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NIR Fluorescence

Bing Bai, Chenxu Yan, Yutao Zhang, Zhiqian Guo, Wei-Hong Zhu
A curcuminoid difluoroboron-based tumor-targeting GGT-activatable fluorescent probe (Glu-DFB-biotin) is designed, which has remarkable characteristics of dual-channel and light-up near-infrared (NIR) fluorescence. Furthermore, Glu-DFB-biotin can differentiate hepatic cancer cells from normal cells and is successfully employed for real-time tracking of endogenous GGT activity in living cells.
October 17, 2018: Chemical Communications: Chem Comm
Sarah Madeline Fothergill, Caoimhe Joyce, Fang Xie
To increase disease survival rates, there is a vital need for diagnosis at very preliminary stages. Then, low concentrations of biomarkers are present which must be effectively detected and quantified for reliable diagnosis. Fluorescent biosensing is commonly enabled through the labelling of these biomarkers with nanostructures and fluorophores. Metal Enhanced Fluorescence (MEF) is a phenomenon whereby the intensity of a fluorescent biosensor signal can be considerably enhanced by placing a metallic nanostructure and fluorophore in close proximity...
October 16, 2018: Nanoscale
Hu Ou, Jing Chen, Pengfei Gao, Gangfeng Li, Shijie Du, Haiyan Fu, Qiong Shi, Lu Xu
BACKGROUND: This paper investigated the feasibility of data fusion of NIR and fluorescence spectroscopy for rapid analysis of cheap vegetable oils in Chinese Camellia Oleifera Abel. (COA) oil. Because practical frauds usually involve adulterations of multiple known and unknown cheap oils, traditional analytical methods aimed at detecting one or more known adulterants are insufficient to identify adulterated COA oil. Therefore, untargeted analysis was performed by developing class models of pure COA oil using robust one-class partial least squares (OCPLS)...
October 16, 2018: Journal of the Science of Food and Agriculture
Damayanti Bagchi, V S Sharan Rathnam, Peter Lemmens, Indranil Banerjee, Samir Kumar Pal
Nanomaterials with antimicrobial properties triggered by external stimuli appear to be a promising and innovative substitute for the destruction of antibiotic-resistant superbugs as they can induce multiple disruptions in the cellular mechanism. This study demonstrates the use of squaraine (SQ) dye as the photosensitive material, activated in the near-infrared tissue-transparent therapeutic window. The dye has been covalently attached to the ZnO nanoparticle surface, forming ZnO-SQ nanohybrids. The formation of the nanohybrids is confirmed using Fourier transform infrared and other optical spectroscopic methods...
September 30, 2018: ACS Omega
Jen-Shyang Ni, Pengfei Zhang, Tao Jiang, Yuncong Chen, Huifang Su, Dong Wang, Zhen-Qiang Yu, Ryan T K Kwok, Zujin Zhao, Jacky W Y Lam, Ben Zhong Tang
Aggregation-induced emission (AIE) luminogens (AIEgens) with red/near-infrared (NIR) emissions are appealing for applications in optoelectronics and biomedical engineering owing to their intrinsic advantages of efficient solid-state emission, low background, and deep tissue penetration. In this context, an AIEgen with long-wavelength emission is synthesized by introducing tetraphenylethene (TPE) to the periphery of electron-deficient spiro-benzo[d]imidazole-2,1'-cyclohexane (BI). The resulting AIEgen, abbreviated as 2TPE-BI, adopts a donor-acceptor structure and shows bathochromic absorption and emission with a larger Stokes shift of 157 nm in acetonitrile than that based on benzo[c][1,2,5]thiadiazole...
October 15, 2018: Advanced Materials
Pan Yuan, Zheng Ruan, Tuanwei Li, Youliang Tian, Quan Cheng, Lifeng Yan
Tumor environmental sensitive polypeptide integrated photosensitizers is a platform for imaging-guided photodynamic therapy (PDT). However, the photosensitizer leakage during blood circulation, poor accumulation in tumor tissue and inferior quantum yield of singlet oxygen are still challenges. Herein, NHS-active boron-dipyrromethene derivative with bromine substituted NHS-BODIPY-Br2 was first synthesized, which possessed high singlet oxygen generation efficiency and near infrared (NIR) fluorescence, and then it was conjugated to a sharp pH (6...
October 11, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Muhammad Raisul Abedin, Siddesh Umapathi, Harika Mahendrakar, Tunyaboon Laemthong, Holly Coleman, Denise Muchangi, Santimukul Santra, Manashi Nath, Sutapa Barua
BACKGROUND: Engineered inorganic nanoparticles (NPs) are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases however, functionalization is not sufficient: the particles become either coated by a corona of serum proteins or precipitate out of the solvent. We show that by changing the coating of magnetic iron oxide NPs using poly-L-lysine (PLL) polymer the colloidal stability of the dispersion is improved in aqueous solutions including water, phosphate buffered saline (PBS), PBS with 10% fetal bovine serum (FBS) and cell culture medium, and the internalization of the NPs toward living mammalian cells is profoundly affected...
October 13, 2018: Journal of Nanobiotechnology
S Favril, E Stock, S Hernot, M Hesta, I Polis, K Vanderperren, H de Rooster
Sentinel lymph node (SLN) mapping is a valuable and crucial diagnostic procedure in staging malignancies. We compared two non-invasive techniques, near-infrared (NIR) fluorescence imaging and contrast-enhanced ultrasound (CEUS), to identify the SLNs in 3 superficial anatomical regions in an animal model. Six healthy laboratory dogs were included in a proof-of-concept trial. A NIR fluorescent dye (Indocyanine Green) and microbubbles (Sonovue) were consecutively injected subdermally in the inguinal, axillary, and popliteal region to map the SLNs...
October 11, 2018: Veterinary and Comparative Oncology
Wei Sheng, Setare Tahmasebi Nick, Elizabeth M Santos, Xinliang Ding, Jun Zhang, Chrysoula Vasileiou, James Geiger, Babak Borhan
FR-1V, a fluorene-based aldehydic chromophore, binds its target protein as an imine to yield a highly bathochromic pigment, CF-2, a prototypic protein-dye tagging system whose NIR emission can be spatiotemporally switched ON by rapid UV-light activation. This is achieved through photoisomerization of the imine and its subsequent protonation. We demonstrate a no-wash protocol for live cell imaging of subcellular compartments in a variety of mammalian cell lines with minimal fluorescence background.
October 11, 2018: Angewandte Chemie
Hainan Yang, Zaijia Liu, Xufeng Li, Zhenfeng Zhang, Deji Chen, Hui Lian
Herein, a tumor-targeted multifunctional theranostic agent was synthetized using a facile method, combining four clinically approved materials: artesunate (Arte), human serum albumin (HSA), folic acid (FA), and indocyanine green (ICG). The obtained nanocomposites (FA-IHA NPs) showed an excellent photo- and physiological stability. The ICG in the FA-IHA NPs was used not only for near infrared (NIR) fluorescence imaging, but also for photothermal and photodynamic (PTT-PDT) therapy under a single NIR irradiation...
October 11, 2018: Nanoscale Research Letters
Leire de Juan-Fernández, Peter W Münich, Arjun Puthiyedath, Belén Nieto-Ortega, Santiago Casado, Luisa Ruiz-González, Emilio M Pérez, Dirk M Guldi
We describe the synthesis of rotaxane-type species composed of macrocyclic porphyrin rings mechanically interlocked with SWCNT threads. The formation of mechanically interlocked SWCNTs (MINTs) proceeds with chiral selectivity, and was confirmed by spectroscopic and analytical techniques and adequate control experiments, and corroborated by high-resolution electron microscopy. From a thorough characterization of the MINTs through UV-vis-NIR absorption, fluorescence, Raman, and transient absorption spectroscopy we analyse in detail the electronic interactions of the porphyrins and the SWCNTs in the ground and excited states...
September 7, 2018: Chemical Science
Ting-Ting Zhang, Cong-Hui Xu, Wei Zhao, Yu Gu, Xiang-Ling Li, Jing-Juan Xu, Hong-Yuan Chen
Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO2 ) and gold nanoshell coated silicon nanoparticles for synergistic chemo-photothermal therapy of hypoxia solid tumors. In highly reducing tumor tissues, the outer MnO2 nanosheet with the loaded drug would be dissociated by intracellular glutathione (GSH), resulting in on-demand drug release, as well as generating Mn2+ ions which provided high contrast magnetic resonance imaging (MRI), and fluorescence imaging (FI) in vitro and in vivo ...
September 7, 2018: Chemical Science
Penghui Cheng, Jianjian Zhang, Jiaguo Huang, Qingqing Miao, Chenjie Xu, Kanyi Pu
Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of diseases. Although an abnormally high RONS level has been identified in keloids - a benign dermal tumour developed after lesion, the ability of employing RONS probes for keloid detection has not yet been exploited. Herein, we report two near-infrared (NIR) fluorescent probes ( CyTF and CyBA ) that can specifically distinguish keloid fibroblasts from normal dermal fibroblasts...
August 14, 2018: Chemical Science
Suk Ho Hong, Yan Li, Joo Beom Eom, Yongdoo Choi
Background: Atherosclerosis is a major global health concern. Targeting macrophages is hypothesized as an alternative treatment for atherosclerosis. Methods: We synthesized alginate-based cisplatin-loaded nanogels (TANgel) as a pH-responsive drug-releasing theranostic nanoplatform for macrophage cells. Carboxylic acid groups of alginic acid were modified with iminodiacetic acid (IDA) to enhance chelation of platinum ions. The near infrared (NIR) fluorophore ATTO655 was conjugated to the modified alginic acid...
September 2018: Quantitative Imaging in Medicine and Surgery
Hironobu Wada, Jinzi Zheng, Alexander Gregor, Kentaro Hirohashi, Hsin-Pei Hu, Priya Patel, Hideki Ujiie, Tatsuya Kato, Takashi Anayama, David A Jaffray, Kazuhiro Yasufuku
OBJECTIVE: A novel liposomal nanoparticle, CF800, that co-encapsulates indocyanine green for near-infrared (NIR) imaging and iohexol for CT imaging has shown preferential tumor accumulation after intravenous injection via the enhanced permeability and retention (EPR) effect. We hypothesized that CF800-enhanced NIR imaging would facilitate intraoperative localization of small lung nodules. METHODS: A rabbit VX2 lung tumor model was implemented. CF800 was injected intravenously followed by sequential CT acquisitions to track the biodistribution of CF800...
October 5, 2018: Annals of Thoracic Surgery
Sakkarapalayam M Mahalingam, Sumith A Kularatne, Carrie H Myers, Pravin Gagare, Mohammad Norshi, Xin Liu, Sunil Singhal, Philip S Low
Because the most reliable therapy for cancer involves quantitative resection of all diseased tissue, considerable effort has been devoted to improving a surgeon's ability to locate and remove all malignant lesions. With the aid of improved optical imaging equipment, we and others have focused on developing tumor-targeted fluorescent dyes to selectively illuminate cancer nodules during surgery. We describe here the design, synthesis, optical properties, in vitro and in vivo tumor specificity/affinity, pharmacokinetics, preclinical toxicology and some clinical application of a folate receptor (FR)-targeted NIR dye (OTL38) that concentrates specifically in cancer tissues and clears rapidly from healthy tissues...
October 8, 2018: Journal of Medicinal Chemistry
Yu Gao, Huijuan Zhang, Yingying Zhang, Tingting Lv, Lu Zhang, Ziying Li, Xiaodong Xie, Fengqiao Li, Haijun Chen, Lee Jia
The outcome of molecular targeted therapies is restricted by the ambiguous molecular subtypes of non-small cell lung cancer (NSCLC) which are difficult to be defined with druggable mutations, and the inevitable emergence of drug-resistance. Here we used the Cu-catalyzed click chemistry to synthesize a chitosan-based self-assembled nanotheranostics (CE7Ns) composing of a near-infrared (NIR) fluorescent photosensitizer Cy7 and molecular targeted drug erlotinib. The well-characterized CE7Ns can release erlotinib and Cy7 fast under acidic condition in the presence of lysozyme, distinguish three molecular subtypes of NSCLC and specifically bind to the erlotinib-sensitive EGFR-mutated PC-9 cells...
October 8, 2018: Molecular Pharmaceutics
Sorel Kurbegovic, Karina Juhl, Hao Chen, Chunrong Qu, Bingbing Ding, Julie Maja Leth, Krzysztof Tadeusz Drzewiecki, Andreas Kjær, Zhen Cheng
Optical imaging strategies for improving delineation of glioblastoma (GBM) is highly desired for guiding surgeons to distinguish cancerous tissue from healthy and precious brain tissue. Fluorescence imaging (FLI) in the second near-infrared window (NIR-II) outperforms traditional NIR-I imaging with better tissue penetration, higher spatial and temporal resolution, and less auto fluorescence and scattering. Because of high expression in GBM and many other tumors, urokinase Plasminogen Activator Receptor (uPAR) is an attractive and well proven target for FLI...
October 8, 2018: Bioconjugate Chemistry
Yongquan Wu, Aiping Shi, Yuanyan Li, Hong Zeng, Xiaoyong Chen, Jie Wu, Xiaolin Fan
Peroxynitrite (ONOO-) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO- in physiological conditions is imperative for elucidating its functions. However, studies on high signal-to-noise-ratio (SNR) fluorescence imaging of ONOO- in vivo for its detection are currently lacking. Thus, a novel NIR xanthene fluorescence probe (NOF2) for the endogenous detection of ONOO- is designed and synthesized...
October 8, 2018: Analyst
Zihnil Adha Islamy Mazrad, Pham Thi My Phuong, Cheong A Choi, Insik In, Kang Dae Lee, Sung Young Park
In the present study, pH/redox responsive cationic polymer dot (CD) was successfully prepared for a near-infrared (NIR)-mediated simultaneously controllable photothermal temperature guided imaging off/on system to monitor therapeutic delivery. The carbonized disulfide crosslinked branched-polyethyleneimine (bPEI) with a folic acid (FA) conjugation as the targeting moiety and a partially ionic complex between anionic indocyanine green (ICG) and bPEI-based CD (ICG-CD). This was responsive to mild reductive (GSH) and acidic tumor conditions, which enabled the simultaneous biodegradation of those hydrophobic and complex sites...
October 4, 2018: ChemMedChem
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