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Chuanyin Sun, Guanhua Xu, Jin Lin
BACKGROUND: It can be difficult to distinguish between IgG4-related lymphadenopathy and multicentric Castleman's disease (MCD) because these conditions cannot be differentially diagnosed using immunohistochemical staining alone. In this study, we analyzed the clinical features of IgG4-related lymphadenopathy and MCD patients. METHODS: We retrospectively analyzed 27 patients with MCD, including 20 with plasma cell-type (PC-type) and 7 with hyaline vascular (HV) features (mixed-type)...
October 1, 2018: Clinical Laboratory
Adélia Correia Lúcio, Christiane Boaventura Lourenço, Benito Pereira Damasceno, Maria Helena Baena de Moraes Lopes, Carlos Arturo Levi D'ancona
OBJECTIVE: The aim of this study was to investigate if detrusor overactivity (DO) can be influenced by a pelvic floor muscle (PFM) contraction in multiple sclerosis-associated overactive bladder (MS) and idiopathic overactive bladder (OAB) volunteers and compare urodynamic findings between the two groups. DESIGN: Eighteen women with MS and seventeen women with OAB responded the OAB-V8 questionnaire and performed urodynamic study (UDS) with electromyography of PFM to confirm the presence of a 15-seconds PFM contraction during a DO, when present...
October 18, 2018: American Journal of Physical Medicine & Rehabilitation
Chloe Hannan, Aimee J Palumbo, Megan C Fisher Thiel, Eve Weiss, Thomas Seacrist
OBJECTIVE: Recently developed advanced driver assistance systems (ADAS) have the potential to compensate for teen driving errors and reduce overall crash risk. To date, very limited research has been conducted on the suitability of ADAS for teen drivers-the population most likely to benefit from such systems. The opportunity for ADAS to reduce the frequency and severity of crashes involving teen drivers is hindered when there is a lack of trust, acceptance, and use of those technologies...
October 18, 2018: Traffic Injury Prevention
Andrea Falegnami, Federico Bilotta, Francesco Pugliese, Francesco Costantino, Giulio Di Gravio, Massimo Tronci, Riccardo Patriarca
RATIONALE, AIMS, AND OBJECTIVES: The application of resilience in health care requires the shift from a cause-effect approach to a systemic approach, yet few tools have been developed to measure resilience potential in this specific context. This study tests a resilience assessment grid (RAG) questionnaire to measure the resilience of anaesthesiologists, with a cross-country survey. METHOD: A study was conducted with an analytic hierarchy process (AHP) questionnaire containing 57 detailed questions; 16 nations and 172 respondents were involved in the study...
October 18, 2018: Journal of Evaluation in Clinical Practice
Daiana Colledani, Dora Capozza, Rossella Falvo, Gian Antonio Di Bernardo
The main goal of the present study was to validate the Work-related Basic Need Satisfaction (W-BNS) scale in the Italian social context. Three studies were carried out. Study 1 was conducted on two samples of employees. Exploratory factor analysis and parallel analysis were run on the first sample, whereas confirmatory factor analyses were run on the second. Results supported the three-dimensional structure of the W-BNS scale. Study 2 was conducted on a third sample of employees. Results supported the construct validity of the scale, by showing that needs for competence, autonomy, and relatedness were associated with job resources (social support, job autonomy, professional growth), low burnout, and job attitudes (job satisfaction, turnover intentions, commitment)...
2018: Frontiers in Psychology
Holly Feen-Calligan, Julie Moreno, Emma Buzzard
This article is a descriptive study of two groups who came together through service-learning: The first group is graduate art therapy students enrolled in a research class, who partnered with six community agencies to help them prepare assignments for undergraduate service-learning students in a subsequent semester. The art therapy research students also assisted the agencies with program evaluation. The second group is the six directors of the community agencies who were preparing for service-learning students enrolled in an art history class titled Art as A Social Practice...
2018: Frontiers in Psychology
Janusz K Rybakowski
The use of lithium for the prevention of recurrences in mood disorders has a 55-year history. Nowadays, lithium is universally accepted as the first-choice mood-stabilizer (MS) for maintenance treatment of bipolar disorder. In addition to its mood-stabilizing properties, lithium exerts anti-suicidal, immunomodulatory and neuroprotective action which may further substantiate its clinical usefulness. Despite these facts, the use of lithium in mood disorders has been greatly underutilized. The reasons include the introduction and promoting other MS as well as a perception of lithium as a "toxic drug" due to its side effects, mainly thyroid, renal and cognitive disturbances...
2018: Frontiers in Molecular Neuroscience
Kristin D Bradley, Christie Schumacher, Jill S Borchert, Mary Ann Kliethermes, Deborah K Anderson
PURPOSE: The reliability and validity of a survey tool that aims to assess and stratify patient care services provided by ambulatory care pharmacists were evaluated. METHODS: The Tool for Assessing Ambulatory Care Pharmacist Practice (TAAPP) was developed by updating the Pharmaceutical Care Clinical Pharmacist Questionnaire. The TAAPP is organized into 2 sections that include 5 domains derived from the Pharmacists' Patient Care Process (PPCP). The first section of the TAAPP gathers the demographic information of the respondents as well as practice site characteristics...
October 17, 2018: American Journal of Health-system Pharmacy: AJHP
Léa Delbos, Elsa Parot-Schinkel, Hady El Hachem, Guillaume Legendre, Philippe Descamps, Lisa Boucret, Véronique Ferré-L'Hotellier, Pauline Jeanneteau, Cécile Dreux, Catherine Morinière, Pascale May-Panloup, Pierre-Emmanuel Bouet
BACKGROUND: To date, there is no consensus on the ideal management strategy of patients with poor ovarian response (POR) to controlled ovarian stimulation (COS) for in vitro fertilization (IVF). Currently, these patients are given the choice of: (1) canceling the cycle; (2) proceeding with COS regardless of the poor response, and performing the oocyte retrieval and transfer of embryos when available; or (3) conversion to an intrauterine insemination (IUI). When the decision to proceed with the COS cycle is taken, it is not clear whether IVF or conversion to IUI is the best choice...
October 17, 2018: Trials
John M Pezzuto
Resveratrol was first isolated in 1939 by Takaoka from Veratrum grandiflorum O. Loes. Following this discovery, sporadic descriptive reports appeared in the literature. However, spurred by our seminal paper published nearly 60 years later, resveratrol became a household word and the subject of extensive investigation. Now, in addition to appearing in over 20,000 research papers, resveratrol has inspired monographs, conferences, symposia, patents, chemical derivatives, etc. In addition, dietary supplements are marketed under various tradenames...
October 11, 2018: Biomolecules & Therapeutics
Rachael L Hardison, Alistair Harrison, Rachel M Wallace, Derek R Heimlich, Meghan E O'Bryan, Robert P Sebra, Heather W Pinkett, Sheryl S Justice, Kevin M Mason
Bacterial pathogens must sense, respond and adapt to a myriad of dynamic microenvironmental stressors to survive. Adaptation is key for colonization and long-term ability to endure fluctuations in nutrient availability and inflammatory processes. We hypothesize that strains adapted to survive nutrient deprivation are more adept for colonization and establishment of chronic infection. In this study, we detected microevolution in response to transient nutrient limitation through mutation of icc. The mutation results in decreased 3',5'-cyclic adenosine monophosphate phosphodiesterase activity in nontypeable Haemophilus influenzae (NTHI)...
October 17, 2018: PLoS Pathogens
Erdal Kurnaz, Şenay Savaş-Erdeve, Semra Çetinkaya, Zehra Aycan
Background The short stature homeobox-containing (SHOX) gene strongly affects height. Therefore, a better understanding of SHOX haploinsufficiency could be advantageous to early diagnosis and treatment. We investigated the rate of SHOX haploinsufficiency in patients of short stature and documented their anthropometric measurements. Methods Between 2010 and 2017, we evaluated 86 patients (70 females, 16 males; age 4.3-18 years) with clinical diagnoses of short stature and Madelung deformity (MD). Clinical abnormalities are presented for patients with MD with and without SHOX haploinsufficiency as determined by fluorescence in situ hybridisation (FISH)...
October 17, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Birgit A Greiner, Sheilah Nolan, Dervla A M Hogan
Background: Research with physical therapists reveals high rates of work-related musculoskeletal injuries, especially low back pain, with early career onset. Less focus has been given to upper limb disorder (ULD) in these professionals who are frequently performing repetitive arm/hand and precision finger motions during work. Objective: The objective was to estimate prevalence of body-site-specific upper limb (UL) symptoms and diagnosed ULD in Irish chartered physiotherapists, physical therapists, and athletic therapists, with adjustment for leisure time injury, and document first onset of specific UL symptoms...
October 17, 2018: Physical Therapy
Rachel Lenzi, Catherine Packer, Kathleen Ridgeway, Troy D Moon, Ann F Green, Lazaro González-Calvo, Holly M Burke
Women First was a combined economic and social empowerment intervention implemented between 2010 and 2015 in Zambézia Province, Mozambique. The intervention was designed to reduce adolescent girls' risk of HIV and gender-based violence, improve school attendance and empower girls. However, perceptions of girls' improved respectfulness also emerged as an unanticipated effect during the programme evaluation. In this paper, we explore emic definitions of respect and girls' good behaviour and perceptions of how the intervention caused improvements in behaviour from the perspective of intervention participants, their heads of household, influential men in their lives, and community members...
October 17, 2018: Culture, Health & Sexuality
Renata Górska, Bartłomiej Górski
BACKGROUND: Bacterial plaque control plays a key role in the prevention of caries and periodontal diseases. Hygiene negligence in this respect may influence the state of gingiva, and - in the long term - the number of lost teeth. The recommended method of mechanical control of dental plaque is tooth brushing twice a day. OBJECTIVES: The aim of the study was to assess the frequency of tooth brushing, the use of various oral hygiene accessories, the number of preserved teeth, and the occurrence of gingival bleeding in adult Poles, based on a questionnaire study...
July 2018: Dental and medical problems
Hanno M Witte, Armin Riecke, Thomas Mayer, Tobias Bartscht, Dirk Rades, Hendrik Lehnert, Hartmut Merz, Sebastian Fetscher, Harald Biersack, Niklas Gebauer
PURPOSE: The introduction of immunochemotherapy has led to a significant improvement in treatment results and prognosis of diffuse large B-cell non-Hodgkins lymphoma (DLBCL) both at initial diagnosis and in relapse. Trofosfamide, an oxazaphosphorine derivative, has been utilized as alternative treatment option for patients with lymphoproliferative diseases unsuitable for conventional chemotherapy agents and protocols because of age, comorbidity, or poor performance score. While data on the activity and safety of single-agent trofosfamide have been published, the potential value of this agent in immunochemotherapy in combination with anti-CD20 antibodies such as rituximab has not been investigated to our knowledge...
October 16, 2018: Journal of Cancer Research and Clinical Oncology
Renate Schmelz, Stephan Miehlke, Christian Thiede, Stefan Brueckner, Monic Dawel, Matthias Kuhn, Agnes Ruskoné-Formestraux, Manfred Stolte, Christina Jentsch, Jochen Hampe, Andrea Morgner
BACKGROUND: In Helicobacter pylori (H. pylori) positive stage I gastric low-grade MALT lymphoma, eradication is the accepted first-line therapy. The role of eradication therapy in lymphoma > stage IE is still unclear. However, about 20% of patients show persistent lymphoma following successful eradication or primary H. pylori-negative lymphoma. A prospective study for salvage radiation therapy with standard 36 Gy in comparison to a reduced dose of 25.2 Gy is still missing. METHODS: A prospective, multicentre study investigated the efficacy of eradication in H...
October 16, 2018: Journal of Gastroenterology
Khanya Z Bisholo, Shanaz Ghuman, Firoza Haffejee
BACKGROUND:  The highest burden of food-borne diseases is in Africa. Despite this, food safety does not seem to be a major concern in many African countries. There is also a lack of concern within rural areas of South Africa. AIM:  The aim of this study was to determine the prevalence of food-borne diseases in rural areas in the Eastern Cape, South Africa, by comparing data obtained from a cross-sectional survey and clinic records. SETTING:  The study was conducted in Ncera, Mpongo and Needscamp villages in the Eastern Cape, South Africa...
September 27, 2018: African Journal of Primary Health Care & Family Medicine
Chengliang Mao, Feili Chen, Yanwen Li, Xinmiao Jiang, Sichu Liu, Hanguo Guo, Ling Huang, Xiaojuan Wei, Zhanli Liang, Wenyu Li, Kai Tang
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare disease affecting the brain, leptomeninges, spinal cord, cerebrospinal fluid, or vitreoretinal compartment, without evidence of systemic disease. Prognosis is still poor after intensive methotrexate-based chemotherapy. METHODS: Clinical data of 91 cases treated in a tertiary referral center during a 13-year period were retrospectively reviewed. RESULTS: The estimated median PFS and OS for all cohort was 39...
October 13, 2018: World Neurosurgery
J Wen, A Helmbrecht, M A Elliot, J Thomson, M E Persia
An experiment was conducted to evaluate the total Trp requirement of first cycle laying hens from 41 to 60 wk of age. In total, 270 Hy-Line W36 laying hens were randomly allocated to six treatments with 15 replicate groups of three birds for each experimental unit. A Trp-deficient basal diet was formulated with corn, corn gluten meal, and soybean meal with determined Trp, Lys, and crude protein concentrations of 0.096%, 0.873%, and 15.0%, respectively. Synthetic L-Trp was supplemented to the basal diet in 0...
October 15, 2018: Poultry Science
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