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NIR Fluorescence

Xuechen Li, Ruoyao Zhang, Lifang Guo, Huamiao Zhang, Fangfang Meng, Rui Yang, Chuanya Li, Zhiqiang Liu, Xiaoqiang Yu
The mitochondrial membrane potential (MMP) definitely reflects mitochondrial function. Thus, it is very essential to found a physical parameter as MMP indicator. At present, available parameters are either fluorescent intensity of monochromatic probes such as rhodamine 123 or a ratio of fluorescent intensity at different wavelengths of dual-color dyes such as JC-1, but the inconvenience in practice as well as serious effect of loading concentrations on experimental results limited their application. To address this concern, herein, we found a reliable and easily obtainable co-localization coefficient (CLC) of a fluorescent probe as new MMP indicator and developed a target switchable fluorescent probe (Mito-Lyso) to attain the aim...
December 14, 2018: Analytical Chemistry
A Dankowska, W Kowalewski
The potential of selected spectroscopic methods - UV-Vis, synchronous fluorescence and NIR as well a data fusion of the measurements by these methods - for the classification of tea samples with respect to the production process was examined. Four classification methods - Linear Discriminant Analysis (LDA), Quadratic Discriminant Analysis (QDA), Regularized Discriminant Analysis (RDA) and Support Vector Machine (SVM) - were used to analyze spectroscopic data. PCA analysis was applied prior to classification methods to reduce multidimensionality of the data...
December 1, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Vincenzo Grande, Chia-An Shen, Marco Deiana, Marta Dudek, Joanna Olesiak-Banska, Katarzyna Matczyszyn, Frank Würthner
Fluorescence imaging probes for specific G-quadruplex (G4) conformations are of considerable interest in biomedical research. Herein, we present the synthesis and the binding properties of a new water-soluble near-infrared (NIR) amphiphilic squaraine dye ( CAS-C1 ) which is capable of selective detection of parallel over non-parallel and non G4 topologies. The striking changes in its linear optical response upon binding to parallel G4s give rise to high fluorescence quantum yields ( Φ f ≈ 0.7) and one-photon molecular brightness in the far-red-NIR region...
November 28, 2018: Chemical Science
Ya Wang, Xiaoyu Huang, Yunyun Tang, Jianhua Zou, Peng Wang, Yewei Zhang, Weili Si, Wei Huang, Xiaochen Dong
Emerging treatment approaches, such as gas therapy (GT), photodynamic therapy (PDT) and photothermal therapy (PTT), have received widespread attention. The development of an intelligent multifunctional nano-platform responding to tumor microenvironments for multimodal therapy is highly desirable. Herein, a near-infrared (NIR) light-responsive nitric oxide (NO) photodonor (4-nitro-3-trifluoromethylaniline, NF) and a pH-sensitive group (dimethylaminophenyl) have been introduced into a diketopyrrolopyrrole core (denoted as DPP-NF)...
November 14, 2018: Chemical Science
Juan Ou-Yang, Yongfei Li, Wen-Li Jiang, Shuang-Yan He, Hong-Wen Liu, Chun-Yan Li
The ability to early detect cancer in an accurate and rapid fashion is of critical importance for cancer diagnosis and accurate resection in surgery. γ-Glutamyltranspeptidase (GGT) is overexpressed in several human cancers while keeps low expression in normal microenvironment, and thus recognized as an important cancer biomarker. To date, rational design of a zero cross-talk ratiometric near-infrared (NIR) GGT fluorescent probe for efficiently cancer diagnosis in various biological samples is still a big challenge...
December 12, 2018: Analytical Chemistry
Qian Li, Lihong Sun, Mengmeng Hou, Qiubing Chen, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Environmental stimuli, including pH, light and temperature, have been utilized for activating controlled drug delivery to achieve efficient antitumor therapeutics while minimizing undesirable side effects. In this study, a multifunctional nanoplatform based on hollow mesoporous copper sulfide nanoparticles (H-CuS NPs) was developed by loading the interior cavity of the NPs with a drug-loaded phase change material (PCM, 1-tetradecanol). Doxorubicin (DOX) and chlorin e6 (Ce6) were selected as the model chemotherapeutic drug and photosensitizer, respectively, which were encapsulated in H-CuS NPs via the PCM to form H-CuS@PCM/DOX/Ce6 (HPDC) NPs...
December 12, 2018: ACS Applied Materials & Interfaces
Fernanda Ramos-Gomes, Wiebke Möbius, Luigi Bonacina, Frauke Alves, Marietta Andrea Markus
Recently, second harmonic generation (SHG) nanomaterials have been generated that are efficiently employed in the classical (NIR) and extended (NIR-II) near infrared windows using a multiphoton microscope. The aim was to test bismuth ferrite harmonic nanoparticles (BFO-HNPs) for their ability to monitor pulmonary macrophages in mice. BFO-loaded MH-S macrophages are given intratracheally to healthy mice or BFO-HNPs are intranasally instilled in mice with allergic airway inflammation and lung sections of up to 100 μM are prepared...
December 10, 2018: Small
Beena Kumari, Akanksha Yadav, Sushree P Pany, P I Pradeepkumar, Sriram Kanvah
Guanine (G) quadruplexes (G4) are nucleic acid secondary structures formed by G-rich sequences, commonly found in human telomeric and oncogene-promoter regions, have emerged as targets for regulation of multiple biological processes. Considering their importance, targeting the G-quadruplex structure with small molecular binders is extremely pertinent. In this work, red emitting water soluble fluorophores bearing push-pull substituents were synthesized and examined for their interaction with human telomeric G4 and duplex (ds) -DNAs...
October 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
Yuehui Zhao, Keyan Wei, Fanpeng Kong, Xiaonan Gao, Kehua Xu, Bo Tang
NADH and NADPH are ubiquitous coenzymes in all living cells and play vital roles in numerous redox reactions in cellular energy metabolism. To accurately detect the distribution and dynamic changes of NAD(P)H under physi-ological condition is essential for understanding its biological functions and pathological roles. In this work, we developed a near-infrared (NIR) emission fluorescent small-molecule probe (DCI-MQ) composed of a dicyanoisophorone chromophore conjugated with a quinolinium moiety for in vivo NAD(P)H detection...
December 11, 2018: Analytical Chemistry
Xunzhou Yu, Danfeng He, Ximu Zhang, Hongmei Zhang, Jinlin Song, DeZhi Shi, Yahan Fan, Gaoxing Luo, Jun Deng
Since generating toxic reactive oxygen (ROS) is largely dependent on oxygen, bacteria infected wounds hypoxia significantly inhibits photodynamic therapy's (PDT) antibacterial efficiency. Therefore, a novel therapeutic method for eradicating multidrug-resistant bacteria is developed based on the light-activated alkyl free radical generation (that is oxygen-independent). According to the polydopamine coated carboxyl graphene (PDA@CG), an initiator-loaded and pH-sensitive heat-producible hybrid of bactericides was synthesized...
December 7, 2018: ACS Applied Materials & Interfaces
Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu, Lin Tian
BACKGROUND: Silicosis is a common occupational disease, characterized by silicotic nodules and diffuse pulmonary fibrosis. We demonstrated an anti-fibrotic effect of bone marrow mesenchymal stem cells (BMSCs) in silica-induced lung fibrosis. In the present study, we sought to clarify the homing ability of BMSCs and the specific mechanisms for their effects. METHODS AND RESULTS: The biodistribution of BMSCs was identified by near-infrared fluorescence (NIRF) imaging in vivo and in vitro...
December 4, 2018: Stem Cell Research & Therapy
Ziming Zheng, Hongjuan Li, Shiguo Sun, Yongqian Xu
Abnormal level of proteins is proved to be associated with diseases. Thus, protein sensing is helpful for clinical diagnosis and therapy. However, there is a great variety of protein species and relatively low concentration of each protein in complicated biological systems including other non-protein biomolecules. Therefore, it remains challenging to develop an effective method for detecting protein with high selectivity and sensitivity. Herein, a new self-assembly method based on a robust dye SQSS of which two squaraine molecules were conjugated through disulfide bond was developed for highly selective and sensitive detection of serum albumin (SA) in aqueous solution and live cells...
December 4, 2018: ACS Applied Materials & Interfaces
Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Rie Takashima, Masaki Morishita, Toshiyasu Sakane, Akira Yamamoto
l-cysteine (Cys)- and l-serine (Ser)-modified, third-generation polyamidoamine (PAMAM) dendrimer with multiple reduced thiols (Ser-PAMAM-Cys) was synthesized as a kidney-targeting reactive oxygen species (ROS) scavenger to help prevent renal ischemia/reperfusion injury. Ser-PAMAM-Cys effectively scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and ROS (hydrogen peroxide and hydroxyl radical) in phosphate-buffered saline (PBS). In addition, ~64% of 111 In-labeled Ser-PAMAM-Cys accumulated in mouse kidney 3 h after intravenous administration...
December 1, 2018: Pharmaceutics
Caterina Santi, Lorenzo Casali, Christian Franzini, Alessio Rollo, Vincenzo Violi
Recently, Indocyanine Green (ICG)-enhanced fluorescence has been introduced in laparoscopic colorectal surgery to provide detailed anatomical informations. The aim of our study is the application of ICG imaging during laparoscopic colorectal resections: to assess anastomotic perfusion to reduce the risk of anastomotic leak, to facilitate vascular dissection when vascular anatomy of tumor site is unclear, and to identify ureter to prevent iatrogenic injury. After the transection, 5 ml of ICG solution is intravenously injected...
December 3, 2018: Updates in Surgery
Jacopo Desiderio, Stefano Trastulli, Alessandro Gemini, Domenico Di Nardo, Giorgio Palazzini, Amilcare Parisi, Vito D'Andrea
In recent years, some researchers have tried to find a way to improve the surgical identification of the lymphatic drainage routes and lymph node stations during radical gastrectomy, thus starting a new research frontier in this field called " navigation surgery". Among the different reported solutions, the introduction of the indocyanine green (ICG) has drawn attention for its characteristics, a fluorescence dye that can be detected in the near infrared spectral band (NIR). A fluorescence imaging technology has been integrated in the latest version of the Da Vinci robotic system and surgeons have extensively reported their experiences in colorectal and hepato-biliary surgery for tumors, vascular and lymphatic structures visualization...
October 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Longguang Tang, Xiaoli Sun, Nian Liu, Zijian Zhou, Fei Yu, Xianzhong Zhang, Xiaolian Sun, Xiaoyuan Chen
To meet the criteria of effective theranostics, biocompatible nanomedicine endowing intrinsic therapeutic and imaging properties have gained extraordinary momentum. In this study, an ultra-stable near-infrared (NIR) dye croconaine (CR780) was engineered with arginine-glycine-aspartic acid (RGD) peptide and polyethylene glycol (PEG), which was then self-assembled into uniform nanoparticles (NPs). These RGD-CR780-PEG5K assemblies were radiolabeled with 125 I through a facile standard Iodo-Gen method. The resulting [125 I]RGD-CR780-PEG5K NPs showed effective accumulation in αv β3 integrin expressing glioblastoma, as evidenced by single photon emission computed tomography (SPECT)/CT and NIR fluorescence imaging...
April 27, 2018: ACS applied nano materials
Junichi Kaneko, Takashi Kokudo, Yoshinori Inagaki, Kiyoshi Hasegawa
Indocyanine green (ICG) is not new in the field of liver surgery. Early studies performed in the 1980s and 1990s revealed the value of the ICG clearance test in predicting post-hepatectomy morbidity and mortality. ICG clearance and retention tests are crucial for determining precise liver function before liver surgery and offer several benefits for safe surgery. Whereas ICG is well-known and has long history in medicine, recent progress in infrared light technology over the last decade has highlighted another feature of ICG...
2018: Translational Gastroenterology and Hepatology
Vadim G Pischik, Aleksandr Kovalenko
Background: According to recent studies, thoracoscopic segmentectomy is an acceptable alternative to lobectomy for treating different lung diseases. This approach appears to have equivalent rates of postoperative morbidity with potentially similar long-term results even in selected lung cancer patients. At the same time, surgical success is highly dependent on intraoperative interpretation of segmental anatomy. We aimed to analyze our lung segmentectomy experience and identify the role of indocyanine green (ICG)-fluorescence for intersegmental plane detection...
November 2018: Journal of Thoracic Disease
Bingbing Ding, Yuling Xiao, Hui Zhou, Xiao Zhang, Chunrong Qu, Fuchun Xu, Zixin Deng, Zhen Cheng, Xuechuan Hong
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes with both absorption and emission in NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in NIR-IIa (1300-1400 nm) sub-window under 1064 nm excitation with that in NIR-II window under 808 nm excitation...
December 2, 2018: Journal of Medicinal Chemistry
Gongchun Li, Yongxiang Liu, Xiaopeng Yang, Yong Ye
A near-infrared ICT-based fluorescent probe LX was successfully obtained. LX which detection limit is low as 22.2 nm shows excellent selectivity and high sensitivity to diazane. LX can selectively detected diazane from other species over a wide pH (3-10) range. A obvious color change of solution from yellow to orange can be found, allowing the naked eye to detect. The sensing mechanism was reasonably detected by ESI-MS and DFT calculations. In addition, LX succeed in the visualization of diazane in living cells and the detection of diazane in water samples...
November 29, 2018: Journal of Fluorescence
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