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Subcutaneous oedema

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https://www.readbyqxmd.com/read/29922355/ischaemic-haemorrhagic-stroke-in-a-child-with-new-onset-type-1-diabetes-mellitus
#1
Noor Shafina Mohd Nor, Choong Yi Fong, Kartini Rahmat, Wan Mun Vanessa Lee, Azriyanti Anuar Zaini, Muhammad Yazid Jalaludin
Cerebral oedema is the most common neurological complication of diabetic ketoacidosis (DKA). However, ischaemic and haemorrhagic brain injury has been reported infrequently. A 10-year old girl who was previously well presented with severe DKA. She was tachycardic with poor peripheral perfusion but normotensive. However, two fast boluses totalling 40 ml/kg normal saline were given. She was transferred to another hospital where she was intubated due to drowsiness. Rehydration fluid (maintenance and 48-hour correction for 7...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29848519/subcutaneous-oedema-of-upper-limbs-heralding-an-aggressive-form-of-dermatomyositis
#2
Mohit Shukla, Rishi Patel, Halyna Kuzyshyn, David Feinstein
Subcutaneous oedema is a rare presenting clinical manifestation of dermatomyositis. In this case, we report a 44-year-old man presenting with bilateral upper extremity predominant swelling and weakness. The proximal muscle weakness, dysphagia and presence of Gottron's papules as well poikiloderma like skin changes led to the clinical diagnosis of dermatomyositis. He received aggressive treatment with high-dose glucocorticoids and required intravenous immunoglobulin with improvement in his symptoms.
May 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29674403/unexpected-case-of-pneumomediastinum-and-subcutaneous-emphysema-primary-or-secondary-aetiology
#3
Amanda J L Cheng, Timothy J Sadler
A 77-year-old man was admitted with a relapse of antineutrophil cytoplasmic antibody-positive vasculitis with pulmonary involvement and acute kidney injury. There was a background of pulmonary fibrosis (non-specific interstitial pneumonia type pattern) and superadded pulmonary haemorrhage, acute pulmonary oedema and sepsis. The patient was intubated for 4 days and remained dependent on high flow oxygen and continuous positive airway pressure after extubation. A chest radiograph performed 2 weeks after extubation demonstrated unexpected, extensive pneumomediastinum and subcutaneous emphysema...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29560421/a-comparison-of-statistical-associations-between-oedema-in-the-lumbar-fat-on-mri-bmi-and-back-fat-thickness-bft
#4
Wayne West, Doreen Brady-West, Keon P West
Purpose: To compare the relationship between obesity markers Body Mass Index (BMI) and Back Fat Thickness (BFT) and oedema in the lumbo-sacral subcutaneous adipose tissue. Patients and methods: A retrospective study was performed of consecutive Magnetic Resonance Imaging examinations on 149 adults (95 females and 54 males) scanned at 1.5T between October 1 and December 31, 2010. The extent of oedema was graded from 1 to 8 based on the number of involved anatomical segments on the Fat Sat sequence...
January 2018: Heliyon
https://www.readbyqxmd.com/read/29535373/propeller-flaps-in-eyelid-reconstruction
#5
Saul N Rajak, Shyamala C Huilgol, Masahiro Murakami, Dinesh Selva
PURPOSE: Propeller flaps are island flaps that reach the recipient site through an axial rotation. The flap has a subcutaneous pedicle on which it pivots, thereby resembling a helicopter propeller. We present our series of propeller flaps for the reconstruction of large eyelid defects. METHODS: This is a retrospective review of the clinical case notes of eight patients that underwent tumour excision with reconstruction with a cutaneous propeller flap supplied by a non-perforator orbicularis pedicle between July and December 2016...
July 2018: Eye
https://www.readbyqxmd.com/read/29396376/calcitonin-gene-related-peptide-is-a-potent-inducer-of-oedema-in-rat-orofacial-tissue
#6
Bárbara F G de Queiroz, Marcella P A de Almeida, Y S Bakhle, Janetti N Francischi
BACKGROUND AND AIMS: This study aimed to assess the potential of calcitonin-gene related peptide (CGRP), a neuropeptide released from sensory nerves, to induce oedema in orofacial tissue. EXPERIMENTAL APPROACH: Wistar rats (150-200 g) anesthetized with isoflurane were injected intraorally with CGRP (100 μl; 8-33 pmol) in the right side of the mouth. The contralateral side was injected with the same volume of physiological saline. Increased cheek thickness (in mm), as a measure of oedema formation, was assayed bilaterally with a digital caliper before (T = 0) and up to 24 h following injection of CGRP...
April 2018: Neuropeptides
https://www.readbyqxmd.com/read/29378651/safety-tolerability-and-immunogenicity-of-an-active-anti-a%C3%AE-40-vaccine-abvac40-in-patients-with-alzheimer-s-disease-a-randomised-double-blind-placebo-controlled-phase-i-trial
#7
Ana-María Lacosta, María Pascual-Lucas, Pedro Pesini, Diego Casabona, Virginia Pérez-Grijalba, Iván Marcos-Campos, Leticia Sarasa, Jesus Canudas, Hassnae Badi, Inmaculada Monleón, Itziar San-José, Josep Munuera, Octavio Rodríguez-Gómez, Carla Abdelnour, Asunción Lafuente, Mar Buendía, Mercè Boada, Lluis Tárraga, Agustín Ruiz, Manuel Sarasa
BACKGROUND: Immunotherapy targeting the amyloid-β (Aβ) peptide is a promising strategy for the treatment of Alzheimer's disease (AD); however, none of the active or passive vaccines tested have been demonstrated to be effective to date. We have developed the first active vaccine against the C-terminal end of Aβ40 , ABvac40, and assessed its safety and tolerability in a phase I clinical trial. METHODS: A randomised, double-blind, placebo-controlled, parallel-group, phase I study of ABvac40 was conducted with patients aged 50-85 years with mild to moderate AD...
January 29, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29331635/sotatercept-with-long-term-extension-for-the-treatment-of-anaemia-in-patients-with-lower-risk-myelodysplastic-syndromes-a-phase-2-dose-ranging-trial
#8
Rami Komrokji, Guillermo Garcia-Manero, Lionel Ades, Thomas Prebet, David P Steensma, Joseph G Jurcic, Mikkael A Sekeres, Jesus Berdeja, Michael R Savona, Odile Beyne-Rauzy, Aspasia Stamatoullas, Amy E DeZern, Jacques Delaunay, Gautam Borthakur, Robert Rifkin, Thomas E Boyd, Abderrhamane Laadem, Bond Vo, Jennie Zhang, Marie Puccio-Pick, Kenneth M Attie, Pierre Fenaux, Alan F List
BACKGROUND: Myelodysplastic syndromes are characterised by ineffective erythropoiesis leading to anaemia. Sotatercept (ACE-011) is a novel activin receptor type IIA fusion protein that acts as a ligand trap to neutralise negative regulators of late-stage erythropoiesis. The aim of the study was to establish a safe and effective dose of sotatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes. METHODS: This open-label, multicentre, dose-ranging, phase 2 trial took place at 11 treatment centres in the USA and France...
February 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29325550/acute-onset-high-morbidity-primary-photosensitisation-in-sheep-associated-with-consumption-of-the-casbah-and-mauro-cultivars-of-the-pasture-legume-biserrula
#9
Jane C Quinn, Yuchi Chen, Belinda Hackney, Muhammad Shoaib Tufail, Leslie A Weston, Panayiotis Loukopoulos
BACKGROUND: Primary photosensitisation (PS) subsequent to ingestion of the pasture legume Biserrula pelecinus L. (biserrula) has recently been confirmed in grazing livestock. Given the potential utility of this pasture species in challenging climates, a grazing trial was undertaken to examine if both varieties 'Casbah' and 'Mauro' were able to cause photosensitisation in livestock, and if this could be mitigated by grazing in winter, or in combination with other common pasture species...
January 11, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29227981/gamma-secretase-inhibitors-attenuate-neurotrauma-and-neurogenic-acute-lung-injury-in-rats-by-rescuing-the-accumulation-of-hypertrophic-microglia
#10
Hung-Jung Lin, Chien-Chin Hsu, Chung-Ching Chio, Yu-Feng Tian, Mao-Tsun Lin, Ting-Wei Lin, Chih-Hsien Chang, Ching-Ping Chang
BACKGROUND/AIMS: In response to traumatic brain injury (TBI), activated microglia exhibit changes in their morphology from the resting ramified phenotype toward the activated hypertrophic or amoeboid phenotype. Here, we provide the first description of the mechanism underlying the neuroprotective effects of γ-secretase inhibitors on TBI outcomes in rats. METHODS: The neuroprotective effects of γ-secretase inhibitors such as LY411575 or CHF5074 on TBI-induced neurotoxicity were analysed using a neurological motor function evaluation, cerebral contusion assay, immunohistochemical staining for microglia phenotypes, lung injury score and Evans Blue dye extravasation assay of brain and lung oedema...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29072662/-the-potential-of-physiotherapy-after-rhinoplasty
#11
T A Aleksanyan
This article presents the results of the evaluation of the effectiveness of physiotherapy during the postoperative period following rhinoplastic surgery based on the analysis of the dynamics of the clinical symptoms in 374 patients divided into two groups. The main group was comprised of 286 (86.5%) patients who had undergone the comprehensive postoperative rehabilitation with the use of the chosen physiotherapeutic procedures while the group of comparison consisted of 88 (23.5%) patients treated othrerwise...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28806938/cystoid-macular-oedema-associated-with-rosai-dorfman-disease-a-case-report
#12
Rubens Camargo Siqueira, Antonio Augusto Velasco E Cruz
BACKGROUND: The aim of this study is to report a case of cystoid macular oedema (CME) associated with Rosai-Dorfman Disease (RDD). CASE PRESENTATION: A 52-year-old male initially presented with a two-month history of a congested left eye. At presentation, visual acuity was 20/20 in the right eye and 20/80 in the left eye. Biomicroscopy showed conjunctival hyperaemia in the left eye with a slight elevation, suggesting a subconjunctival mass. Retinal fluorescein angiography and optical coherence tomography (OCT) revealed the presence of CME in the left eye...
August 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28738858/erythema-nodosum-masking-nephrogenic-systemic-fibrosis-as-initial-skin-manifestation
#13
Kar Wah Fuah, Christopher Thiam Seong Lim
BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a complication of the gadolinium-based contrast agent used in imaging studies. It is typically characterised by hard, erythematous and indurated skin plaques with surrounding subcutaneous oedema. Distinct papules and subcutaneous nodules can also be seen. Fibrocytes in NSF are immunohistochemically positive for CD34. CASE PRESENTATION: We present a case of NSF occurred after gadolinium exposure in which the initial presentation mimics an erythema nodosum (EN)-like picture...
July 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28738733/cases-of-mortality-in-little-penguins-eudyptula-minor-in-new-zealand-associated-with-avian-malaria
#14
D C Sijbranda, S Hunter, L Howe, B Lenting, L Argilla, B D Gartrell
CASE HISTORY A little penguin (Eudyptula minor) of wild origin, in captivity at Wellington Zoo, became inappetent and lethargic in March 2013. Despite supportive care in the zoo's wildlife hospital, the bird died within 24 hours. CLINICAL FINDINGS Weight loss, dehydration, pale mucous membranes, weakness, increased respiratory effort and biliverdinuria were apparent on physical examination. Microscopic evaluation of blood smears revealed intra-erythrocytic stages of Plasmodium spp. and a regenerative reticulocytosis in the absence of anaemia...
November 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28690388/-23-na-mri-and-myometry-to-compare-eplerenone-vs-glucocorticoid-treatment-in-duchenne-dystrophy
#15
COMPARATIVE STUDY
Philip A Glemser, Heike Jaeger, Armin M Nagel, Andreas E Ziegler, David Simons, Heinz-Peter Schlemmer, Frank Lehmann-Horn, Karin Jurkat-Rott, Marc-André Weber
In this pilot study we tested whether a low dose application of a mild diuretic substance such as eplerenone is beneficial in early stages of Duchenne muscular dystrophy using 23 Na und 1 H imaging, myometry, and clinical testing versus the glucocorticoid gold standard. Two 7-years old patients with DMD were examined on a 3T MRI system. 1 H MRI and 23 Na density-adapted 3-dimensional radial MRI sequences were performed both before and 1, 3 and 6 months after therapy with eplerenone respectively cortisone. We quantified fatty infiltration on T1-weighted images using subcutaneous fat as reference and fat fraction with a two-point DIXON sequence...
March 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/28667506/a-rare-presentation-of-nephrotic-syndrome
#16
Debabrata Mukherjee, Sourabh Sharma, Debashish Mahapatra, Ranjith K Nair, Bhaskar Datt, Dhawal Arora
Nephrotic syndrome usually presents with oedema due to fluid accumulation in subcutaneous space. Renal subcapsular fluid accumulation is a rare presentation. We present a rare case of membranoproliferative glomerulonephritis which presented with bilateral subcapsular fluid collection and was successfully managed by percutaneous drainage and treating the underline pathology.
November 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28649751/long-term-management-of-chronic-spontaneous-urticaria-with-omalizumab
#17
M Pinto Gouveia, A Gameiro, A Pinho, M Gonçalo
BACKGROUND: Clinical trials have shown the efficacy of omalizumabs efficacy in refractory chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), but real-life management strategies are lacking. AIM: To assess the long-term efficacy and safety of omalizumab, and to identify predictive factors and optimum dosage regimens. METHODS: This was a prospective study of 13 patients (11 women, 2 men) with severe CSU [weekly urticaria activity score (UAS7) > 28] resistant to anti-H1 antihistamines...
October 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28629605/ct-findings-in-11-patients-with-tafro-syndrome-a-variant-of-multicentric-castleman-s-disease
#18
T Kiguchi, C Sato, K Takai, Y Nakai, Y Kaneko, M Matsuki
AIM: To assess detailed computed tomography (CT) findings in patients with the recently described thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome, in order to contribute to imaging interpretation in the challenging diagnosis of this disease. MATERIALS AND METHODS: The institutional review board approved this retrospective study and waived the need for informed consent. Eleven patients (six men, five women; mean age, 52.5 years) with confirmed TAFRO syndrome were included in this study...
October 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28606058/risk-factors-of-lower-limb-cellulitis-in-a-level-two-healthcare-facility-in-cameroon-a-case-control-study
#19
Tsi Njim, Leopold Ndemnge Aminde, Valirie Ndip Agbor, Louise Daniele Toukam, Sara Saheb Kashaf, Eric O Ohuma
BACKGROUND: Cellulitis is a common infection of the skin and subcutaneous tissues. It is associated with significant morbidity from necrosectomies and amputations especially in sub-Saharan Africa. We aimed at identifying the risk factors and burden of lower limb cellulitis to inform preventive strategies in Cameroon. METHODS: This was a hospital-based case-control study carried out in the Bamenda Regional Hospital (BRH) between September 2015 and August 2016. Cases were defined as consenting adults admitted to the surgical unit who presented with a localised area of lower limb erythema, warmth, oedema and pain, associated with fever (temperature ≥ 38 °C) and/or chills of sudden onset...
June 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28456757/panniculus-morbidus-obesity-related-abdominal-wall-lymphoedema
#20
Michael G Fadel, Michail Chatzikonstantinou, Charlotte Gilchrist, Brian Andrews
A 52-year-old female patient presented with a massive abdominal wall swelling that adversely affected her lifestyle. Imaging revealed significant subcutaneous oedema and the presence of grossly distended veins. Subsequently, she underwent a 'toilet' panniculectomy and abdominoplasty. We describe the surgical technique used to retract the lymphoedematous tissue facilitating excisional surgery, and discuss the pathophysiology of this condition and the possible contribution of venous obstruction to the development of subcutaneous oedema...
April 29, 2017: BMJ Case Reports
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