Alexandre M Sorlin, Marina López-Álvarez, Jacob Biboy, Joe Gray, Sarah J Rabbitt, Junaid Ur Rahim, Sang Hee Lee, Kondapa Naidu Bobba, Joseph Blecha, Mathew F L Parker, Robert R Flavell, Joanne Engel, Michael Ohliger, Waldemar Vollmer, David M Wilson
Imaging is increasingly used to detect and monitor bacterial infection. Both anatomic (X-rays, computed tomography, ultrasound, and MRI) and nuclear medicine ([111 In]-WBC SPECT, [18 F]FDG PET) techniques are used in clinical practice but lack specificity for the causative microorganisms themselves. To meet this challenge, many groups have developed imaging methods that target pathogen-specific metabolism, including PET tracers integrated into the bacterial cell wall. We have previously reported the d-amino acid derived PET radiotracers d-methyl-[11 C]-methionine, d-[3-11 C]-alanine, and d-[3-11 C]-alanine-d-alanine, which showed robust bacterial accumulation in vitro and in vivo ...
March 25, 2024: JACS Au