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Infection hematology

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https://www.readbyqxmd.com/read/30096417/current-time-to-positivity-of-blood-cultures-in-the-febrile-neutropenia-a-tool-to-be-used-in-stewardship-de-escalation-strategies
#1
P Puerta-Alcalde, Cardozo C, M Suárez-Lledó, O Rodríguez-Núñez, L Morata, C Fehér, F Marco, A Del Río, J A Martínez, J Mensa, M Rovira, J Esteve, A Soriano, C Garcia-Vidal
OBJECTIVES: We aimed to describe the current time to positivity (TTP) of blood cultures in onco-hematological patients with febrile neutropenia. We assessed the probability of having multidrug-resistant gram-negative bacilli (MDR-GNB) bloodstream infection (BSI) 24h after cultures were taken, to use this information for antibiotic de-escalation strategies. METHODS: BSI episodes were prospectively collected (2003-2017). When a patient experienced more than one BSI, only one episode was randomly chosen...
August 7, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30091024/clinical-outcome-of-granulocyte-transfusion-therapy-for-the-treatment-of-refractory-infection-in-neutropenic-patients-with-hematological-diseases
#2
Biqi Zhou, Tiemei Song, Yufeng Feng, Ziling Zhu, Weirong Chang, Yuejun Liu, Aining Sun, Depei Wu, Yang Xu
Neutropenic patients with hematological diseases are prone to severe infections. Granulocyte transfusion therapy (GTX) is considered as a logical therapeutic approach for these problems. However, the efficacy and complications of GTX have not been well identified. We retrospectively analyzed the clinical outcomes of GTX therapy in our hospital from 2009 to 2015. After 117 granulocyte transfusions for 47 patients, 72.3% of these patients' infections were effectively improved, and the overall survival rates at 30 and 120 days were 66...
August 8, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30090002/-helicobacter-pylori-and-extragastric-diseases-a-review
#3
REVIEW
Antonietta Gerarda Gravina, Rocco Maurizio Zagari, Cristiana De Musis, Lorenzo Romano, Carmelina Loguercio, Marco Romano
Helicobacter pylori ( H. pylori ) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract...
August 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30088429/high-28-day-mortality-in-critically-ill-patients-with-sepsis-and-concomitant-active-cancer
#4
Yong-Gang Wang, Jian-Cang Zhou, Kang-Song Wu
Objective This study was performed to explore the characteristics and outcomes of patients with sepsis accompanied by active cancer who were admitted to the intensive care unit (ICU). Methods The baseline characteristics, infection profiles, and outcomes of patients with sepsis were retrospectively analyzed according to the presence of concomitant active cancer. The association between concomitant active cancer and 28-day mortality was explored. Results Of 23,956 patients with sepsis, 1574 (6.6%) had concomitant active cancer...
August 8, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30083074/kala-azar-and-leukemia-a-rare-association
#5
Ali Bay, Elif Habibe Aktekin, Fahriye Ekşi, Murat Özcan
Visceral leishmaniasis is an infectious disease that infects and multiplies in macrophages of the liver, spleen, and bone marrow. The most common clinical features are fever, splenomegaly, and anemia. Anemia, leucopenia, and thrombocytopenia are the main hematologic abnormalities commonly seen in visceral leishmaniasis. These findings can be seen in several types of hematologic disorders. The findings are similar to most hematologic disorders and so may make diagnosis problematic. It is difficult to confirm when it is seen except in epidemiologic areas...
March 2018: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/30081867/safety-and-tolerability-of-quizartinib-a-flt3-inhibitor-in-advanced-solid-tumors-a-phase-1-dose-escalation-trial
#6
Kyriakos P Papadopoulos, Eytan Ben-Ami, Amita Patnaik, Denise Trone, Jianke Li, George D Demetri
BACKGROUND: Quizartinib, an inhibitor of class III receptor tyrosine kinases (RTKs), is currently in phase 3 development for the treatment of acute myeloid leukemia (AML) bearing internal tandem duplications in the FLT3 gene. Aberrant RTK signaling is implicated in the pathogenesis of a variety of solid tumors, suggesting that inhibiting quizartinib-sensitive RTKs may be beneficial in precision cancer therapy. METHODS: This was a phase 1, open-label, modified Fibonacci dose-escalation study of orally administered quizartinib in patients with advanced solid tumors whose disease progressed despite standard therapy or for which there was no available standard treatment...
August 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30080899/type-i-ifns-drive-hematopoietic-stem-and-progenitor-cell-collapse-via-impaired-proliferation-and-increased-ripk1-dependent-cell-death-during-shock-like-ehrlichial-infection
#7
Julianne N P Smith, Yubin Zhang, Jing Jing Li, Amanda McCabe, Hui Jin Jo, Jackson Maloney, Katherine C MacNamara
Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe infections, thus we sought to investigate the impact of type I IFNs on hematopoiesis in a tick-borne infection with a virulent ehrlichial pathogen that causes shock-like disease. During infection, IFNα/β induced severe bone marrow (BM) loss, blunted infection-induced emergency myelopoiesis, and reduced phenotypic HSPCs and HSCs...
August 6, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/30079788/candidemia-in-the-patient-with-malignancy
#8
Joana Alves, Pedro Palma, Daniela Azevedo, Jordi Rello
Invasive fungal infections are a common life-threatening disease and a major cause of morbidity, particularly in patients with malignancies, and Candida spp. is the most common isolated fungi in bloodstream. Candidemia is the focus of this review, which covers an approach to diagnosis and treatment, with an emphasis on patients with malignancies. Acute leukemia, lymphoma or myelodysplastic syndrome, are the most common hematological malignancies associated with candidemia, while among solid tumors gastrointestinal cancer has the majority of fungemia cases...
August 6, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/30078793/-reference-guide-for-adult-chronic-neutropenia
#9
Yasuhisa Yokoyama, Akiyoshi Takami, Yasuo Mori, Shinya Sato, Takahiro Suzuki, Masahiko Gosho, Naoshi Obara, Yasushi Miyazaki, Koichi Akashi, Shigeru Chiba
Chronic neutropenia is a rare hematological entity characterized by isolated neutropenia without anemia or thrombocytopenia. The diagnostic criteria and classification of chronic neutropenia have been more elusive in adult cases than pediatric cases. We herein propose the Reference Guide for Adult Chronic Neutropenia. In this guide, diagnosis of chronic neutropenia is based on recurrent or continuous neutropenia defined by absolute neutrophil count (ANC) less than 1,500/µl for over three or more months. Severity of chronic neutropenia is defined as follows: severe, ANC <500/µl; moderate, ANC between 500 and 1,000/µl; mild, ANC between 1,000 and 1,500/µl...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/30078782/accreditation-of-a-multiplex-real-time-pcr-assay-for-detection-and-semi-quantitative-determination-of-pathogens-responsible-of-sexually-transmitted-infections
#10
Sylvain Robinet, François Parisot
Preliminary evaluation of qualitative and semi-quantitative clinical laboratory measurements is a prerequisite for the accreditation of clinical laboratories, according to the French committee of accreditation guidelines following the European reference standard EN ISO 15189. Numerous papers have been published regarding biochemistry, hematology or immunology. However, data are still lacking for molecular biology. We report our experience and present the performance characteristics of Allplex™ STI Essential real time PCR assay for the detection of seven pathogens, among which some are systematically responsible of sexually-transmitted infections...
August 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/30075527/a-prospective-quality-improvement-initiative-in-adult-hemophagocytic-lymphohistiocytosis-to-improve-testing-and-a-framework-to-facilitate-trigger-identification-and-mitigate-hemorrhage-from-retrospective-analysis
#11
Samuel A Merrill, Rakhi Naik, Michael B Streiff, Satish Shanbhag, Sophie Lanzkron, Evan M Braunstein, Alison M Moliterno, Robert A Brodsky
Hemophagocytic lymphohistiocytosis (HLH) is a highly fatal, hyperinflammatory syndrome in adults triggered by an underlying illness in most cases. As such, suspicion of HLH dictates further investigation to identify the HLH trigger and determine treatment. HLH is clinically challenging due to diverse presentations and underlying triggers, provider unfamiliarity, and bleeding complications. Clinically, we observed diagnostic error from incorrect testing and cognitive biases (interleukin-2 confused with soluble interleukin-2 receptor and natural killer cell quantification confused with functional assays)...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30072185/red-cell-distribution-width-an-unacknowledged-predictor-of-mortality-and-adverse-outcomes-following-revision-arthroplasty
#12
Arash Aali-Rezaie, Pouya Alijanipour, Noam Shohat, Hamed Vahedi, Carol Foltz, Javad Parvizi
BACKGROUND: Revision total joint arthroplasties (TJAs) have been empirically associated with significant postoperative morbidity and mortality. Red blood cell distribution width (RDW), a frequently measured hematological parameter, has been shown to predict mortality in hip fracture patients. However, its utility in risk-stratifying patients before revision TJA remains unknown. The aim of this study was to investigate the possible relationship between preoperative RDW levels and outcome of revision arthroplasty in terms of mortality, adverse outcomes, and length of hospital stay...
July 4, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30071632/in-hospital-surgery-as-a-risk-factor-for-onset-of-ampc-producing-escherichia-coli-blood-stream-infections
#13
Ruchir Chavada, Deborah Tong, Michael Maley
There has been a progressive rise in the incidence of blood stream infections (BSI) caused by multidrug-resistant Gram-negative organisms (MDR GN), which cause increased morbidity and mortality. For this reason, recent studies have focused on risk factors of acquisition of carbapenemase-producing Enterobacteriaceae and extended-spectrum beta-lactamase producers. However, there is limited data on risk factors for BSI caused by AmpC-producing Enterobacteriaceae (AmpC EC), especially in low prevalence settings such as Australia...
August 1, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/30066769/paraneoplastic-sweet-s-syndrome
#14
Daniela Gomes Cunha, Gabriella Campos-do-Carmo, Julia Macchione Marujo, Gustavo Costa Verardino
Sweet's syndrome is a rare dermatosis with little-known pathogenesis, associated with some clinical conditions such as infections, autoimmune diseases, inflammatory bowel diseases, vaccination, medications and neoplasms. Hematologic malignancies are the diseases most related to paraneoplastic Sweet's syndrome, but this clinical entity can also be found occasionally in some solid tumors, including genitourinary tract tumors. We report a rare case of paraneoplastic Sweet's syndrome associated with the diagnosis of cervical cancer...
July 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/30066000/laurus-nobilis-laurel-aqueous-leaf-extract-s-toxicological-and-anti-tumor-activities-in-hpv16-transgenic-mice
#15
B Medeiros-Fonseca, V F Mestre, B Colaço, M J Pires, T Martins, R M Gil da Costa, M J Neuparth, R Medeiros, Magda S S Moutinho, Maria Inês Dias, Lillian Barros, M M S M Bastos, L Félix, C Venâncio, Isabel C F R Ferreira, L M Antunes, P A Oliveira
Cancers induced by human papillomavirus (HPV) infection remain a significant public health threat, fueling the study of new therapies. Laurel (Laurus nobilis) compounds and extracts recently showed in vitro activity against HPV-transformed cell lines. This work aims to evaluate the in vivo efficacy and hepatic toxicity of a laurel extract in a transgenic mouse model of HPV16-induced cancer. The extract was administered in drinking water (20 mg per animal per day) for three consecutive weeks, using four experimental groups (n = 10) (group I: HPV16-/- without treatment, group II: treated HPV16-/-, group III: HPV16+/- without treatment and group IV: treated HPV16+/-)...
August 1, 2018: Food & Function
https://www.readbyqxmd.com/read/30065810/obstructive-bacterial-cystitis-following-cystotomy-in-a-persian-cat
#16
Zahra Nikousefat, Mohammad Hashemnia, Moosa Javdani, Ali Ghashghaii
Feline lower urinary tract diseases are known to be life threatening conditions in cats, especially when they occur as obstructive diseases in males. Early diagnosis and treatment is necessary, otherwise it may lead to death. A 3-year-old male Persian cat was referred to the clinic with a history of anuria, lethargy, loss of appetite and exploratory cystotomy 6 months ago due to urethral obstruction following urolithiasis. Urinary bladder was enlarged and painful on palpation and urine accumulation was observed in ultrasonography...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/30064602/subcutaneous-granuloma-annulare
#17
Tatiana Ţăranu, Mirela Grigorovici, Magda Constantin, Mihaela Paula Toader
Dear Editor, Subcutaneous granuloma annulare (SGA) is considered a rare clinical variant of granuloma annulare, a common self-healing chronic inflammatory disorder that may appear in childhood as well as in adult age (1-3). A 29-year-old female patient reported the onset of several small subcutaneous nodules on the dorsal aspect of the second interphalangeal joint of the left medius finger and the left elbow, accompanied by vague joint pain, had occurred 13 years ago. Specific markers for rheumatoid arthritis were negative, leading to a diagnosis of sero-negative rheumatoid arthritis, for which treatment with methotrexate was initiated...
December 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/30063976/evaluation-of-oxidative-stress-and-antioxidant-status-serum-trace-mineral-levels-and-cholinesterases-activity-in-cattle-infected-with-anaplasma-marginale
#18
Bijan Esmaeilnejad, Mousa Tavassoli, Awat Samiei, Nasser Hajipour, Abbas Imani-Baran, Farhad Farhang-Pajuh
This study was undertaken to assess the influence of an Anaplasma marginale infection on oxidative stress and antioxidant status, trace elements and cholinesterase as markers of the inflammatory process and biomarkers of oxidative imbalance. An infected group comprised of 35 crossbred Holstein cattle, about 2-3 years old, naturally infected with Anaplasma marginale, were divided into 4 subgroups according to their parasitemia rates (<1%, 1-10%, 10-20%, >20%) and also 10 healthy cattle as control were selected...
July 28, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30062389/combined-medical-and-surgical-management-of-hepatic-mucormycosis-in-an-adult-with-acute-myeloid-leukemia-case-report-and-review-of-the-literature
#19
Mansi Shah, Jeremy Nel, Abdulrahman Almansouri, David Van Duin, David A Gerber
Hepatic mucormycosis is a disease caused by a ubiquitous fungus which is especially important in patients with hematologic malignancies. We present a case of an adult patient with acute myeloid leukemia who developed the infection after undergoing chemotherapy. His successful management was an integrated approach of a minimally invasive surgical resection with anti-fungal therapy. We describe the management of this patient and a review of the literature.
July 30, 2018: Mycopathologia
https://www.readbyqxmd.com/read/30060095/whole-blood-transcriptional-signatures-composed-of-erythropoietic-and-nrf2-regulated-genes-differ-between-cerebral-malaria-and-severe-malarial-anemia
#20
Srinivas Nallandhighal, Gregory S Park, Yen-Yi Ho, Robert O Opoka, Chandy C John, Tuan M Tran
Background: Among the severe malaria syndromes, severe malarial anemia (SMA) is the most common, whereas cerebral malaria (CM) is the most lethal. However, the mechanisms that lead to CM and SMA are unclear. Methods: We compared transcriptomic profiles of whole blood obtained from Ugandan children with acute CM (n=17) or SMA (n=17) and community children without Plasmodium falciparum infection (n=12) and determined the relationships between gene expression, hematological indices, and relevant plasma biomarkers...
July 28, 2018: Journal of Infectious Diseases
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