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Clinical outcome research initiative

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https://www.readbyqxmd.com/read/30515610/the-use-of-3d-laparoscopic-imaging-systems-in-surgery-eaes-consensus-development-conference-2018
#1
Alberto Arezzo, Nereo Vettoretto, Nader K Francis, Marco Augusto Bonino, Nathan J Curtis, Daniele Amparore, Simone Arolfo, Manuel Barberio, Luigi Boni, Ronit Brodie, Nicole Bouvy, Elisa Cassinotti, Thomas Carus, Enrico Checcucci, Petra Custers, Michele Diana, Marilou Jansen, Joris Jaspers, Gadi Marom, Kota Momose, Beat P Müller-Stich, Kyokazu Nakajima, Felix Nickel, Silvana Perretta, Francesco Porpiglia, Francisco Sánchez-Margallo, Juan A Sánchez-Margallo, Marlies Schijven, Gianfranco Silecchia, Roberto Passera, Yoav Mintz
BACKGROUND: The use of 3D laparoscopic systems is expanding. The European Association of Endoscopic Surgery (EAES) initiated a consensus development conference with the aim of creating evidence-based statements and recommendations for the surgical community. METHODS: Systematic reviews of the PubMed and Embase libraries were performed to identify evidence on potential benefits of 3D on clinical practice and patient outcomes. Statements and recommendations were prepared and unanimously agreed by an international surgical and engineering expert panel which were presented and voted at the EAES annual congress, London, May 2018...
December 4, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30515006/developing-a-minimum-data-set-mds-for-cardiac-electronic-implantable-devices-implantation
#2
Hadi Kazemi-Arpanahi, Ali Vasheghani-Farahani, Abdolvahab Baradaran, Nilofar Mohammadzadeh, Marjan Ghazisaeedi
Background: There is no established minimum data set (MDS) for cardiovascular implantable electronic devices (CIEDs), which have led to a lack of standardized assessment criteria in this field to ensure access to a reliable and coherent set of data. Objective: To establish the minimum data set of CIEDs implantation that enables consistency in data gathering, uniform data reporting and data exchange in clinical and research information systems. Methods: This descriptive and cross-sectional study was conducted in 2018...
October 2018: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/30514400/dexamethasone-for-adult-patients-with-a-symptomatic-chronic-subdural-haematoma-dex-csdh-trial-study-protocol-for-a-randomised-controlled-trial
#3
Angelos G Kolias, Ellie Edlmann, Eric P Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J Hutchinson
BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20% recurrence of the CSDH. Steroids, such as dexamethasone, have been identified as a potential therapy for reducing recurrence risk in surgically treated CSDHs. They have also been used as a conservative treatment option, thereby avoiding surgery altogether. The hypothesis of the Dex-CSDH trial is that a two-week course of dexamethasone in symptomatic patients with CSDH will lead to better functional outcome at six months...
December 4, 2018: Trials
https://www.readbyqxmd.com/read/30513095/menopausal-hormone-therapy-and-the-incidence-of-carpal-tunnel-syndrome-in-postmenopausal-women-findings-from-the-women-s-health-initiative
#4
Tala Al-Rousan, Jeffrey A Sparks, Mary Pettinger, Rowan Chlebowski, JoAnn E Manson, Andrew M Kauntiz, Robert Wallace
IMPORTANCE: Carpal tunnel syndrome (CTS) is a common and debilitating condition that commonly affects postmenopausal women. OBJECTIVE: To determine the effect of menopausal hormone therapy (HT) in healthy postmenopausal women on CTS risk. DESIGN: We conducted a secondary analysis of the Women's Health Initiative's (WHI) HT trials linked to Medicare claims data. Separate intention-to-treat analyses were performed for the two trials; the conjugated equine estrogens alone (CEE alone) and the trial of CEE plus medroxyprogesterone acetate (MPA) trial...
2018: PloS One
https://www.readbyqxmd.com/read/30513071/utilization-of-high-cost-interventions-for-targeted-clinical-conditions-during-the-early-stages-of-aco-development-in-a-commercially-insured-population
#5
Siting Zhou, Michael Ciarametaro, Bingcao Wu, Joseph Singer, Robert W Dubois
This study compared utilization patterns of high-cost services and medications for patients receiving care from Accountable Care Organization (ACO)-participating physicians and those receiving care from non-ACO physicians during the initial phases of ACO development in a commercially insured environment. Patients ≥18 years (≥40 years for chronic obstructive pulmonary disease [COPD]) with prevalent rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 2 diabetes, COPD, or chronic low back pain between January 1, 2012, and August 31, 2014 were identified in the HealthCore Integrated Research DatabaseSM ...
December 4, 2018: Population Health Management
https://www.readbyqxmd.com/read/30511879/apixaban-to-prevent-venous-thromboembolism-in-patients-with-cancer
#6
Marc Carrier, Karim Abou-Nassar, Ranjeeta Mallick, Vicky Tagalakis, Sudeep Shivakumar, Ariah Schattner, Philip Kuruvilla, Danny Hill, Silvana Spadafora, Katerine Marquis, Mateya Trinkaus, Anna Tomiak, Agnes Y Y Lee, Peter L Gross, Alejandro Lazo-Langner, Robert El-Maraghi, Glenwood Goss, Gregoire Le Gal, David Stewart, Timothy Ramsay, Marc Rodger, Debra Witham, Philip S Wells
BACKGROUND: Patients with active cancer have an increased risk of venous thromboembolism, which results in substantial morbidity, mortality, and health care expenditures. The Khorana score (range, 0 to 6, with higher scores indicating a higher risk of venous thromboembolism) has been validated to identify patients with cancer at elevated risk for this complication and may help select those who could benefit from thromboprophylaxis. METHODS: We conducted a randomized, placebo-controlled, double-blind clinical trial assessing the efficacy and safety of apixaban (2...
December 4, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30511593/the-adult-adhd-quality-measures-initiative
#7
Stephen V Faraone, Michael J Silverstein, Kevin Antshel, Joseph Biederman, David W Goodman, Oren Mason, Andrew A Nierenberg, Anthony Rostain, Mark A Stein, Lenard A Adler
OBJECTIVE: Quality measures (QMs; also known as Quality Indicators) quantify health care processes, outcomes, patient perceptions, and organizational structure and/or systems that are relevant to the provision of high-quality health care. We describe the first phase of a project that has as its ultimate goal the creation and validation of QMs for tracking the screening, diagnosis, treatment, and clinical follow-up of adults with ADHD. This will fill an important gap in the field of Adult ADHD because QMs for adult ADHD do not exist...
December 4, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/30511118/modifying-the-minimum-criteria-for-diagnosing-amnestic-mci-to-improve-prediction-of-brain-atrophy-and-progression-to-alzheimer-s-disease
#8
Eero Vuoksimaa, Linda K McEvoy, Dominic Holland, Carol E Franz, William S Kremen
Mild cognitive impairment (MCI) is a heterogeneous condition with variable outcomes. Improving diagnosis to increase the likelihood that MCI reliably reflects prodromal Alzheimer's Disease (AD) would be of great benefit for clinical practice and intervention trials. In 230 cognitively normal (CN) and 394 MCI individuals from the Alzheimer's Disease Neuroimaging Initiative, we studied whether an MCI diagnostic requirement of impairment on at least two episodic memory tests improves 3-year prediction of medial temporal lobe atrophy and progression to AD...
December 4, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/30509216/protocol-for-the-development-of-a-core-outcome-set-for-pelvic-girdle-pain-including-methods-for-measuring-the-outcomes-the-pgp-cos-study
#9
Francesca Wuytack, Annelie Gutke, Britt Stuge, Siv Mørkved, Christina Olsson, Hilde Stendal Robinson, Nina K Vøllestad, Birgitta Öberg, Lena Nilsson Wikmar, Juan Jose Saldaña Mena, Valerie Smith
BACKGROUND: Pelvic Girdle Pain (PGP) is an important cause of disability and economic cost worldwide. There is a need for effective preventative and management strategies. Emerging studies measure a variety of outcomes rendering synthesis and translation to clinical practice difficult. A Core Outcome Set (COS) can address this problem by ensuring that data are relevant, useful and usable for making well-informed healthcare choices. The aim of this study is to develop a consensus-based PGP-COS, including agreement on methods (e...
December 3, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/30508190/the-route-of-administration-timing-duration-and-dose-of-postmenopausal-hormone-therapy-and-cardiovascular-outcomes-in-women-a-systematic-review
#10
Clare Oliver-Williams, Marija Glisic, Sara Shahzad, Elizabeth Brown, Cristina Pellegrino Baena, Mahmuda Chadni, Rajiv Chowdhury, Oscar H Franco, Taulant Muka
BACKGROUND: The effect of postmenopausal hormone therapy (HT) on cardiovascular disease (CVD) risk remains controversial. OBJECTIVE AND RATIONALE: We aimed to systematically review the evidence regarding the role of dose, route of hormone administration, timing of initiation and duration of HT on cardiovascular risk among postmenopausal women. SEARCH METHODS: The electronic databases Medline Ovid, Web of Science and Cochrane Central were systematically searched to identify studies published before 30 January 2018...
December 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30504299/jak2-and-other-genes-be-nimble-with-mpn-diagnosis-prognosis-and-therapy
#11
REVIEW
Michele Ciboddo, Ann Mullally
Now that the spectrum of somatic mutations that initiate, propagate, and drive the progression of myeloproliferative neoplasms (MPNs) has largely been defined, recent efforts have focused on integrating this information into clinical decision making. In this regard, the greatest progress has been made in myelofibrosis, in which high-molecular-risk mutations have been identified and incorporated into prognostic models to help guide treatment decisions. In this chapter, we focus on advances in 4 main areas: (1) What are the MPN phenotypic driver mutations? (2) What constitutes high molecular risk in MPN (focusing on ASXL1 )? (3) How do we risk-stratify patients with MPN? And (4) What is the significance of molecular genetics for MPN treatment? Although substantial progress has been made, we still have an incomplete understanding of the molecular basis for phenotypic diversity in MPN, and few rationally designed therapeutic approaches to target high-risk mutations are available...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30503978/what-is-the-role-of-elective-neck-dissection-in-the-management-of-patients-with-buccal-squamous-cell-carcinoma-and-clinically-negative-neck-findings
#12
Jasjit K Dillon, Akashdeep S Villing, Richard S Jones, Neal D Futran, Hans C Brockhoff, Eric R Carlson, Thomas Schlieve, Deepak Kademani, Ketan Patel, Scott T Claiborne, Eric J Dierks, Yedeh P Ying, Brent B Ward
PURPOSE: Buccal squamous cell carcinoma (BSCC) is rare in the United States. Given its location, few anatomic barriers to spread exist and it has been found to have a high locoregional recurrence rate. The role of elective neck dissection (END) in patients with clinically negative neck findings (N0) is not clear. This study aims to answer the following research question: Among patients with N0 BSCC, does END improve locoregional control rates, distant metastasis rates, and 2- and 5-year survival rates? MATERIALS AND METHODS: A retrospective cohort study was conducted...
November 7, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30496533/cognitive-behavioral-treatments-for-insomnia-cbt-i-and-pain-cbt-p-in-adults-with-comorbid-chronic-insomnia-and-fibromyalgia-clinical-outcomes-from-the-spin-randomized-controlled-trial
#13
Christina S McCrae, Jacob Williams, Daniela Roditi, Ryan Anderson, Jennifer M Mundt, Mary Beth Miller, Ashley F Curtis, Lori B Waxenberg, Roland Staud, Richard B Berry, Michael E Robinson
Objectives: To examine the effects of cognitive behavioral treatments for insomnia (CBT-I) and pain (CBT-P) in patients with comorbid fibromyalgia and insomnia. Methods: 113 patients (Mage=53, SD=10.9) were randomized to eight sessions of CBT-I (n=39), CBT-P (n=37), or a waitlist control (WLC, n=37). Primary [self-reported sleep onset latency (SOL), wake after sleep onset (WASO), sleep efficiency (SE), sleep quality (SQ), pain ratings)] and secondary outcomes [dysfunctional attitudes about sleep (DBAS); actigraphy and polysomnography SOL, WASO, and SE; McGill Pain Questionnaire; Pain Disability Index; depression; anxiety] were examined at post-treatment and 6-months...
November 28, 2018: Sleep
https://www.readbyqxmd.com/read/30488971/the-caregiving-phenomenon-and-caregiver-participation-in-dementia
#14
REVIEW
Sara Garcia-Ptacek, Beth Dahlrup, Ann-Katrin Edlund, Helle Wijk, Maria Eriksdotter
BACKGROUND: Dementia presents barriers to the collaboration between individuals and the healthcare system. Caregivers perform multiple functions helping patients with basic and instrumental activities but also communicating and mediating the dyads' needs within the broader social group. Interventions focusing on caregivers show that caregiver burden can be reduced, improving patient outcomes in a cost-effective way, but the generalisation of these findings is limited by several factors such as low participation rates of caregivers in studies...
November 29, 2018: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/30488765/the-comit-id-study-developing-core-outcome-domains-sets-for-clinical-trials-of-sound-psychology-and-pharmacology-based-interventions-for-chronic-subjective-tinnitus-in-adults
#15
Deborah A Hall, Harriet Smith, Alice Hibbert, Veronica Colley, Haúla F Haider, Adele Horobin, Alain Londero, Birgit Mazurek, Brian Thacker, Kathryn Fackrell
Subjective tinnitus is a chronic heterogeneous condition that is typically managed using intervention approaches based on sound devices, psychologically informed therapies, or pharmaceutical products. For clinical trials, there are currently no common standards for assessing or reporting intervention efficacy. This article reports on the first of two steps to establish a common standard, which identifies what specific tinnitus-related complaints ("outcome domains") are critical and important to assess in all clinical trials to determine whether an intervention has worked...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/30487985/real-world-presentation-with-heart-failure-in-primary-care-do-patients-selected-to-follow-diagnostic-and-management-guidelines-have-better-outcomes
#16
Alex Bottle, Dani Kim, Paul P Aylin, F Azeem Majeed, Martin R Cowie, Benedict Hayhoe
Objective: To describe associations between initial management of people presenting with heart failure (HF) symptoms in primary care, including compliance with the recommendations of the National Institute for Health and Care Excellence (NICE), and subsequent unplanned hospitalisation for HF and death. Methods: This is a retrospective cohort study using data from general practices submitting records to the Clinical Practice Research Datalink. The cohort comprised patients diagnosed with HF during 2010-2013 and presenting to their general practitioners with breathlessness, fatigue or ankle swelling...
2018: Open Heart
https://www.readbyqxmd.com/read/30485500/how-hsa-mir-495-performed-in-the-tumorigenesis-of-pancreatic-adenocarcinoma-by-bioinformatics-analysis
#17
Yuemei Yang, Yanfeng Wang, Shizhong Liu, Xiaoling Zhao, Rujing Jia, Yu Xiao, Ming Zhang, Xiaoou Li, Ji Li, Wenze Wang
INTRODUCTION: Pancreatic adenocarcinoma (PAAD) is one of the most fatal cancers in the world for early metastasis, extensive invasion, and poor prognosis with a 5-year survival rate less than 5%. However, the underlying mechanisms are poorly understood. Therefore, it is urgent to explore molecular markers for early diagnosis or therapy target to improve the outcome of PAAD. METHODS: We retrieved transcriptome data as well as clinical information from patients with PAAD in The Cancer Genome Altas (TCGA) database...
November 28, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30484101/rates-and-impact-of-adherence-to-recommended-care-for-unhealthy-alcohol-use
#18
Kimberly A Hepner, Susan M Paddock, Katherine E Watkins, Katherine J Hoggatt, Lisa V Rubenstein, Andy Bogart, Praise O Iyiewuare, Susan C Rosenbluth, Harold Alan Pincus
BACKGROUND: Unhealthy alcohol use is a major worldwide health problem. Yet few studies have assessed provider adherence to the alcohol-related care recommended in clinical practice guidelines, nor links between adherence to recommended care and outcomes. OBJECTIVES: To describe quality of care for unhealthy alcohol use and its impacts on drinking behavior RESEARCH DESIGN: Prospective observational cohort study of quality of alcohol care for the population of patients screening positive for unhealthy alcohol use in a large Veterans Affairs health system...
November 27, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/30483899/impact-of-image-guidance-on-toxicity-and-tumour-outcome-in-moderately-hypofractionated-external-beam-radiotherapy-for-prostate-cancer
#19
B A Jereczek-Fossa, A Maucieri, G Marvaso, S Gandini, C Fodor, D Zerini, G Riva, O Alessandro, A Surgo, S Volpe, G Fanetti, S Arculeo, M A Zerella, S Parisi, P Maisonneuve, A Vavassori, F Cattani, R Cambria, C Garibaldi, A Starzyńska, G Musi, O De Cobelli, M Ferro, F Nolè, D Ciardo, R Orecchia
To report toxicity and efficacy outcome of moderately hypofractionated image-guided external-beam radiotherapy in a large series of patients treated for prostate cancer (PCa). Between 10/2006 and 12/2015, 572 T1-T3N0M0 PCa patients received 70.2 Gy in 26 fractions at 2.7 Gy/fraction: 344 patients (60%) with three-dimensional conformal radiotherapy (3D-CRT) and 228 (40%) with intensity-modulated radiotherapy (IMRT). Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria and Houston definition (nadir + 2) were used for toxicity and biochemical failure evaluation, respectively...
November 27, 2018: Medical Oncology
https://www.readbyqxmd.com/read/30482777/variability-of-outcome-measures-in-trials-of-intravenous-therapy-in-acute-severe-paediatric-asthma-a-systematic-review
#20
Charmaine S Gray, Colin V E Powell, Franz E Babl, Stuart R Dalziel, Simon Craig
OBJECTIVE: To determine the variability of primary and secondary outcomes used in trials of intravenous bronchodilators in children with acute severe paediatric asthma. METHODS: Systematic search of MEDLINE, EMBASE, Cochrane CENTRAL and the WHO International Clinical Trials Registry Platform for randomised trials in children (less than18 years) with acute severe paediatric asthma comparing intravenous bronchodilator therapy to another treatment. Initial search was performed on 7 January 2016 with an updated search performed on 6 September 2018...
November 27, 2018: Emergency Medicine Journal: EMJ
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