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Osteoarthritis and platelet rich plasma treatment.

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https://www.readbyqxmd.com/read/30300216/optimizing-clinical-use-of-biologics-in-orthopaedic-surgery-consensus-recommendations-from-the-2018-aaos-nih-u-13-conference
#1
Constance R Chu, Scott Rodeo, Nidhi Bhutani, Laurie R Goodrich, Johnny Huard, James Irrgang, Robert F LaPrade, Christian Lattermann, Ying Lu, Bert Mandelbaum, Jeremy Mao, Louis McIntyre, Allan Mishra, George F Muschler, Nicolas S Piuzzi, Hollis Potter, Kurt Spindler, John M Tokish, Rocky Tuan, Kenneth Zaslav, William Maloney
Concern that misinformation from direct-to-consumer marketing of largely unproven "biologic" treatments such as platelet-rich plasma and cell-based therapies may erode the public trust and the responsible investment needed to bring legitimate biological therapies to patients have resulted in calls to action from professional organizations and governing bodies. In response to substantial patient demand for biologic treatment of orthopaedic conditions, the American Academy of Orthopaedic Surgeons convened a collaborative symposium and established a consensus framework for improving and accelerating the clinical evaluation, use, and optimization of biologic therapies for musculoskeletal diseases...
October 8, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/30274850/platelet-rich-plasma-myth-or-reality
#2
A Martínez-Martínez, F Ruiz-Santiago, J García-Espinosa
Platelet-rich plasma (PRP) is a preparation for therapeutic purposes that is increasingly accepted for various musculoskeletal disorders, due to its theoretical potential to repair tissues with poor healing capacity. Several randomised clinical trials have investigated the capacity of PRP to repair tendons, ligaments, muscles and cartilage, and to date there is level 1a evidence to support its use for lateral epicondylitis, osteoarthritis of the knee, plantar fasciitis and rotator cuff tendinopathy; and level 1b for patellar tendinopathy and osteoarthritis of the hip...
September 28, 2018: Radiología
https://www.readbyqxmd.com/read/30259330/platelet-rich-plasma-in-the-foot-and-ankle
#3
REVIEW
Peter R Henning, Benjamin J Grear
PURPOSE OF REVIEW: Platelet-rich plasma has become an increasingly popular treatment option within the orthopedic community to biologically enhance and stimulate difficult-to-heal musculoskeletal tissues. This review evaluates the recent literature on platelet-rich plasma use in the treatment of foot and ankle pathologies. RECENT FINDINGS: Recent literature has demonstrated platelet-rich plasma to have a possible benefit in the treatment of Achilles pathology, chronic plantar fasciitis, osteochondral lesions of the talus, ankle osteoarthritis, and diabetic foot ulcers...
September 26, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/30246605/a-contemporary-view-of-platelet-rich-plasma-therapies-moving-toward-refined-clinical-protocols-and-precise-indications
#4
Isabel Andia, Nicola Maffulli
The positive extensive clinical experience with platelet-rich plasma (PRP) in different medical areas has prompted researchers to explore clinical opportunities for optimized PRP therapies. PRP is safe but we have to make it more effective. The growing diversity of formulations and presentations enrich the field of PRP research and offer hope to refine clinical indications. Moving toward targeting the right disease phenotypes with the right PRP formulation or combination product (PRP + cell products) can offer opportunities to change treatment options in osteoarthritis and nonhealing wounds...
September 24, 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/30195704/treatment-of-knee-meniscus-pathology-rehabilitation-surgery-and-orthobiologics
#5
REVIEW
Paul S Chirichella, Steven Jow, Stephen Iacono, Hannah E Wey, Gerard A Malanga
The meniscal tear treatment paradigm traditionally begins with conservative measures such as physical therapy with referral for operative management for persistent or mechanical symptoms. As a result, the partial meniscectomy is performed more than any other orthopedic procedure in the United States. This treatment paradigm has shifted because the recent literature has supported the attempt to preserve or repair the meniscus whenever possible given its importance for the structural integrity of the knee joint and the risk of early osteoarthritis associated after meniscus excision...
September 7, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/30189436/what-is-the-price-and-claimed-efficacy-of-platelet-rich-plasma-injections-for-the-treatment-of-knee-osteoarthritis-in-the-united-states
#6
Nicolas S Piuzzi, Mitchell Ng, Ariel Kantor, Kenneth Ng, Stephanie Kha, Michael A Mont, George F Muschler
Platelet-rich plasma (PRP) injections are often used for the treatment of knee osteoarthritis (OA), despite clinical value and cost-effectiveness not being definitely established. PRP injections are considered as a potential means of reducing pain and improving function in patients with knee OA, in the hope of delaying or avoiding the need for surgical intervention. Centers that offer PRP injections usually charge patients out of pocket and directly market services. Therefore, the purpose of this study was to quantify the current (1) prices and (2) marketed clinical efficacy of autologous PRP injections for knee OA...
September 6, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/30186448/clinical-therapy-of-hyaluronic-acid-combined-with-platelet-rich-plasma-for-the-treatment-of-knee-osteoarthritis
#7
Wenxing Yu, Peng Xu, Guiling Huang, Lin Liu
Knee osteoarthritis is the most common degenerative disease of the joints caused by articular cartilage injury, degradation of the joint edge and subchondral bone hyperplasia. Various treatments are used to alleviate the symptoms of patients with knee osteoarthritis, including analgesics and intra-articular injections. Platelet-rich plasma (PRP) is an autologous and multifunctional platelet concentrate of the blood, which stimulates the cartilage healing process and improves the damage caused by articular disease...
September 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30140705/autophagy-is-independent-of-the-chondroprotection-induced-by-platelet-rich-plasma-releasate
#8
Fan Yang, Haoran Hu, Wenjing Yin, Guangyi Li, Ting Yuan, Xuetao Xie, Changqing Zhang
Background: Platelet-rich plasma (PRP) has been shown to be a promising therapeutic agent against osteoarthritis (OA), whereas its chondroprotection mechanism is not fully elucidated. Autophagy is considered an important biological process throughout the development of OA. Therefore, the objective of the present study is to investigate the role of autophagy in the chondroprotection and compare the effects of releasate between L-PRP and P-PRP. Methods: PRP were prepared from rat blood...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30128934/clinical-and-radiographic-comparison-of-a-single-lp-prp-injection-a-single-hyaluronic-acid-injection-and-daily-nsaid-administration-with-a-52-week-follow-up-a-randomized-controlled-trial
#9
David Buendía-López, Manuel Medina-Quirós, Miguel Ángel Fernández-Villacañas Marín
BACKGROUND: Knee osteoarthritis (OA) is a disease with a high prevalence in the adult population. Nonsteroidal anti-inflammatory drugs (NSAID) or intra-articular injections [hyaluronic acid (HA) or platelet-rich plasma (PRP)] can provide clinical benefit. Magnetic resonance imaging (MRI) has proven to be useful for the evaluation of cartilage volume and thickness in knee osteoarthritis. The purpose of this study was to evaluate the benefit provided by PRP injection in comparison with hyaluronic acid and NSAID in knee OA patients and to compare the radiographic evolution at the 52-week follow-up...
August 20, 2018: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/30084822/effectiveness-of-thrombin-collagen-and-autologous-platelet-rich-plasma-in-total-hip-arthroplasty-hemostasis-a-prospective-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Eric N Bowman, Michael P McCabe, Kevin B Cleveland
Bovine derived thrombin-collagen combined with autologous platelet-rich plasma (PRP) has shown promise as a topical, surgical hemostatic agent. The purpose of this study was to determine the effect of thrombin-collagen-PRP on perioperative blood loss in total hip arthroplasty (THA). A prospective, single-blinded, randomized, controlled study comparing thrombin-collagen-PRP use to standard treatment was performed. All patients undergoing elective primary THA for osteoarthritis by a single physician at a single institution were included...
December 0: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/30055602/efficacy-of-intra-articular-injections-of-platelet-rich-plasma-as-a-symptom-and-disease-modifying-treatment-for-knee-osteoarthritis-the-restore-trial-protocol
#11
Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell
BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. As such, it has the potential to improve both symptoms and joint structure. The aim of this clinical trial is to determine whether a series of injections of PRP into the knee joint will lead to a significantly greater reduction in knee pain, and less loss of medial tibial cartilage volume over 12 months when compared to a series of placebo saline injections in people with knee OA...
July 28, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30023361/pooled-platelet-rich-plasma-lysate-therapy-increases-synoviocyte-proliferation-and-hyaluronic-acid-production-while-protecting-chondrocytes-from-synoviocyte-derived-inflammatory-mediators
#12
Jessica M Gilbertie, Julie M Long, Alicia G Schubert, Alix K Berglund, Thomas P Schaer, Lauren V Schnabel
Platelet-rich plasma (PRP) preparations are being used with moderate success to treat osteoarthritis (OA) in humans and in veterinary species. Such preparations are hindered, however, by being autologous in nature and subject to tremendous patient and processing variability. For this reason, there has been increasing interest in the use of platelet lysate preparations instead of traditional PRP. Platelet lysate preparations are acellular, thereby reducing concerns over immunogenicity, and contain high concentrations of growth factors and cytokines...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/30020117/nonoperative-treatments-for-knee-osteoarthritis-an-evaluation-of-treatment-characteristics-and-the-intra-articular-placebo-effect-a-systematic-review
#13
Christopher Vannabouathong, Mohit Bhandari, Asheesh Bedi, Vickas Khanna, Patrick Yung, Vijay Shetty, Moin Khan
BACKGROUND: Guidelines recommending various nonoperative treatments for patients with knee osteoarthritis remain inconsistent. Much of this controversy relates to what constitutes a clinically important effect. The purposes of the present study were to compare treatment effect sizes from recent meta-analyses evaluating pharmacological or medical device interventions for the treatment of knee osteoarthritis and to further assess the clinical impact that the intra-articular placebo effect may have on intra-articular injection therapies...
July 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29958266/is-platelet-rich-plasma-effective-for-osteoarthritis
#14
Diego Ubilla, Joaquín Ananías, Luis Ortiz-Muñoz, Sebastián Irarrázaval
INTRODUCTION: Despite varied non-surgical alternatives for the treatment of osteoarthritis, many patients remain symptomatic. In the last decade, the use of intra-articular platelet-rich plasma (PRP) has been proposed as an option. However, there is controversy about its clinical benefit and safety. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
June 25, 2018: Medwave
https://www.readbyqxmd.com/read/29921309/is-local-platelet-rich-plasma-injection-clinically-superior-to-hyaluronic-acid-for-treatment-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#15
Yalong Di, Changxu Han, Liang Zhao, Yizhong Ren
BACKGROUND: In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis. METHODS: The Cochrane Central Register of Controlled Trials, PubMed, and Embase databases were searched for English-language, human in vivo studies on the treatment of symptomatic knee osteoarthritis with intra-articular PRP compared with HA. The following keywords were used for the search: "platelet-rich plasma," "PRP," "platelet-rich fibrin," "PRF," "platelet," "plasma," "arthritis," "osteoarthritis," "gonarthrosis," and "degeneration...
June 19, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29920524/use-of-a-platelet-rich-plasma-collagen-scaffold-as-a-bioenhanced-repair-treatment-for-management-of-partial-cruciate-ligament-rupture-in-dogs
#16
Susannah J Sample, Molly A Racette, Eric C Hans, Nicola J Volstad, Susan L Schaefer, Jason A Bleedorn, Jeffrey P Little, Kenneth R Waller, Zhengling Hao, Walter F Block, Peter Muir
Dogs are commonly affected with cruciate ligament rupture (CR) and associated osteoarthritis (OA), and frequently develop a second contralateral CR. Platelet rich plasma (PRP) is a component of whole blood that contains numerous growth factors, which in combination with a collagen scaffold may act to promote bioenhanced primary repair of ligament. This study tested the hypothesis that treatment of partial stable CR stifles with an intra-articular collagen scaffold and PRP would decrease the disease progression, synovitis and risk of complete CR over a 12-month study period...
2018: PloS One
https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#17
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
October 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29878617/clinical-outcomes-are-associated-with-changes-in-ultrasonographic-structural-appearance-after-platelet-rich-plasma-treatment-for-knee-osteoarthritis
#18
RANDOMIZED CONTROLLED TRIAL
Hamada S Ahmad, Sherief E Farrag, Amr E Okasha, Aisha O Kadry, Tamer B Ata, Amir A Monir, Ibrahim Shady
BACKGROUND: Hyaluronic acid (HA) and platelet-rich plasma (PRP) are two treatment options used for knee osteoarthritis (KOA) but studies comparing the efficacy of the two yield conflicting results. In addition, the association of clinical outcomes of PRP intra-articular injections with changes in the ultrasonography structural appearance of the knee has not been investigated. AIM: To compare the efficacy of PRP and HA intra-articular injections as mono-therapeutic options for primary KOA, and to determine whether the clinical outcomes are associated with changes in the ultrasonography structural appearance...
May 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29871367/stem-cells-for-the-treatment-of-knee-osteoarthritis-a-comprehensive-review
#19
Lei Zhao, Alan D Kaye, Alaa Abd-Elsayed
BACKGROUND: Knee osteoarthritis (KOA) is a very challenging condition to treat and can be resistant to medications, procedures, and even surgery. Surgery may not be an option for some patients due to obesity or comorbidities. Regenerative medicine utilizing stem cells, platelet rich plasma (PRP), amniotic fluid, and cytokine modulation is very promising in the treatment of KOA. OBJECTIVE: This is a review article to evaluate the current evidence about regenerative medicine therapies in the treatment of KOA...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29849470/systematic-clinical-evidence-review-of-nasha-durolane-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#20
REVIEW
Ross Leighton, Jane Fitzpatrick, Helen Smith, Daniela Crandall, Carl R Flannery, Thierry Conrozier
Background: Pain and limitations in joint mobility associated with knee osteoarthritis (OA) are clinically challenging to manage, and advanced progression of disease can often lead to total knee arthroplasty. Intra-articular injection of hyaluronic acid (HA), also referred to as viscosupplementation, is a non-surgical treatment approach for OA, the effectiveness of which may depend on the HA composition, and the length of time over which it resides in the joint. One of the available options for such therapies includes NASHA (Durolane HA), a non-animal, biofermentation-derived product, which is manufactured using a process that stabilizes the HA molecules to slow down their rate of degradation and produce a unique formulation with a terminal half-life of ~1 month...
2018: Open Access Rheumatology: Research and Reviews
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