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Cardiovascular depression

Jasvinder A Singh, John D Cleveland
We used the 5% random Medicare claims from Americans 65 years or older from 2006-2012 to examine the association of gout with the risk of developing incident (new) depression using multivariable-adjusted Cox proportional hazards model, adjusting for demographics (age, race, sex), common cardiovascular medications, allopurinol, and febuxostat and medical comorbidity. Of the 1.69 million people, 142,596 developed depression. In multivariable-adjusted analyses, gout was independently associated with 42% higher hazard of depression in older adults, confirmed in sensitivity analyses...
December 2018: Psychiatry Research
Michael Kellner, Christoph Muhtz, Åsa Weinås, Stjepan Ćurić, Alexander Yassouridis, Klaus Wiedemann
While the impact of childhood trauma on basal and dynamic cortisol regulation has widely been studied, the most abundant steroid hormones dehydroepiandrosterone (DHEA) and its sulphated derivative DHEA-S have received little attention in this context. One-hundred in-door patients suffering from major depression or an anxiety disorder filled in the Childhood Trauma Questionaire. A low dose dexamethasone suppression test (DST) measuring DHEA, DHEA-S and cortisol was performed. Furthermore, various cardiovascular risk parameters were measured...
December 2018: Psychiatry Research
Guannan He, Yanchun Liang, Yan Chen, William Yang, Jun S Liu, Mary Qu Yang, Renchu Guan
BACKGROUND: Nowadays, because of the huge economic burden on society causing by obesity and diabetes, they turn into the most serious public health challenges in the world. To reveal the close and complex relationships between diabetes, obesity and other diseases, search the effective treatment for them, a novel model named as representative latent Dirichlet allocation (RLDA) topic model is presented. RESULTS: RLDA was applied to a corpus of more than 337,000 literatures of diabetes and obesity which were published from 2007 to 2016...
December 14, 2018: BMC Systems Biology
Emma Thomas, Mojtaba Lotfaliany, Sherry L Grace, Brian Oldenburg, C Barr Taylor, David L Hare, Wp Thanuja Rangani, Ds Anoja F Dheerasinghe, Dominique A Cadilhac, Adrienne O'Neil
BACKGROUND: Ageing populations and increasing survival following acute coronary syndrome has resulted in large numbers of people living with cardiovascular disease and at high risk of hospitalizations. Rising hospital admissions have a significant financial cost to the healthcare system. AIM: The purpose of this study was to determine whether cardiac rehabilitation is protective against long-term hospital readmission (frequency and length) following acute coronary syndrome...
December 14, 2018: European Journal of Cardiovascular Nursing
Mayara K A Ribeiro, Tereza R M Alcântara-Silva, Jordana C M Oliveira, Tamara C Paula, João B R Dutra, Gustavo R Pedrino, Karina Simões, Romes B Sousa, Ana C S Rebelo
BACKGROUND: Mothers of preterm infants often have symptoms of anxiety and depression, recognized as risk factors for the development of cardiovascular diseases and associated with low rates of heart rate variability (HRV). This study aimed to evaluate the influence of music therapy intervention on the autonomic control of heart rate, anxiety, and depression in mothers. METHODS: Prospective randomized clinical trial including 21 mothers of preterms admitted to the Neonatal Intensive Care Unit of a tertiary hospital, recruited from August 2015 to September 2017, and divided into control group (CG; n = 11) and music therapy group (MTG; n = 10)...
December 13, 2018: BMC Psychology
Dorothy A Fink, Lawrence M Nelson, Reed Pyeritz, Josh Johnson, Stephanie L Sherman, Yoram Cohen, Shai E Elizur
Abnormalities in the X-linked FMR1 gene are associated with a constellation of disorders, which have broad and profound implications for the person first diagnosed, and extended family members of all ages. The rare and pleiotropic nature of the associated disorders, both common and not, place great burdens on (1) the affected families, (2) their care providers and clinicians, and (3) investigators striving to conduct research on the conditions. Fragile X syndrome, occurring more severely in males, is the leading genetic cause of intellectual disability...
2018: Frontiers in Genetics
María Elena Soto, Roberto Cano, C Sergio Criales, Leonel Avendaño, Nilda Espínola, Carlos García
Introduction: Pectus excavatum (PE) and carinatum (PC) are common in Marfan syndrome (SM) and similar syndromes (SS). Patients can evolve without symptoms. In some there is depression, social adjustment disorders, pulmonary and cardiovascular symptoms in which there is controversy about their relationship with the structural damage of the thorax. Objective: To assess the prevalence of the type of thoracic deformity in patients with MS and SS in a historical and current cohort and to analyze the clinical, pulmonary and cardiovascular impact...
2018: Gaceta Médica de México
Giovanni Ostuzzi, Giulia Turrini, Chiara Gastaldon, Davide Papola, Lauren Rayner, Rosangela Caruso, Luigi Grassi, Matthew Hotopf, Corrado Barbui
To assess the efficacy and acceptability of antidepressants in adults with ischemic heart disease (IHD). We gathered all available randomized-controlled trials comparing antidepressants versus placebo or other antidepressants in adults with IHD. The primary outcome was depressive symptoms at the study endpoint, as measured by validated rating scales. We pooled data in a meta-analysis using a random-effects model. The confidence in the estimates (or certainty of the evidence) was assessed using the GRADE approach...
December 10, 2018: International Clinical Psychopharmacology
Eduard Vieta, Willie R Earley, Maria V Burgess, Suresh Durgam, Changzheng Chen, Yan Zhong, Ágota Barabássy, György Németh
Lack of treatment response is a critical problem in major depressive disorder (MDD). Cariprazine is a D3-preferring dopamine D3/D2 receptor partial agonist and 5-HT1A partial agonist. This phase 3, multicenter, open-label, long-term (26-week), flexible-dose (1.5-4.5 mg/day) study assessed the long-term safety and tolerability of cariprazine used adjunctively with antidepressant therapy in adult patients with MDD who had either completed a lead-in study (n=311) or had been newly recruited (n=131). A higher percentage of continuing patients (66...
December 5, 2018: International Clinical Psychopharmacology
Josep Roca, Akos Tenyi, Isaac Cano
Due to profound changes occurring in biomedical knowledge and in health systems worldwide, an entirely new health and social care scenario is emerging. Moreover, the enormous technological potential developed over the last years is increasingly influencing life sciences and driving changes toward personalized medicine and value-based healthcare. However, the current slow progression of adoption, limiting the generation of healthcare efficiencies through technological innovation, can be realistically overcome by fostering convergence between a systems medicine approach and the principles governing Integrated Care...
December 11, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Rosário Serrão, Carmela Piñero, Jorge Velez, Daniela Coutinho, Fernando Maltez, Sara Lino, Rui Sarmento E Castro, Ana Paula Tares, Patrícia Pacheco, Maria João Lopes, Kamal Mansinho, Ana Cláudia Miranda, Isabel Neves, Ricardo Correia de Abreu, Joana Almeida, Leonor Pássaro
OBJECTIVES: To characterize the profile of NARC in older HIV-1-infected population and explore the factors associated with multiple NARC. METHODS: Multicenter, cross-sectional study including HIV-1-infected patients ≥50 years, virologically suppressed and on a stable ART regimen for at least 6 months. Multiple regression model explored the association of demographic and clinical variables with the number of NARC. RESULTS: Overall, 401 patients were enrolled...
October 25, 2018: International Journal of Infectious Diseases: IJID
Laith Alexander, Philip L R Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Gemma J Cockcroft, Hannah F Clarke, Angela C Roberts
Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within ventromedial prefrontal cortex, but the causal roles of specific subregions remain unidentified. We addressed these issues by combining intracerebral microinfusions with cardiovascular and behavioral monitoring in marmoset monkeys to show that over-activation of primate subgenual anterior cingulate cortex (sgACC, area 25) blunts appetitive anticipatory, but not consummatory, arousal, whereas manipulations of adjacent perigenual ACC (pgACC, area 32) have no effect...
November 30, 2018: Neuron
Serdar Sever, Su Golder, Patrick Doherty
BACKGROUND: The literature suggests that comorbid depression, defined in this paper as a history of depression prior to a cardiovascular event, has an impact on later onset depression as well as constituting increased risk of mortality and adverse cardiac events. However, which factors are associated with depression, specifically in patients with comorbid depression, is unclear. Therefore, this paper investigates the factors associated with depression in patients with comorbid depression attending cardiac rehabilitation (CR)...
December 10, 2018: BMC Cardiovascular Disorders
Jenny M Cundiff, J Richard Jennings, Karen A Matthews
This article examines whether emotional suppression is associated with socioeconomic position (SEP) in a community sample of Black and White men, and whether emotional suppression may help explain the aggregation of multiple biopsychosocial risk factors for cardiovascular disease at lower SEP (social support, depression, cardiovascular stress reactivity). Aim 1 tests whether multiple indicators of SEP show a consistent graded association with self-reported trait suppression, and whether suppression mediates associations between SEP and perceived social support and depressive affect...
December 10, 2018: Personality & Social Psychology Bulletin
Elizabeth Novack Wright, Alexandra Hanlon, Alicia Lozano, Anne M Teitelman
Intimate partner violence (IPV), the physical, sexual, psychological abuse or control by a former or current intimate partner, affects almost one third of women in the United States. IPV exposure can result in many negative outcomes including physical injury, increased stress, and depression. Currently, there is a growing body of literature examining the link between IPV victimization and poor heart health. However, there is little known on how IPV affects cardiovascular disease (CVD) risk among young adult women and what outcomes associated with IPV victimization may be increasing this risk...
December 7, 2018: Journal of Interpersonal Violence
Duygu Koçyiğit, Lale Tokgözoğlu, Meral Kayıkçıoğlu, Servet Altay, Sinan Aydoğdu, Cem Barçın, Cem Bostan, Hüseyin Altuğ Çakmak, Alp Burak Çatakoğlu, Samim Emet, Oktay Ergene, Ali Kemal Kalkan, Barış Kaya, Cansın Kaya, Cihangir Kaymaz, Nevrez Koylan, Hakan Kültürsay, Aytekin Oğuz, Ebru Özpelit, Serkan Ünlü
OBJECTIVE: It has been reported that women receive fewer preventive recommendations regarding pharmacological treatment, lifestyle modifications, and cardiac rehabilitation compared with men who have a similar risk profile. This study was an investigation of the impact of gender on cardiovascular risk profile and secondary prevention measures for coronary artery disease (CAD) in the Turkish population. METHODS: Statistical analyses were based on the European Action on Secondary and Primary Prevention through Intervention to Reduce Events (EUROASPIRE)-IV cross-sectional survey data obtained from 17 centers in Turkey...
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Stylianos Panopoulos, Maria Tektonidou, Alexandros A Drosos, Stamatis-Nick Liossis, Theodoros Dimitroulas, Alexandros Garyfallos, Lazaros Sakkas, Dimitrios Boumpas, Paraskevi V Voulgari, Dimitrios Daoussis, Konstantinos Thomas, Georgios Georgiopoulos, Georgios Vosvotekas, Dimitrios Vassilopoulos, Petros P Sfikakis
BACKGROUND: Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studied in isolated diseases, comparative studies between different autoimmune diseases are limited. In this study, we compared the prevalence of common comorbidities between patients with systemic sclerosis (SSc) and patients with rheumatoid arthritis (RA). METHODS: Between 2016 and 2017, 408 consecutive patients with SSc, aged 59 ± 13 years (87% women), were matched 1:1 for age and gender with 408 patients with RA; mean disease duration was 10 ± 8 and 9 ± 8 years, respectively...
December 4, 2018: Arthritis Research & Therapy
Hyun Bin Kwon, Heenam Yoon, Sang Ho Choi, Jae-Won Choi, Yu Jin Lee, Kwang Suk Park
We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI). Time- and frequency-domain, and fractal HRV parameters were derived from 5-min electrocardiogram segments during light sleep, deep sleep, rapid eye movement (REM) sleep, and the pre- and post-sleep wake periods...
November 12, 2018: Psychiatry Research
Nawal Bent-Ennakhil, Marie Cécile Périer, Patrik Sobocki, Dan Gothefors, Gunnar Johansson, Dominique Milea, Jean-Philippe Empana
OBJECTIVE: To assess the incidence of cardiovascular diseases (CVD) and type-2-diabetes in patients with psychiatric disorders. METHODS: A population-based study was conducted using the Swedish national health registries. Patients were identified from the Electronic Medical Records (EMR) in 20 primary care centers and were categorized in four diagnosis cohorts according to their first psychiatric diagnosis: bipolar disorder, schizophrenia, major depressive disorder, or other mood disorder...
December 4, 2018: Nordic Journal of Psychiatry
Jessica A Grieger, Tina Bianco-Miotto, Luke E Grzeskowiak, Shalem Y Leemaqz, Lucilla Poston, Lesley M McCowan, Louise C Kenny, Jenny E Myers, James J Walker, Gus A Dekker, Claire T Roberts
BACKGROUND: Obesity increases the risk for developing gestational diabetes mellitus (GDM) and preeclampsia (PE), which both associate with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in women in later life. In the general population, metabolic syndrome (MetS) associates with T2DM and CVD. The impact of maternal MetS on pregnancy outcomes, in nulliparous pregnant women, has not been investigated. METHODS AND FINDINGS: Low-risk, nulliparous women were recruited to the multi-centre, international prospective Screening for Pregnancy Endpoints (SCOPE) cohort between 11 November 2004 and 28 February 2011...
December 2018: PLoS Medicine
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