keyword
https://read.qxmd.com/read/38496523/machine-learning-assisted-spectral-fingerprinting-for-immune-cell-phenotyping
#21
Aceer Nadeem, Sarah Lyons, Aidan Kindopp, Amanda Jamieson, Daniel Roxbury
Spectral fingerprinting has emerged as a powerful tool, adept at identifying chemical compounds and deciphering complex interactions within cells and engineered nanomaterials. Using near-infrared (NIR) fluorescence spectral fingerprinting coupled with machine learning techniques, we uncover complex interactions between DNA-functionalized single-walled carbon nanotubes (DNA-SWCNTs) and live macrophage cells, enabling in situ phenotype discrimination. Through the use of Raman microscopy, we showcase statistically higher DNA-SWCNT uptake and a significantly lower defect ratio in M1 macrophages as compared to M2 and naïve phenotypes...
March 8, 2024: bioRxiv
https://read.qxmd.com/read/38495974/galactosyl-bodipy-based-nanoparticles-as-a-type-i-photosensitizer-for-hepg2-cell-targeted-photodynamic-therapy
#22
JOURNAL ARTICLE
Jin-Yu Liu, Ye Tian, Lei Dong
We report a galactosyl diiodo-BODIPY-based nanoparticles as type-I photosensitizer (PS) with high water solubility for HepG2 cell targeted photodynamic therapy. Functionalized galactoside and glucoside were introduced into diiodo-BODIPY to obtain BP1 and BP2, respectively. The glycolyl PSs could self-assemble to form the nanoparticles BP1-NP and BP2-NP with red-shifted near-infrared (NIR) absorption and fluorescence at 682 nm and 780 nm, as well as excellent chemo- and photo-stability. In comparison to the monomer in DMSO, the aggregated photosensitizers in the nanoparticles enabled the sensitization of oxygen to superoxide (O2 ˙- ) through a type-I process, while repressing the generation of singlet oxygen (1 O2 ) through a type-II process...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38492413/eudragit-s100-coated-nanodiamond-based-nanoparticles-as-an-oral-chemo-photothermal-delivery-system-for-local-treatment-of-colon-cancer
#23
JOURNAL ARTICLE
Yupei Su, Hao Pan, Jiahui Wang, Dandan Liu, Weisan Pan
Oral colonic nano-drug delivery system has received more and more attention in the treatment of colon cancer due to local precision treatment and reduction of drug system distribution. However, the complex and harsh gastrointestinal environment and the retention of nanoparticles in the colon limit its development. To this end, we designed Eudragit S100 (ES) coated nanoparticles (ES@PND-PEG-TPP/DOX). Polydopamine coated nanodiamond (PND) was modified with amino-functionalized polyethylene glycol (NH2 -PEG-NH2 ) and triphenylphosphine (TPP) successively...
March 13, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38491201/synergistic-effect-of-mesoporous-silica-nanocarrier-assisted-photodynamic-therapy-and-anticancer-agent-activity-on-lung-cancer-cells
#24
JOURNAL ARTICLE
Burcu Güleryüz, Ayşe Işık, Murat Gülsoy
Investigating combined treatment methodologies is crucial for addressing the complex nature of cancer. As an emerging strategy, nano-biotechnology encourages the design of unique nanocarriers possessing simultaneous therapeutic application properties. This study aims to explore the combined effects of photodynamic and anticancer treatments using a multifunctional nanocarrier system co-administering the photosensitizer IR780 and the anticancer agent curcumin (Cur) on lung cancer cells. Nanocarriers were prepared by encapsulation IR780 and Cur inside polyethylene glycol-capped mesoporous silica nanoparticles (Cur&IR780@MSN)...
March 16, 2024: Lasers in Medical Science
https://read.qxmd.com/read/38487713/a-transferrin-receptor-targeting-dual-modal-mr-nir-fluorescent-imaging-probe-for-glioblastoma-diagnosis
#25
JOURNAL ARTICLE
Jiaqi Hao, Huawei Cai, Lei Gu, Yiqi Ma, Yan Li, Beibei Liu, Hongyan Zhu, Fanxin Zeng, Min Wu
The prognosis of glioblastoma (GBM) remains challenging, primarily due to the lack of a precise, effective imaging technique for comprehensively characterization. Addressing GBM diagnostic challenges, our study introduces an innovative dual-modal imaging that merges near-infrared (NIR) fluorescent imaging with magnetic resonance imaging (MRI). This method employs superparamagnetic iron oxide nanoparticles coated with NIR fluorescent dyes, specifically Cyanine 7, and targeted peptides. This synthetic probe facilitates MRI functionality through superparamagnetic iron oxide nanoparticles, provides NIR imaging capability via Cyanine 7 and enhances tumor targeting trough peptide interactions, offering a comprehensive diagnostic tool for GBM...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38484040/tumor-microenvironment-activatable-nanoprodrug-system-for-in-situ-fluorescence-imaging-and-therapy-of-liver-cancer
#26
JOURNAL ARTICLE
Can Xie, Yongbo Peng, Zhen Zhang, Kun Luo, Qiaomei Yang, Libin Tan, Liyi Zhou
The development of new imaging and treatment nanoprodrug systems is highly demanded for diagnosis and therapy of liver cancer, a severe disease characterized by a high recurrence rate. Currently, available small molecule drugs are not possible for cancer diagnosis because of the fast diffusion of imaging agents and low efficacy in treatment due to poor water solubility and significant toxic side effects. In this study, we report the development of a tumor microenvironment activatable nanoprodrug system for the diagnosis and treatment of liver cancer...
March 14, 2024: Analytical Chemistry
https://read.qxmd.com/read/38475023/near-infrared-fluorescence-imaging-sensor-with-laser-diffuser-for-visualizing-photoimmunotherapy-effects-under-endoscopy
#27
JOURNAL ARTICLE
Toshihiro Takamatsu, Hideki Tanaka, Tomonori Yano
The drug efficacy evaluation of tumor-selective photosensitive substances was expected to be enabled by imaging the fluorescence intensity in the tumor area. However, fluorescence observation is difficult during treatments that are performed during gastrointestinal endoscopy because of the challenges associated with including the fluorescence filter in the camera part. To address this issue, this study developed a device that integrates a narrow camera and a laser diffuser to enable fluorescence imaging through a forceps port...
February 25, 2024: Sensors
https://read.qxmd.com/read/38473852/dual-emissive-zn-ii-naphthalocyanines-synthesis-structural-and-photophysical-characterization-with-theory-supported-insights-towards-soluble-coordination-compounds-with-visible-and-near-infrared-emission
#28
JOURNAL ARTICLE
Sidharth Thulaseedharan Nair Sailaja, Iván Maisuls, Alexander Hepp, Dana Brünink, Nikos L Doltsinis, Andreas Faust, Sven Hermann, Cristian A Strassert
Metal phthalocyaninates and their higher homologues are recognized as deep-red luminophores emitting from their lowest excited singlet state. Herein, we report on the design, synthesis, and in-depth characterization of a new class of dual-emissive (visible and NIR) metal naphthalocyaninates. A 4- N , N -dimethylaminophen-4-yl-substituted naphthalocyaninato zinc(II) complex ( Zn-NMe2 Nc ) and the derived water-soluble coordination compound ( Zn-NMe3 Nc ) exhibit a near-infrared fluorescence from the lowest ligand-centered state, along with a unique push-pull-supported luminescence in the visible region of the electromagnetic spectrum...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38470564/injectable-and-multifunctional-hydrogels-based-on-poly-n-acryloyl-glycinamide-and-alginate-derivatives-for-antitumor-drug-delivery
#29
JOURNAL ARTICLE
Trung Thang Vu, Sung-Han Jo, Seon-Hwa Kim, Byeong Kook Kim, Sang-Hyug Park, Kwon Taek Lim
Chemotherapy is a conventional treatment that uses drugs to kill cancer cells; however, it may induce side effects and may be incompletely effective, leading to the risk of tumor recurrence. To address this issue, we developed novel injectable thermal/near-infrared (NIR)-responsive hydrogels to control drug release. The injectable hydrogel formulation was composed of biocompatible alginates, poly( N -acryloyl glycinamide) (PNAGA) copolymers with an upper critical solution temperature, and NIR-responsive cross-linkers containing coumarin groups, which were gelated through bioorthogonal inverse electron demand Diels-Alder reactions...
March 12, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38470209/rational-design-of-nir-ii-ratiometric-fluorescence-probes-for-accurate-bioimaging-and-biosensing-in-vivo
#30
REVIEW
Tuanwei Li, Yejun Zhang, Feng Wu, Guangcun Chen, Chunyan Li, Qiangbin Wang
Intravital fluorescence imaging in the second near-infrared window (NIR-II, 900-1700 nm) has emerged as a promising method for non-invasive diagnostics in complex biological systems due to its advantages of less background interference, high tissue penetration depth, high imaging contrast, and sensitivity. However, traditional NIR-II fluorescence imaging, which is characterized by the "always on" or "turn on" mode, lacks the ability of quantitative detection, leading to low reproducibility and reliability during bio-detection...
March 12, 2024: Small Methods
https://read.qxmd.com/read/38469719/effect-of-pr3-concentration-in-luminescence-properties-upconversion-mechanism-of-triple-doped-nayf4-yb3-er3-pr3
#31
JOURNAL ARTICLE
Mahla Shahsavr Gocmen, Ayse Dulda
Lanthanide-doped fluoride nanocrystals (NCs) exhibit excellent optical features, including upconversion and downconversion luminescence (UCL and DCL), that can be utilized in a variety of applications. In this study, we have successfully demonstrated the photoluminescence behavior of triple-doped NaYF4: Yb3+, Er3+, Pr3+ NCs in the Vis-NIR region. Herein, highly monodisperse hexagonal phase NaYF4: Yb0.2, Er0.02, Prx nanocrystals in various Pr3+ (x = 0, 0.1, 0.5, and 1 mol %) concentration with ~ 22 nm diameter synthesized by thermal decomposition technique...
March 11, 2024: Methods and Applications in Fluorescence
https://read.qxmd.com/read/38462372/-clinical-observation-of-the-intraocular-distribution-characteristics-of-indocyanine-green-after-epiretinal-membrane-peeling-using-a-fluorescence-detection-system-developed-in-python
#32
JOURNAL ARTICLE
Y Zhang, K R Zhang, S Gao, M X Zhang
Objective: To utilize a Python-based fluorescence area detection system to observe and quantitatively analyze the intraocular distribution characteristics and metabolic patterns of Indocyanine Green (ICG) following epiretinal membrane peeling. Methods: A prospective case series study was conducted on patients with idiopathic epiretinal membrane undergoing vitrectomy at West China Hospital of Sichuan University from March 2019 to March 2021. ICG staining was applied during surgery for peeling the epiretinal membrane and internal limiting membrane...
March 11, 2024: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/38458147/rationally-designed-benzobisthiadiazole-based-covalent-organic-framework-for-high-performance-nir-ii-fluorescence-imaging-guided-photodynamic-therapy
#33
JOURNAL ARTICLE
Xian Zhang, You Dou, Shuang Liu, Peiyao Chen, Yating Wen, Junrong Li, Yao Sun, Ruiping Zhang
Although being applied as photosensitizers for photodynamic therapy, covalent organic frameworks (COFs) fail the precise fluorescence imaging in vivo and phototherapy in deep-tissue, due to short excitation/emission wavelengths. Herein, we propose the first example of NIR-II emissive and benzobisthiadiazole-based COF-980. Comparing to its ligands, the structure of COF-980 could more efficiently reducing the energy gap (ΔES1-T1 ) between the excited state and the triplet state to enhance photodynamic therapy efficiency...
March 8, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38457954/d-a-d-type-based-nir-fluorescence-probe-for-monitoring-the-cysteine-levels-in-pancreatic-cancer-cell-during-ferroptosis
#34
JOURNAL ARTICLE
Jingcan Qin, Jing Wang, Yun Bian, Chengwei Shao
Cysteine (Cys) as a crucial precursor for intracellular glutathione (GSH) synthesis, plays an important role in the redox regulation in ferroptosis, Therefore, evaluating intracellular Cys levels is worthy to better understand ferroptosis-related physiological process. In this work, we constructed a novel NIR coumarin-derived fluorescent probe (NCDFP-Cys) based on a dual-ICT system, the NCDFP-Cys can show fluorescence turn-on response at 717 nm toward Cys over other amino acids, and possess large Stokes shift (Δλ = 167 nm), low detection limit, hypotoxicity...
March 4, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38454013/diversity-community-structure-and-abundance-of-nirs-type-denitrifying-bacteria-on-suspended-particulate-matter-in-coastal-high-altitude-aquaculture-pond-water
#35
JOURNAL ARTICLE
Kuang Chunyi, Sun Wei, Wei Mingken, Xia Chunyu, Li Changxiu
Denitrifying bacteria harboring the nitrate reductase S (nirS) gene convert active nitrogen into molecular nitrogen, and alleviate eutrophication in aquaculture water. Suspended particulate matter (SPM) is an important component of aquaculture water and a carrier for denitrification. SPM with different particle sizes were collected from a coastal high-altitude aquaculture pond in Maoming City, China. Diversity, community structure, abundance of nirS-type denitrifying bacteria on SPM and environmental influencing factors were studied using high-throughput sequencing, fluorescence quantitative PCR, and statistical analysis...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38452203/cell-to-cell-heterogeneity-drives-host-virus-coexistence-in-a-bloom-forming-alga
#36
JOURNAL ARTICLE
Nir Joffe, Constanze Kuhlisch, Guy Schleyer, Nadia Samira Ahlers, Adva Shemi, Assaf Vardi
Algal blooms drive global biogeochemical cycles of key nutrients and serve as hotspots for biological interactions in the ocean. The massive blooms of the cosmopolitan coccolithophore Emiliania huxleyi are often infected by the lytic E. huxleyi virus (EhV), which is a major mortality agent triggering bloom demise. This multi-annual "boom and bust" pattern of E. huxleyi blooms suggests that coexistence is essential for these host-virus dynamics. To investigate host-virus coexistence, we developed a new model system from an E...
March 7, 2024: ISME Journal
https://read.qxmd.com/read/38444309/recent-advances-in-si-rhodamine-based-fluorescent-probes-for-live-cell-imaging
#37
REVIEW
Hisashi Ohno, Eita Sasaki, Sota Yamada, Kenjiro Hanaoka
Fluorescence imaging is a powerful technique for visualizing biological events in living samples with high temporal and spatial resolution. Fluorescent probes emitting far-red to near infrared (NIR) fluorescence are particularly advantageous for in vivo imaging due to their high tissue permeability and low autofluorescence, as well as their suitability for multicolor imaging. Among the far-red to NIR fluorophores, Si-rhodamine is one of the most practical fluorophores for the development of tailor-made NIR fluorescent probes because of the relative ease of synthesis of various derivatives, the unique intramolecular spirocyclization behavior, and the relatively high water solubility and high photostability of the probes...
March 6, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38444198/an-aie-controlled-off-on-cu-2-sensitive-probe-for-early-detection-of-renal-fibrosis
#38
JOURNAL ARTICLE
Jie Zhou, Fusui Luo, Xiaomeng Dong, Huili Ma, Min Guan, Jin Zhang, Yiwen Sun, Junfen Feng
Early detection of renal fibrosis (RF) is very important given that it is irreversible when it progresses to the terminal stage. A key marker of RF pathogenesis is activation of myomyofibroblasts, and its targeted imaging may be a promising approach for early detection of RF, but there is no study has directly imaged activation of renal myomyofibroblasts. Cu2+ plays a major role in the fibrotic activity of myofibroblasts. Herein, inspired by that Cu2+ can complex with bovine serum albumin (BSA), BSA-Ag2 S QDs with aggregation-induced emission (AIE) property were synthesized...
March 5, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38441879/near-infrared-perylenecarboximide-fluorophores-for-live-cell-super-resolution-imaging
#39
JOURNAL ARTICLE
Ze-Hua Wu, Xingfu Zhu, Qiqi Yang, Yulian Zagranyarski, Krishna Mishra, Hilmar Strickfaden, Ronald P Wong, Thomas Basché, Kaloian Koynov, Mischa Bonn, Chen Li, Xiaomin Liu, Klaus Müllen
Organic near-infrared (NIR) photoblinking fluorophores are highly desirable for live-cell super-resolution imaging based on single-molecule localization microscopy (SMLM). Herein we introduce a novel small chromophore, PMIP , through the fusion of perylenecarboximide with 2,2-dimetheylpyrimidine. PMIP exhibits an emission maximum at 732 nm with a high fluorescence quantum yield of 60% in the wavelength range of 700-1000 nm and excellent photoblinking without any additives. With resorcinol-functionalized PMIP ( PMIP-OH ), NIR SMLM imaging of lysosomes is demonstrated for the first time in living mammalian cells under physiological conditions...
March 5, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38441392/development-of-polymethine-dyes-for-nir-ii-fluorescence-imaging-and-therapy
#40
REVIEW
Xin Chen, Jieyan Li, Shubham Roy, Zia Ullah, Jingsi Gu, Haiyan Huang, Chen Yu, Xuejin Wang, Han Wang, Yinghe Zhang, Bing Guo
Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher imaging fidelity in monitoring physiological and pathological processes than clinical visible/NIR-I fluorescence imaging. Notably, the imaging fidelity is heavily dependent on fluorescence agents. So far, indocyanine green, one of the polymethine dyes, with good biocompatibility and renal clearance is the only dye approved by the FDA, but it shows relatively low NIRII brightness. Importantly, tremendous efforts have been devoted to synthesizing polymethine dyes for imaging preclinically and clinically...
March 5, 2024: Advanced Healthcare Materials
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