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Melanoma clinical pathological correlation

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https://www.readbyqxmd.com/read/30117777/a-preliminary-study-on-metadherin-as-a-potential-marker-for-progression-of-diffuse-large-b-cell-lymphoma
#1
Xueling Ge, Xiaohui Sui, Xiaosheng Fang, Yujie Jiang, Mei Ding, Xin Liu, Xin Wang
AIMS: To determine if Metadherin (MTDH) expression levels are positively correlated with the clinical stage of diffuse large B-cell lymphoma (DLBCL) based on MTDH being highly expressed in other type of tumors including melanoma, malignant glioma, breast cancer, and hepatocellular carcinoma. In this study, we investigated the pathologic significance of MTDH and its potential in predicting DLBCL outcomes. MATERIALS AND METHODS: Tissue samples from 50 patients with DLBCL and 22 patients with lymph node reactive hyperplasia were collected and evaluated using immunohistochemical staining, microscopy, and western blotting...
August 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29981911/giant-pediatric-rhabdoid-meningioma-associated-with-a-germline-bap1-pathogenic-variation-a-rare-clinical-case
#2
Ali C Ravanpay, Ariana Barkley, Gabrielle A White-Dzuro, Patrick J Cimino, Luis F Gonzalez-Cuyar, Christina Lockwood, Lia M Halasz, Fuki M Hisama, Manuel Ferreira
Rhabdoid meningiomas are rare WHO grade 3 tumors that tend to follow an aggressive course. Pediatric rhabdoid meningioma is an exceedingly rare pathology commonly found on recurrent tumors in conjunction with lower grade meningioma pathology. Here, we present the case of a pediatric patient who came to us with a giant rhabdoid meningioma occurring in the right tentorium and invading the torcula and multiple venous structures, including the right jugular vein, down to the level of the right atrium. The patient underwent five separate surgeries for management of this tumor...
July 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29945191/pathological-assessment-of-resection-specimens-after-neoadjuvant-therapy-for-metastatic-melanoma
#3
M T Tetzlaff, J L Messina, J E Stein, X Xu, R N Amaria, C Blank, B Van De Wiel, P M Ferguson, R V Rawson, M I Ross, A J Spillane, J E Gershenwald, R P M Saw, T Mitchell, A M Menzies, G V Long, J A Wargo, M A Davies, V G Prieto, J M Taube, R A Scolyer
Background: Clinical trials have recently evaluated safety and efficacy of neoadjuvant therapy among patients with surgically resectable regional melanoma metastases. To capture informative prognostic data connected to pathological response in such trials, it is critical to standardize pathologic assessment and reporting of tumor response after this treatment. Methods: The International Neoadjuvant Melanoma Consortium meetings in 2016 and 2017 assembled pathologists from academic centers to develop consensus guidelines for pathologic examination and reporting of surgical specimens from AJCC (8th Edition) stage IIIB/C/D or oligometastatic stage IV melanoma patients treated with neoadjuvant targeted or immune therapy...
June 25, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29940639/surgical-reconstruction-of-post-tumoral-facial-defects
#4
Camelia Tamaş, Cătălina Teodora Pintilie, Ionuţ Vivi Atănăsoae, Andreea Mioara Corduneanu, Iulia Dabija, Florin Ştefan Olaru, Irina Mihaela Hreniuc, Angela Tecuceanu, Ioana Munteanu, Costel Dobre, Dan Cristian Moraru, Victor Ianole, Ioana Tamaş, Victor Vlad Costan
PURPOSE: The face is an unfortunate location for any type of tumor - malignant or not - with significant esthetic and functional outcomes. To reconstruct a facial defect may seem simple, but can be rather complicated. The aim of this study is to analyze and discuss our results in order to conclude with specific surgical strategies correlated with the morphopathological results. The most important objective for us is to offer the highest level of expertise to our patients and to prove that the symbiosis between the surgical treatment and the work of the Department of Morphopathology is essential in order to maximize the quality of medical care provided for our patients...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29927334/journal-club-primary-anorectal-melanoma-mri-findings-and-clinicopathologic-correlations
#5
Hyo Jung Park, Hyun Jin Kim, Seong Ho Park, Jong Seok Lee, Ah Young Kim, So-Woon Kim, Seung-Mo Hong
OBJECTIVE: The purpose of this study is to evaluate the MRI features of primary anorectal malignant melanoma and to correlate these features with its clinical and pathologic characteristics. MATERIALS AND METHODS: The medical records of 12 patients (five men and seven women; mean age [± SD], 60.8 ± 10.0 years) with pathologically proven primary anorectal melanoma were retrospectively reviewed. MRI findings were analyzed to determine the shape, size, distance from the anal verge, presence of perirectal or anal infiltration, signal intensity on T1- and T2-weighted images, presence of diffusion restriction, contrast enhancement pattern of the lesion, presence of lymphadenopathy, and occurrence of bowel obstruction...
August 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29906309/evolution-of-pigmented-spitz-naevi-with-starburst-pattern-during-childhood
#6
LETTER
G Brancaccio, B Brunetti, E Fulgione, E Moscarella, R Alfano, G Argenziano
No abstract text is available yet for this article.
June 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29894722/clinicopathological-immunohistochemical-and-molecular-correlation-of-neural-crest-transcription-factor-sox10-expression-in-triple-negative-breast-carcinoma
#7
Aparna Harbhajanka, Satyapal Chahar, Kristy Miskimen, Paula Silverman, Lyndsay Harris, Nicole Williams, Vinay Varadan, Hannah Gilmore
The transcription factor SOX10 mediates the differentiation of neural crest-derived cells, and SOX10 by immunohistochemistry(IHC) is used primarily for the diagnosis of melanoma. SOX10 expression has been previously documented in benign breast myoepithelial cells. However there is limited literature on its expression in triple negative breast carcinoma(TNBC). The aim was to study the clinical, pathologic and molecular profiles of SOX10+ tumors in TNBC. Tissue microarrays of TNBC were evaluated for SOX10 expression in 48cases...
June 9, 2018: Human Pathology
https://www.readbyqxmd.com/read/29860765/-the-role-of-preoperative-18-f-fdg-pet-ct-in-lymphatic-metastasis-diagnosis-of-cutaneous-malignant-melanoma-on-extremities-and-trunk
#8
X X Zhang, Y Fang, L B Xu, S F Xu, Z G Zhao, C Sun, P Q Ma, T Liu, S J Yu, W J Zhang
Objective: To evaluate the clinical value of preoperative (18)F-Fludeoxyglucose ((18)F-FDG PET-CT) in lymphatic metastasis diagnosis of cutaneous melanoma on extremities and trunk. Methods: 112 patients with cutaneous melanoma pathologically of extremities and trunk from January 2006 to December 2016, who received (18)F-FDG PET-CT examination preoperatively, were retrospectively reviewed. The correlations between the maximal diameters of lymph nodes, the maximal standard uptake value (SUV) and the diagnostic impression grades of PET-CT examination, and the final pathological diagnosis were analyzed...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29782294/the-value-of-high-frequency-20-mhz-ultrasonography-for-preoperative-measurement-of-cutaneous-melanoma-thickness
#9
Andrea Kozárová, Marek Kozár, Ingrid Tonhajzerová, Táňa Pappová, Eva Minariková
High-frequency ultrasonography has become an important diagnostic tool in dermatovenerology. It is used for assessment of the cutaneous layers in diverse benign and malignant skin lesions and diseases. Herein we present the practical value of preoperative measurement of cutaneous melanoma thickness, the explanation of the possible reasons for different sonographic and histologic Breslow thickness, and the practical importance of high-frequency 20 MHz ultrasonography in preoperative measurements of cutaneous melanoma thickness...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780936/clinical-and-pathological-correlation-of-cotton-wool-spots-in-secondary-angle-closure-glaucoma
#10
Anand Bhatt, Christine Nguyen, Sameh Mosaed, Don Minckler
Purpose: Cotton Wool Spots (CWS) are a commonly described retinal finding in the posterior segment associated with an extensive number of systemic diseases. The appearance of a CWS in the setting of glaucoma has rarely been reported and has not been correlated with pathology to localized loss of the nerve fiber layer previously. In this case report, we augment a previous report of an 18 year old female with a diagnosis of low grade ciliary body melanoma. This patient experienced eventual mechanical angle closure with a CWS appearing in the posterior pole in the setting of acute elevation of intraocular pressure (IOP)...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29763716/prognostic-factors-in-primary-anorectal-melanoma-a-clinicopathologic-study-of-60-cases-in-china
#11
Min Ren, Yawen Lu, Jiaojie Lv, Xuxia Shen, Jincheng Kong, Bo Dai, Yunyi Kong
To investigate the clinicopathologic features and prognostic factors of primary anorectal melanoma, we described the clinical presentations, histopathology, and prognosis of 60 cases in China. Patients' age ranged from 17 to 86years with a female-to-male ratio of 2.33:1. The prevalent anatomic site of tumor was anorectum. The mean tumor thickness was 11.5mm and mean tumor size was 2.9cm. Abdominoperineal resection was performed on 38 (63.3%) patients, while wide local excision on 22 (36.7%) patients. Thirty-three (55...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29762449/time-to-procedure-nuclear-imaging-and-clinicopathological-characteristics-as-predictive-factors-for-sentinel-lymph-node-metastasis-in-cutaneous-melanoma-a-single-center-analysis
#12
Ljiljana Jaukovic, Milica Rajović, Lidija Kandolf Sekulovic, Marija Radulovic, Nenad Stepic, Zeljko Mijuskovic, Nenad Petrov, Boris Ajdinovic
OBJECTIVE: Sentinel lymph node (SLN) biopsy is a widely accepted staging procedure for cutaneous melanoma patients who are at risk of clinically occult nodal metastases. Numerous predictive factors for regional lymph node metastases have been identified; however, few have been found to be reproducibly significant. Also, the role of blue dye in identification was questioned in recent trials. Time to procedure was also found to be predictive of SLN positivity, but this was not confirmed in other studies...
July 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29552665/hemorrhagic-choroidal-melanoma
#13
Patrick Oellers, Natalie Wolkow, Frederick A Jakobiec, Ivana K Kim
Purpose: To demonstrate the clinical pathologic correlation in a hemorrhagic choroidal melanoma. Observations: A 52 year old patient presented with a large choroidal mass associated with vitreous and retinal hemorrhage. The eye was enucleated and histopathology demonstrated epithelioid-type MART1 positive tumor cells consistent with choroidal melanoma. The tumor had broken through Bruch's membrane, which led to localized vascular compression with bleeding into the subretinal space, retina and vitreous...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29484694/colliding-colonizing-or-combining-four-cases-illustrating-the-unique-challenges-presented-by-melanoma-arising-in-conjunction-with-basal-cell-carcinoma
#14
Matthew Dinehart, Mallory S Abate, Thomas Jennings, Jennifer R Kaley, Sara C Shalin
Biphasic lesions comprised of melanocytic and epithelial components are rare entities believed to arise either as a collision of 2 histologically distinct lesions in the same anatomic location or as a singular progenitor tumor differentiating along 2 differing lineages. Regardless of mechanism of origin, these tumors present unique challenges in pathologic interpretation and in determining appropriate measurements, which assigns subsequent prognosis to the patient. We present 4 tumors of melanoma co-existing with basal cell carcinoma (BCC) and discuss relevant literature regarding these biphasic entities...
June 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29467127/quantitative-analysis-of-immune-infiltrates-in-primary-melanoma
#15
Robyn D Gartrell, Douglas K Marks, Thomas D Hart, Gen Li, Danielle R Davari, Alan Wu, Zoë Blake, Yan Lu, Kayleigh N Askin, Anthea Monod, Camden L Esancy, Edward C Stack, Dan Tong Jia, Paul M Armenta, Yichun Fu, Daisuke Izaki, Bret Taback, Raul Rabadan, Howard L Kaufman, Charles G Drake, Basil A Horst, Yvonne M Saenger
Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application. Quantitative multiplex immunofluorescence (qmIF) allows for evaluation of the TME using multiparameter phenotyping, tissue segmentation, and quantitative spatial analysis (qSA). Given that CD3+ CD8+ cytotoxic lymphocytes (CTLs) promote antitumor immunity, whereas CD68+ macrophages impair immunity, we hypothesized that quantification and spatial analysis of macrophages and CTLs would correlate with clinical outcome...
April 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29433548/analytic-validity-of-decisiondx-melanoma-a-gene-expression-profile-test-for-determining-metastatic-risk-in-melanoma-patients
#16
Robert W Cook, Brooke Middlebrook, Jeff Wilkinson, Kyle R Covington, Kristen Oelschlager, Federico A Monzon, John F Stone
BACKGROUND: The DecisionDx-Melanoma test provides prognostic information for patients with cutaneous melanoma (CM). Using formalin-fixed paraffin-embedded primary tumor tissue, the RT-PCR-based test classifies patients into a low- (Class 1) or high-risk (Class 2) category for recurrence based on expression of 31 genes. The current study was designed to assess the analytical validity of this test. METHODS: Inter-assay, inter-instrument, and inter-operator studies were performed to evaluate reliability of the 31-gene expression test results, sample stability and reagent stability...
February 13, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29388348/benign-and-malignant-collision-tumors-of-melanocytic-skin-lesions-with-hemangioma-dermoscopic-and-reflectance-confocal-microscopy-features
#17
L Tognetti, E Cinotti, J L Perrot, M Campoli, M Fimiani, P Rubegni
BACKGROUND: Though the combination/collision of nevi or lentigo simplex and hemangiomas is frequent, the malignant collision tumor melanoma-hemangioma is exceptional and can sometime clinically simulate a benign collision. To date, a series of collision tumors of hemangiomas associated with either benign or malignant melanocytic skin lesions (MSL) has yet to be studied by non-invasive imaging and clinico-pathologic correlates. METHODS: We present 10 cases of patients with collision tumors of hemangioma with different MSL including: 2 in situ lentigo-maligna melanoma, 1 invasive melanoma, 5 melanocytic nevi, and 2 lentigo simplex...
May 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29285379/patient-age-and-cutaneous-malignant-melanoma-elderly-patients-are-likely-to-have-more-aggressive-histological-features-and-poorer-survival
#18
Faruk Tas, Kayhan Erturk
Patient age has been reported as a highly significant and strong predictor of the outcome in patients with cutaneous melanoma. The aim of the present study was to determine the clinical significance of patient age in Turkish patients with cutaneous melanoma. A total of 1,169 patients with pathologically proven cutaneous melanoma were enrolled. Age of patients was classified as young (<40 years), middle-aged (40-59 years) and old (≥60 years). The median age of the patients was 51 years (range, 16-104 years)...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285235/eyes-absent-gene-eya1-is-a-pathogenic-driver-and-a-therapeutic-target-for-melanoma
#19
Joshua Jiawei Zhou, Yuanshen Huang, Xue Zhang, Yabin Cheng, Liren Tang, Xiaodong Ma
EYA1 is a DNA repair enzyme that is induced after DNA damage and is upregulated in melanoma. However, its role in pathogenesis and therapeutic targeting of melanoma is unknown. Our objectives are (1) to study the relationship between EYA1 expression levels and melanoma patients' clinical pathologic parameters including survival; (2) to investigate its impact on cultured melanoma cells in vitro ; and (3) to evaluate EYA1 inhibitors' potential as a treatment of melanoma. Melanoma tissue microarrays were used to assess EYA1 protein expression in 326 melanoma tissues, and to correlate the expression with patients' clinical pathological parameters...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136692/-expression-and-prognostic-values-of-pd-1-pd-l1-and-ido-1-in-sinonasal-malignant-mucosal-melanoma
#20
H Q Liu, B Q Zou, S Y Wang
Objective: To investigate the correlation between the expression of programmed death-1(PD-1), PD ligand-1(PD-L1), indoleamine 2, 3-dioxygenase 1(IDO-1) and clinical parameters in sinonasal malignant mucosal melanoma (SNM). Methods: Samples from 86 SNM patients who did not receive immune-targeted therapy and radio-chemotherapy were analyzed for PD-1, PD-L1, and IDO-1 expression by immunohistochemistry. Results: High clinical/pathologic staging, brain metastases and advanced age were independent risk factors of poor prognosis...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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