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https://www.readbyqxmd.com/read/30541631/novel-tlr2-binding-adjuvant-induces-enhanced-t-cell-responses-and-tumor-eradication
#1
Gijs G Zom, Marian M J H P Willems, Selina Khan, Tetje C van der Sluis, Jan Willem Kleinovink, Marcel G M Camps, Gijsbert A van der Marel, Dmitri V Filippov, Cornelis J M Melief, Ferry Ossendorp
BACKGROUND: Ligands for the Toll-like receptor (TLR) family can induce activation of cells of the innate immune system and are widely studied for their potential to enhance adaptive immunity. Conjugation of TLR2-ligand Pam3CSK4 to synthetic long peptides (SLPs) was shown to strongly enhance the induction of antitumor immunity. To further improve cancer vaccination, we have previously shown that the novel TLR2-L Amplivant (AV), a modified Pam3CSK4, potentiates the maturation effects on murine DCs...
December 12, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/30510846/a-dual-labeled-crgd-based-pet-optical-tracer-for-pre-operative-staging-and-intraoperative-treatment-of-colorectal-cancer
#2
Babs G Sibinga Mulder, Henricus Jm Handgraaf, Danielle J Vugts, Claudia Sewing, Albert D Windhorst, Marieke Stammes, Lioe-Fee de Geus-Oei, Mark W Bordo, J Sven D Mieog, Cornelis Jh van de Velde, John V Frangioni, Alexander L Vahrmeijer
cRGD peptides target integrins associated with angiogenesis (e.g., αv β3 ) and cancer, and have been used as binding ligands for both positron emission tomography (PET) and near-infrared fluorescence (NIRF) optical imaging. This study introduces the hybrid tracer cRGD-ZW800-1-Forte-[89 Zr]Zr-DFO, which is based on a novel zwitterionic fluorophore structure that reduces non-specific background uptake during molecular imaging of tumors. An in vitro binding assay was used to validate tracer performance. 10 nmol ZW800F-cRGD-Zr-DFO was injected in mice (n=7) bearing orthotopic human colorectal tumors (HT29-luc2) for tumor detection with NIRF imaging...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30466939/selenium-biofortified-corn-peptides-attenuating-concanavalin-a-induced-liver-injury-and-structure-characterization
#3
Danjun Guo, Yan Zhang, Juanjuan Zhao, Hui He, Tao Hou
The relationship between hepatoprotective effects of selenium-biofortified corn (Zea mays Linn) peptides (SeCPs) and its antioxidant ability was evaluated and the structure of SeCPs was identified. SeCPs and corn peptides (CPs) both had good antioxidant ability, and the effect of SeCPs was significantly higher than CPs within a certain concentration range (P < 0.05). Additionally, animal experiments indicated that SeCPs (200 mg/kg) had a significantly protective effect against concanavalin A (Con A) induced hepatic lesions, as it significantly declined glutamic-pyruvic transaminase (AST), alanine transaminase (ALT) activities, tumor necrosis factor alpha (TNF-α), interferon (IFN)-γ contents in serum, and malondialdehyde (MDA) contents in liver (P < 0...
January 2019: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30346622/rna-interference-to-control-asian-corn-borer-using-dsrna-from-a-novel-glutathione-s-transferase-gene-of-ostrinia-furnacalis-lepidoptera-crambidae
#4
Yuliang Zhang, Yitong Zhang, Maojie Fu, Guohua Yin, Richard T Sayre, Kayla K Pennerman, Fengshan Yang
Glutathione-S-transferases (GST) comprise a multifunctional protein superfamily, which plays important roles as detoxifiers and antioxidants in insects. The GST in Asian corn borer has not been previously characterized. In this study, we cloned, characterized, and expressed the complete GST genes from the midgut of Asian corn borer. Furthermore, we designed htL4440-OfGST vector to exploit this gene for RNA interference (RNAi) strategy to control this pest. A complete GST cDNA sequence in Asian corn borer was obtained by reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends technology...
September 1, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/30325446/enrichment-of-the-amnion-with-threonine-in-chicken-embryos-affects-the-small-intestine-development-ileal-gene-expression-and-performance-of-broilers-between-1-and-21-days-of-age
#5
A L B Moreira Filho, P R Ferket, R D Malheiros, C J B Oliveira, P C Aristimunha, D E Wilsmann, P E N Givisiez
The effects of in ovo feeding with threonine (Thr) on intestinal morphology, ileal gene expression and performance of broiler chicken between 1 and 21 d of age (d) were assessed. On day 17.5 of incubation, fertile eggs were randomly allotted to 5 treatments of Thr injection in the amniotic fluid (0; 1.75; 3.5; 5.25; 7%, corresponding to 17.5; 35; 52.5 and 70 mg Thr/mL). After hatch, chicks were given a commercial corn-soybean diet up to 21 d. Daily feed intake (FI), body weight (BW), and food conversion ratio (FCR) were measured from 1 to 7, 14, and 21 d of age...
October 15, 2018: Poultry Science
https://www.readbyqxmd.com/read/30289499/a-mono-component-microbial-protease-improves-performance-net-energy-and-digestibility-of-amino-acids-and-starch-and-upregulates-jejunal-expression-of-genes-responsible-for-peptide-transport-in-broilers-fed-corn-wheat-based-diets-supplemented-with-xylanase-and
#6
A J Cowieson, M Toghyani, S K Kheravii, S-B Wu, L F Romero, M Choct
A total of 90 male Ross 308 broiler chicks were used in a digestibility and performance bioassay to explore the effect of reduction in dietary protein and digestible amino acids and inclusion of an exogenous mono-component protease on amino acid digestibility, net energy, jejunal gene expression, and bird performance. Four dietary treatments were created by the supplementation, or not, of 2 control diets with a mono-component exogenous protease. The control diets were corn/wheat/soybean meal-based and were formulated to be either nutritionally adequate or reduced in protein and amino acids (around 3%)...
October 5, 2018: Poultry Science
https://www.readbyqxmd.com/read/30267032/combining-immune-checkpoint-blockade-and-tumor-specific-vaccine-for-patients-with-incurable-human-papillomavirus-16-related-cancer-a-phase-2-clinical-trial
#7
Erminia Massarelli, William William, Faye Johnson, Merrill Kies, Renata Ferrarotto, Ming Guo, Lei Feng, J Jack Lee, Hai Tran, Young Uk Kim, Cara Haymaker, Chantale Bernatchez, Michael Curran, Tomas Zecchini Barrese, Jaime Rodriguez Canales, Ignacio Wistuba, Lerong Li, Jing Wang, Sjoerd H van der Burg, Cornelis J Melief, Bonnie Glisson
Importance: In recurrent human papilloma virus (HPV)-driven cancer, immune checkpoint blockade with anti-programmed cell death 1 (PD-1) antibodies produces tumor regression in only a minority of patients. Therapeutic HPV vaccines have produced strong immune responses to HPV-16, but vaccination alone has been ineffective for invasive cancer. Objective: To determine whether the efficacy of nivolumab, an anti-PD-1 immune checkpoint antibody, is amplified through treatment with ISA 101, a synthetic long-peptide HPV-16 vaccine inducing HPV-specific T cells, in patients with incurable HPV-16-positive cancer...
September 27, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/30234124/a-comparative-review-on-microbiota-manipulation-lessons-from-fish-plants-livestock-and-human-research
#8
REVIEW
Sylvia Brugman, Wakako Ikeda-Ohtsubo, Saskia Braber, Gert Folkerts, Corné M J Pieterse, Peter A H M Bakker
During recent years the impact of microbial communities on the health of their host (being plants, fish, and terrestrial animals including humans) has received increasing attention. The microbiota provides the host with nutrients, induces host immune development and metabolism, and protects the host against invading pathogens (1-6). Through millions of years of co-evolution bacteria and hosts have developed intimate relationships. Microbial colonization shapes the host immune system that in turn can shape the microbial composition (7-9)...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/30213105/primary-structure-analysis-of-antifungal-peptides-from-cultivated-and-wild-cereals
#9
REVIEW
Eugene Rogozhin, Dmitry Ryazantsev, Alexey Smirnov, Sergey Zavriev
Cereal-derived bioactive peptides with antimicrobial activity have been poorly explored compared to those from dicotyledonous plants. Furthermore, there are a few reports addressing the structural differences between antimicrobial peptides (AMPs) from cultivated and wild cereals, which may shed light on significant varieties in the range and level of their antimicrobial activity. We performed a primary structure analysis of some antimicrobial peptides from wild and cultivated cereals to find out the features that are associated with the much higher antimicrobial resistance characteristic of wild plants...
September 12, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/30196834/pdcb-does-not-promote-cns-autoimmunity-in-the-context-of-genetic-susceptibility-but-worsens-its-outcome
#10
Divyanshu Dubey, Rehana Z Hussain, William A Miller-Little, Amber Salter, Richard Doelger, Olaf Stüve
BACKGROUND: Para-dichlorobenzene (PDCB) is an aromatic hydrocarbon contained in mothballs that is potentially neurotoxic. A potential pathogenic role of PDCB in MS pathogenesis has been suggested. METHODS: To determine the ability of chronic PDCB ingestion to induce CNS autoimmunity in a genetically susceptible mammalian species, naive myelin oligodendrocyte glycoprotein peptide (MOGp )35-55 T cell receptor (TCR) transgenic mice (2D2) on the C57Bl/6 background were orally gavaged once daily with corn oil control, 125 mg/kg PDCB, or 250 mg/kg PDCB for 45 days...
October 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/30140186/simple-detection-of-cochliobolus-fungal-pathogens-in-maize
#11
In Jeong Kang, Hyeong Kwon Shim, Jae Hwan Roh, Sunggi Heu, Dong Bum Shin
Northern corn leaf spot and southern corn leaf blight caused by Cochliobolus carbonum (anamorph, Bipolaris zeicola ) and Cochliobolus heterostrophus (anamorph, Bipolaris maydis ), respectively, are common maize diseases in Korea. Accurate detection of plant pathogens is necessary for effective disease management. Based on the polyketide synthase gene (PKS) of Cochliobolus carbonum and the nonribosomal peptide synthetase gene (NRPS) of Cochliobolus heterostrophus , primer pairs were designed for PCR to simultaneously detect the two fungal pathogens and were specific and sensitive enough to be used for duplex PCR analysis...
August 2018: Plant Pathology Journal
https://www.readbyqxmd.com/read/30101541/effects-of-live-yeast-saccharomyces-cerevisiae-and-type-of-cereal-on-rumen-microbial-fermentation-in-a-dual-flow-continuous-culture-fermentation-system
#12
Diego Moya, Alfred Ferret, Marta Blanch, Mari Carmen Fuentes, Jose Ignacio Fandiño, Sergio Calsamiglia
Live yeast additives may help optimize ruminal fermentation of high-grain diets, especially when the starch of the ration is highly fermentable. Eight dual flow continuous culture fermenters were used in a 2 × 2 factorial design in two replicated periods of 9 days (six for adaptation and three for sampling) to determine the effect of live yeast and type of cereal on rumen microbial fermentation and nutrient digestibility. Main factors were the addition of live yeast: no yeast (NY) vs. 2 × 107 CFU of yeast/g of diet (LY); and type of cereal in the diet: corn (CO) vs...
August 12, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/30097019/the-antibiotic-peptaibol-alamethicin-from-trichoderma-permeabilises-arabidopsis-root-apical-meristem-and-epidermis-but-is-antagonised-by-cellulase-induced-resistance-to-alamethicin
#13
Bradley R Dotson, Dia Soltan, John Schmidt, Mariam Areskoug, Kenny Rabe, Corné Swart, Susanne Widell, Allan G Rasmusson
BACKGROUND: Trichoderma fungi live in the soil rhizosphere and are beneficial for plant growth and pathogen resistance. Several species and strains are currently used worldwide in co-cultivation with crops as a biocontrol alternative to chemical pesticides even though little is known about the exact mechanisms of the beneficial interaction. We earlier found alamethicin, a peptide antibiotic secreted by Trichoderma, to efficiently permeabilise cultured tobacco cells. However, pre-treatment with Trichoderma cellulase made the cells resistant to subsequent alamethicin, suggesting a potential mechanism for plant tolerance to Trichoderma, needed for mutualistic symbiosis...
August 10, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/30083676/one-step-formation-of-a-double-pickering-emulsion-via-modulation-of-the-oil-phase-composition
#14
Qijun Ruan, Lihua Zeng, Jiaoyan Ren, Xiaoquan Yang
There are two long-standing issues that are holding back the full exploitation of food-based double emulsions: (i) unavailability of large-scale equipment to ensure efficient nondestructive two-step emulsification and (ii) limited food-grade ingredients available to replace polyglycerol polyricinoleate (PGPR) as the primary emulsifier. To overcome these, a facile one-step emulsification strategy was developed to generate a food-grade W/O/W double Pickering emulsion by using corn-peptide-functionalized calcium phosphate (CP-CaP) particles as the emulsifier...
August 15, 2018: Food & Function
https://www.readbyqxmd.com/read/29961406/potential-effect-of-maternal-dietary-sucrose-or-fructose-syrup-on-cd36-leptin-and-ghrelin-mediated-fetal-programming-of-obesity
#15
Betul Kisioglu, Reyhan Nergiz-Unal
The influence of HFCS (high fructose corn syrup - free fructose) and sucrose (bound fructose) on fetal appetite signals is unknown. This study aimed to determine the effects of HFCS or sucrose on the peptide-mediated appetite regulation in fetal programming of obesity. Sprague Dawley female rats were administered feed and plain water (control) or water containing maltodextrin (vehicle), sucrose, fructose, or HFCS (20%, w/v) for 12 weeks before mating and throughout pregnancy and lactation (ndams = 31; npups = 207)...
July 1, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29876663/correction-to-strategies-of-drug-transporter-quantitation-by-lc-ms-importance-of-peptide-selection-and-digestion-efficiency
#16
Buyun Chen, Liling Liu, Hoangdung Ho, Yuan Chen, Ze Yang, Xiaorong Liang, Jian Payandeh, Brian Dean, Cornelis E C A Hop, Yuzhong Deng
Liling Liu was not noted as the co-first author in the original article. Buyun Chen and Liling Liu contributed equally to the article.
June 6, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29752315/formation-of-immune-complexes-with-a-tetanus-derived-b-cell-epitope-boosts-human-t-cell-responses-to-covalently-linked-peptides-in-an-ex-vivo-blood-loop-system
#17
Erika A K Fletcher, Wendy van Maren, Robert Cordfunke, Jasper Dinkelaar, Jeroen D C Codee, Gijs van der Marel, Cornelis J M Melief, Ferry Ossendorp, Jan Wouter Drijfhout, Sara M Mangsbo
Enhancing T cell responses against both viral and tumor Ags requires efficient costimulation and directed delivery of peptide Ags into APCs. Long peptide vaccines are considered favorable vaccine moieties from a clinical perspective, as they can harbor more than one immunogenic epitope enabling treatment of a broader target population. In addition, longer peptides are not extracellularly loaded on MHC class I; rather, they require intracellular processing and will thereby be presented to T cells mainly by professional APCs, thereby avoiding the risk of tolerance induction...
July 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29718486/identification-and-characterization-of-c-type-lectins-in-ostrinia-furnacalis-lepidoptera-pyralidae
#18
Dongxu Shen, Lei Wang, Jiayue Ji, Qizhi Liu, Chunju An
C-type lectins (CTLs) are a large family of calcium-dependent carbohydrate-binding proteins. They function primarily in cell adhesion and immunity by recognizing various glycoconjugates. We identified 14 transcripts encoding proteins with one or two CTL domains from the transcriptome from Asian corn borer, Ostrinia furnacalis (Guenée; Lepidoptera: Pyralidae). Among them, five (OfCTL-S1 through S5) only contain one CTL domain, the remaining nine (OfIML-1 through 9) have two tandem CTL domains. Five CTL-Ss and six OfIMLs have a signal peptide are likely extracellular while another two OfIMLs might be cytoplasmic...
March 1, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/29708875/detecting-molecular-forms-of-antithrombin-by-lc-mrm-ms-defining-the-measurands
#19
L Renee Ruhaak, Fred P H T M Romijn, Nico P M Smit, Arnoud van der Laarse, Mervin M Pieterse, Moniek P M de Maat, Fred J L M Haas, Cornelis Kluft, Jean Amiral, Piet Meijer, Christa M Cobbaert
No abstract text is available yet for this article.
September 25, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29579950/hydrolysis-and-transepithelial-transport-of-two-corn-gluten-derived-bioactive-peptides-in-human-caco-2-cell-monolayers
#20
Long Ding, Liying Wang, Ting Zhang, Zhipeng Yu, Jingbo Liu
The objective of this paper was to investigate the transepithelial transport of two novel corn gluten-derived antioxidant peptides, YFCLT and GLLLPH, using Caco-2 cell monolayers. Results showed that both of YFCLT and GLLLPH could transport in intact form across Caco-2 cell monolayers with apparent permeability coefficient (Papp ) values of (1.10±0.16)×10-7 cm/s and (1.98±0.23)×10-7 cm/s, respectively. However, it was found that the two peptides were susceptible and easily hydrolyzed by brush border membrane peptidases...
April 2018: Food Research International
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