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Infection hematology

C Fisser, O W Hamer, R Eiber, M Pfeifer, C Lerzer
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease. PAP results from impaired surfactant clearance. In adults, autoimmune pulmonary alveolar proteinosis is present in 90 - 95 % of the cases. In 5 - 10 %, other etiologies such as toxins and dust exposure, hematological disorders and infections have to be considered. Men between 30 - 60 years are commonly affected. Typical symptoms are cough, dyspnea and alteration in ventilatory function. CT scan of the lung is characterised by a crazy paving pattern...
December 7, 2018: Pneumologie
Anne Line Engsbro, Sara Najat, Karin Meinike Jørgensen, Jørgen A L Kurtzhals, Maiken Cavling Arendrup
1,3-β-D-glucan (BG), a cell-wall component of most fungi including Pneumocystis (PC), is recommended by international guidelines for screening for pneumocystis pneumonia (PCP) in hematologic patients. We retrospectively validated the BG test in our tertiary university hospital. Forty-five patients (median age 53 years, 33% female) tested for PC by polymerase chain reaction (PCR) and/or immunoflourescence (IF)-microscopy with a stored blood sample within ±5 days of the PC test were tested by the Fungitell (cutoff <60 and >80 pg/ml)...
December 11, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Antoine Meyer, Jérémie Rudant, Jérôme Drouin, Alain Weill, Franck Carbonnel, Joël Coste
Background: CT-P13 is a biosimilar of the reference product (RP) infliximab, with demonstrated efficacy and safety for some inflammatory arthritides. It was approved for the treatment of Crohn disease (CD) on that basis, without specific studies examining its effects in CD. Objective: To compare the effectiveness and safety of CT-P13 and RP in infliximab-naive patients with CD. Design: Comparative equivalence cohort study. Setting: Système National des Données de Santé (SNDS), a French nationwide health administrative database (1 March 2015 to 30 June 2017)...
December 11, 2018: Annals of Internal Medicine
Hani Ayyash, Mahmoud Sirdah
Objectives: In Gaza Strip, Palestine, β-thalassemia is a major public health problem where more than 300 β-thalassemia major (βTM) patients are currently being managed at governmental hospitals. We set up to evaluate the hematological and biochemical aspects of our βTM patients at the Gaza European hospital and their correlation with iron overload. Methods: Our study included 65 transfusion-dependent βTM, as well as 37 apparently healthy subjects as control group...
November 2018: International Journal of Health Sciences
Yongzhi Qiu, Byungwook Ahn, Yumiko Sakurai, Caroline Hansen, Reginald Tran, Patrice N Mimche, Robert Mannino, Jordan C Ciciliano, Tracey J Lamb, Clinton H Joiner, Solomon F Ofori-Acquah, Wilbur A Lam
Alterations in the mechanical properties of erythrocytes occurring in inflammatory and hematologic disorders such as sickle cell disease (SCD) and malaria often lead to increased endothelial permeability, haemolysis, and microvascular obstruction. However, the associations among these pathological phenomena remain unknown. Here, we report a perfusable, endothelialized microvasculature-on-a-chip featuring an interpenetrating-polymer-network hydrogel that recapitulates the stiffness of blood-vessel intima, basement membrane self-deposition and self-healing endothelial barrier function for longer than 1 month...
2018: Nature Biomedical Engineering
Khushali Jhaveri, Abhay Vakil, Salim R Surani
Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by presence of noncaseating granulomas in the involved organs. The pulmonary interstitium is most commonly affected but extrapulmonary involvement can occur in almost any other organ system. Such an involvement can occur with or without the presence of pulmonary involvement, but isolated extrapulmonary involvement has been noted only in around 10% of cases. Isolated splenomegaly is very rare and an uncommon presentation of sarcoidosis...
2018: Case Reports in Medicine
Renato R Martins, Lunara T Silva, Gabriela G Bessa, Flavio M Lopes
Objective: This study aimed to compare the use of trigger tools and non-targeted chart review as methods for the detection of adverse drug events in an intensive care unit considering the health system of a developing country. Methods: Patients were divided in groups that were submitted to different methods (trigger tool and non-targeted chart review) for adverse drug event detection. Medical records were retrospectively reviewed, and adverse drug events detected during the data collection were analyzed by a multidisciplinary team and classified according to their causality, predictability, severity and damage level...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Hanaa Khalaf Fath-Elbab, Elham Ahmed, Dina Fathy Mansour, Wail Talaat Soliman
Context: Chronic infection by hepatitis C virus causes impairment in neurocognitive function in up to 50% of patients which may not be detected by clinical tests. Aim: Early detection of neurocognitive impairment in chronic hepatitis C patients and investigating the cognitive function in HCV patient by p300 and clinical test. Materials and methods: The study included 60 patients with chronic hepatitis C and 30 healthy controls. Participants were subjected to a biochemical, hematological assessment, mini-mental state examination, Montreal Cognitive Assessment, P300, polymerase chain reaction (PCR), and fibroscan made for hepatitis C patients...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
Hirokazu Kanegane, Akihiro Hoshino, Masatoshi Takagi
Primary immunodeficiency disease (PID) is characterized by an impaired immune system along with recurrent and severe and/or opportunistic infections; these infections are frequently associated with malignancies and autoimmune disorders. Dysregulation of the adaptive immune system leads to an increased risk of malignancies. Various mechanisms contribute to increased tumor susceptibility in patients with PIDs, which are as follows: defective cell-mediated tumor surveillance, defective apoptosis, specific susceptibility to carcinogens, decreased pathogen clearance and over-active inflammatory responses, defects in cytokinesis, impaired control of virus-infected cells, defects in cell cycle control, and impaired cellular response to genotoxic agents...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Peng Xu, Safder S Ganaie, Xiaomei Wang, Zekun Wang, Steve Kleiboeker, Nancy C Horton, Richard F Heier, Marvin J Meyers, John E Tavis, Jianming Qiu
Human parvovirus B19 (B19V), a member of the genus Erythroparvovirus of the family Parvoviridae , is a small non-enveloped virus that has a single-stranded DNA (ssDNA) genome of 5.6 kilobases with two inverted terminal repeats (ITRs). B19V infection often results in severe hematological disorders and fetal death in humans. B19V replication follows a model of rolling hairpin-dependent DNA replication, in which the large non-structural protein NS1 introduces a site-specific single strand nick in the viral DNA replication origins, which locate at the ITRs...
December 10, 2018: Antimicrobial Agents and Chemotherapy
Ana Fernández-Cruz, Natalia Alba, María Auxiliadora Semiglia-Chong, Belén Padilla, Gabriela Rodríguez-Macías, Mi Kwon, Emilia Cercenado, Esther Chamorro-de-Vega, Marina Machado, Laura Pérez-Lago, Darío García de Viedma, José Luis Díez Martín, Patricia Muñoz
BACKGROUND: We present our experience in patients with hematologic malignancy and Pseudomonas aeruginosa infection treated with ceftolozane-tazobactam. MATERIALS/METHODS: We performed a single-center case-control study including all patients with hematologic malignancy and P. aeruginosa infection treated with ceftolozane-tazobactam (study group) and compared them with similar patients not treated with ceftolozane-tazobactam (control group) to assess safety and efficacy...
December 10, 2018: Antimicrobial Agents and Chemotherapy
Srinivas Ramishetti, Dan Peer
Lymphocytes are the gatekeepers of the body's immune system and are involved in pathogenesis if their surveillance is stalled by inhibitory molecules or when they act as mediators for viral entry. Engineering lymphocytes in order to restore their functions is an unmet need in immunological disorders, cancer and in lymphotropic viral infections. Recently, the FDA approved several therapeutic antibodies for blocking inhibitory signals on T cells. This has revolutionized the field of solid tumor care, together with chimeric antigen receptor T cell (CAR-T) therapy that did the same for hematological malignancies...
December 5, 2018: Advanced Drug Delivery Reviews
Efrat Saraf Lavi, Amit Pal, Drew Bleicher, Kyungmin Kang, Charif Sidani
Spinal emergencies and urgent conditions must be recognized early so that the diagnosis can be quickly confirmed and treatment can be instituted to possibly prevent permanent loss of function. The American College of Radiology provides guidelines for recognition of patients presenting with myelopathy or acute low back pain who require further evaluation for suspicion of more serious problems and contribute to appropriate imaging utilization. Spinal emergencies include spinal cord compression secondary to vertebral fracture or space occupying lesion, spinal infection or abscess, vascular or hematologic damage, severe disc herniation, and spinal stenosis...
December 2018: Seminars in Ultrasound, CT, and MR
Leonardo Potenza, Maria N Chitasombat, Nikolay Klimko, Francesca Bettelli, Giulia Dragonetti, Maria Ilaria Del Principe, Marcio Nucci, Alessandro Busca, Nicola Fracchiolla, Mariarita Sciumè, Angelica Spolzino, Mario Delia, Valentina Mancini, Gian Paolo Nadali, Michela Dargenio, Olga Shadrivova, Federico Bacchelli, Franco Aversa, Maurizio Sanguinetti, Mario Luppi, Dimitrios P Kontoyiannis, Livio Pagano
BACKGROUND: Rhodotorula spp are uncommon yeasts able to cause infections with high mortality rates. Rhodotorula infections have been associated with the presence of central venous catheter (CVC), immunosuppression, exposure to antifungals and the presence of either solid or hematologic malignancies. However, in this latter setting, only a few cases have so far been reported. OBJECTIVES: We have conducted a survey for Rhodotorula infections in hematologic patients...
December 7, 2018: Mycoses
Marina Machado, Rita Azeredo, Filipa Fontinha, Sergio Fernández-Boo, Luis E C Conceição, Jorge Dias, Benjamín Costas
Methionine presents a pivotal role in the regulation of many cellular events with crucial impact on the immune system, such as in processes involved in the control of inflammation and polyamines synthesis. Accordingly, the present study aimed to assess the modulatory effects of dietary methionine on the European seabass ( Dicentrarchus labrax ) immune status, inflammatory response and disease resistance to Photobacterium damselae subsp. piscicida ( Phdp ). For this purpose, fish were randomly distributed in three independent groups (three replicates per group) and each was fed the corresponding diet: a control diet (CTRL) formulated to meet the established amino acid requirements for the species; a diet supplemented with methionine at 0...
2018: Frontiers in Immunology
Seyed Amineh Hojati, Elham Maserat, Mohammad Ghorbani, Alireza Safarpour, Mohammad Reza Fattehi
Introduction: Patients with drug addiction have high risk for hepatitis C virus (HCV). Effective treatment response is essential to optimize treatment for drug abusers infected by hepatitis C virus. Aim: The aim of this present study was to show that hepatitis C treatment in patients with drug addiction is effective like patients without drug addiction. Material and Methods: Total amount of 57 patients with hepatitis C (25 drug abuser and 32 non-drug abuser) that referred to Shahid Motahari clinic of Shiraz were selected...
November 2018: Medical Archives
Mitchell E Horwitz, Stephen Wease, Beth Blackwell, David Valcarcel, Francesco Frassoni, Jaap Jan Boelens, Stefan Nierkens, Madan Jagasia, John E Wagner, Jurgen Kuball, Liang Piu Koh, Navneet S Majhail, Patrick J Stiff, Rabi Hanna, William Y K Hwang, Joanne Kurtzberg, Daniela Cilloni, Laurence S Freedman, Pau Montesinos, Guillermo Sanz
PURPOSE: Increasing the number of hematopoietic stem and progenitor cells within an umbilical cord blood (UCB) graft shortens the time to hematopoietic recovery after UCB transplantation. In this study, we assessed the safety and efficacy of a UCB graft that was expanded ex vivo in the presence of nicotinamide and transplanted after myeloablative conditioning as a stand-alone hematopoietic stem-cell graft. METHODS: Thirty-six patients with hematologic malignancies underwent transplantation at 11 sites...
December 4, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Julio Maquera-Afaray, Giancarlo Pérez-Lazo, Rómulo Rodriguez, Ricardo Illescas, Lourdes Rodriguez, José Hidalgo, Beatriz Bustamante, Celina Herrera, Alberto Díaz
Fusarium species are a group of fungi that cause superficial infections, locally invasive and disseminated disease, which occur mainly in immunocompromised hosts, and occasionally in immunocompetent individuals. We present three cases that show three different clinical forms of Fusarium spp. disease that affected different types of patients (patients with hematological malignancy, chronic kidney disease in peritoneal dialysis and post-surgical for osteoarticular pathology), each with its own characteristics that merit discussion...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Getachew Ferede, Moges Tiruneh, Ebba Abate, Yitayih Wondimeneh, Endalamaw Gadisa, Rawleigh Howe, Abraham Aseffa, Belay Tessema
BACKGROUND: Dengue is one of the most common arboviral diseases with increased outbreaks annually in tropical and subtropical areas. In Ethiopia, there are no data regarding clinical, hematological and biochemical parameters which are very important in the clinical management of dengue patients. Hence this study was carried out to provide the first baseline data of clinical, hematological and biochemical profiles of patients infected with dengue virus. METHODS: A cross-sectional study was carried out among febrile patients in northwest Ethiopia from March 2016 to May 2017...
December 4, 2018: BMC Infectious Diseases
Ying Zhan, Lihua Wang, Guangyang Liu, Xiaohui Zhang, Jingci Yang, Yuxia Pan, Jianmin Luo
Hematological patients who accept chemotherapy always develop secondary tumor or even die of severe infections. As an important central lymphoid organ, the thymus is frequently damaged during chemotherapy. Previous studies showed that the mesenchymal stem cells (MSCs) can promote the proliferation and repair of epithelial cells in thymus. The purpose of our study is to investigate the reparative effects of human adipose-derived mesenchymal stem cells (hADMSCs) for chemotherapy treated damaged thymus. 80 mice were randomly divided into four groups: normal group, model control group, hADMSCs untreated group and hADMSCs treated group...
December 4, 2018: Stem Cells and Development
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