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https://www.readbyqxmd.com/read/28734808/-congenital-cytomegalovirus-infection-manifesting-as-neonatal-respiratory-distress-in-an-hiv-exposed-uninfected-newborn
#1
A Pham, H El Mjati, N Nathan, F Kieffer, D Mitanchez
BACKGROUND: Cytomegalovirus (CMV) is one of the most common intrauterine infections, affecting approximately 1% of all live births. There are few reports on congenital CMV infections manifesting as isolated pneumonitis. CASE REPORT: We report a case of congenital CMV with neonatal respiratory distress affecting an HIV-exposed uninfected infant. This infant required noninvasive ventilation beginning within the first 15min of life. The initial chest X-ray showed diffuse bilateral ground-glass opacifications...
July 19, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28734785/impact-of-magnetic-stirring-on-stainless-steel-integrity-effect-on-biopharmaceutical-processing
#2
Christopher Thompson, Kelly Wilson, Yoen Joo Kim, Min Xie, William K Wang, Michaela Wendeler
Stainless steel containers are widely used in the pharmaceutical and biopharmaceutical industry for the storage of buffers, process intermediates, and purified drug substance. They are generally held to be corrosion resistant, biocompatible, and non-reactive, although it is well established that trace amounts of metal ions can leach from stainless steel equipment into biopharmaceutical products. We report here that the use of stainless steel containers in conjunction with magnetic stirring bars leads to significantly aggravated metal contamination, consisting both of metal particles and significantly elevated metal ions in solution, the degree of which is several orders of magnitude higher than described for static conditions...
July 19, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28732979/sonocatalytic-degradation-of-reactive-yellow-39-using-synthesized-zro2-nanoparticles-on-biochar
#3
Alireza Khataee, Berkant Kayan, Peyman Gholami, Dimitrios Kalderis, Sema Akay, Laleh Dinpazhoh
ZrO2-biochar (ZrO2-BC) nanocomposite was prepared by a modified sonochemical/sol-gel method. The physicochemical properties of the prepared nanocomposite were evaluated using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray fluorescence, Fourier transform infrared spectroscopy and Brunauer-Emmett-Teller model. The sonocatalytic performance of ZrO2-BC was investigated in sonochemical degradation of Reactive Yellow 39 (RY39). The high observed sonocatalytic activity of the ZrO2-BC sample could be interpreted by the mechanisms of sonoluminescence and hot spots...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732936/oxygen-and-indocyanine-green-loaded-microparticles-for-dual-mode-imaging-and-sonodynamic-treatment-of-cancer-cells
#4
Rong Ma, Qiang Wu, Ting Si, Shufang Chang, Ronald X Xu
Oxygen and Indocyanine Green (ICG) loaded microparticles (OI-MPs) were fabricated by a gas-driven coaxial flow focusing (CFF) process for dual-mode imaging and sonodynamic therapy (SDT). The produced OI-MPs agent showed stable optical properties, superior imaging depth in near infrared (NIR) fluorescence imaging, and enhanced acoustic contrast after ultrasound mediation. We hypothesized that encapsulating ICG and oxygen in microparticles would enhance reactive oxygen species (ROS) production in SDT. This hypothesis was validated in a cell-free environment...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732928/sonocatalytic-degradation-of-an-anthraquinone-dye-using-tio2-biochar-nanocomposite
#5
Alireza Khataee, Berkant Kayan, Peyman Gholami, Dimitrios Kalderis, Sema Akay
TiO2-biochar (TiO2-BC) nanocomposite was synthesized by sol-gel method. The characteristics of the prepared nanocomposite were examined using X-ray fluorescence, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and N2 adsorption-desorption analysis. The performance of synthesized TiO2-BC nanocomposite as efficient sonocatalyst was studied for the degradation of Reactive Blue 69 (RB69). Sonocatalytic degradation of RB69 in the presence of TiO2-BC nanocomposite could be explained by the mechanisms of hot spots and sonoluminescence...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28731693/isolable-bis-triarylamine-dications-analogues-of-thiele-s-chichibabin-s-and-m%C3%A3-ller-s-hydrocarbons
#6
Gengwen Tan, Xinping Wang
Since the pioneering work by Thiele and Chichibabin, who synthesized the first diradicals bridged by phenylene and biphenylene groups in 1904 and 1907, respectively, numerous efforts have been devoted to synthesizing stable diradicals during the last few decades, and several strategies have been developed to stabilize these highly reactive diradicals. In this Account, we describe the synthesis and characterization of isolable bis(triarylamine) dications, nitrogen analogues of Thiele's, Chichibabin's, and Müller's hydrocarbons, which represent facilely accessible, stable diradicals by replacing carbinyl centers with isoelectronic aminium centers...
July 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28731456/upregulation-of-tet-activity-with-ascorbic-acid-induces-epigenetic-modulation-of-lymphoma-cells
#7
N Shenoy, T Bhagat, E Nieves, M Stenson, J Lawson, G S Choudhary, T Habermann, G Nowakowski, R Singh, X Wu, A Verma, T E Witzig
The Ten Eleven Translocation (TET) enzymes have been found to be mutated in both diffuse large B-cell (DLBCL) and peripheral T-cell (PTCL) lymphomas resulting in DNA hypermethylation. Recent studies in embryonal stem cells showed that ascorbic acid (AA) is a cofactor for TET with a binding site at the catalytic domain, and enhances TET activity. We hypothesized that AA could potentially enhance TET activity in lymphoma cells to cause DNA demethylation, reactivate expression of tumor suppressor genes and enhance chemosensitivity...
July 21, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28729216/self-assembled-aunps-for-ingrain-pigmentation-of-silk-fabrics-with-antibacterial-potency
#8
Hanan B Ahmed, Nancy S El-Hawary, Hossam E Emam
Nanogold was self-assembled for ingrain pigmentation of silk fabric with antibacterial properties. The functional groups of silk macromolecular polymeric chains were exploited for generation and stabilization of nanogold. Hydrogen peroxide was used for activation of silk molecular chains through increasing their reactivity and accessibility to be functionalized as manufacturer of nanogold without using any external agents. Effect of procedure sequencing was studied through addition of peroxide firstly (group A) and with Au salt (group B)...
July 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28728028/direct-evidence-of-the-photocatalytic-generation-of-reactive-oxygen-species-ros-in-a-bi2w2o9-layered-structure
#9
S Obregón, M A Ruíz-Gómez, D B Hernández-Uresti
In the present work, the Bi2W2O9 photocatalyst has been prepared by an easy and prompt co-precipitation route. From the structural characterization, we have stated that the formation of the Bi2W2O9 is accompanied by a small amount of the Bi2WO6 oxide, which gradually decreases by increasing the calcination temperature. The conduction and valence band edges of the Bi2W2O9 semiconductor were experimentally estimated for the first time using the X-ray photoelectron (XPS) and diffuse reflectance (DRS) spectroscopies...
July 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28727448/extensive-survey-of-antibody-invariant-positions-for-efficient-chemical-conjugation-using-expanded-genetic-codes
#10
Akifumi Kato, Mitsuo Kuratani, Tatsuo Yanagisawa, Kazumasa Ohtake, Akiko Hayashi, Yoshimi Amano, Kaname Kimura, Shigeyuki Yokoyama, Kensaku Sakamoto, Yasuhisa Shiraishi
The site-specific chemical conjugation of proteins, following synthesis with an expanded genetic code, promises to advance antibody-based technologies, including antibody drug conjugation and the creation of bispecific Fab dimers. The incorporation of non-natural amino acids into antibodies not only guarantees site specificity but also allows the use of bio-orthogonal chemistry. However, the efficiency of amino acid incorporation fluctuates significantly among different sites, thereby hampering the identification of useful conjugation sites...
July 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28727264/phosphorylated-polyacrylonitrile-fiber-as-an-efficient-and-greener-acetalization-catalyst
#11
Gang Xu, Jian Cao, Yali Zhao, Lishuo Zheng, Minli Tao, Wenqin Zhang
A novel solid acid catalyst (PANEAPF) was developed by immobilization of phosphoric acid on polyacrylonitrile fiber via covalent bond. Various characterization techniques such as elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), etc. were utilized to confirm the successful grafting and the stability of the fiber catalysts during application. The PANEAPF showed high catalytic activity in the acetalization of aldehydes due to the high utilization efficiency of its functionalized acid sites...
July 20, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28724203/huprine-x-attenuates-the-neurotoxicity-induced-by-kainic-acid-especially-brain-inflammation
#12
J Relat, B Pérez, P Camps, D Muñoz-Torrero, A Badia, M V Clos
Huprine X (HX) is a synthetic anticholinesterasic compound that exerts a potent inhibitory action on acetylcholinesterase (AChE) activity, an agonist effect on cholinergic receptors, neuroprotective activity in different neurotoxicity models in vivo and in vitro and cognition enhancing effects in non-transgenic (C57BL/6) and transgenic (3xTg-AD, APPswe) mice. In the present study, we assessed the ability of HX (0.8 mg/kg, 21 days) to prevent the damage induced by kainic acid (KA; 28 mg/kg) regarding apoptosis, glia reactivity and neurogenesis in mouse brain...
July 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28723816/importance-of-physical-qualities-for-speed-and-change-of-direction-ability-in-elite-female-soccer-players
#13
Stacey Emmonds, G Nicholson, C Beggs, B Jones, A Bissas
The purpose of this study was to determine the importance of physical qualities for speed and change of direction (CoD) ability in female soccer players. Data were collected on 10 female soccer players who were part of a professional English Women's Super League team. Player assessments included anthropometric (stature and body mass), body composition (dual-energy X-ray absorptiometry), speed (10m, 30m sprint), CoD ability (505 agility), aerobic (Yo-Yo Intermittent Recovery Test), lower-body strength (bilateral knee extensions) and power (countermovement jump [CMJ], squat jump [SJ], 30cm drop jump [DJ]) measures...
July 17, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28723098/a-new-area-in-main-group-chemistry-zerovalent-monoatomic-silicon-compounds-and-their-analogues
#14
Shenglai Yao, Yun Xiong, Matthias Driess
Monoatomic zerovalent main-group element complexes emerged very recently and attracted increasing attention of both theoretical and experimental chemists. In particular, zerovalent silicon complexes and their congeners (metallylones) stabilized by neutral Lewis donors are of significant importance not only because of their intriguing electronic structure but also because they can serve as useful building blocks for novel chemical species. Featuring four valence electrons as two lone pairs at the central atoms, such complexes may form donor-acceptor adducts with Lewis acids...
July 19, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28722787/synthesis-and-direct-sintering-of-nanosized-miv-miii-o2-x-hydrated-oxides-as-electrolyte-ceramics
#15
Nicolas Clavier, Yanis Cherkaski, Julien Martinez, Sophie Costis, Théo Cordara, Fabienne Audubert, Laurent Brissonneau, Nicolas Dacheux
Highly reactive and nanosized Th1-xYxO2-x/2 or Ce0.8Ln0.2O1.9 mixed oxides were prepared through the initial precipitation of hydroxide precursors which were further dried under vacuum. Whatever the chemical system investigated, the characterization of the powdered samples evidenced a rapid aging process leading to hydrated oxides. The thermal behavior of these samples was further investigated and first showed a two-step dehydration process, with the successive departure of adsorbed then constitutive water, both yielding a drastic drop of the powders reactivity (i...
July 19, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28722330/tunable-biogenic-manganese-oxides
#16
Alexandr Nikolaevich Simonov, Rosalie K Hocking, Lizhi Tao, Thomas Gengenbach, Timothy Williams, Xi-Ya Fang, Hannah J King, Shannon A Bonke, Dijon A Hoogeveen, Christine A Romano, Bradley M Tebo, Lisandra L Martin, William H Casey, Leone Spiccia
Influence of the conditions for aerobic oxidation of Mn2+(aq) catalysed by the MnxEFG protein complex on the morphology, structure and reactivity of the resulting biogenic manganese oxides (MnOx) is explored. Physical characterisation of MnOx includes scanning and transmission electron microscopies, X-ray photoelectron and K-edge Mn, Fe X-ray absorption spectroscopies. This characterisation reveals that the MnOx materials share the structural features of birnessite, yet differ in the degree of structural disorder...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28722230/alkoxides-of-trivacant-lacunary-polyoxometalates
#17
Takuo Minato, Kosuke Suzuki, Kazuya Yamaguchi, Noritaka Mizuno
Lacunary polyoxometalates (POMs) are useful rigid multidentate inorganic ligands to construct multinuclear metal oxo clusters and inorganic-organic hybrid materials. However, the use of multivacant lacunary POMs often suffers from their undesired condensation reactions at the highly reactive vacant sites. Herein, we report the introduction of alkoxy protecting groups into the vacant sites of lacunary POMs in organic media for the first time. By reacting organic solvent-soluble trivacant lacunary Keggin-type POMs with methanol, six methoxy groups were successfully introduced into the vacant sites, resulting in the formation of the alkoxides (Ix-OMe; X = Si, Ge)...
July 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28720601/a-case-of-progressive-orthopnoea-and-shoulder-pain-secondary-to-bilateral-diaphragmatic-paralysis
#18
Anna Herbert, Waseem Asrar Khan, Salem Madi
A 45-year-old man with a raised body mass index presented with an acute history of right lower chest pain and increasing breathlessness. C reactive protein, D dimer and cardiac echocardiography were negative, with mild bibasal atelectasis the only positive reported finding from erect chest X-ray and CT pulmonary angiogram. He was discharged with antibiotics for a chest infection. He remained severely breathless and was referred to the sleep-related breathing disorders clinic. He described shoulder pain, daytime tiredness and sleeping upright due to a ââ'¬Ëœsuffocatingââ'¬â"¢ sensation...
July 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28718972/enhancement-of-mtor-signaling-contributes-to-acquired-x-ray-and-c-ion-resistance-in-mouse-squamous-carcinoma-cell-line
#19
Katsutoshi Sato, Rikako Azuma, Takashi Imai, Takashi Shimokawa
Our aim was to evaluate whether repetition of C-ion (carbon ion beam) irradiation induces radioresistance as well as repeated X-ray irradiation in cancer cell lines, and to find the key molecular pathway for radioresistance by comparing radioresistant cancer cells with their parental cells. A mouse squamous cell carcinoma cell line, NR-S1, and radioresistant cancer cells, NR-S1-C30 (C30) and NR-S1-X60 (X60) established by repetition of C-ion and X-ray irradiation respectively, were used. X-ray and C-ion sensitivity, changes in lysosome, mitochondria, intracellular ATP and ROS (reactive oxygen species) level, and mTOR (mechanistic target of rapamycin) signaling were evaluated...
July 18, 2017: Cancer Science
https://www.readbyqxmd.com/read/28718286/functionalized-selenium-nanosystem-as-radiation-sensitizer-of-125i-seeds-for-precise-cancer-therapy
#20
Yahui Yang, Qiang Xie, Zhennan Zhao, Lizhen He, Leung Chan, Yingxiang Liu, Yongle Chen, Mingjun Bai, Tao Pan, Yanni Qu, Long Ling, Tianfeng Chen
Although radiotherapy has been extensively applied in cancer treatment, external beam radiation therapy is still difficult to avoid damage to adjacent normal tissues in the process of delivering a sufficient radiation dose to the tumor sites of patients. To overcome this limitation, chemoradiotherapy, as a combination of chemotherapy and radiotherapy of radioactive seed, has been proposed to decrease the damage for tumor surrounding tissues and enhance the radiosensitivity of solid tumors. In the study, we designed and synthesized folic acid-conjugated selenium nanoparticles (FA@SeNPs) as cancer-targeting agent, which could be synergistically enhanced by the radioactive 125I seeds to realize anticancer efficacy and inhibited colony formation ability...
July 18, 2017: ACS Applied Materials & Interfaces
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