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NIR Fluorescence

Yu Liu, Xu-Man Chen, Yong Chen, Qilin Yu, Bo-Han Gu
Organelle-targeted cell imaging still remains a key challenge in supramolecular chemistry in recent years. Herein, we report a two-stage mediated near-infrared (NIR) emissive supramolecular assembly for lysosome-targeted cell imaging. In this system, 4,4'-anthracene-9,10-diylbis(ethene-2,1-diyl))bis(1-ethylpyridin-1-ium) bromide (ENDT) has been synthesized as an organic dye with weak fluorescence emission at 625nm. When ENDT complexes with cucurbit[8]uril (CB[8]), this binary supramolecular complex assembles into nanorods and achieve a near-infrared fluorescence emission (655 nm) and fluorescence enhancement as the first stage...
August 11, 2018: Angewandte Chemie
Eva Achbergerová, Daniela Šmejkalová, Gloria Huerta-Angeles, Karel Souček, Martina Hermannová, Hana Vágnerová, Robert Vícha, Vladimír Velebný
Development of delivery systems which allow real-time visual inspection of tumors is critical for effective therapy. Near-infrared (NIR) fluorophores have a great potential for such an application. To overcome NIR dyes short blood circulation time and increase tumor accumulation, a NIR dye, cypate, was associated with oleyl hyaluronan, which can self-assemble into polymeric aggregates. The cypate association with oleyl hyaluronan was performed either by a covalent linkage, or physical entrapment. The two systems were compared for tumor targeting and contrast enhancement using BALB/c mice bearing 4T1 breast cancer tumors...
October 15, 2018: Carbohydrate Polymers
Chenxu Yan, Zhiqian Guo, Yajing Liu, Ping Shi, He Tian, Wei-Hong Zhu
The translation of biomarker sensing into programmable diagnostics or therapeutic applications in vivo is greatly challenging, especially for eliminating the 'false positive' signals from OR logic gates. Herein we present a sense-of-logic dual-channel nanoprobe, operating through a sequence-activated AND logic gate by responding ultra-sensitively to pH changes and being subsequently triggered with biothiol for the controllable release of anti-cancer drugs. Specifically, programmable drug release is conducted in a multistage tumor microenvironment (acidic endocytic organelles followed by abnormal glutathione-overexpressing cell cytosol), which is synchronous with dual-channel near-infrared (NIR) fluorescence output...
August 7, 2018: Chemical Science
Prabhpreet Singh, Lalit Singh Mittal, Kapil Kumar, Poonam Sharma, Gaurav Bhargava, Subodh Kumar
We report Pb2+-mediated interlocked hexagonal self-assembly associated with the near-IR (660 nm) 'turn-on' detection of Pb2+ ions (LOD = 25 nM) in water using a perylene diimide derivative (PDI-HQ). The PDI-HQ-Pb2+ complex was further used to develop a fluorescent NIR ensemble for the detection of thiols.
August 8, 2018: Chemical Communications: Chem Comm
Xiao Zheng, Fan Zhang, Yawei Zhao, Jing Zhang, Jianati Dawulieti, Yue Pan, Lianzhi Cui, Madi Sun, Dan Shao, Mingqiang Li, Kan He, Ming Zhang, Jing Li, Li Chen
Despite the vital role miRNA-27a plays in driving the development and progress of liver cancer, miRNA-based inhibition therapy is hampered due to its undesired degradation and off-target effects. Herein, a multifunctional nanoparticle for noninvasive tracking of targeted delivery of anti-miR-27a oligonucleotides against liver cancer was constructed. Methods: Dual-fluorescent conjugates (QD-HA-PEI) were first fabricated through crosslinking hyaluronic acid (HA), polyethyleneimine (PEI) and near-infrared (NIR) fluorescent quantum dots (QDs) via a facile one-pot approach...
2018: Theranostics
Ugo Caruso, Barbara Panunzi, Rosita Diana, Simona Concilio, Lucia Sessa, Rafi Shikler, Shiran Nabha, Angela Tuzi, Stefano Piotto
The effects of aggregation-induced emission (AIE) and of aggregation caused quenching (ACQ) were observed and discussed on two solid materials based on a phenylenevinylene (PV) and a dicyano-PV structure. The brightest emitter in solid films shows a high fluorescence quantum yield in the deep red/near IR (DR/NIR) region (75%). The spectroscopic properties of the two crystalline solids have been described and compared in terms of crystallographic data and time dependent DFT analysis. The influence of the cyano-substituents on AIE/ACQ mechanism activation was discussed...
August 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shiwu Li, Xia Ling, Yuhan Lin, Anjun Qin, Meng Gao, Ben Zhong Tang
Photoactivatable fluorescent probes are ideal tools for organelle study with a significant advantage of high spatiotemporal resolution. However, conventional photo-caged fluorophores for organelle-specific imaging suffer from several drawbacks, such as aggregation-caused quenching (ACQ), instability under ambient light, low photoactivation efficiency, and toxic photo-cleavage byproducts. Herein, we propose a strategy for in situ generation of photoactivatable aggregation-induced emission (AIE) probes of 2-(2-hydroxyphenyl)-benzothiazolines from easily available disulfide and thiol substrates through tandem S-S bond reduction and intramolecular cyclization reaction...
July 14, 2018: Chemical Science
Jeffery Chakedis, Lawrence A Shirley, Alicia M Terando, Roman Skoracki, John E Phay
BACKGROUND: Injury to the thoracic duct (TD) is the most common complication after a left lateral neck dissection, and it carries a high degree of morbidity. Currently, no routine diagnostic imaging is used to assist with TD identification intraoperatively. This report describes the first clinical experience with lymphangiography using indocyanine green (ICG) during lateral neck dissections. METHODS: In six patients undergoing left lateral neck dissection (levels 2-4) for either thyroid cancer or melanoma, 2...
August 3, 2018: Annals of Surgical Oncology
Zheng Zheng, Tianfu Zhang, Haixiang Liu, Yuncong Chen, Ryan T K Kwok, Chao Ma, Pengfei Zhang, Herman H-Y Sung, Ian D Williams, Jacky W Y Lam, Kam Sing Wong, Ben Zhong Tang
Far red/near-infrared (NIR) fluorescent materials possessing the characteristics of strong two-photon absorption and aggregation-induced emission (AIE) as well as specific targeting capability are much sought after for bioimaging and therapeutic applications for their deeper penetration depth and higher resolution. Herein, a series of dipolar far red/NIR AIE luminogens with strong push-pull effect are designed and synthesized. The obtained fluorophores display bright far red/NIR solid-state fluorescence with high quantum yield of up to 30%, large Stokes shifts of up to 244 nm and large two-photon absorption cross-section of up to 887 GM...
August 3, 2018: ACS Nano
Yasuharu Oguchi, Tetsuju Sekiryu, Mika Takasumi, Yuko Hashimoto, Minoru Furuta
PURPOSE: To determine histopathologic characteristics of near-infrared autofluorescence (NIR-AF) and short-wave autofluorescence (SW-AF) in ocular tissue. STUDY DESIGN: Retrospective study. METHODS: Unstained specimens from four enucleated eyes with uveal melanoma were prepared for evaluation by fluorescence microscopy. The filter settings for SW-AF were 450-490 nm for excitation, 500-550 nm for emission and for NIR-AF 672.5-747.5 nm and 765-855 nm respectively...
August 2, 2018: Japanese Journal of Ophthalmology
JinHong Jiang, YaLi Peng, XueYa Liang, Shu Li, Xin Chang, LongFei Li, Min Chang
Cortistatin-14 (CST-14), a recently discovered cyclic neuropeptide, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus. However, the role of CST-14 in the control of depression processes is not still clarified. Here, we tested the behavioral effects of CST-14 in the in a variety of classical rodent models of depression [forced swimming test (FST), tail suspension test (TST) and novelty-suppressed feeding test]...
2018: Frontiers in Pharmacology
Congping Chen, Zhuoyi Liang, Biao Zhou, Xuesong Li, Caleb Lui, Nancy Y Ip, Jianan Qu
Abnormal deposition of brain amyloid is a major hallmark of Alzheimer's disease (AD). The toxic extracellular amyloid plaques originating from the aberrant aggregation of beta-amyloid (Aβ) protein are considered to be the major cause of clinical deficits such as memory loss and cognitive impairment. Two-photon excited fluorescence (TPEF) microscopy provides high spatial resolution, minimal invasiveness and long-term monitoring capability. TPEF imaging of amyloid plaques in AD transgenic mice models has greatly facilitated the studies of AD pathological mechanism...
August 1, 2018: ACS Chemical Neuroscience
Jade E Jones, Susheel Bhanu Busi, Jonathan B Mitchem, James M Amos-Landgraf, Michael R Lewis
The goal of these studies was to use a tumor-targeting, near-infrared (NIR) fluorescent peptide to evaluate early detection and to guide surgical removal of polyps in a genetically engineered rat model of spontaneous colorectal cancer. This peptide, LS301, was conjugated to Cy7.5 and applied topically to the colon of adenoma-bearing Pirc rats. Ten minutes after administration, rats underwent targeted NIR laser colonoscopy. Rats were also evaluated by white light colonoscopy and narrow-band imaging, for comparison to the NIR technique...
January 2018: Molecular Imaging
Mohamed E El-Khouly
The singlet-singlet and triplet-triplet energy transfer studies between two light harvesting phthalocyanine derivatives namely, zinc tert-butyl phthalocyanine ZnTBPc, and zinc octabutyloxy phthalocyanine ZnOBuPc, have been investigated to mimic the efficient energy-transfer process among the chlorophyll units in the natural photosynthesis. Optical absorption and emission studies showed the strong absorption and fluorescence bands for ZnOBuPc in the NIR region, which are largely red-shifted compared to that of the ZnTBPc...
July 24, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Guanglei Li, Yu Otsuka, Takuya Matsumiya, Toshiyuki Suzuki, Jianye Li, Masashi Takahashi, Koji Yamada
In this study, a series of new red and near-infrared (NIR) dyes derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) were developed by introducing thiophene and its derivatives to the 3- and 5- positions of the dichloroBODIPY core. For the first time, cyclictriol boronates and N-methyliminodiacetic acid (MIDA) boronate were used as organoboron species to couple with 3,5-dichloroBODIPY via the one-step Suzuki⁻Miyaura cross-coupling. Six kinds of thieno-expended BODIPY dyes were synthesized in acceptable yields ranging from 31% to 79%...
July 27, 2018: Materials
Ji Qi, Chaowei Sun, Dongyu Li, Hequn Zhang, Wenbin Yu, Abudureheman Zebibula, Jacky W Y Lam, Wang Xi, Liang Zhu, Fuhong Cai, Peifa Wei, Chunlei Zhu, Ryan T K Kwok, Lina L Streich, Robert Prevedel, Jun Qian, Ben Zhong Tang
Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is the shallow penetration depth. Two-photon fluorescence microscopic imaging with excitation in the longer-wavelength near-infrared (NIR) region (> 1100 nm) and emission in the NIR-I region (650-950 nm) is a good choice to realize deep-tissue and high-resolution imaging. Here, we report ultradeep two-photon fluorescence bioimaging with 1300-nm NIR-II excitation and NIR-I emission (peak ~810 nm) based on a NIR aggregation-induced emission luminogen (AIEgen)...
July 30, 2018: ACS Nano
Junwei Zhao, Hai-Lou Li, Ya-Jie Liu, Ya-Min Li, Li-Juan Chen, Guo-Yu Yang
In the presence of the larger [H2N(CH3)2]+ and K+ counter cations as structure-stabilizing agents, a class of unprecedented selenium and lanthanide (Ln) simultaneously bridging tetra-vacant Dawson-like selenotungstate aggregates [H2N(CH3)2]2Na9K2H19{[Ln4W4 Se4O22(H2O)5](Se2W14O52)2}2*60H2O [Ln = TbIII (1), DyIII (2), HoIII (3), ErIII (4), TmIII (5), YbIII (6)] have been obtained by reaction of the one-pot assembly reaction of Na2WO4*2H2O, Ln(NO3)3*6H2O and Na2SeO3 under moderately acidic aqueous conditions and structurally characterized by elemental analyses, IR spectra, single-crystal X-ray diffraction, powder X-ray diffraction (PXRD) and thermogravimetric (TG) analyses...
July 30, 2018: Chemistry, An Asian Journal
Taku Sato, Mudathir Bakhit, Kyouichi Suzuki, Jun Sakuma, Masazumi Fujii, Yuta Murakami, Yuhei Ito, Ulrich Sure, Kiyoshi Saito
BACKGROUND: Intraoperative indocyanine green videoangiography (ICG-VA) has been reported to be utilized in various cerebrovascular surgeries, wherein the blood flow is noticeably shown in white with a black background. ICG flow alone, but not other structures, can be observed using ICG-VA. We developed a novel high-resolution intraoperative imaging system using laser light source for simultaneously visualizing both visible light and near-infrared (NIR) fluorescence images of ICG-VA. METHODS: We used a novel system for 14 cerebrovascular cases...
July 27, 2018: Cerebrovascular Diseases Extra
Eman Shawky, Reham S Ibrahim
Quality control of propolis being a complex mixture of compounds that are very difficult to analyze and standardize is certainly challenging. Shown on the example of 35 Egyptian propolis samples, a strategy for an improved quality control was demonstrated in which efficacy-directed fingerprint analysis of high-performance thin-layer chromatography (HPTLC) fingerprints were evaluated in combination with Near Infra-Red spectrometry (NIRS) to realize precise discrimination and high quality assessment of chemical and effective consistency of propolis samples that are collected from various geographical locations in Egypt...
July 23, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Xiaodong Zeng, Yuling Xiao, Jiacheng Lin, Shanshan Li, Hui Zhou, Jinxia Nong, Guozhen Xu, Hongbo Wang, Fuchun Xu, Junzhu Wu, Zixin Deng, Xuechuan Hong
The development of novel biodegradable and nontoxic fluorophores that integrate diagnosis and therapy for effective cancer treatment has obtained tremendous attention in the past decades. In this report, water-soluble and biocompatible small-molecule near-infrared II (NIR-II) fluorescent dye H2a-4T complexed with fetal bovine serum (FBS) and Cetuximab proteins with excellent optical properties and targeting ability is prepared. High spatial and temporal resolution imaging of hind limb vasculature and the lymphatic system of living mice using H2a-4T@FBS complex is demonstrated in precise NIR-II imaging-guided sentinel lymph node surgery...
July 26, 2018: Advanced Healthcare Materials
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