Jin-Rong Guo, Kai-Yue He, Jia-Li Yuan, Wang An, Wei-Tao Yin, Qiu-Tong Li, Li-Yuan Lu, Jing-Yu Yang, Meng-Jie Liu, Yu-Jia Li, Yuan Zhao, Qi Yang, Xin-Yuan Lei, Fan Gao, Lei Zhang, Dan-Hui Wu, Jun-Qi Li, Zi-Long Zhao, Huai Liu, Ling-Jun Zhu, Xiong-Yan Xiang, Qian-Hui Sun, Yong-Ping Jian, Zhi-Xiang Xu
Esophageal carcinoma is amongst the prevalent malignancies worldwide, characterized by unclear molecular classifications and varying clinical outcomes. The PI3K/AKT/mTOR signaling, one of the frequently perturbed dysregulated pathways in human malignancies, has instigated the development of various inhibitory agents targeting this pathway, but many ESCC patients exhibit intrinsic or adaptive resistance to these inhibitors. Here, we aim to explore the reasons for the insensitivity of ESCC patients to mTOR inhibitors...
2024: International Journal of Biological Sciences