keyword
https://read.qxmd.com/read/38520693/matrilin-3-supports-neuroprotection-in-ischemic-stroke-by-suppressing-astrocyte-mediated-neuroinflammation
#1
JOURNAL ARTICLE
Xianyong Zhou, Yongming Zhu, Defei Gao, Min Li, Liang Lin, Zhanxiang Wang, Huaping Du, Yuan Xu, Jin Liu, Yang He, Yi Guo, Shuai Wang, Shigang Qiao, Yingshi Bao, Yuan Liu, Huiling Zhang
In the brain, the role of matrilin-3, an extracellular matrix component in cartilage, is unknown. Here, we identify that matrilin-3 decreased in reactive astrocytes but was unchanged in neurons after ischemic stroke in animals. Importantly, it declined in serum of patients with acute ischemic stroke. Genetic or pharmacological inhibition or supplementation of matrilin-3 aggravates or reduces brain injury, astrocytic cell death, and glial scar, respectively, but has no direct effect on neuronal cell death. RNA sequencing demonstrates that Matn3-/- mice display an increased inflammatory response profile in the ischemic brain, including the nuclear factor κB (NF-κB) signaling pathway...
March 21, 2024: Cell Reports
https://read.qxmd.com/read/38423151/dysregulated-syvn1-promotes-cav1-protein-ubiquitination-and-accentuates-ischemic-stroke
#2
JOURNAL ARTICLE
Chunjie Gu, Yang Liu, Xiuli An, Gang Yin, Chenghe Sun
BACKGROUND: Stroke is a major cause of death and severe disability, and there remains a substantial need for the development of therapeutic agents for neuroprotection in acute ischemic stroke (IS) to protect the brain against damage before and during recanalization. Caveolin-1 (CAV1), an integrated protein that is located at the caveolar membrane, has been reported to exert neuroprotective effects during IS. Nevertheless, the mechanism remains largely unknown. Here, we explored the upstream modifiers of CAV1 in IS...
February 27, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38371456/extracellular-vesicles-maintain-blood-brain-barrier-integrity-by-the-suppression-of-caveolin-1-cd147-vegfr2-mmp-pathway-after-ischemic-stroke
#3
JOURNAL ARTICLE
Yiyang Li, Jiali Chen, Xingping Quan, Ying Chen, Yan Han, Jinfen Chen, Li Yang, Youhua Xu, Xu Shen, Ruibing Wang, Yonghua Zhao
BACKGROUND: Ischemic stroke (IS) causes tragic death and disability worldwide. However, effective therapeutic interventions are finite. After IS, blood-brain barrier (BBB) integrity is disrupted, resulting in deteriorating neurological function. As a novel therapeutic, extracellular vesicles (EVs) have shown ideal restorative effects on BBB integrity post-stroke; however, the definite mechanisms remain ambiguous. In the present study, we investigated the curative effects and the mechanisms of EVs derived from bone marrow mesenchymal stem cells and brain endothelial cells (BMSC-EVs and BEC-EVs) on BBB integrity after acute IS...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/37716034/escin-avoids-hemorrhagic-transformation-in-ischemic-stroke-by-protecting-bbb-through-the-ampk-cav-1-mmp-9-pathway
#4
JOURNAL ARTICLE
Xiaohui Sun, Zhaofeng Liu, Lin Zhou, Runchen Ma, Xiaofan Zhang, Tian Wang, Fenghua Fu, Yunjie Wang
BACKGROUND: Hemorrhagic transformation (HT) seriously affects the clinical application of recombinant tissue plasminogen activator (rt-PA). The main strategy for combating HT is to keep the blood-brain barrier (BBB) stable. Escin is the active ingredient of Aesculus hippocastanum and a natural mixture of triterpene saponins, and may play a part in mitigation of HT. PURPOSE: This study sought to investigate the effect of Escin in improving rt-PA-induced HT, explore possible mechanisms, and provide new ideas for the treatment of clinical HT...
September 9, 2023: Phytomedicine
https://read.qxmd.com/read/37598879/caveolin-1-aggravates-neurological-deficits-by-activating-neuroinflammation-following-experimental-intracerebral-hemorrhage-in-rats
#5
JOURNAL ARTICLE
Demao Cao, Bing Li, Cheng Cao, Juyi Zhang, Xiang Li, Haiying Li, Zhengquan Yu, Haitao Shen, Ming Ye
BACKGROUND: Intracerebral hemorrhage (ICH) is one of the stroke subtypes with the highest mortality. Secondary brain injury is associated with neurological dysfunction and poor prognosis after ICH. Caveolin-1 (CAV1) is the key protein of Caveolae. Previous studies have shown that CAV1 plays an important role in central nervous system diseases, and pointed out that in a collagenase-induced ICH model in vivo, CAV1 is associated with neuroinflammatory activation and poor neurological prognosis...
October 2023: Experimental Neurology
https://read.qxmd.com/read/37592190/factors-influencing-collateral-circulation-formation-after-indirect-revascularization-for-moyamoya-disease-a-narrative-review
#6
REVIEW
Gan Gao, Si-Meng Liu, Fang-Bin Hao, Qian-Nan Wang, Xiao-Peng Wang, Min-Jie Wang, Xiang-Yang Bao, Cong Han, Lian Duan
Indirect revascularization is one of the main techniques for the treatment of Moyamoya disease. The formation of good collateral circulation is a key measure to improve cerebral blood perfusion and reduce the risk of secondary stroke, and is the main method for evaluating the effect of indirect revascularization. Therefore, how to predict and promote the formation of collateral circulation before and after surgery is important for improving the success rate of indirect revascularization in Moyamoya disease...
August 17, 2023: Translational Stroke Research
https://read.qxmd.com/read/37349971/mir-199a-5p-enhances-neuronal-differentiation-of-neural-stem-cells-and-promotes-neurogenesis-by-targeting-cav-1-after-cerebral-ischemia
#7
JOURNAL ARTICLE
Hua-Qian Jin, Wei-Feng Jiang, Xin-Tian Zheng, Lin Li, Yan Fang, Yan Yang, Xiao-Wei Hu, Li-Sheng Chu
AIMS: MicroRNAs (miRs) are involved in endogenous neurogenesis, enhancing of which has been regarded as a potential therapeutic strategy for ischemic stroke treatment; however, whether miR-199a-5p mediates postischemic neurogenesis remains unclear. This study aims to investigate the proneurogenesis effects of miR-199a-5p and its possible mechanism after ischemic stroke. METHODS: Neural stem cells (NSCs) were transfected using Lipofectamine 3000 reagent, and the differentiation of NSCs was evaluated by immunofluorescence and Western blotting...
June 22, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/36855156/comparative-study-of-extracellular-vesicles-derived-from-mesenchymal-stem-cells-and-brain-endothelial-cells-attenuating-blood-brain-barrier-permeability-via-regulating-caveolin-1-dependent-zo-1-and-claudin-5-endocytosis-in-acute-ischemic-stroke
#8
JOURNAL ARTICLE
Yiyang Li, Bowen Liu, Tingting Zhao, Xingping Quan, Yan Han, Yaxin Cheng, Yanling Chen, Xu Shen, Ying Zheng, Yonghua Zhao
BACKGROUND: Blood-brain barrier (BBB) disruption is a major adverse event after ischemic stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB permeability after IS, while the pros and cons of Cav-1 on BBB permeability remain controversial. Numerous studies revealed that extracellular vesicles (EVs), especially stem cells derived EVs, exerted therapeutic efficacy on IS; however, the mechanisms of BBB permeability needed to be clearly illustrated. Herein, we compared the protective efficacy on BBB integrity between bone marrow mesenchymal stem cells derived extracellular vesicles (BMSC-EVs) and EVs from brain endothelial cells (BEC-EVs) after acute IS and investigated whether the mechanism was associated with EVs antagonizing Cav-1-dependent tight junction proteins endocytosis...
February 28, 2023: Journal of Nanobiotechnology
https://read.qxmd.com/read/36746844/the-prognostic-value-of-caveolin-1-levels-in-ischemic-stroke-patients-after-mechanical-thrombectomy
#9
JOURNAL ARTICLE
Qingguang Wang, Haiming Cao, Yan E, Siyu Wang, Shuaiyu Chen, Huiwen Lian, Meng Wang, Junshan Zhou, Yi Xie, Xiaohao Zhang
BACKGROUND AND PURPOSE: The impact of serum caveolin-1 (Cav-1) on clinical outcomes in patients after mechanical thrombectomy (MT) is unclear. We aimed to investigate the association between serum cav-1 levels and the 3-month functional outcome. METHODS: We prospectively enrolled and analyzed patients with an anterior circulation large vessel occlusion who underwent MT. Serum cav-1 concentrations were tested after admission. The primary outcome was a 90-day modified Rankin Scale score of 3-6...
February 6, 2023: Neurological Sciences
https://read.qxmd.com/read/36639607/treatment-of-ischemic-stroke-by-atorvastatin-loaded-pegylated-liposome
#10
JOURNAL ARTICLE
Reju George Thomas, Ja-Hae Kim, Ji-Hye Kim, Jungwon Yoon, Kang-Ho Choi, Yong-Yeon Jeong
There is insufficient evidence on the effect of nanoparticles, particularly liposomes loaded with a statin, on acute ischemic stroke. We investigated the impact of atorvastatin-loaded PEG (polyethylene glycol) conjugated liposomes (LipoStatin) on the outcomes in rats with cerebral ischemia-reperfusion. PEGylated liposome loaded with atorvastatin was developed as a nanoparticle to specifically accumulate in an ischemic region and release the drug to ameliorate the harmful effects of the stroke. LipoStatin was administered to rats with transient middle cerebral artery occlusion through the tail vein immediately after reperfusion (LipoStatin group)...
January 14, 2023: Translational Stroke Research
https://read.qxmd.com/read/36289917/expression-of-amyloid-precursor-protein-caveolin-1-alpha-beta-and-gamma-secretases-in-penumbra-cells-after-photothrombotic-stroke-and-evaluation-of-neuroprotective-effect-of-secretase-and-caveolin-1-inhibitors
#11
JOURNAL ARTICLE
Svetlana Sharifulina, Andrey Khaitin, Valeria Guzenko, Yuliya Kalyuzhnaya, Valentina Dzreyan, Alexandr Logvinov, Natalia Dobaeva, Yan Li, Lei Chen, Bin He, Svetlana Demyanenko
Our studies reveal changes in the expression of the main participants in the processing of amyloid precursor protein (APP) in neurons and astrocytes after photothrombotic stroke (PTS). Here we show the increase in the level of N- and C-terminal fragments of APP in the cytoplasm of ischemic penumbra cells at 24 h after PTS and their co-immunoprecipitation with caveolin-1. The ADAM10 α-secretase level decreased in the rat brain cortex on the first day after PTS. Levels of γ-secretase complex proteins presenilin-1 and nicastrin were increased in astrocytes, but not in neurons, in the penumbra after PTS...
October 20, 2022: Biomedicines
https://read.qxmd.com/read/36152520/endothelial-caveolin-1-regulates-cerebral-thrombo-inflammation-in-acute-ischemia-reperfusion-injury
#12
JOURNAL ARTICLE
Xiaohao Zhang, Pengyu Gong, Ying Zhao, Ting Wan, Kang Yuan, Yunyun Xiong, Min Wu, Mingming Zha, Yunzi Li, Teng Jiang, Xinfeng Liu, Ruidong Ye, Yi Xie, Gelin Xu
BACKGROUND: Thrombo-inflammation is an important checkpoint that orchestrates infarct development in ischemic stroke. However, the underlying mechanism remains largely unknown. Here, we explored the role of endothelial Caveolin-1 (Cav-1) in cerebral thrombo-inflammation. METHODS: The correlation between serum Cav-1 level and clinical outcome was analyzed in acute ischemic stroke patients with successful recanalization. Genetic manipulations by endothelial-specific adeno-associated virus (AAV) and siRNA were applied to investigate the effects of Cav-1 in thrombo-inflammation in a transient middle cerebral artery occlusion (tMCAO) model...
September 21, 2022: EBioMedicine
https://read.qxmd.com/read/35961528/treadmill-exercise-decreases-cerebral-edema-in-rats-with-local-cerebral-infarction-by-modulating-aqp4-polar-expression-through-the-caveolin-1-trpv4-signaling-pathway
#13
JOURNAL ARTICLE
Anqi Zhu, Yao Lin, Xuanbo Hu, Zaizai Lin, Yongqiang Lin, Qingfeng Xie, Shaobo Ni, Hui Cheng, Qiaoya Lu, Shanshan Lai, Guoyuan Pan, Xiang Chen, Wei Pang, Chan Liu
Rehabilitation therapy is beneficial for patients with ischemic stroke. Our previous study showed that treadmill training is conducive to neurological function in rats that underwent middle cerebral artery occlusion (MCAO). However, whether exercise benefits cerebral edema and the underlying mechanism remain unclear. This study investigated the influence of treadmill exercise on brain edema and the mechanism of its formation and elimination. The MCAO model was established with Sprague-Dawley (SD) rats, and lentivirus-mediated caveolin-1 shRNA was used to investigate the role of caveolin-1 in brain edema...
October 1, 2022: Brain Research Bulletin
https://read.qxmd.com/read/35615065/endothelial-%C3%AE-catenin-deficiency-causes-blood-brain-barrier-breakdown-via-enhancing-the-paracellular-and-transcellular-permeability
#14
JOURNAL ARTICLE
Basharat Hussain, Cheng Fang, Xiaowen Huang, Ziying Feng, Yuxuan Yao, Yu Wang, Junlei Chang
Disruption of the blood-brain barrier (BBB) causes or contributes to neuronal dysfunction and several central nervous system (CNS) disorders. Wnt/β-catenin signaling is essential for maintaining the integrity of the adult BBB in physiological and pathological conditions, including stroke. However, how the impairment of the endothelial Wnt/β-catenin signaling results in BBB breakdown remains unclear. Furthermore, the individual contributions of different BBB permeability-inducing mechanisms, including intercellular junction damage, endothelial transcytosis, and fenestration, remains unexplored...
2022: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/35557625/caveolin-1-promoted-collateral-vessel-formation-in-patients-with-moyamoya-disease
#15
JOURNAL ARTICLE
Jinbing Zhao, Zhiqiang Yu, Yanping Zhang, Cheng Qiu, Guangxu Zhang, Lijiu Chen, Shengxue He, Jun Ma
Background: Caveolin-1 (Cav-1) plays pivotal roles in the endothelial function and angiogenesis postischemia. Moyamoya disease (MMD) is characterized by progressive artery stenosis with unknown etiology. We aim to determine whether serum Cav-1 levels of patients with MMD were associated with collateral vessel formation after bypass surgery. Methods: We studied serum Cav-1 levels of 130 patients with MMD (16 with RNF213 p.R4810K mutation and 114 without RNF213 p...
2022: Frontiers in Neurology
https://read.qxmd.com/read/35350885/-caveolin-1-alleviates-diabetes-associated-cognitive-dysfunction-through-modulating-neuronal-ferroptosis-mediated-mitochondrial-homeostasis
#16
JOURNAL ARTICLE
Wenxin Tang, Yansong Li, Shuxuan He, Tao Jiang, Nan Wang, Mengyu Du, Bo Cheng, Wei Gao, Yan Li, Qiang Wang
Aims: Iron metabolism is involved in many biological processes in the brain. Alterations in iron homeostasis have been associated with several neurodegenerative disorders. Instead of stroke and ischemic heart disease, dementia has become the second leading cause of mortality among the type 2 diabetes mellitus (T2DM) population. Therefore, we attempted to investigate the role of ferroptosis in diabetes-associated cognitive dysfunction (DACD). Results: We evaluated ferroptosis hallmarks in the hippocampus of T2DM (high-fat diet/streptozotocin, HFD/STZ) mice, primary hippocampal neurons, as well as in the blood of patients...
November 2022: Antioxidants & Redox Signaling
https://read.qxmd.com/read/34984586/cav-1-protein-levels-in-serum-and-infarcted-brain-correlate-with-hemorrhagic-volume-in-a-mouse-model-of-thromboembolic-stroke-independently-of-rt-pa-administration
#17
JOURNAL ARTICLE
Carme Gubern-Mérida, Pau Comajoan, Gemma Huguet, Isaac García-Yebenes, Ignacio Lizasoain, María Angeles Moro, Irene Puig-Parnau, Juan Manuel Sánchez, Joaquín Serena, Elisabet Kádár, Mar Castellanos
Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for acute ischemic stroke. However, its administration is still limited due to the associated increased risk of hemorrhagic transformation (HT). rt-PA may exacerbate blood-brain barrier (BBB) injury by several mechanisms that have not been fully elucidated. Caveolin-1 (Cav-1), a major structural protein of caveolae, has been linked to the endothelial barrier function. The effects of rt-PA on Cav-1 expression remain largely unknown...
January 5, 2022: Molecular Neurobiology
https://read.qxmd.com/read/34569521/biomarkers-in-the-prediction-of-hemorrhagic-transformation-in-acute-stroke-a-systematic-review-and-meta-analysis
#18
Soumya Krishnamoorthy, Gurpreet Singh, Jithu Jose K, Biju Soman, Christian Foerch, W Taylor Kimberly, Mónica Millán, Milena Świtońska, Ilaria Maestrini, Régis Bordet, Konark Malhotra, Laura Mechtouff, P N Sylaja
BACKGROUND: Hemorrhagic transformation (HT) is a complication that occurs spontaneously or after thrombolysis in acute ischemic stroke (AIS) and can increase morbidity and mortality. The association of biomarkers with the risk of HT has been variably reported. We conducted a systematic review of the literature and meta-analysis and sought to compare blood biomarkers associated with HT and its subtypes by evaluating its predictability and correlation with outcome in AIS. METHODS: The study protocol was registered in the PROSPERO database (CRD42020201334) and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2022: Cerebrovascular Diseases
https://read.qxmd.com/read/34381413/rnf213-and-gucy1a3-in-moyamoya-disease-key-regulators-of-metabolism-inflammation-and-vascular-stability
#19
REVIEW
Yohei Mineharu, Susumu Miyamoto
Moyamoya disease is an idiopathic chronically progressive cerebrovascular disease, which causes both ischemic and hemorrhagic stroke. Genetic studies identified RNF213 / Mysterin and GUCY1A3 as disease-causing genes. They were also known to be associated with non-moyamoya intracranial large artery disease, coronary artery disease and pulmonary artery hypertension. This review focused on these two molecules and their strong linker, calcineurin/NFAT signaling and caveolin to understand the pathophysiology of moyamoya disease and related vascular diseases...
2021: Frontiers in Neurology
https://read.qxmd.com/read/34344565/notoginsenoside-r1-intervenes-degradation-and-redistribution-of-tight-junctions-to-ameliorate-blood-brain-barrier-permeability-by-caveolin-1-mmp2-9-pathway-after-acute-ischemic-stroke
#20
JOURNAL ARTICLE
Bowen Liu, Yiyang Li, Yan Han, Shengpeng Wang, Hua Yang, Yonghua Zhao, Ping Li, Yitao Wang
BACKGROUND: The leakage of blood-brain barrier (BBB) is main pathophysiological change in acute stage of ischemic stroke, which not only deteriorates neurological function, but also increases the risk of hemorrhagic transformation after thrombolysis. PURPOSE/STUDY DESIGN: This article investigates the efficacy of Notoginsenoside R1, an active ingredient of Panax notoginseng, on BBB permeability and explores related mechanisms after acute ischemic stroke. METHODS: In vivo, male Sprague-Dawley rats (260-280 g) were selected and randomly divided into 6 groups: sham group, model group, low, middle and high doses of Notoginsenoside R1 groups and positive drug Dl-3-n-Butylphthalide group...
September 2021: Phytomedicine
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