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Vitamin D supplementation

Parminder Singh
Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Bone diseases such as rickets in children, osteomalacia and osteoporosis in adults are related with vitamin D insufficiency...
January 2018: Journal of the Association of Physicians of India
Yan Yang, Shi Qiu, Linghui Deng, Xi Tang, Xinrui Li, Qiang Wei, Ping Fu
BACKGROUND: Mineral bone disease constitutes a common complication of post-kidney transplantation, leading to great disability. As there is no consensus on the optimal treatment for post-kidney transplant recipients (KTRs), we aimed to evaluate the efficacy and safety of bisphosphonate and its combined therapies. METHODS: We incorporated relevant trials to perform a network meta-analysis from direct and indirect comparisons. We searched PubMed, Embase and the CENTRAL and the reference lists of relevant articles up to August 1, 2017, for randomized controlled trials...
October 19, 2018: BMC Nephrology
Rodolfo Oliveira Leal, Laura Frau Pascual, Juan Hernandez
Percutaneous ultrasound-guided radiofrequency heat-ablation (UG-RHA) is a therapeutic option for dogs with primary hyperparathyroidism (PHPTH) but information about its outcome is still controversial. This retrospective study aimed to evaluate the outcome and complications of UG-RHA in dogs with PHPTH. The medical records of dogs with PHPTH submitted to UG-RHA between June 2012 and September 2015 in a French referral center were retrospectively reviewed. Eight cases were included. No sex predisposition was found...
October 18, 2018: Veterinary Sciences
Asako Murayama, Hiroshi Saitoh, Akiko Takeuchi, Norie Yamada, Takuya Matsumura, Masaaki Shiina, Masamichi Muramatsu, Takaji Wakita, Michio Imawari, Takanobu Kato
Supplementation with vitamin D (VD) has been reported to improve the efficacy of interferon-based therapy for chronic hepatitis C. We found that 25-hydroxyvitamin D3 (25-(OH)D3 ), one of the metabolites of VD, has antiviral effects by inhibiting the infectious virus production of the hepatitis C virus (HCV). In this study, to clarify the underlying mechanisms of the anti-HCV effects, we searched VD derivatives that have anti-HCV effects and identified the common target molecule in the HCV life cycle by using an HCV cell culture system...
October 16, 2018: Antiviral Research
Jennifer C Yu, Ksenya Shliakhtsitsava, YunZu M Wang, Megan Paul, Lauge Farnaes, Victor Wong, Jenny Kim, Courtney D Thornburg
Nutritional deficiencies, including deficiencies of vitamin B12, copper, and vitamin C, may result in cytopenias and hematological symptoms. Early recognition of these deficiencies is imperative for prompt treatment and improvement in hematologic and other manifestations. We describe 5 cases which illustrate the hematologic manifestations of nutritional deficiencies and challenges to initial diagnosis and management. Supplementation of the deficient vitamin or micronutrient in all of these cases resulted in rapid resolution of cytopenias, hemorrhage, and other associated hematologic symptoms...
October 18, 2018: Journal of Pediatric Hematology/oncology
Khalid K Abdul-Razzak, Safa'a O Almanasrah, Bayan A Obeidat, Aws G Khasawneh
BACKGROUND: Anxiety and depression are globally-common disorders. In Jordan, the number of people visiting psychiatric clinics has been increasing over the past few years. Low level of vitamin D is associated with musculoskeletal pain (MSP) and is increasingly linked to the pathology of mental disorders. OBJECTIVE: To assess the prevalence of vitamin D deficiency among psychiatric outpatients and their response to vitamin D supplementation. MATERIALS AND METHODS: 74 outpatients and gender- and age-matched controls were involved...
October 19, 2018: International Journal of Clinical Pharmacology and Therapeutics
Irene Lara-Corrales, Christina M Huang, Patricia C Parkin, Gustavo A Rubio-Gomez, Claudia J Posso-De Los Rios, Jonathon Maguire, Elena Pope
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a pruritic eczematous rash. Evidence surrounding the role of serum vitamin D (VD) in modifying disease severity is inconsistent. OBJECTIVES: To determine whether VD levels are correlated with AD severity and the effects of VD supplementation on disease modification. METHODS: This was a 2-phase study, using a cross-sectional design to evaluate the relationship between VD level and severity, as well as a double-blinded, randomized control trial to elucidate the effects of VD supplementation...
October 18, 2018: Journal of Cutaneous Medicine and Surgery
Silvia Maggini, Adeline Pierre, Philip C Calder
As humans age, the risk and severity of infections vary in line with immune competence according to how the immune system develops, matures, and declines. Several factors influence the immune system and its competence, including nutrition. A bidirectional relationship among nutrition, infection and immunity exists: changes in one component affect the others. For example, distinct immune features present during each life stage may affect the type, prevalence, and severity of infections, while poor nutrition can compromise immune function and increase infection risk...
October 17, 2018: Nutrients
Abdullah Al-Taiar, Mona AlKhabbaz, Abdur Rahman, Reem Al-Sabah, Lemia Shaban, Saeed Akhtar
Few studies have investigated the association between Acne vulgaris (AV) and vitamin D level. In this study we aimed to investigate the association between 25-hydroxyvitamin D (25-OH-VitD) level and AV in a country with plenty of sunshine. A cross-sectional study was conducted on 714 adolescents who were randomly selected from public schools using multistage cluster random sampling with probability proportional to size. 25-OH-VitD levels were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
October 17, 2018: Nutrients
Wenhao Chen, Changyi Yang, Hanqiang Chen, Baoquan Zhang
The present study aims to analyze the risk factors for metabolic bone disease (MBD) of prematurity.A total of 238 preterm infants who were born at <34 weeks of gestation and were hospitalized for at least 6 weeks in the Department of Neonatology, Fujian Maternity and Children Hospital between January 1, 2011 and November 30, 2015 were enrolled in the study. Sixteen preterm infants diagnosed with MBD were selected as the case group, and 32 non-MBD preterm infants were matched 2:1 at admission into the study...
October 2018: Medicine (Baltimore)
Menglian Lv, Shengyi Yang, Lingkai Cai, Li-Qiang Qin, Bing-Yan Li, Zhongxiao Wan
SCOPE: To explore how quercetin would affect memory impairments in APP/PS1 mice under different vitamin D status. METHODS AND RESULTS: APP/PS1 mice were divided into 4 groups, i.e. control (CON), and Low, Medium and High VD (LVD, MVD and HVD) supplemented with quercetin. During Morris Water Maze test, mice of LVD group functioned best for improving cognitive function demonstrated by reduced latency to platform, and increased number of crossing and swimming distance in the target quadrant...
October 17, 2018: Molecular Nutrition & Food Research
Mark Loeb, Anh Duc Dang, Vu Dinh Thiem, Vitheya Thanabalan, Biao Wang, Nguyen Binh Nguyen, Hung Thi Mai Tran, Tan Minh Luong, Pardeep Singh, Marek Smieja, Jonathon Maguire, Eleanor Pullenayegum
BACKGROUND: It is uncertain whether Vitamin D can reduce respiratory infection. OBJECTIVE: To determine if vitamin D supplementation reduces influenza and other upper viral respiratory tract infections. METHODS: 1,300 healthy children and adolescents between the ages of 3 and 17 years were randomized to vitamin D (14,000U weekly) or placebo for eight months in Vietnam. The primary outcome was reverse transcriptase (RT) -PCR confirmed influenza infection and the co-primary outcome was multiplex PCR confirmed non-influenza respiratory viruses...
October 16, 2018: Influenza and Other Respiratory Viruses
Thomas Richards, C Wright
BACKGROUND: Recruits undergoing military training experience a particularly high incidence of stress fractures. The role of combined calcium and vitamin D (25-OHD) deficiency and subsequent supplementation has been well described in the literature, but the role of 25-OHD deficiency alone is less well understood, particularly its influence on recovery once a stress fracture has been incurred. METHODS: Retrospective data of recruits who had incurred stress fractures were collected (n=37)...
October 15, 2018: Journal of the Royal Army Medical Corps
Sara Tagliaferri, Debora Porri, Rachele De Giuseppe, Matteo Manuelli, Francesco Alessio, Hellas Cena
Increased oxidative stress has been implicated as a potential causal factor in the development of several diseases. In the last decade, an extensive literature has been produced on vitamin D, not limited to its well-known function like a steroid hormone on skeletal tissue, but for its potential pleiotropic role in human health. Several researchers have suggested relationships between vitamin D intake and health outcomes such as cancer prevention and increased immunity, or possible role in preventing diabetes, and in inflammation...
October 17, 2018: Nutrition Research Reviews
Yanbin Zhu, Song Liu, Wei Chen, Bo Liu, Hongzhi Lv, Xiaolin Zhang, Yingze Zhang
OBJECTIVE: The aim of the study was to report the incidence of low-energy fracture since menopause in postmenopausal women ≤70 years and to explore associated risk factors METHODS:: This was a part of the Chinese National Fracture Survey (CNFS), which was carried out in eight provinces of China mainland between January and May 2015. Data on 68,783 postmenopausal women ≤70 years were extracted from the CNFS database for calculations and analyses. RESULTS: A total of 309 women were confirmed to have low-energy fractures in 2014, indicating the incidence of 449...
October 15, 2018: Menopause: the Journal of the North American Menopause Society
Ana Isabel Ospina-Caicedo, Alex Darío Cardona-Rincon, Juan Manuel Bello-Gualtero, Rafael Valle-Onate, Consuelo Romero-Sanchez, P Chalem-Choueka Philippe, Gloria Vasquez Duque
BACKGROUND: Systemic Lupus Erythematosus [SLE] involves genetic, environmental, and hormonal alterations, including Vitamin D deficiency. OBJECTIVE: To evaluate the association between vitamin D levels with anti-dsDNA, complement proteins, immunoglobulins levels and disease activity scores Methods: A cross-sectional study was performed. The levels of 25-OH vitamin D were measured in patients older than 18 years with SLE according to ACR/97 [American College of Rheumatology 1997] from 2013 to 2015...
October 15, 2018: Current Rheumatology Reviews
Yosuke Mukai, Hidetoshi Eguchi
No abstract text is available yet for this article.
October 15, 2018: Annals of Surgical Oncology
Stefan Pilz, Armin Zittermann, Rima Obeid, Andreas Hahn, Pawel Pludowski, Christian Trummer, Elisabeth Lerchbaum, Faustino R Pérez-López, Spyridon N Karras, Winfried März
Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the "active vitamin D hormone" calcitriol support the important role of vitamin D in this setting...
October 12, 2018: International Journal of Environmental Research and Public Health
David Scott, Aya Mousa, Negar Naderpoor, Maximilian P J de Courten, Robert Scragg, Barbora de Courten
Recent trials do not support a role for vitamin D supplementation in prevention or treatment of type 2 diabetes mellitus, although effects may differ in Asian populations. In this pilot secondary analysis of a placebo-controlled randomised trial of overweight or obese individuals with low 25-hydroxyvitamin D (25(OH)D<50 nmol/L), we examined whether vitamin D supplementation improved insulin sensitivity or body composition in participants of Asian ethnicity. Amongst 65 trial participants, 33 reported being of Asian descent (mean ± SD age 30 ± 7 years; 67% male)...
October 12, 2018: Journal of Steroid Biochemistry and Molecular Biology
Elizabeth M Curtis, Nevena Krstic, Eloïse Cook, Stefania D'Angelo, Sarah R Crozier, Rebecca J Moon, Robert Murray, Emma Garratt, Paula Costello, Jane Cleal, Brogan Ashley, Nicholas J Bishop, Stephen Kennedy, Aris T Papageorghiou, Inez Schoenmakers, Robert Fraser, Saurabh V Gandhi, Ann Prentice, M Kassim Javaid, Hazel M Inskip, Keith M Godfrey, Christopher G Bell, Karen A Lillycrop, Cyrus Cooper, Nicholas C Harvey
We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass. We therefore used an existing randomised trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation. The Maternal Vitamin D Osteoporosis Study (MAVIDOS) was a multicentre, double-blind, randomised, placebo-controlled trial of 1000IU/day cholecalciferol or matched placebo from 14 weeks' gestation until delivery...
October 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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