
October 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30343214/a-sialo-oligosaccharide-rich-mucin-like-molecule-specifically-detected-in-the-submandibular-glands-of-aged-mice
#13
Mayu Iida, Yu-Ki Matsuno, Atsushi Watanabe, Mitsuo Maruyama, Akihiko Kameyama, Kimi Yamakoshi
OBJECTIVES: Mucins are heavily glycosylated large glycoproteins produced in the salivary glands that contribute to salivary viscosity. This study aimed to characterize age-related changes in mucin production in mouse submandibular salivary gland (SMG). METHODS: The paraffin sections of the SMGs of the young and aged mice were stained with HE or Alcian blue (AB). SMGs mucins derived from the young and aged mice were separated using supported molecular matrix electrophoresis (SMME)...
October 12, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/30340912/submandibular-gland-is-a-suitable-site-for-alpha-synuclein-pathology-in-parkinson-disease
#14
Junghwan Shin, Sung-Hye Park, Chaewon Shin, Ji-Hoon Kim, Tae Jin Yun, Han-Joon Kim, Beomseok Jeon
OBJECTIVE: To validate the role of α-synuclein (AS) pathology in submandibular gland (SMG) as a biomarker for Parkinson disease (PD). METHODS: We performed ultrasonography (USG) guided core needle biopsy of SMG in PD patients and procured SMG biopsy tissues or surgical excision specimens from non-PD patients as controls. Then, we compared AS deposition in the SMG tissues between the PD patients and the controls. We recruited 16 PD patients in this study. In each individual, two core needle biopsy tissues were obtained from the left submandibular gland under USG guidance...
April 19, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30338701/potential-therapeutic-effects-of-induced-pluripotent-stem-cells-on-induced-salivary-gland-cancer-in-experimental-rats
#15
Yasmine Alaa El-Din, Dina Sabry, Amal Hassan Abdelrahman, Safa Fathy
Salivary gland neoplasms exhibit complex histopathology in a variety of tumor types and treatment options depend largely on the stage of the cancer. Induced pluripotent stem cells (iPS) have been investigated for treating induced salivary gland cancer and for restoring salivary gland function. We investigated iPS treatment for salivary gland cancer both in vitro and in vivo. For our study in vitro, we re-programmed human skin fibroblasts to form iPS cells using a plasmid containing Oct4, Sox2, L-MYC and LIN28...
October 19, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/30336621/eight-week-consumption-of-high-sucrose-diet-has-a-pro-oxidant-effect-and-alters-the-function-of-the-salivary-glands-of-rats
#16
Mateusz Maciejczyk, Jan Matczuk, Małgorzata Żendzian-Piotrowska, Wiesława Niklińska, Katarzyna Fejfer, Izabela Szarmach, Jerzy Robert Ładny, Izabela Zieniewska, Anna Zalewska
A high-sucrose diet (HSD) is widely known for its cariogenic effects and promotion of obesity, insulin resistance, type 2 diabetes, and cancer. However, the impact of the HSD diet on the salivary gland function as well as the level of salivary oxidative stress is still unknown and requires evaluation. Our study is the first to determine both redox balance and oxidative injury in the parotid and submandibular glands of rats fed the HSD diet compared to the control group. We have demonstrated that uric acid concentration and the activity of superoxide dismutase and peroxidase varied significantly in both the submandibular and parotid glands of HSD rats vs...
October 17, 2018: Nutrients
https://www.readbyqxmd.com/read/30320688/the-periangular-approach-to-the-posterior-mandible-a-novel-approach-and-technique
#17
Neel Patel, Robert Cronyn
There exist 2 classic extraoral approaches to the posterior aspect of the mandible, namely the submandibular or Risdon approach, and the retromandibular approach. Despite their widespread use, there still exist concerns of damage to surrounding structures, in particular cranial nerve VII, as well as vascular structures and salivary glands. Evidence of facial nerve palsy has been shown to be as high as 48% in the patient with the Risdon approach, and as high as 30% in the retromandibular approach. The authors wish to propose a more conservative, technically easier, and less time-consuming approach to the posterior mandible, with less risk of damage to the branches of the facial nerve, as well as other structures such as the facial vessels and the parotid gland...
November 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30310647/renal-clear-cell-carcinoma-metastasis-to-submandibular-gland-case-report-and-review-of-the-literature
#18
F Higuera, L A Boccalatte, M J Labanca, A Jaén Del Valle, J J Larrañaga, M F Figari
Metastases from renal clear cell carcinoma (RCCC) to the head and neck (HN) region are rare, representing 8-14% of all RCCC metastases, with the thyroid gland being the most common site of RCCC metastasis in the HN. Metastatic tumors that are located in the salivary glands have a prevalence of 5%, while the submandibular gland is only involved in 1% of the cases. We present the case of a 74-year-old female patient with metastasis to the submandibular gland, 11 years after radical nephrectomy for a RCCC.
October 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30309505/rho-associated-kinase-inhibitor-enhances-the-culture-condition-of-isolated-mouse-salivary-gland-cells-in-vitro
#19
Choongseong Han, Geun Ho An, Dong-Hun Woo, Jong-Hoon Kim, Hee-Kyung Park
Hyposalivation because of curative radiation therapy in patients with head and neck cancer is a major concern. At present, there is no effective treatment for hyposalivation, highlighting the importance of cell therapy as a new therapeutic approach. To provide functional cells for cell replacement therapy, it is important to overcome the limitations of current in vitro culture methods for isolated salivary gland cells. Here, we suggest an improved culture condition method for the cultivation of isolated salivary gland cells...
October 2018: Tissue & Cell
https://www.readbyqxmd.com/read/30307625/principal-component-analysis-modeling-of-head-and-neck-anatomy-using-daily-cone-beam-ct-images
#20
Panagiotis Tsiamas, Hassan Bagher-Ebadian, Farzan Siddiqui, Chang Liu, Christian A Hvid, Joshua P Kim, Stephen L Brown, Benjamin Movsas, Indrin J Chetty
PURPOSE: To model Head-and-Neck anatomy from daily Cone Beam-CT (CBCT) images over the course of fractionated radiotherapy using principal component analysis (PCA). METHODS AND MATERIALS: Eighteen oropharyngeal Head-and-Neck cancer patients, treated with volumetric modulated arc therapy (VMAT), were included in this retrospective study. Normal organs, including the parotid and submandibular glands, mandible, pharyngeal constrictor muscles (PCMs), and spinal cord were contoured using daily CBCT image datasets...
October 11, 2018: Medical Physics
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