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https://www.readbyqxmd.com/read/28430422/gauging-donor-acceptor-properties-and-redox-stability-of-chelating-click-derived-triazoles-and-triazolylidenes-a-case-study-with-rhenium-i-complexes
#1
Lisa Suntrup, Sinja Klenk, Johannes Klein, Sebastian Sobottka, Biprajit Sarkar
Bidentate ligands containing at least one triazole or triazolylidene (mesoionic carbene, MIC) unit are extremely popular in contemporary chemistry. One reason for their popularity is the similarities as well as differences in the donor/acceptor properties that these ligands display in comparison to their pyridine or other N-heterocyclic carbene counterparts. We present here seven rhenium(I) carbonyl complexes where the bidentate ligands contain combinations of pyridine/triazole/triazolylidene. These are the first examples of rhenium(I) complexes with bidentate 1,2,3-triazol-5-ylidene-containing ligands...
April 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28429736/single-step-one-pot-synthesis-of-tio2-nanosheets-doped-with-sulfur-on-reduced-graphene-oxide-with-enhanced-photocatalytic-activity
#2
Weilin Wang, Zhaofeng Wang, Jingjing Liu, Zhu Luo, Steven L Suib, Peng He, Guqiao Ding, Zhengguo Zhang, Luyi Sun
A hybrid photocatalyst based on anatase TiO2 was designed by doping TiO2 with sulfur and incorporating reduced graphene oxide (TiO2-S/rGO hybrid), with an aim to narrow the band gap to potentially make use of visible light and decrease the recombination of excitons, respectively. This TiO2-S/rGO hybrid was successfully synthesized using a one-pot hydrothermal method via single-step reaction. The structure and morphology of the TiO2-S/rGO hybrid catalyst was carefully characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS)...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429668/the-role-of-mitochondria-associated-reactive-oxygen-species-in-the-amyloid-%C3%AE-induced-production-of-angiogenic-factors-by-arpe-19-cells
#3
L Wu, X Tan, L Liang, H Yu, C Wang, D Zhang, A Kijlstra, P Yang
OBJECTIVE: This study aimed to investigate the mechanisms whereby Amyloid-beta (Aβ) induces the production of angiogenic factors by a human retinal pigment epithelial cell line (ARPE-19) cells. METHODS: ARPE-19 cells obtained from the American Type Culture Collection (ATCC) were utilized in this study. The expression level of vascular endothelial growth factor (VEGF), Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and complement activation fragments C3a and C5a were measured by Real-time quantitative PCR (RT-PCR) and Enzyme-linked immunosorbent assay (ELISA)...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28429351/tgf%C3%AE-1-protects-myocardium-from-apoptosis-and-oxidative-damage-after-ischemia-reperfusion
#4
Y-F Liu, Y-Y Chu, X-Z Zhang, M Zhang, F-G Xie, M Zhou, H-H Wen, A-H Shu
OBJECTIVE: Myocardial apoptosis is an important pathologic basis of ischemia-reperfusion injury (I/R). Transforming growth factor β1 (TGFβ1) participates in the regulation of oxidative damage and apoptosis. TGFβ1 is upregulated in the repair process of I/R injury. It is speculated that TGFβ1 over-expression is involved in the endogenous protective mechanism of I/R injury. This study explores the significance of TGFβ1 in myocardial cell apoptosis after I/R. MATERIALS AND METHODS: Rat myocardial I/R injury model was established...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429292/preparation-of-chloramphenicol-amino-acid-combinations-exhibiting-enhanced-dissolution-rates-and-reduced-drug-induced-oxidative-stress
#5
Vanesa B Sterren, Virginia Aiassa, Claudia Garnero, Yamila Garro Linck, Ana K Chattah, Gustavo A Monti, Marcela R Longhi, Ariana Zoppi
Chloramphenicol is an old antibiotic agent that is re-emerging as a valuable alternative for the treatment of multidrug-resistant pathogens. However, it exhibits suboptimal biopharmaceutical properties and toxicity profiles. In this work, chloramphenicol was combined with essential amino acids (arginine, cysteine, glycine, and leucine) with the aim of improving its dissolution rate and reduce its toxicity towards leukocytes. The chloramphenicol/amino acid solid samples were prepared by freeze-drying method and characterized in the solid state by using Fourier transform infrared spectroscopy, powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and solid-state nuclear magnetic resonance...
April 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28429287/protective-effect-of-selenoprotein-x-against-oxidative-stress-induced-cell-apoptosis-in-human-hepatocyte-lo2-cells-via-the-p38-pathway
#6
Jia-Yong Tang, Ai-Hua He, Gang Jia, Guang-Mang Liu, Xiao-Ling Chen, Jing-Yi Cai, Hai-Ying Shang, Jin-Qiu Liao, Hua Zhao
Oxidative stress, as mediated by ROS (reactive oxygen species), is a significant factor in initiating the cells damaged by affecting cellular macromolecules and impairing their biological functions; SelX, a selenoprotein also known as MsrB1 belonging to the methionine sulfoxide reductase (Msr) family, is the redox repairing enzyme and involved in redox-related functions. In order to more precisely analyze the relationship between oxidative stress, cell oxidative damage, and SelX, we stably overexpressed porcine Selx full-length cDNA in human normal hepatocyte (LO2) cells...
April 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28428422/quantitative-3d-evolution-of-colloidal-nanoparticle-oxidation-in-solution
#7
Yugang Sun, Xiaobing Zuo, Subramanian K R S Sankaranarayanan, Sheng Peng, Badri Narayanan, Ganesh Kamath
Real-time tracking of the three-dimensional (3D) evolution of colloidal nanoparticles in solution is essential for understanding complex mechanisms involved in nanoparticle growth and transformation. We used time-resolved small-angle and wide-angle x-ray scattering simultaneously to monitor oxidation of highly uniform colloidal iron nanoparticles, enabling the reconstruction of intermediate 3D morphologies of the nanoparticles with a spatial resolution of ~5 angstroms. The in situ observations, combined with large-scale reactive molecular dynamics simulations, reveal the details of the transformation from solid metal nanoparticles to hollow metal oxide nanoshells via a nanoscale Kirkendall process-for example, coalescence of voids as they grow and reversal of mass diffusion direction depending on crystallinity...
April 21, 2017: Science
https://www.readbyqxmd.com/read/28428059/the-decreased-growth-performance-and-impaired-immune-function-and-structural-integrity-by-dietary-iron-deficiency-or-excess-are-associated-with-tor-nf-%C3%AE%C2%BAb-p38mapk-nrf2-and-mlck-signaling-in-head-kidney-spleen-and-skin-of-grass-carp-ctenopharyngodon-idella
#8
Yan-Lin Guo, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Qiu Zhou, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
This study was conducted to investigate the effects of dietary iron on the growth, and immune function and structural integrity in head kidney, spleen and skin as well as the underlying signaling of young grass carp (Ctenopharyngodon idella). Total 630 grass carp (242.32 ± 0.58 g) were fed diets containing graded levels of iron at 12.15 (basal diet), 35.38, 63.47, 86.43, 111.09, 136.37 mg/kg (diets 2-6 were added with ferrous fumarate) and 73.50 mg/kg (diet 7 was added with ferrous sulfate) diet for 60 days...
April 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28426671/effect-of-mitochondrially-targeted-carboxy-proxyl-nitroxide-on-akt-mediated-survival-in-daudi-cells-significance-of-a-dual-mode-of-action
#9
Gokul Variar, Tarun Pant, Apoorva Singh, Abinaya Ravichandran, Sushant Swami, Balaraman Kalyanaraman, Anuradha Dhanasekaran
Vicious cycles of mutations and reactive oxygen species (ROS) generation contribute to cancer progression. The use of antioxidants to inhibit ROS generation promotes cytostasis by affecting the mutation cycle and ROS-dependent survival signaling. However, cancer cells select mutations to elevate ROS albeit maintaining mitochondrial hyperpolarization (Δψm), even under hypoxia. From this perspective, the use of drugs that disrupt both ROS generation and Δψm is a viable anticancer strategy. Hence, we studied the effects of mitochondrially targeted carboxy proxyl nitroxide (Mito-CP) and a control ten carbon TPP moiety (Dec-TPP+) in the human Burkitt lymphoma cell line (Daudi) and normal peripheral blood mononuclear cells under hypoxia and normoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28426076/an-amidato-divalent-ytterbium-cluster-synthesis-and-molecular-structure-its-reactivity-to-carbodiimides-and-application-in-the-guanylation-reaction
#10
Chao Gong, Hao Ding, Chengrong Lu, Bei Zhao, Yingming Yao
A divalent ytterbium amidate 1 ([Yb3L6]·2C7H8 for short) was synthesized via amine-elimination of Yb[N(SiMe3)2]2(TMEDA) with an amide proligand N-2,6-diisopropylphenylbenzamide HL (L = 2,6-(i)Pr2C6H3NC(O)Ph) and structurally characterized to be a trinuclear symmetric cluster. Further studies on the reduction of (i)PrN[double bond, length as m-dash]C[double bond, length as m-dash]N(i)Pr by complex 1 provide Yb(iii) complex 2 in hexane-THF ([(YbL2)2(μ-N(i)PrCN(i)Pr)][YbL3(THF)]·C7H8), which is composed of two subunits in a unit cell, one is a bridged Yb(iii) carbene, just the same as complex 4 ([(YbL2)2(μ-N(i)PrCN(i)Pr)]·3C7H8) obtained in the same reaction in toluene, and the other is a homoleptic monomeric Yb(iii) amidate (YbL3)...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28425858/nano-encapsulation-of-dietary-phytoconstituent-capsaicin-on-emulsome-evaluation-of-anticancer-activity-through-the-measurement-of-liver-oxidative-stress-in-rats
#11
Tapan Kumar Giri, Kaustav Pramanik, Tapan Kumar Barman, Subhasis Maity
Protective effects of capsaicin (CAP) loaded nano-emulsomes (EML) was evaluated against the oxidative stress of rat livers induced through sodium fluoride (NaF). EML was prepared by thin film hydration method that is development of thin lipid film followed by hydration and sonication. EML was characterized by Fourier transform infrared (FT-IR) spectroscopy and X-ray diffraction (XRD) techniques. In vitro drug release study of optimized formulation showed that 50% of CAP was released within 50.21 min while 85% CAP was released in 227...
April 19, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28425705/facile-aqueous-phase-synthesis-of-ptau-bi2o3-hybrid-catalyst-for-efficient-electro-oxidation-of-ethanol
#12
Sumanta Sarkar, Rajkumar Jana, Hiranmayee Vadlamani, Swetha Ramani, Dundappa Mumbaraddi, Sebastian C Peter
In this work, we present a facile aqueous phase synthesis of a hybrid catalyst consists of PtAu alloy supported on Bi2O3 microspheres. Multistep reduction of HAuCl4 and K2PtCl4 salts on Bi2O3 and subsequent annealing leads to the formation of this hybrid catalyst. To the best of our knowledge, this is the first report of using Bi2O3 as a catalyst support in Fuel cell applications. The material was characterized by powder X-ray diffraction and various microscopic techniques. This composite showed remarkable activity as well as stability towards the electro-oxidation of ethanol in comparison to commercially available Pt/C...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28425700/reaction-of-the-tricyanoborate-dianion-b-cn-3-2-with-hgcl2
#13
Eduard Bernhardt, Vera Bernhardt-Pitchougina, Carsten Jenne
The very reactive [B(CN)3](2-) dianion has a strongly nucleophilic boron atom and can be used for the synthesis of tricyanoborates, which otherwise are difficult to access. Herein the reaction of this anion with HgCl2 is reported. The main product is the anionic mercury complex [Hg(B(CN)3)2](2-). Heteronuclear NMR spectroscopic experiments shows that the reaction proceeds via the intermediate [ClHgB(CN)3](2-). Even though [Hg(B(CN)3)2](2-) is the main product, it is difficult to obtain it in pure form, because it slowly decomposes in the presence of water and air to [(NC)HgB(CN)3](-)...
April 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28425294/reactivity-of-a-base-stabilized-germanium-i-dimer-toward-group-9-metal-i-chloride-and-dimanganese-decacarbonyl
#14
Muhammad Luthfi Bin Ismail, Fu-Quan Liu, Wai-Leung Yim, Rakesh Ganguly, Yongxin Li, Cheuk-Wai So
The reactivity of the 2-imino-5,6-methylenedioxylphenylgermanium(I) dimer toward group 9 metal(I) chloride and dimanganese decacarbonyl is described. [LGe:]2 (1, L = 2-imino-5,6-methylenedioxylphenyl) underwent a disproportionation reaction with 1.5 equiv of group 9 metal(I) chloride [MCl(cod)]2 (M = Rh, Ir) in toluene to afford a mixture of the group 9 metallogermylene-chlorometal(I) complexes [LGeμ-{M(cod)}2Cl] (M = Rh (2), Ir (4)) and chlorogermylene-chlorometal(I) complexes [L(Cl)GeM(cod)Cl] (M = Rh (3), Ir (5)), respectively...
April 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28422989/the-lack-of-btk-does-not-impair-monocytes-and-polymorphonuclear-cells-functions-in-x-linked-agammaglobulinemia-under-treatment-with-intravenous-immunoglobulin-replacement
#15
Filomena Monica Cavaliere, Alessandro Prezzo, Caterina Bilotta, Metello Iacobini, Isabella Quinti
The lack of BTK in X-linked agammaglobulinemia (XLA) patients does not affect monocytes and polymorphonuclear cells (PMN) phenotype and functions. In this study, we show that XLA patients had an increased frequency of the intermediate monocytes subset and that BTK-deficient monocytes and PMN had a normal expression of receptors involved in the activation and cellular responses. We demonstrate that BTK is not required for migration, phagocytosis and the production of reactive oxygen species (ROS) following engagement of FC gamma receptors (FcγR)...
2017: PloS One
https://www.readbyqxmd.com/read/28418047/an-ftir-emission-study-of-the-products-of-no-a-2-%C3%AE-v-0-1-o2-collisions
#16
Julian Few, James D Fletcher, Gus Hancock, Jennifer L Redmond, Grant A D Ritchie
Collisional quenching of NO A(2)Σ(+) (v = 0, 1) by O2 has been studied through the detection of vibrationally excited products by time-resolved Fourier transform infrared emission spectroscopy. Non-reactive quenching of NO A(2)Σ(+) (v = 0) produces a vibrational distribution in NO X(2)Π which has been quantified for v = 2-22, and is found to be bimodal. The results are consistent with two quenching channels. The first forms the ground X(3)Σ or low-lying a (1)Δg electronic state of O2 with a distribution including high vibrational levels of NO X(2)Π which is slightly hotter than statistical...
April 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28416829/-clinical-characteristics-and-prognosis-of-cultured-negative-pyogenic-spondylitis
#17
Y P Cui, C Mi, X D Shi, B Wang, Y X Pan, Y F Lin
OBJECTIVE: There are limited data describing the clinical characteristics and prognosis of culture negative pyogenic spondylitis. The aim of this study was to investigate the treatment, prognosis and clinical characteristics of culture negative pyogenic spondylitis. METHODS: A retrospective study reviewed 74 patients who were diagnosed with spondylitis in Peking University First Hospital from January 2010 to December 2015. A total of 27 patients suffered from pyogenic spondylitis...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28414168/decompression-alone-versus-fusion-for-pyogenic-spondylodiscitis
#18
Sung Hyun Noh, Ho Yeol Zhang, Hyun Sun Lim, Hyeon Jin Song, Kyung Hwa Yang
BACKGROUND CONTEXT: A spinal infection is a serious problem for a spine surgeon, and there is currently much debate regarding how best to treat pyogenic spondylodiscitis using antibiotics and the instrumentations that have been developed to date. PURPOSE: The purpose of this study was to determine which is better method for treating pyogenic spondylodiscitis. STUDY DESIGN/SETTING: A retrospective chart review was performed. PATIENT SAMPLE: Thirty-one patients with pyogenic spondylodiscitis underwent surgical treatment between 2000 and 2016 at the authors' institution...
April 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28412813/singlet-oxygen-detection-on-a-nanostructured-porous-silicon-thin-film-via-photonic-luminescence-enhancements
#19
S N Aisyiyah Jenie, Sally E Plush, Nicolas H Voelcker
Because reactive oxygen species are involved in a range of pathologies, developing analytical tools for this group of molecules opens new vistas for biomedical diagnostics. Herein, we fabricate a porous silicon microcavity (pSiMC) functionalized with luminescent singlet oxygen ((1)O2) probe EuA ((Eu(III)-2,2',2″-(10-(2-((4-(2-((4-(2-((anthracen-9-ylmethyl)amino)ethyl)-1H-1,2,3-triazol-1-yl)amino)-2-oxoethyl)-2-oxo-1,2-dihydroquinolin-7-yl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid) as proof of concept of an optical sensor for reactive oxygen species...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28412491/rapid-degradation-of-atrazine-by-hydroxyl-radical-induced-from-montmorillonite-templated-subnano-sized-zero-valent-copper
#20
Ran Hong, Zupei Guo, Juan Gao, Cheng Gu
In this study, subnano-sized zero-valent copper (ZVC) was synthesized using montmorillonite clay mineral as the template. The discrete distribution of surface charge on montmorillonite effectively separates the formed ZVC particles and inhibits their aggregation. X-ray diffraction result indicates that the size of ZVC particles on montmorillonite is ∼6 Å, which is much smaller than nano-ZVC prepared by conventional method. The montmorillonite templated ZVC (ZVCMMT) shows superior reactivity as indicated by the degradation of atrazine, over 90% atrazine (15 μM) could be degraded in a few min...
April 8, 2017: Chemosphere
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