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Floris F van den Brand, Carin M J van Nieuwkerk, Bart J Verwer, Ynto S de Boer, Nanne K H de Boer, Chris J J Mulder, Elisabeth Bloemena, Christine M Bakker, Jan M Vrolijk, Joost P H Drenth, Adriaan C I T L Tan, Frank Ter Borg, Martijn J Ter Borg, Sven J van den Hazel, Akin Inderson, Maarten E Tushuizen, Gerd Bouma
BACKGROUND: Azathioprine (AZA) and mercaptopurine (MP) are the cornerstone of steroid-sparing strategies in autoimmune hepatitis (AIH). Up to 20% of patients do not tolerate or respond to these regimens. AIM: To retrospectively evaluate the tolerability and efficacy of tioguanine (thioguanine) (TG) therapy in selected patients with AIH and AIH variant syndromes. METHODS: Records of 52 patients who received TG therapy were retrieved from nine hospitals in the Netherlands...
August 15, 2018: Alimentary Pharmacology & Therapeutics
Intan Nurma Yulita, Mohamad Ivan Fanany, Aniati Murni Arymurthy
Objectives: Polysomnography is essential to diagnose sleep disorders. It is used to identify a patient's sleep pattern during sleep. This pattern is obtained by a doctor or health practitioner by using a scoring process, which is time consuming. To overcome this problem, we developed a system that can automatically classify sleep stages. Methods: This paper proposes a new method for sleep stage classification, called the fast convolutional method. The proposed method was evaluated against two sleep datasets...
July 2018: Healthcare Informatics Research
Franck Duclos, Lynn M Abell, David G Harden, Kristen Pike, Kimberly Nowak, Gregory A Locke, Gerald J Duke, Xiaoqin Liu, Gayani Fernando, Scott A Shaw, Benjamin P Vokits, Nicholas R Wurtz, Andrew Viet, Meriah N Valente, Sylwia Stachura, Paul Sleph, Javed A Khan, Ji Gao, Ashok R Dongre, Lei Zhao, Ruth R Wexler, David A Gordon, Ellen K Kick
Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to invading pathogens. Myeloperoxidase has been implicated in several chronic pathological diseases due to the chronic production of hypochlorous acid, as well as other reactive radical species. A high throughput screen and triaging protocol was developed to identify a reversible inhibitor of myeloperoxidase toward the potential treatment of chronic diseases such as atherosclerosis...
November 1, 2017: MedChemComm
Marie Simonin, Benjamin P Colman, Weiyi Tang, Jonathan D Judy, Steven M Anderson, Christina M Bergemann, Jennifer D Rocca, Jason M Unrine, Nicolas Cassar, Emily S Bernhardt
The environmental fate and potential impacts of nanopesticides on agroecosystems under realistic agricultural conditions are poorly understood. As a result, the benefits and risks of these novel formulations compared to the conventional products are currently unclear. Here, we examined the effects of repeated realistic exposures of the Cu(OH)2 nanopesticide, Kocide 3000, on simulated agricultural pastureland in an outdoor mesocosm experiment over 1 year. The Kocide applications were performed alongside three different mineral fertilization levels (Ambient, Low, and High) to assess the environmental impacts of this nanopesticide under low-input or conventional farming scenarios...
2018: Frontiers in Microbiology
Mohit Butaney, Nannan Thirumavalavan, Mark S Hockenberry, E Will Kirby, Alexander W Pastuszak, Larry I Lipshultz
Penile duplex ultrasound (PDU), combined with pharmacologic stimulation of erection, is the gold standard for the evaluation of multiple penile conditions. A 30-question electronic survey was distributed to members of the International Society for Sexual Medicine (ISSM). The survey assessed the variability in current PDU practice patterns, technique, and interpretation. Chi-square test was used to determine the association between categorical variables. Approximately 9.5% of all 1996 current ISSM members completed the survey...
August 14, 2018: International Journal of Impotence Research
Kimberley Sancton, Leila Sloss, Jonathan Berkowitz, Nardia Strydom, Rita McCracken
OBJECTIVE: To describe the demographic characteristics of patients who present to the emergency department (ED) for low-acuity issues and to explore their self-reported contact with other sources of primary health care before presenting to the ED. DESIGN: Survey distributed in the ED waiting room. SETTING: A high-volume ED in Vancouver, BC. PARTICIPANTS: A total of 232 respondents aged 18 years or older in the ED waiting room...
August 2018: Canadian Family Physician Médecin de Famille Canadien
Simon Soudet, David Fajgenbaum, Claire Delattre, Alexandra Forestier, Eric Hachulla, Pierre Yves Hatron, David Launay, Louis Terriou
Patients with HHV-8-negative/idiopathic multicentric Castleman disease (iMCD) experience systemic inflammatory symptoms and polyclonal lymphoproliferation due to an unknown etiology. Schnitzler's syndrome (SS) is characterized by recurrent urticarial rash, monoclonal IgM gammopathy, and other clinical signs of inflammation. To our knowledge, we report the first case of iMCD associated with SS and the fourth case of anakinra inducing a complete response for an iMCD patient. A forty-four year old woman with a history of a recurrent urticarial rash, presented to our hospital complaining of 6 months of night sweats, fever, chronic urticaria, iliac bone pain, and generalized lymphadenopathy...
August 11, 2018: Current Research in Translational Medicine
Jessalyn M Hadfield, Elizabeth C Bowdridge, Ida Holásková, Ted H Elsasser, Robert A Dailey
Innate immune response to a lipopolysaccharide (LPS) challenge varies among sheep breeds. How different breeds respond to bacterial infections impacts management practices of sheep producers. Hence, clinical response, acute-phase response, and gene expression of pro- and anti-inflammatory markers in peripheral white blood cells (WBCs) were examined after an LPS challenge in Dorset and Suffolk ewes. Ewes received either PBS or 2.5 µg/kg LPS (i.v.) 4 to 5 d after onset of synchronized estrus. Blood was collected via jugular venipuncture intermittently for 24 h to determine WBC counts...
August 9, 2018: Journal of Animal Science
Rafael Ferreira-Garcia, Rafael Christophe da Rocha Freire, José Carlos Appolinário, Michelle N Levitan, Roseane Dorte Halkjær-Lassen, João Romildo Bueno, Antonio E Nardi
BACKGROUND: Few therapeutic options are available for patients with electroconvulsive therapy-resistant major depressive disorder (ECT-r MDD), leaving a substantial proportion of this population beyond treatment possibilities. The combination of monoamine oxidase inhibitors and tricyclic antidepressants could be a potential strategy for managing ECT-r MDD, and the specific association of amitriptyline and tranylcypromine may offer additional tolerability advantages. Although promising, in our knowledge, no studies have examined until now the effectiveness of this combination in ECT-r MDD...
August 14, 2018: Journal of Clinical Psychopharmacology
Ariel M Pani, Bob Goldstein
Wnts are evolutionarily conserved signaling proteins with essential roles in development and disease that have often been thought to spread between cells and signal at a distance. However, recent studies have challenged this model, and whether long-distance extracellular Wnt dispersal occurs and is biologically relevant is debated. Understanding fundamental aspects of Wnt dispersal has been limited by challenges with observing endogenous ligands in vivo , which has prevented directly testing hypotheses. Here, we have generated functional, fluorescently tagged alleles for a C...
August 14, 2018: ELife
Gregory S Day, Alexander Rae-Grant, Melissa J Armstrong, Tamara Pringsheim, Stacey S Cofield, Ruth Ann Marrie
Background: Persons with multiple sclerosis (MS) may now choose from a broad array of approved disease-modifying treatments (DMTs). The priority that patients and practitioners assign to specific clinical outcomes is likely to influence the MS DMT selection process. Methods: We invited 9,126 participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry and 18 members of the American Academy of Neurology MS DMT guideline development panel to complete a brief survey prioritizing outcomes of importance to MS DMT selection...
June 2018: Neurology. Clinical Practice
Xiaocen Wang, Pengtao Gong, Xu Zhang, Shan Li, Xiangyun Lu, Chunyan Zhao, Qile Yu, Zhengkai Wei, Yongjun Yang, Qun Liu, Zhengtao Yang, Jianhua Li, Xichen Zhang
Neospora caninum is an intracellular protozoan parasite closely related to Toxoplasma gondii that mainly infects canids as the definitive host and cattle as the intermediate host, resulting in abortion in cattle and leading to financial losses worldwide. Commercial vaccines or drugs are not available for the prevention and treatment of bovine neosporosis. Knowledge about the hallmarks of the immune response to this infection could form the basis of important prevention strategies. The innate immune system first responds to invading parasite and subsequently initiates the appropriate adaptive immune response against this parasite...
2018: Frontiers in Immunology
Zheng Ruan, Natarajan Kannan
Mutational activation of epidermal growth factor receptor (EGFR) in human cancers involves both point mutations and complex mutations (insertions and deletions). In particular, short in-frame insertion mutations within a conserved αC-β4 loop in the EGFR kinase domain are frequently observed in tumor samples and patients harboring these mutations are insensitive to first-generation EGFR inhibitors. Despite the prevalence and clinical relevance of insertion mutations, the mechanisms by which these mutations regulate EGFR activity and contribute to drug sensitivity are poorly understood...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Cedric M Panje, Konstantin J Dedes, Klazien Matter-Walstra, Matthias Schwenkglenks, Oliver Gautschi, Marco Siano, Daniel M Aebersold, Ludwig Plasswilm, Judith E Lupatsch
BACKGROUND: Novel systemic therapies have improved the prognosis of metastatic non-small cell lung cancer (NSCLC), but costs of some of these drugs are a matter of ongoing debate. More recently, local therapies (LT) such as radiotherapy and surgery have been suggested as additional treatment in oligometastatic NSCLC demonstrating an improved progression-free survival (PFS) in a phase II trial compared to maintenance chemotherapy (MC) alone. The aim of this analysis was to assess the cost-effectiveness of local therapies in oligometastatic NSCLC...
August 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Youn Joo Lee, Sung Hun Kim, Bong Joo Kang, Yun Ju Kim
PURPOSE:  To evaluate the time-intensity curve (TIC) parameters on contrast-enhanced ultrasound (CEUS) for early prediction of the response of breast cancer to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:  This prospective study included 41 patients with breast cancer. CEUS was performed before and after the first cycle of NAC. TIC parameters were analyzed for different regions of interest (ROIs). ROI 1 targeted the hotspot area of greatest enhancement, ROI 2 delineated the area of hyperenhancement, ROI 3 included the entire tumor on grayscale ultrasound, and ROI 4 encircled the normal parenchyma...
August 13, 2018: Ultraschall in der Medizin
Renee Lovi, John Hurley, Marie Hutchinson
Health care professionals are frequently one of the first points of contact in episodes of intimate partner violence (IPV). This paper presents qualitative data from a larger research project on IPV-related content in undergraduate curriculum for Australian health care professionals. IPV is a serious public health issue with findings from this paper supporting the proposition that key health care workers such as nurses, midwives and paramedics are ill prepared to respond to the challenges it poses. OBJECTIVE: This study sought to better understand the barriers and facilitators to the inclusion of IPV-related content into undergraduate curricula for nurses, midwives and paramedics...
August 1, 2018: Nurse Education Today
Fan Bai, Limei Wang, Zhongtang Li, Lirong Yi, Zongchao Zuo, Cheng Zhang, Yajun Shan, Chao Yang, Renjun Peng, Rifang Yang, Zuyin Yu, Yuwen Cong
PURPOSE: The risk of radiation exposure is considered to have increased in recent years. For convenience and simple administration, development of an effective orally administered radioprotective agent is highly desirable. The steroid 5-AED has been evaluated as both a radioprotector and a radiomitigator in mice and nonhuman primates, however, poor oral bioavailability has limited its development, while a variant compound, 17α-Ethinyl-androst-5-ene-3β, 17β-diol (EAD), exhibits significant oral bioavailability...
August 10, 2018: International Journal of Radiation Oncology, Biology, Physics
Ahmed Elgendy, Sherif Shehata, Ahmed Medhat Zaki, Sameh Shehata
This study aims to investigate the management of Wilms tumor by the Egyptian pediatric surgical association (EPSA) consultants. After approval of the EPSA executive board, a questionnaire was distributed individually to all consultants attending the general assembly of EPSA 2017 annual congress. Of 88 consultants, responses were received from 61. Palpable abdominal mass was indicated by 72.13% of respondents as the commonest presenting symptom. Concerning the imaging requested, computed tomography was reported by 80...
August 10, 2018: Journal of Pediatric Hematology/oncology
Kavinash Loganathan, Shogo Moriya, Ishwar S Parhar
Ambient light and temperature affect reproductive function by regulating kisspeptin and gonadotrophin-releasing hormone (GnRH) in vertebrates. Melatonin and melatonin receptors, as well as the two-pore domain K+ channel-related K+ (TREK) channels, are affected by light and/or temperature; therefore, these molecules could modulate kisspeptin and GnRH against ambient light and temperature. In this study, we investigated the effect of light and temperature, which affect melatonin levels in gene expression levels of TREK channels, kisspeptin, and GnRH...
August 13, 2018: Zebrafish
Erik G Prytz, Caroline Norén, Carl-Oscar Jonson
OBJECTIVE: We sought to investigate whether expert-novice differences in visual search behavior found in other domains also apply to accident scenes and the emergency response domain. BACKGROUND: Emergency service professionals typically arrive at accidents only after being dispatched when a civilian witness has called an emergency dispatch number. Differences in visual search behavior between the civilian witness (usually a novice in terms of emergency response) and the professional first responders (experts at emergency response) could thus result in the experts being given insufficient or erroneous information, which would lead them to arrive unprepared for the actual situation...
August 13, 2018: Human Factors
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