keyword
https://read.qxmd.com/read/38390905/thrombosis-prophylaxis-following-trauma
#1
JOURNAL ARTICLE
Johannes Bösch, Mirjam Bachler, Dietmar Fries
PURPOSE OF REVIEW: This review explores the persistent occurrence of venous thromboembolic events (VTE) in major trauma patients despite standard thrombosis prophylaxis with low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH). It investigates the inadequacies of standard pharmacologic prophylaxis and proposes alternative approaches not covered in current trauma guidelines. RECENT FINDINGS: Recent studies highlight the effectiveness of monitoring and adjusting subcutaneous LMWH doses based on anti-Xa levels for the purpose of reducing VTE in trauma patients...
January 24, 2024: Current Opinion in Anaesthesiology
https://read.qxmd.com/read/38278170/evaluating-the-efficacy-and-safety-of-pozelimab-in-patients-with-cd55-deficiency-with-hyperactivation-of-complement-angiopathic-thrombosis-and-protein-losing-enteropathy-disease-an-open-label-phase-2-and-3-study
#2
JOURNAL ARTICLE
Ahmet Ozen, Voranush Chongsrisawat, Asena Pinar Sefer, Burcu Kolukisa, Jessica J Jalbert, Karoline A Meagher, Taylor Brackin, Hagit Baris Feldman, Safa Baris, Elif Karakoc-Aydiner, Rabia Ergelen, Ivan J Fuss, Heather Moorman, Narissara Suratannon, Kanya Suphapeetiporn, Lorah Perlee, Olivier A Harari, George D Yancopoulos, Michael J Lenardo
BACKGROUND: CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) is an ultra-rare genetic disorder characterised by intestinal lymphatic damage, lymphangiectasia, and protein-losing enteropathy caused by overactivation of the complement system. We assessed the efficacy and safety of pozelimab, an antibody blocking complement component 5. METHODS: This open-label, single-arm, historically controlled, multicentre phase 2 and 3 study evaluated ten patients with CHAPLE disease...
January 23, 2024: Lancet
https://read.qxmd.com/read/38272517/subsequent-development-of-kawasaki-disease-following-acute-human-adenovirus-infection-among-siblings
#3
JOURNAL ARTICLE
Ashwini Sankannaavr, Divyashree Puttalinga, Praveen S Bagalkot
We report a middle-childhood girl presented with high-grade fever and headache for 4 days. Following this, the child developed mucocutaneous symptoms. She had a notable family history of autoimmune disease. Tests revealed increased inflammatory markers. On the sixth day of illness, a two-dimensonal echocardiogram showed an enlarged coronary artery, diagnosed as incomplete Kawasaki disease (KD) and treated with IVIG and aspirin.Within a week, her younger sibling, an early-childhood girl presented with features of viral prodrome, developed mucocutaneous lesions and subcutaneous oedema of limbs...
January 24, 2024: BMJ Case Reports
https://read.qxmd.com/read/38025329/empiric-anti-giardia-therapy-in-non-diarrheal-protein-losing-enteropathy-a-focus-on-children-with-monogenic-humoral-immunodeficiency
#4
JOURNAL ARTICLE
Tariq Al Farsi, Khwater Ahmed, Nashet Al Sukaiti
Background and Aim: Chronic giardia infection can lead to non-erosive gastrointestinal disorders, including protein-losing enteropathy (PLE). This report describes non-diarrheal PLE in chronic giardiasis in children with defective humoral immunity. Methods: The retrospective report is related to 2 children known to have a monogenic inborn error of immunity. The first patient is a 13-year-old boy with X-linked agammaglobulinemia (Patient-1), and the second is a 5-year-old boy with NF-kB inducing kinase (NIK) deficiency infection...
2023: Qatar Medical Journal
https://read.qxmd.com/read/37900657/iatrogenic-breast-lymphoedema-incidence-diagnosis-and-associated-risk-factors
#5
JOURNAL ARTICLE
Mohamed Ibrahim, Hany Habashy, Sherif Monib
While upper limb lymphoedema following breast and axillary surgery is well established in the literature, breast lymphoedema is rarely documented. Our primary objective was to identify risk factors of breast lymphoedema, and our secondary aim was to assess the possibility of using a breast ultrasound scan to assess breast lymphoedema. This study was a case series analysis, including patients who had wide local excision for primary breast cancer treatment between January 2013 and January 2018. Patients' demographics, including age, weight, body mass index (BMI), breast volume, tumour characteristics, and histological findings, were noted...
September 2023: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/37817710/nodular-posterior-scleritis-with-associated-choroiditis-masquerading-as-a-choroidal-tumour-a-case-report
#6
Muhammad Amer Awan, Fatima Mohsin, Abdullah Ahmed, Muhammad Suhail Sarwar, Tahir Hashmi
A case of nodular posterior scleritis in a 25-year-old male who presented with a 14-day history of unilateral decline in vision, pain, and redness in his right eye. Slit lamp examination of the right eye revealed dilated episcleral vessels present nasally as well as a choroidal mass at the nasal periphery of the fundus, associated with choroidal oedema. Systemic evaluation and imaging of the choroidal mass were performed to rule out choroidal tuberculoma and choroidal metastasis. Ultrasound B-scan of the right eye showed marked thickening of the nasalsclera resulting in sympathetic choroidal oedema without the characteristic T-sign...
September 2023: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/37801141/clinical-profile-of-anti-nxp-2-antibody-positive-inflammatory-myositis-and-outcome-in-an-indian-population
#7
JOURNAL ARTICLE
Abhilasha Manwatkar, Shivraj Padiyar, Aswin Nair, Avanish Jha, Sathish Kumar, Bijesh Yadav, John Antony Jude Prakash, John Kumar Das, John Mathew
INTRODUCTION: Myositis-specific antibodies (MSA) play an important role in the clinical presentation and prognosis of patients with idiopathic inflammatory myositis (IIM). Anti-NXP-2 is one of the newly described MSA. OBJECTIVE: We aimed to describe various clinical presentations associated with anti-NXP2 antibodies and assess response to treatment. METHODS: In this retrospective study, the electronic medical records of all patients who tested positive for anti-NXP2 during June 2019 to April 2022 were screened...
October 6, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37772339/bluetongue-disease-in-sheep-in-new-south-wales-april-2023
#8
JOURNAL ARTICLE
P D Kirkland, D S Finlaison, A Biddle, M Parsons, H Austin, S Boland, G Roach, R McKinnon, E Braddon, S Britton
In 2016, bluetongue virus (BTV), serotype 16 (BTV-16), was detected in New South Wales (NSW) in sentinel cattle for the first time. Over the next 6 years, BTV-16 has been detected regularly and over an increasing area of the BTV zone in NSW. In April 2023, disease was reported in sheep on two farms on the Northern Tablelands of NSW. The consistent clinical signs included reduced exercise tolerance, facial swelling, serous nasal discharges with encrustation of the nasal plane, subcutaneous oedema of the neck and brisket and variable congestion of the coronary band...
September 29, 2023: Australian Veterinary Journal
https://read.qxmd.com/read/37713268/anakinra-in-cerebral-haemorrhage-to-target-secondary-injury-resulting-from-neuroinflammation-action-study-protocol-of-a-phase-ii-randomised-clinical-trial
#9
JOURNAL ARTICLE
M P Cliteur, A G van der Kolk, G Hannink, J Hofmeijer, Wmt Jolink, Cjm Klijn, Fhbm Schreuder
BACKGROUND: Inflammation plays a vital role in the development of secondary brain injury after spontaneous intracerebral haemorrhage (ICH). Interleukin-1 beta is an early pro-inflammatory cytokine and a potential therapeutic target. AIM: To determine the effect of treatment with recombinant human interleukin-1 receptor antagonist anakinra on perihematomal oedema (PHO) formation in patients with spontaneous ICH compared to standard medical management, and investigate whether this effect is dose-dependent...
September 15, 2023: European Stroke Journal
https://read.qxmd.com/read/37596179/triple-negative-breast-cancer-predictive-model-of-early-recurrence-based-on-mri-features
#10
JOURNAL ARTICLE
X Yu, J Xiang, Q Zhang, S Chen, W Tang, X Li, Y Sui, W Liu, Q Kong, Y Guo
AIM: To develop an integrated model based on preoperative magnetic resonance imaging (MRI) features for predicting early recurrence in patients with triple-negative breast cancer (TNBC). MATERIALS AND METHODS: Women with TNBC who underwent breast MRI and surgery between 2009 and 2019 were evaluated retrospectively. Two breast radiologists reviewed MRI images independently based on the Breast Imaging Reporting and Data System Lexicon (BI-RADS), and classified the breast oedema scores on T2-weighted imaging (WI) as no oedema, peritumoural oedema, prepectoral oedema, or subcutaneous oedema...
July 29, 2023: Clinical Radiology
https://read.qxmd.com/read/37559057/anti-inflammatory-and-antioxidant-efficacy-of-lavender-oil-in-experimentally-induced-thrombosis
#11
JOURNAL ARTICLE
Valeriu Mihai But, Adriana Elena Bulboacă, Vasile Rus, Tamás Ilyés, Mădălina Luciana Gherman, Sorana D Bolboacă
BACKGROUND: Lavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive properties. Thrombosis and inflammation are interplayed processes that interact and influence one another. Our research compared three routes of administration to assess the efficacy of pretreatment with LO on carrageenan-induced thrombosis in rat tail. MATERIALS AND METHODS: Wistar-Bratislava white rats were randomly divided into five groups of ten rats each and pretreated 3 consecutive days prior the inducement of thrombosis to with one dose of LO (150 mg/kg body weight (b...
August 9, 2023: Thrombosis Journal
https://read.qxmd.com/read/37538928/whole-body-mri-revealed-generalized-subcutaneous-oedema-in-a-patient-with-juvenile-dermatomyositis
#12
Yuji Fujita, Shigeko Kuwashima, Ryosuke Sakurai, Atsushi Suzuki, George Imataka, Hadzki Matsuda, Kazuyuki Ishida, Takashi Matsushita, Ichizo Nishino, Shigemi Yoshihara
No abstract text is available yet for this article.
2023: Rheumatology Advances in Practice
https://read.qxmd.com/read/37522493/facial-and-body-contouring-with-1444%C3%A2-nm-nd-yag-laser-assisted-lipolysis-clinical-evidence
#13
JOURNAL ARTICLE
Domenico Piccolo, Mohammed Hussein Mutlag, Irene Fusco, Paolo Bonan
BACKGROUND: Body contouring is a significant area of dermatologic and plastic surgery. Surgical procedures, like surgical lipectomy, and less invasive procedures, such as various liposuction techniques, are the two main ways to reduce fat. AIM: Our study showed that 1444 nm Nd:YAG laser-assisted lipolysis used with appropriate and specific parameters effectively destroys adipose tissue avoiding these risks and determining a safe clinical application. METHOD: A subcutaneous, 1444 nm Nd:YAG laser was used on 132 patients (range, 18-73 years; 109 women and 23 men with Fitzpatrick skin phototypes ranging between II and V) requiring body and face contouring...
July 2023: Skin Research and Technology
https://read.qxmd.com/read/37452707/phase-ii-randomised-placebo-controlled-clinical-trial-of-interleukin-1-receptor-antagonist-in-intracerebral-haemorrhage-blocking-the-cytokine-il-1-in-ich-bloc-ich
#14
RANDOMIZED CONTROLLED TRIAL
Adrian R Parry-Jones, Katie Stocking, Mary Joan MacLeod, Brian Clarke, David J Werring, Keith W Muir, Andy Vail
PURPOSE: Recombinant human interleukin-1 receptor antagonist (anakinra) is an anti-inflammatory with efficacy in animal models of stroke. We tested the effect of anakinra on perihaematomal oedema in acute intracerebral haemorrhage (ICH) and explored effects on inflammatory markers. METHODS: We conducted a multicentre, randomised, double-blind, placebo-controlled trial in patients with acute, spontaneous, supratentorial ICH between May 2019 and February 2021. Patients were randomised to 100 mg subcutaneous anakinra within 8 h of onset, followed by five, 12-hourly, 100 mg subcutaneous injections, or matched placebo...
September 2023: European Stroke Journal
https://read.qxmd.com/read/37435706/eyelid-involvement-of-primary-cutaneous-lymphomas-a-clinical-perspective
#15
REVIEW
Can Baykal, Tugba Atci
Eyelids may be affected in systemic, ocular adnexal and primary cutaneous lymphomas (PCLs). The frequency of eyelid involvement in PCLs is still not well known and it is not a predilection site for any type. While primary cutaneous T-cell lymphomas (CTCLs) are more commonly seen than primary cutaneous B-cell lymphomas (CBCLs), especially mycosis fungoides (MF) as by far the most frequent type, B cell lymphomas are reported to be the commonest type in eyelid localization on the contrary. PCLs may be located on the eyelids, as the sole manifestation or in association with the involvement of other parts of the eye and elsewhere of the body...
July 12, 2023: Australasian Journal of Dermatology
https://read.qxmd.com/read/37363590/henoch-sch%C3%A3-nlein-purpura-with-antecedent-allergic-diseases-in-a-4-year-old-child-a-case-report
#16
JOURNAL ARTICLE
Satkirti Bista, Yuvraj Adhikari, Sammridhi Karmacharya, Sagar Joshi, Shikha Pandey, Nawaraj Adhikari
UNLABELLED: Henoch-Schönlein purpura (HSP)/immunoglobulin A vasculitis is an acute immunoglobulin-mediated vascular disorder compromising a triad of non-blanchable purpuric rashes, colicky abdominal pain and haematuria. Incidence ranging for large populations has been most common vasculitis among children with a mean age of 6years. Disease presentation ranges from small petechial rash to the most severe form of renal involvement so early diagnosis is important. CASE PRESENTATION: Here the authors present a 4-year-old girl with antecedent allergic history associated HSP...
June 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37270177/sixth-cranial-nerve-palsy-and-dense-cerebral-venous-sinus-thrombosis-in-a-child-with-nephrotic-syndrome
#17
JOURNAL ARTICLE
Sucheta Parija, Nikita Dash, Genickson Jeyaraj
Nephrotic syndrome (NS) is a common glomerular disease characterised by massive proteinuria, hypoalbuminaemia, oedema and hyperlipidaemia. Cerebral venous sinus thrombosis (CVST) is a rare complication in children with NS. Here, we report a case of relapsing NS on steroid therapy, in a male in early childhood who presented with symptoms of headache, vomiting and double vision. On prism cover test there was 25 PD esotropia with abduction restriction in the left eye. Fundus examination showed bilateral papilloedema...
June 2, 2023: BMJ Case Reports
https://read.qxmd.com/read/37230746/axial-spondylarthritis-following-covid-19-infection
#18
JOURNAL ARTICLE
Rajesh Gopalarathinam, Shainy Nawimana, Arvind Nune
Although SARS-CoV-2 syndrome primarily affects the lungs, systemic manifestations have been reported. New rheumatic immune-mediated inflammatory diseases have been reported following SARS-CoV-2 infection. We present a case of a woman in her mid-30s who developed inflammatory back pain due to bilateral sacroiliitis with erosions after contracting SARS-CoV-2 infection. Her inflammatory markers on presentation were normal. MRI of the sacroiliac joints demonstrated bone marrow oedema and erosive changes in both sacroiliac joints...
May 25, 2023: BMJ Case Reports
https://read.qxmd.com/read/37086648/the-spatio-temporal-relationship-between-concurrent-lesion-and-brain-atrophy-changes-in-early-multiple-sclerosis-a-post-hoc-analysis-of-the-reflexion-study
#19
JOURNAL ARTICLE
Giordano Gentile, Rozemarijn M Mattiesing, Iman Brouwer, Ronald A van Schijndel, Bernard M J Uitdehaag, Jos W R Twisk, Ludwig Kappos, Mark S Freedman, Giancarlo Comi, Dominic Jack, Frederik Barkhof, Nicola De Stefano, Hugo Vrenken, Marco Battaglini
BACKGROUND: White matter (WM) lesions and brain atrophy are present early in multiple sclerosis (MS). However, their spatio-temporal relationship remains unclear. METHODS: Yearly magnetic resonance images were analysed in 387 patients with a first clinical demyelinating event (FCDE) from the 5-year REFLEXION study. Patients received early (from baseline; N = 258; ET) or delayed treatment (from month-24; N = 129; DT) with subcutaneous interferon beta-1a...
April 5, 2023: NeuroImage: Clinical
https://read.qxmd.com/read/37051882/evaluation-of-the-tolerance-of-ceftriaxone-by-subcutaneous-route-in-patients-%C3%A2-75%C3%A2-years-old-in-geriatric-departments-a-prospective-observational-study
#20
JOURNAL ARTICLE
Thomas Renoncourt, Justine Dossoubadjiokila, Lisa Mondet, Pauline-Eva Pecquet, Nysrine Bennouna, Valerie Gras-Champel, Youssef Bennis, Frédéric Bloch
OBJECTIVES: The subcutaneous (SC) route provides an alternative to the IV or oral route for drug administration in the elderly. The benefits of SC administration have been proven for hydration but are still debated for antibiotics because tolerance remains uncertain, especially in the frail geriatric population. Here, we aimed to improve current knowledge concerning the tolerance profile of ceftriaxone SC administration at both the systemic and cutaneous level, as well as in terms of pain...
April 13, 2023: Journal of Antimicrobial Chemotherapy
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